LOCUS       NM_001108677            5300 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus metal-regulatory transcription factor 1 (Mtf1),
            mRNA.
ACCESSION   NM_001108677 XM_001055855 XM_342910
VERSION     NM_001108677.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5300)
  AUTHORS   Valsecchi V, Laudati G, Cuomo O, Sirabella R, Annunziato L and
            Pignataro G.
  TITLE     The hypoxia sensitive metal transcription factor MTF-1 activates
            NCX1 brain promoter and participates in remote postconditioning
            neuroprotection in stroke
  JOURNAL   Cell Death Dis 12 (5), 423 (2021)
   PUBMED   33931586
  REMARK    GeneRIF: The hypoxia sensitive metal transcription factor MTF-1
            activates NCX1 brain promoter and participates in remote
            postconditioning neuroprotection in stroke.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5300)
  AUTHORS   Kim JH, Jeon J, Shin M, Won Y, Lee M, Kwak JS, Lee G, Rhee J, Ryu
            JH, Chun CH and Chun JS.
  TITLE     Regulation of the catabolic cascade in osteoarthritis by the
            zinc-ZIP8-MTF1 axis
  JOURNAL   Cell 156 (4), 730-743 (2014)
   PUBMED   24529376
REFERENCE   3  (bases 1 to 5300)
  AUTHORS   Chowanadisai W, Graham DM, Keen CL, Rucker RB and Messerli MA.
  TITLE     Neurulation and neurite extension require the zinc transporter
            ZIP12 (slc39a12)
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9903-9908 (2013)
   PUBMED   23716681
REFERENCE   4  (bases 1 to 5300)
  AUTHORS   Kimura T, Li Y, Okumura F, Itoh N, Nakanishi T, Sone T, Isobe M and
            Andrews GK.
  TITLE     Chromium(VI) inhibits mouse metallothionein-I gene transcription by
            preventing the zinc-dependent formation of an MTF-1-p300 complex
  JOURNAL   Biochem J 415 (3), 477-482 (2008)
   PUBMED   18605988
REFERENCE   5  (bases 1 to 5300)
  AUTHORS   Starzynski RR, Goncalves AS, Muzeau F, Tyrolczyk Z, Smuda E,
            Drapier JC, Beaumont C and Lipinski P.
  TITLE     STAT5 proteins are involved in down-regulation of iron regulatory
            protein 1 gene expression by nitric oxide
  JOURNAL   Biochem J 400 (2), 367-375 (2006)
   PUBMED   16886906
REFERENCE   6  (bases 1 to 5300)
  AUTHORS   Joshi B, Ordonez-Ercan D, Dasgupta P and Chellappan S.
  TITLE     Induction of human metallothionein 1G promoter by VEGF and heavy
            metals: differential involvement of E2F and metal transcription
            factors
  JOURNAL   Oncogene 24 (13), 2204-2217 (2005)
   PUBMED   15735762
REFERENCE   7  (bases 1 to 5300)
  AUTHORS   Langmade SJ, Ravindra R, Daniels PJ and Andrews GK.
  TITLE     The transcription factor MTF-1 mediates metal regulation of the
            mouse ZnT1 gene
  JOURNAL   J Biol Chem 275 (44), 34803-34809 (2000)
   PUBMED   10952993
REFERENCE   8  (bases 1 to 5300)
  AUTHORS   Koza RA, Hohmann SM, Guerra C, Rossmeisl M and Kozak LP.
  TITLE     Synergistic gene interactions control the induction of the
            mitochondrial uncoupling protein (Ucp1) gene in white fat tissue
  JOURNAL   J Biol Chem 275 (44), 34486-34492 (2000)
   PUBMED   10931824
REFERENCE   9  (bases 1 to 5300)
  AUTHORS   Gunes C, Heuchel R, Georgiev O, Muller KH, Lichtlen P, Bluthmann H,
            Marino S, Aguzzi A and Schaffner W.
  TITLE     Embryonic lethality and liver degeneration in mice lacking the
            metal-responsive transcriptional activator MTF-1
  JOURNAL   EMBO J 17 (10), 2846-2854 (1998)
   PUBMED   9582278
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342910.3, XM_001055855.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132282,
                              SAMD00132292 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5300
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5300
                     /gene="Mtf1"
                     /note="metal-regulatory transcription factor 1"
                     /db_xref="GeneID:362591"
                     /db_xref="RGD:1308956"
     exon            1..85
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..541
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2164
                     /gene="Mtf1"
                     /note="metal response element binding transcription factor
                     1; metal regulatory transcription factor 1-like"
                     /codon_start=1
                     /product="metal regulatory transcription factor 1"
                     /protein_id="NP_001102147.1"
                     /db_xref="GeneID:362591"
                     /db_xref="RGD:1308956"
                     /translation="MGEHSPDDNIIFFKGEEDDLTPHDKMLRFVDDNGLVPSSSGTVY
                     DRTTVLIEQDPGTLEDDEDDVQCGEHLPFLVEGEEGFLIDQEAMSQGYVQHIISPDQI
                     HLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQ
                     KTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKA
                     HQRLHTGKTFNCESQGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLK
                     THVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGTAYSALPQHNGSEDTNHS
                     LYLSELGLLSTDSELQENSSSTQDQDLSTISPAIIFESMFQNPDDPAIQDDPLHTAAL
                     IDSFNGDAESVSDVPPPAGNSASLSLPLVLQPGISEPPQPLLPASTPSAPPPAPSLGP
                     GSQPAAFGSPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPPQTIVPGLSVVAGAPAS
                     AATVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAILQSSLV
                     MGEQNLQWILNGATSSPQNQEQIQQASKVEQVYFTTAVPVASSTGSSVQQIGLSVPVI
                     IIKQEEACQCQCACRDSAKERAAGRRKGCSSPPPPEPNPQPPDGPSLQLPP"
     exon            542..780
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..912
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..986
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1123
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1201
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1304
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1903
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1967
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..5300
                     /gene="Mtf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgacgctagg gacaggtggg ggcaatcatg gtgccgctgg ggaggggaga agctgccgct
       61 gccgctgttg ccgggagccg cggagaaagg ccattacctt ttcatttctc acaattgggc
      121 tgagcacaag tgaaccatgg gggaacacag tccagacgac aacatcatct tctttaaggg
      181 agaggaagat gacctaaccc cgcatgacaa gatgctcagg tttgtggatg acaacggact
      241 ggtgccttcc tcatctggaa ctgtttatga taggaccact gttctcatag aacaggaccc
      301 tggcactttg gaggatgatg aagacgatgt acagtgtgga gaacacttgc cttttctggt
      361 ggaaggtgaa gagggcttcc taatagatca ggaagcaatg tcccagggtt acgtacaaca
      421 cattatctca ccagatcaga ttcatttgac tataaaccct ggttccacgc ccatgccaag
      481 aaacattgaa ggtgcgactc ttactctgca gtcggaatgt cctgaaacga aacggaaaga
      541 agtaaagcgg taccagtgca cctttgaggg atgcccgcgc acctacagca cagcaggcaa
      601 cctacgcacc caccagaaga ctcaccgagg agagtacacc tttgtctgta atcaggaggg
      661 ctgtggcaag gccttcctca cctcctacag cctcaggatc catgtgcgag tgcacacaaa
      721 ggagaagcca tttgagtgtg acgtgcaggg ctgtgagaag gcattcaaca cactgtacag
      781 gttgaaagca catcagaggc ttcacacagg gaaaacgttt aactgtgaat ctcaaggctg
      841 cagcaagtac ttcaccacac tcagtgatct gcggaagcac attcgaaccc atacaggaga
      901 aaagccattt cgatgtgatc atgacggctg tggaaaagca tttgcagcaa gccaccacct
      961 taaaactcac gtccgtacac acactggcga aagacccttc ttctgcccca gtaacggctg
     1021 tgagaagaca tttagcactc agtacagtct caaaagtcac atgaaaggtc acgataacaa
     1081 aggcaccgcg tacagtgcac ttcctcaaca caatggatca gaggatacaa atcactcact
     1141 ttatctgagt gagttgggcc ttctgtccac ggattctgaa ttgcaagaaa attccagttc
     1201 gacacaggac caggacctca gcacaatttc accagcaatc atctttgaat caatgttcca
     1261 gaatcctgac gaccctgcga ttcaggatga ccctctgcac acagctgcct tgattgacag
     1321 cttcaacgga gatgcagaat ctgtcagtga tgtcccaccg cctgcaggaa attcagcgtc
     1381 tttatctctt ccacttgtac tgcagcctgg catctccgag ccaccccagc ctctgctgcc
     1441 agcctcaact ccgtccgctc ctccacctgc tccctcccta ggacctggtt cccagccagc
     1501 tgcatttggc agcccccctg ctctcttaca acctccagaa gtgcctgttc cccacagcac
     1561 acagtttgct gctaatcatc aagagtttct tccgcacccc caggcgccac cccagaccat
     1621 cgtaccagga ctctctgttg ttgctggggc tcctgcatca gcagcaacag tggcatcagc
     1681 cgtggcagca ccagccccac cacaaagtac tactgagccc ctgcctgcta tggtccagac
     1741 tctgcccctg ggtgccaact ctgtcctaac taataatccc accataacca tcaccccaac
     1801 tcctaacacg gcaatcctgc agtccagcct agtcatggga gagcagaact tacagtggat
     1861 attgaacggt gccaccagtt caccacaaaa ccaagaacaa attcagcaag catcgaaagt
     1921 ggagcaggtg tactttacca ccgcagtacc agtagccagt agcacaggga gctctgttca
     1981 gcagattggc ctcagtgttc ctgtgatcat catcaaacaa gaggaggcct gtcagtgtca
     2041 gtgtgcgtgc cgggactctg cgaaggagcg ggcggccggc cggagaaagg gatgttcttc
     2101 cccaccccct ccagagccga acccccagcc tcctgatggg cccagcctgc aactgccacc
     2161 ctagacttct ccctcatccc tgcccccctc atcctcctcc accggaccct cttcctgtga
     2221 gcaaagcaga caggctgagg ctcctcagac cctccaaaat gttaagtgcc atggatgtgt
     2281 cagagttcct gtccctccag agcctggaca ccccgtccaa tccggttcac agtgaagcac
     2341 tactgcaggg gtagaggaaa gagcctggcc agcagcttct ccaggggaag ggcctgtgcg
     2401 cacccctcca ggaacagggt gagcagggag tgccggccgg gtgtgatgct gcctgccgtc
     2461 atggggtcag aaattggaag gatgaagaaa tctgccatct gaaagcctca cctttcagac
     2521 atattttctt tactcatacc ccaggaacat ccattttaag gaactgatct ttggaggaaa
     2581 aaacaaaaaa agaaaaaaaa aaaaagctaa gttataagtg aactgtctgg ctgcactgta
     2641 tgtcactttt gcttattgtt atgtgaactt ggaaattaag gttacttgta tgcataaaag
     2701 ttctaaatga aagggtgtgg tttccatcaa tttggtactg cccatcattt gcactggggt
     2761 cattgtggat tgggcaggag agttcactgt gccgggtgtt gctcttctgt gtctttaatc
     2821 tgaggcagca cctggagggc cagaccaccg cgctgtgaca gcgggtaatg gcaagggcag
     2881 aggagagctg tgagttagac agggagaggt gtttgttgtt ggcttggttt ctgtggagct
     2941 tggagtagaa gcagagggcc gtgccctgta tcctgctcag tcctaggggg cagctgcagg
     3001 cctcctggcc atagtgaaga tgtggttctg cagggccgag gcaactgttg acagctctgt
     3061 tgataatgct aaagcgatct ctagcacagc cacagtcttt gccttcttgg ctcttcccat
     3121 ttctcagtgc ttgtcagtgc ttgaggcttg gagttcatct ctcctaagga agcgccttat
     3181 tttatcctaa agtaaatgag aggctcgtgg ccagcggctg ccagggtctg cctgccttgg
     3241 gtgacgtttg tttcctcaga gcagaagggc tgcttttcca gggaaagtac gagctaaggg
     3301 agctggacga ggcttcaggc ggtcggcagg catctggtac ccagttctag cgaggctttt
     3361 ctgtcatcct ctcccacctg catcgctctt gtctcttaga cttgcataca gcctcataca
     3421 gtgcaaacgg tgacatgatc tctaaacaaa caggaataaa aacctaaaat gatgatattc
     3481 tactcagggt aaaacaaaaa atccccttcc accaaaaagc ctgaagctcg cagtcagtta
     3541 cctcatttgg agtgtttcgt tgagttgtta caggactttt tttattagtc catagaatta
     3601 cacccatctc cttgcctttg actccaggtt attgcctctt caaacataag tacaatctat
     3661 aggagaatgg ggtgtggctg ttctttggtg gccattggtg tttggcaagc tcagaaggta
     3721 gctggatccg gagactagag gaggcctttg cctcccacaa gaagcagggt ccggtgcccc
     3781 aacaggacaa ccagagagct gtgtaggttg agccttaggg ccagctagga tggtgaccct
     3841 tgtcttcagg caagatattt aaggacaact ggccaagagg gtcatggcag cagtattgag
     3901 aagcggcaca ggtacaagca gctgatctcc cattccagga atgtgaattt ctgatgttct
     3961 acacccctcc cccccaaaaa agttgatggg tttgggtgac catagacctc cgcagaaatc
     4021 caaaaggtag gaagagccct ctattggcac aatggttagt ccttctgggg accaactgct
     4081 tgggtgtagg tttgtccttt gctgtctctg ggatttgcac tcacaggaag ctttgcaagt
     4141 gagcttgtac caagaggcag tgatggccct cccgcttact ctgcctgtga tggctgggag
     4201 ctgctgacat aggaaacagg agcctaggga ggatgtgtgg aaggctttaa tggtttaaat
     4261 atggcttctt ggttagctag ggctgtgctc ctaatgtcca ttcctgggtc attggctttt
     4321 caccctccac agttggggta gtgaagaaac atttgagcag tgttgagacc aaagtgttgc
     4381 taggtgaagg agttcagtga ttttagaaca catgagactc tcagatccaa agagcttttg
     4441 ggaagtgagg gctttgcttg cagtcagtgg ttgtgcagag ctgctgtgtg acccatggca
     4501 gacacttctg ccatcgttac cagcagtcct cccccatcct tccacaagcc ctacccctaa
     4561 tgccaaggac cttggagaag acggagtctc ccagctaaac aagagccaga aagacccttc
     4621 atggaaagag tgttttctcc agggaatgac cataggttag gtaaggccaa gaagagtgag
     4681 ttcaagcagg tcactttaag cctttccttc cacagcagcc atcaccactg tccccctgca
     4741 gagcctactg gggtgaccac tggtcagcag tggggctgtg gacctaggag gtggtcaggt
     4801 aatcttggtc ccaccaaact gccttataaa tgtggccctt cccaggcagg aaggtaaggc
     4861 cgagggaaga tagctcaggc tccctgacgg ggtctgacca atctcatggg gcagcactag
     4921 tttggccaca ggagtgctgt catttattga cttactctag tttaggagag gccttgagat
     4981 gtggagagcc ctctaggtag aatgtagcag ggcttctctt ccctttcaga gtcaataaat
     5041 gggaaaaggt ggtgttccgg gttaaggcag taggctgacg gggtaatgga agtgcctgag
     5101 gttttcctga ggctttgtat gatgctgaat gtgtccagaa cctcatattg atattttaaa
     5161 gaaataataa aataaaaagc actttaggtt actttatctt taacccaatt ggtgcaattt
     5221 ctattgtgta tgtatatata tacatatata ctttccacaa agttttattt tttgctcaga
     5281 ataaaagtta agttgaggtg
//
