LOCUS       NM_001100898            2575 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus metal response element binding transcription
            factor 2 (Mtf2), mRNA.
ACCESSION   NM_001100898 XM_001056894 XM_341180
VERSION     NM_001100898.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2575)
  AUTHORS   Herz HM, Garruss A and Shilatifard A.
  TITLE     SET for life: biochemical activities and biological functions of
            SET domain-containing proteins
  JOURNAL   Trends Biochem Sci 38 (12), 621-639 (2013)
   PUBMED   24148750
  REMARK    Review article
REFERENCE   2  (bases 1 to 2575)
  AUTHORS   Simon JA and Kingston RE.
  TITLE     Occupying chromatin: Polycomb mechanisms for getting to genomic
            targets, stopping transcriptional traffic, and staying put
  JOURNAL   Mol Cell 49 (5), 808-824 (2013)
   PUBMED   23473600
  REMARK    Review article
REFERENCE   3  (bases 1 to 2575)
  AUTHORS   Musselman CA, Avvakumov N, Watanabe R, Abraham CG, Lalonde ME, Hong
            Z, Allen C, Roy S, Nunez JK, Nickoloff J, Kulesza CA, Yasui A, Cote
            J and Kutateladze TG.
  TITLE     Molecular basis for H3K36me3 recognition by the Tudor domain of
            PHF1
  JOURNAL   Nat Struct Mol Biol 19 (12), 1266-1272 (2012)
   PUBMED   23142980
REFERENCE   4  (bases 1 to 2575)
  AUTHORS   Ballare C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G,
            Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA and Di
            Croce L.
  TITLE     Phf19 links methylated Lys36 of histone H3 to regulation of
            Polycomb activity
  JOURNAL   Nat Struct Mol Biol 19 (12), 1257-1265 (2012)
   PUBMED   23104054
REFERENCE   5  (bases 1 to 2575)
  AUTHORS   Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J,
            Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T,
            Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N and Koseki
            H.
  TITLE     Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component
            of PRC2 that can differentially modulate polycomb activity both at
            the Hox gene cluster and at Cdkn2a genes
  JOURNAL   Mol Cell Biol 31 (2), 351-364 (2011)
   PUBMED   21059868
  REMARK    Erratum:[Mol Cell Biol. 2014 Jul;34(14):2773]
REFERENCE   6  (bases 1 to 2575)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 2575)
  AUTHORS   Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J,
            Krogan NJ, Reiter JF and Stanford WL.
  TITLE     Polycomb-like 2 associates with PRC2 and regulates transcriptional
            networks during mouse embryonic stem cell self-renewal and
            differentiation
  JOURNAL   Cell Stem Cell 6 (2), 153-166 (2010)
   PUBMED   20144788
REFERENCE   8  (bases 1 to 2575)
  AUTHORS   Mididoddi S, McGuirt JP, Sens MA, Todd JH and Sens DA.
  TITLE     Isoform-specific expression of metallothionein mRNA in the
            developing and adult human kidney
  JOURNAL   Toxicol Lett 85 (1), 17-27 (1996)
   PUBMED   8619255
REFERENCE   9  (bases 1 to 2575)
  AUTHORS   Inouye C, Remondelli P, Karin M and Elledge S.
  TITLE     Isolation of a cDNA encoding a metal response element binding
            protein using a novel expression cloning procedure: the one hybrid
            system
  JOURNAL   DNA Cell Biol 13 (7), 731-742 (1994)
   PUBMED   7772254
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EV774388.1,
            BC093403.1 and BC160928.1.
            
            On or before Nov 23, 2008 this sequence version replaced
            XM_001056894.1, XM_341180.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101925.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                EV774388.1         36-75
            41-1421             BC093403.1         1-1381
            1422-2575           BC160928.1         991-2144
FEATURES             Location/Qualifiers
     source          1..2575
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2575
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /note="metal response element binding transcription factor
                     2"
                     /db_xref="GeneID:360905"
                     /db_xref="RGD:1304727"
     exon            1..238
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..2015
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /codon_start=1
                     /product="metal-response element-binding transcription
                     factor 2"
                     /protein_id="NP_001094368.1"
                     /db_xref="GeneID:360905"
                     /db_xref="RGD:1304727"
                     /translation="MRDSTGAGNSLVHKRSPSRRNQKTSASLNKLSLQDGHKAKKPAC
                     KFEEGQDVLARWSDGLFYLGTIKKINILKQSCFITFEDSSKSWVLWKDIQTGATGSGE
                     MVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQCVFATTT
                     KRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQ
                     CCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYN
                     LSVIHKKKYFDSELELMTYINDNWDRLHPGELADTPKSERYEHVLEALNDYKTMFMSG
                     KEIKKKKHLFGLRIRVPPVPPNVAFKAEKEPEGTSHEFKIKGRKASKPTSDSREVSNG
                     IEKKGKKKSVGRPPGPYTRKMIQKTAEPPLGKESVSENPALDLPCSIGRTEGVAHSSN
                     TSDVDLTGASSAKETTSSSIPRHYGLSDSRKRTRTGRSWPASIPHLRRRRGRLPRRAL
                     HTQNSEVVKDDEGKEDYQFEELNTEILNNLADQELQLNHLKNSITSYFGAAGRIACGE
                     KYRVLARRVTLDGKVQYLVEWEGATAS"
     exon            239..437
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            438..519
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            520..615
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            616..716
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            717..865
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            866..961
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1030
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1154
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1222
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1393
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1499
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1552
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1657
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..2549
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaatggcg aagggctgta gcgaagtggt ctgtgtttga ggccggtgtg agaacgcata
       61 ttctcctccc caatcctcgt ccccaaggaa ttcagtgcgt gtgtgtgcgt gagcgcaggg
      121 ttcccgctgg ggcgggtgcc cagtgagtgc ccggactcgc ggggaagcgc ccacgggaac
      181 gtgattgctt ctattttcct gtatgaagcg gttggcacca cttaagtgac cgaatgagag
      241 actctacagg agcaggtaat tcactggtcc acaagcggtc tccttcacgt cgaaaccaaa
      301 agacctcagc atccttgaac aagctgtctt tacaggatgg acataaagcc aaaaaaccag
      361 catgtaaatt tgaagagggt caagatgtct tagctagatg gtcagatggc ttgttttatc
      421 ttggaactat caaaaagata aacattttga aacagagctg cttcatcaca tttgaggaca
      481 gttctaagtc ctgggttctc tggaaggaca tccaaacagg agccactggg agtggggaaa
      541 tggtctgtac aatatgtcaa gaagagtatt cagaagcacc taatgaaatg gttatctgtg
      601 ataagtgcgg tcaaggatat catcagctgt gtcatacgcc tcatattgac tcgagtgtga
      661 tcgattcaga tgaaaagtgg ctttgtcgac agtgcgtttt tgcaacaaca acaaagaggg
      721 gtggtgcact taagaaagga ccaaatgcca aagcactgca agtcatgaag cagacattac
      781 cctatagcgt ggctgacctt gaatgggatg caggtcataa aaccaacgtt cagcagtgct
      841 actgctactg tggaggccct ggagactggt atttaaagat gctgcagtgc tgcaaatgta
      901 agcagtggtt tcatgaggct tgtgtccaat gccttcaaaa gccaatgctg tttggagata
      961 ggttttatac atttatttgc tctgtctgca gttctggacc agaatacctc aaacgtctac
     1021 cattacagtg ggtagatata gcacacctat gcctttacaa cctaagtgtt attcacaaga
     1081 agaagtactt tgactctgaa cttgagctta tgacatacat taatgacaac tgggacagat
     1141 tgcaccctgg agagctggca gacacgccca aatctgaaag atatgagcat gttctggagg
     1201 cattaaatga ttacaagacc atgtttatgt ctgggaaaga aataaagaag aagaagcatt
     1261 tgtttgggtt gcgaattcgt gttcctcctg tgccaccaaa tgtggctttc aaagcagaga
     1321 aagaacctga aggaacatcc catgaattta aaattaaagg cagaaaggca tccaaaccta
     1381 catctgactc cagggaagta agcaatggga tagaaaaaaa aggaaagaaa aaatctgtag
     1441 gtcgtcctcc tggcccatat acaagaaaaa tgattcagaa aactgctgag ccgcctttgg
     1501 gtaaggaatc agtttcagag aatcctgcgt tggatttacc ttgttctata gggagaactg
     1561 agggagttgc acattcatcc aatacctcag atgtggacct cacgggtgct tccagtgcaa
     1621 aagaaactac ctcgtctagc attcccaggc attatgggtt atctgactct agaaaaagaa
     1681 ctcgcacggg aagatcgtgg cctgcttcaa taccacattt gcggagaaga agaggtcgcc
     1741 ttccacgaag agcactccat actcagaact cagaagttgt aaaagatgat gaaggcaaag
     1801 aagattacca gtttgaagaa cttaacacag aaatcctgaa taacttagca gatcaggagt
     1861 tacagctcaa tcacctgaaa aactccatca ctagttattt tggtgccgca ggtagaatag
     1921 catgtggaga gaaataccgg gttctggctc gccgcgtgac gctggatgga aaggtgcagt
     1981 atctcgtgga gtgggaagga gcgactgcat cctgactgta ggactaagcc ttgtgttcac
     2041 tgcctcgtgc tctgttggta cagttcaaaa aaggtgtggg cttcattatc tttcttagaa
     2101 aaacaaacag aaaacacaaa aatactcaca agaggagagg atactggcct taacatgtac
     2161 ttgtcaatgt tacggatatt gtcataaaaa gatatctttt aaaaatcaga ggagagactt
     2221 aattttttta aatcttaaga tttgtagact gtttctagga taggatatta aacatgattc
     2281 aaacccatgc atggtgttag atacttttta taattattcc attgagtcaa tttttgtgat
     2341 tagtggttat cagagcaaac agatcatgta gatagcacaa gtatttggag aaacattgtg
     2401 tgttttgtta ccaaaatgtt ggaaagattt atttcaatac ccttttagat ttcataaagt
     2461 acagtgtata taatgtctac tgaaagactg taaaatattg aaatttcttt caagcaaaat
     2521 gtaaaaaata tattgagcct gtaaattgca aaaaaaaaaa aaaaaaaaaa aaaaa
//
