LOCUS       NM_001006960            1382 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus mitochondrial fission process 1 (Mtfp1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001006960 XM_214075
VERSION     NM_001006960.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1382)
  AUTHORS   Kreymerman,A., Buickians,D.N., Nahmou,M.M., Tran,T., Galvao,J.,
            Wang,Y., Sun,N., Bazik,L., Huynh,S.K., Cho,I.J., Boczek,T.,
            Chang,K.C., Kunzevitzky,N.J. and Goldberg,J.L.
  TITLE     MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron
            Development, Axonal Growth, and Injury Responses
  JOURNAL   Sci Rep 9 (1), 10669 (2019)
   PUBMED   31337818
  REMARK    GeneRIF: MTP18 is a Novel Regulator of Mitochondrial Fission in CNS
            Neuron Development, Axonal Growth, and Injury Responses.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1382)
  AUTHORS   Aung,L.H.H., Li,Y.Z., Yu,H., Chen,X., Yu,Z., Gao,J. and Li,P.
  TITLE     Mitochondrial protein 18 is a positive apoptotic regulator in
            cardiomyocytes under oxidative stress
  JOURNAL   Clin Sci (Lond) 133 (9), 1067-1084 (2019)
   PUBMED   31015359
  REMARK    GeneRIF: suggesting that Mtp18 and Drp1 are interdependent in
            apoptotic cascade
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1382)
  AUTHORS   Wei,Q., Sun,H., Song,S., Liu,Y., Liu,P., Livingston,M.J., Wang,J.,
            Liang,M., Mi,Q.S., Huo,Y., Nahman,N.S., Mei,C. and Dong,Z.
  TITLE     MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in
            ischemic acute kidney injury
  JOURNAL   J Clin Invest 128 (12), 5448-5464 (2018)
   PUBMED   30325740
REFERENCE   5  (bases 1 to 1382)
  AUTHORS   Sollanek,K.J., Burniston,J.G., Kavazis,A.N., Morton,A.B.,
            Wiggs,M.P., Ahn,B., Smuder,A.J. and Powers,S.K.
  TITLE     Global Proteome Changes in the Rat Diaphragm Induced by Endurance
            Exercise Training
  JOURNAL   PLoS One 12 (1), e0171007 (2017)
   PUBMED   28135290
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1382)
  AUTHORS   da Silva,A.F., Mariotti,F.R., Maximo,V. and Campello,S.
  TITLE     Mitochondria dynamism: of shape, transport and cell migration
  JOURNAL   Cell Mol Life Sci 71 (12), 2313-2324 (2014)
   PUBMED   24442478
  REMARK    Review article
REFERENCE   7  (bases 1 to 1382)
  AUTHORS   Palmer,C.S., Osellame,L.D., Stojanovski,D. and Ryan,M.T.
  TITLE     The regulation of mitochondrial morphology: intricate mechanisms
            and dynamic machinery
  JOURNAL   Cell Signal 23 (10), 1534-1545 (2011)
   PUBMED   21683788
  REMARK    Review article
REFERENCE   8  (bases 1 to 1382)
  AUTHORS   Gispert,S., Ricciardi,F., Kurz,A., Azizov,M., Hoepken,H.H.,
            Becker,D., Voos,W., Leuner,K., Muller,W.E., Kudin,A.P., Kunz,W.S.,
            Zimmermann,A., Roeper,J., Wenzel,D., Jendrach,M.,
            Garcia-Arencibia,M., Fernandez-Ruiz,J., Huber,L., Rohrer,H.,
            Barrera,M., Reichert,A.S., Rub,U., Chen,A., Nussbaum,R.L. and
            Auburger,G.
  TITLE     Parkinson phenotype in aged PINK1-deficient mice is accompanied by
            progressive mitochondrial dysfunction in absence of
            neurodegeneration
  JOURNAL   PLoS One 4 (6), e5777 (2009)
   PUBMED   19492057
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1382)
  AUTHORS   Tondera,D., Czauderna,F., Paulick,K., Schwarzer,R., Kaufmann,J. and
            Santel,A.
  TITLE     The mitochondrial protein MTP18 contributes to mitochondrial
            fission in mammalian cells
  JOURNAL   J Cell Sci 118 (Pt 14), 3049-3059 (2005)
   PUBMED   15985469
REFERENCE   10 (bases 1 to 1382)
  AUTHORS   Tondera,D., Santel,A., Schwarzer,R., Dames,S., Giese,K., Klippel,A.
            and Kaufmann,J.
  TITLE     Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent
            protein, affects mitochondrial morphology and induces apoptosis
  JOURNAL   J Biol Chem 279 (30), 31544-31555 (2004)
   PUBMED   15155745
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083713.1.
            
            On Nov 22, 2004 this sequence version replaced XM_214075.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083713.1, EV769864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1382
                     /gene="Mtfp1"
                     /gene_synonym="Mtp18"
                     /note="mitochondrial fission process 1"
                     /db_xref="GeneID:289745"
                     /db_xref="RGD:1359705"
     exon            1..192
                     /gene="Mtfp1"
                     /gene_synonym="Mtp18"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..626
                     /gene="Mtfp1"
                     /gene_synonym="Mtp18"
                     /note="mitochondrial protein 18 kDa; mitochondrial 18 kDa
                     protein"
                     /codon_start=1
                     /product="mitochondrial fission process protein 1"
                     /protein_id="NP_001006961.1"
                     /db_xref="GeneID:289745"
                     /db_xref="RGD:1359705"
                     /translation="MSEQQRQSTERDLYRDTWVRYLGYANEVGEAFRSLVPKAVVWLS
                     YGVSSSYVLADAIDKGKKAGEVPSPEAGRSTRMALAVVDTFVWQSLASVAIPGFTINR
                     LCAASLYVLGTMTRWPLNVRKWTTTTLGLLAIPVIVHPIDRSVDFLLDSSLRKLYPSV
                     GKPSTP"
     exon            193..320
                     /gene="Mtfp1"
                     /gene_synonym="Mtp18"
                     /inference="alignment:Splign:2.1.0"
     exon            321..553
                     /gene="Mtfp1"
                     /gene_synonym="Mtp18"
                     /inference="alignment:Splign:2.1.0"
     exon            554..1354
                     /gene="Mtfp1"
                     /gene_synonym="Mtp18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggacctg tccttcagtc tcggactact ggcgggttct tgcctagtgt tagccaagtg
       61 ctagtggaga caagagttgt ggtgagactc taatctgcag tgactcctac cgtgcccggg
      121 aagtcatgtc ggagcagcag cggcagagca ccgagcgcga cctctaccgg gacacgtggg
      181 tgcgctacct gggctacgcc aatgaagtgg gggaggcttt ccgctccctg gttcctaaag
      241 ctgtggtgtg gttgagctat ggcgtgtcca gctcctatgt cttggccgat gccatagaca
      301 aaggcaagaa ggcaggagag gtgccaagcc ctgaagcagg ccgcagtacc agaatggccc
      361 tggctgtggt agataccttc gtgtggcagt ctctggcctc tgtggccatt ccgggcttca
      421 ccatcaaccg tctgtgtgct gcctctctct atgtcttggg tactatgacc cgctggcccc
      481 tgaatgtccg caaatggacc accaccacac ttgggctgct ggccatccct gtcattgtcc
      541 accccattga caggtcggta gacttcctcc tggactccag cctgcgcaag ctgtacccgt
      601 cagtggggaa gcccagcacc ccctgaccct gtcctgtgcc ctgcccgggg ttgacccact
      661 cacatcaaag aacatggcta cgtggctctt tggggtccat ggtgctgtca tctgaacata
      721 gagatgaagg ccctgaggag tagtgggcag tgagtcccag ggttggaacc caaccttgtc
      781 tgcattagtg gccatggctg tgctgagtgg gaacgaacac tggctagcct gtcttttgaa
      841 atcttttttt aaaagtattt attttgtgtg tataagtgtt ttacttgcat gtatgtatgt
      901 tcaccaccct tagaggttaa aagaggcgat tagatctccc tgaaactgga ggtagggatg
      961 gttgtgagcc accatgtggg tgctgagaac tgaatctggt tcctctgcag gagcagccag
     1021 tgctctaacc actaaagtac ctcttagcct ctgggcctat cttctgatgg aaaagttata
     1081 ccctcctgtg gaggagaagg ttattaaggc ccagagaggg cagggaatac tcctgagatc
     1141 acatgacaag tgaggaccag gcttctagct attctaagtc actttgtgat gatgtggctg
     1201 agtaacttag ggaaagatac agaggtacag catttgggac actcagggca gagtctctgg
     1261 ccagcccatc cctgctgcag gagctgctgg ggcctggtcg agaggcagga caatcacaaa
     1321 ccaagtgcta acctaataaa actttcaaaa atggaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aa
//
