LOCUS       NM_053499               1506 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mitochondrial transcription termination factor 1
            (Mterf1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_053499
VERSION     NM_053499.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1506)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 1506)
  AUTHORS   Yakubovskaya,E., Mejia,E., Byrnes,J., Hambardjieva,E. and
            Garcia-Diaz,M.
  TITLE     Helix unwinding and base flipping enable human MTERF1 to terminate
            mitochondrial transcription
  JOURNAL   Cell 141 (6), 982-993 (2010)
   PUBMED   20550934
REFERENCE   3  (bases 1 to 1506)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   4  (bases 1 to 1506)
  AUTHORS   Li,X., Zhang,L.S. and Guan,M.X.
  TITLE     Cloning and characterization of mouse mTERF encoding a
            mitochondrial transcriptional termination factor
  JOURNAL   Biochem Biophys Res Commun 326 (2), 505-510 (2005)
   PUBMED   15582606
REFERENCE   5  (bases 1 to 1506)
  AUTHORS   Prieto-Martin,A., Montoya,J. and Martinez-Azorin,F.
  TITLE     Phosphorylation of rat mitochondrial transcription termination
            factor (mTERF) is required for transcription termination but not
            for binding to DNA
  JOURNAL   Nucleic Acids Res 32 (7), 2059-2068 (2004)
   PUBMED   15087485
  REMARK    GeneRIF: The DNA-binding activity of mTERF is unaffected by the
            phosphorylation or dephosphorylation state, however, only the
            phosphorylated form of the protein is active for termination
            activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1506)
  AUTHORS   Enriquez,J.A., Fernandez-Silva,P., Garrido-Perez,N.,
            Lopez-Perez,M.J., Perez-Martos,A. and Montoya,J.
  TITLE     Direct regulation of mitochondrial RNA synthesis by thyroid hormone
  JOURNAL   Mol Cell Biol 19 (1), 657-670 (1999)
   PUBMED   9858589
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ292524.1.
            
            [WARNING] On Aug 20, 2024 this sequence was replaced by
            NM_053499.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ292524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132265, SAMD00132268
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..1506
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="mitochondrial transcription termination factor 1"
                     /db_xref="GeneID:85261"
                     /db_xref="RGD:621318"
     exon            1..86
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /inference="alignment:Splign:2.1.0"
     exon            87..214
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /inference="alignment:Splign:2.1.0"
     exon            215..1503
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1370
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /function="mitochondrial transcription termination"
                     /note="transcription termination factor, mitochondrial;
                     transcription termination factor 1, mitochondrial"
                     /codon_start=1
                     /product="transcription termination factor 1,
                     mitochondrial precursor"
                     /protein_id="NP_445951.1"
                     /db_xref="GeneID:85261"
                     /db_xref="RGD:621318"
                     /translation="MASRNIWRVRRNFLFDLRGWVPQYSAEVFLKSIPFRPFSVECNS
                     KDGENGDLLNNLLTMGVDVDMARRRQPGVFNKAVTNEQELKMFLLSKGASDKVIGSII
                     SRYPRAITRTPESLSKRWDLWREIMASDLEIVNILERSPESFFRSNNNLNLENNIKFL
                     CSVGLTHKCLCRLLTSAPRTFSNSLNLNKQMVEFLQETGISLGHNNPTDFVRKIISKN
                     PSILIQSTKRVKTNIEFLQSTFNLDKEDLLLLICGPGARILDLSNDCTKRNYTNIKKR
                     LLSLGCTEEEVQKFVLSYLNMIFLSEKKFNDKIDCLLEEKISTSQILENPRVLDSSIH
                     TLKTRIRELAHAGYDVSTSSIALLSWSQRRYEAKLKRLSG"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
ORIGIN      
        1 gtaaaaggtg tctaccgcga gctttggtac cggacgcgaa tacaaagttg agttcaggct
       61 ggggttggag agacgctgta ccgttggatt tctcttgaat gttctgtgga tgttcatctg
      121 tctaccatga tgctaagcat ctgaagagaa cgcactgtat agggtagtaa tctttaaccc
      181 taaaggcttc gtatgtgtat ggcttttatg tatggacttg aaaagctttg gactatcctg
      241 tgataatggc atcaagaaac atctggcgtg tgagaaggaa cttcctcttt gatttaagag
      301 gttgggtgcc ccaatattca gcagaagttt tcctcaagtc gattccattc aggcctttta
      361 gtgtggaatg taacagtaaa gacggggaga atggggacct actcaacaac ttactcacca
      421 tgggagttga tgtcgacatg gcaaggagac gacagcctgg agtttttaac aaggctgtca
      481 cgaatgagca ggagctgaag atgttccttc tgtccaaagg agcaagtgac aaagtgattg
      541 gtagcatcat atcaagatat ccacgagcca taacacgcac tcccgaaagt ctttcaaaac
      601 ggtgggatct gtggagagag attatggcat cagaccttga aattgtaaat attttggagc
      661 gttctcctga atccttcttt cggtctaata acaacctaaa cttagagaat aacataaagt
      721 tcctctgctc tgttgggttg actcataagt gcctctgccg actgttgacc agtgctccca
      781 ggaccttctc caacagtctg aatttgaata aacaaatggt tgaatttttg caggagaccg
      841 gtatatcctt aggtcacaat aatcccacag attttgtcag gaagataatt tctaaaaatc
      901 cttccatctt aattcagagc accaaacgtg tgaaaactaa cattgaattt ttacagtcaa
      961 ctttcaactt agacaaagag gacctgctgc ttctgatatg tggtccagga gctagaatct
     1021 tagacctttc caacgactgt accaaaagaa actacacaaa catcaaaaag aggctgctct
     1081 ctctcggatg cactgaggag gaggtacaga agtttgtcct aagctatctg aatatgatct
     1141 tcttgtcaga gaaaaagttc aatgataaaa tagactgcct cctagaagag aaaatcagta
     1201 cttcacaaat acttgaaaat ccaagggtat tagactcgag catacatact ttaaaaactc
     1261 gcatcagaga gttggcacat gctgggtatg acgtgagcac ctcaagcatt gctctgctgt
     1321 cctggagtca gagacgatat gaagctaaac tgaagagatt aagtgggtag gccagtgcag
     1381 gcggagtcac caggaatctt gcaagtagag tgctggttcc agtttggact tttcaaacag
     1441 gagagatttt tttaaataat ttttttactt aaatcattta aataaatatt ttaaaatatt
     1501 taaaaa
//
