LOCUS       NP_001094368             593 aa            linear   ROD 26-FEB-2024
DEFINITION  metal-response element-binding transcription factor 2 [Rattus
            norvegicus].
ACCESSION   NP_001094368 XP_001056894 XP_341181
VERSION     NP_001094368.1
DBSOURCE    REFSEQ: accession NM_001100898.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 593)
  AUTHORS   Herz HM, Garruss A and Shilatifard A.
  TITLE     SET for life: biochemical activities and biological functions of
            SET domain-containing proteins
  JOURNAL   Trends Biochem Sci 38 (12), 621-639 (2013)
   PUBMED   24148750
  REMARK    Review article
REFERENCE   2  (residues 1 to 593)
  AUTHORS   Simon JA and Kingston RE.
  TITLE     Occupying chromatin: Polycomb mechanisms for getting to genomic
            targets, stopping transcriptional traffic, and staying put
  JOURNAL   Mol Cell 49 (5), 808-824 (2013)
   PUBMED   23473600
  REMARK    Review article
REFERENCE   3  (residues 1 to 593)
  AUTHORS   Musselman CA, Avvakumov N, Watanabe R, Abraham CG, Lalonde ME, Hong
            Z, Allen C, Roy S, Nunez JK, Nickoloff J, Kulesza CA, Yasui A, Cote
            J and Kutateladze TG.
  TITLE     Molecular basis for H3K36me3 recognition by the Tudor domain of
            PHF1
  JOURNAL   Nat Struct Mol Biol 19 (12), 1266-1272 (2012)
   PUBMED   23142980
REFERENCE   4  (residues 1 to 593)
  AUTHORS   Ballare C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G,
            Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA and Di
            Croce L.
  TITLE     Phf19 links methylated Lys36 of histone H3 to regulation of
            Polycomb activity
  JOURNAL   Nat Struct Mol Biol 19 (12), 1257-1265 (2012)
   PUBMED   23104054
REFERENCE   5  (residues 1 to 593)
  AUTHORS   Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J,
            Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T,
            Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N and Koseki
            H.
  TITLE     Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component
            of PRC2 that can differentially modulate polycomb activity both at
            the Hox gene cluster and at Cdkn2a genes
  JOURNAL   Mol Cell Biol 31 (2), 351-364 (2011)
   PUBMED   21059868
  REMARK    Erratum:[Mol Cell Biol. 2014 Jul;34(14):2773]
REFERENCE   6  (residues 1 to 593)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (residues 1 to 593)
  AUTHORS   Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J,
            Krogan NJ, Reiter JF and Stanford WL.
  TITLE     Polycomb-like 2 associates with PRC2 and regulates transcriptional
            networks during mouse embryonic stem cell self-renewal and
            differentiation
  JOURNAL   Cell Stem Cell 6 (2), 153-166 (2010)
   PUBMED   20144788
REFERENCE   8  (residues 1 to 593)
  AUTHORS   Mididoddi S, McGuirt JP, Sens MA, Todd JH and Sens DA.
  TITLE     Isoform-specific expression of metallothionein mRNA in the
            developing and adult human kidney
  JOURNAL   Toxicol Lett 85 (1), 17-27 (1996)
   PUBMED   8619255
REFERENCE   9  (residues 1 to 593)
  AUTHORS   Inouye C, Remondelli P, Karin M and Elledge S.
  TITLE     Isolation of a cDNA encoding a metal response element binding
            protein using a novel expression cloning procedure: the one hybrid
            system
  JOURNAL   DNA Cell Biol 13 (7), 731-742 (1994)
   PUBMED   7772254
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EV774388.1,
            BC093403.1 and BC160928.1.
            
            On or before Nov 23, 2008 this sequence version replaced
            XP_001056894.1, XP_341181.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101925.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..593
                     /product="metal-response element-binding transcription
                     factor 2"
                     /calculated_mol_wt=66748
     Region          45..98
                     /region_name="Tudor_MTF2"
                     /note="Tudor domain found in metal-response
                     element-binding transcription factor 2 (MTF2) and similar
                     proteins; cd20450"
                     /db_xref="CDD:410521"
     Site            order(56,60..62,80..82,84)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410521"
     Region          104..156
                     /region_name="PHD1_MTF2"
                     /note="PHD finger 1 found in metal-response
                     element-binding transcription factor 2 (MTF2); cd15578"
                     /db_xref="CDD:277053"
     Site            order(104,118..122,126,149)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277053"
     Region          203..254
                     /region_name="PHD2_MTF2"
                     /note="PHD finger 2 found in metal-response
                     element-binding transcription factor 2 (MTF2); cd15580"
                     /db_xref="CDD:277055"
     Site            order(203,215..219,223,247)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277055"
     Region          544..591
                     /region_name="Mtf2_C"
                     /note="Polycomb-like MTF2 factor 2; pfam14061"
                     /db_xref="CDD:464077"
     CDS             1..593
                     /gene="Mtf2"
                     /gene_synonym="RGD1304727"
                     /coded_by="NM_001100898.1:234..2015"
                     /db_xref="GeneID:360905"
                     /db_xref="RGD:1304727"
ORIGIN      
        1 mrdstgagns lvhkrspsrr nqktsaslnk lslqdghkak kpackfeegq dvlarwsdgl
       61 fylgtikkin ilkqscfitf edsskswvlw kdiqtgatgs gemvcticqe eyseapnemv
      121 icdkcgqgyh qlchtphids svidsdekwl crqcvfattt krggalkkgp nakalqvmkq
      181 tlpysvadle wdaghktnvq qcycycggpg dwylkmlqcc kckqwfheac vqclqkpmlf
      241 gdrfytfics vcssgpeylk rlplqwvdia hlclynlsvi hkkkyfdsel elmtyindnw
      301 drlhpgelad tpkseryehv lealndyktm fmsgkeikkk khlfglrirv ppvppnvafk
      361 aekepegtsh efkikgrkas kptsdsrevs ngiekkgkkk svgrppgpyt rkmiqktaep
      421 plgkesvsen paldlpcsig rtegvahssn tsdvdltgas sakettsssi prhyglsdsr
      481 krtrtgrswp asiphlrrrr grlprralht qnsevvkdde gkedyqfeel nteilnnlad
      541 qelqlnhlkn sitsyfgaag riacgekyrv larrvtldgk vqylvewega tas
//
