LOCUS       NM_133398               2231 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus metadherin (Mtdh), mRNA.
ACCESSION   NM_133398 XM_003750334 XM_006241522
VERSION     NM_133398.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Xiang,Y., Duan,Y., Peng,Z., Huang,H., Ding,W., Chen,E., Liu,Z.,
            Dou,C., Li,J., Ou,J., Wan,Q., Yang,B. and He,Z.
  TITLE     Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells
            Promote Vascular Calcification Through Astrocyte-Elevated Gene-1
  JOURNAL   Calcif Tissue Int 111 (1), 73-86 (2022)
   PUBMED   35195734
  REMARK    GeneRIF: Microparticles from Hyperphosphatemia-Stimulated
            Endothelial Cells Promote Vascular Calcification Through
            Astrocyte-Elevated Gene-1.
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Wang,Y., Zhang,W., Zhu,X., Wang,Y., Mao,X., Xu,X. and Wang,Y.
  TITLE     Upregulation of AEG-1 Involves in Schwann Cell Proliferation and
            Migration After Sciatic Nerve Crush
  JOURNAL   J Mol Neurosci 60 (2), 248-257 (2016)
   PUBMED   27351433
  REMARK    GeneRIF: AEG-1 was expressed mainly in Schwann cells of the distal
            sciatic nerve segment from injury.  Interference of AEG-1 inhibited
            both proliferation and migration of Schwann cells.
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2231)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   6  (bases 1 to 2231)
  AUTHORS   Emdad,L., Sarkar,D., Su,Z.Z., Randolph,A., Boukerche,H., Valerie,K.
            and Fisher,P.B.
  TITLE     Activation of the nuclear factor kappaB pathway by astrocyte
            elevated gene-1: implications for tumor progression and metastasis
  JOURNAL   Cancer Res 66 (3), 1509-1516 (2006)
   PUBMED   16452207
REFERENCE   7  (bases 1 to 2231)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 2231)
  AUTHORS   Kang,D.C., Su,Z.Z., Sarkar,D., Emdad,L., Volsky,D.J. and
            Fisher,P.B.
  TITLE     Cloning and characterization of HIV-1-inducible astrocyte elevated
            gene-1, AEG-1
  JOURNAL   Gene 353 (1), 8-15 (2005)
   PUBMED   15927426
REFERENCE   9  (bases 1 to 2231)
  AUTHORS   Britt,D.E., Yang,D.F., Yang,D.Q., Flanagan,D., Callanan,H.,
            Lim,Y.P., Lin,S.H. and Hixson,D.C.
  TITLE     Identification of a novel protein, LYRIC, localized to tight
            junctions of polarized epithelial cells
  JOURNAL   Exp Cell Res 300 (1), 134-148 (2004)
   PUBMED   15383321
REFERENCE   10 (bases 1 to 2231)
  AUTHORS   Sutherland,H.G., Lam,Y.W., Briers,S., Lamond,A.I. and Bickmore,W.A.
  TITLE     3D3/lyric: a novel transmembrane protein of the endoplasmic
            reticulum and nuclear envelope, which is also present in the
            nucleolus
  JOURNAL   Exp Cell Res 294 (1), 94-105 (2004)
   PUBMED   14980505
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133398.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF100421.2, SRR26643295.28375.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-691               JAXUCZ010000007.1  67192660-67193350
            692-793             JAXUCZ010000007.1  67208780-67208881
            794-878             JAXUCZ010000007.1  67220475-67220559
            879-1055            JAXUCZ010000007.1  67221235-67221411
            1056-1121           JAXUCZ010000007.1  67222718-67222783
            1122-1358           JAXUCZ010000007.1  67224204-67224440
            1359-1457           JAXUCZ010000007.1  67229897-67229995
            1458-1582           JAXUCZ010000007.1  67237466-67237590
            1583-1690           JAXUCZ010000007.1  67240852-67240959
            1691-1831           JAXUCZ010000007.1  67243630-67243770
            1832-1988           JAXUCZ010000007.1  67247056-67247212
            1989-2231           JAXUCZ010000007.1  67247886-67248128
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2231
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="metadherin"
                     /db_xref="GeneID:170910"
                     /db_xref="RGD:620992"
     exon            1..691
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..2059
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="lysine-rich CEACAM1 co-isolated protein; metastasis
                     adhesion protein; LYRIC"
                     /codon_start=1
                     /product="protein LYRIC"
                     /protein_id="NP_596889.1"
                     /db_xref="GeneID:170910"
                     /db_xref="RGD:620992"
                     /translation="MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEP
                     KRYPSWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEVTPPTPAPEDP
                     AQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEIPEDEVVRTPRSITAKQPPETDKKNEK
                     SKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDS
                     TIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNE
                     NITVNGGGWSEKSVKLSSQLSAGEEKWNSVPPASAGKRKTEQSAWTQDPGDTNANGKD
                     WGRNWSDRSIFSGIGSTAEPVSQSTTSDYQWDGSRNQPHIDDEWSGLNGLSSADPSSD
                     WNAPAEEWGNWVDEDRASLLKSQEPISNDQKDSDDDKEKGEGALPTGKSKKKKKKKKK
                     QGEDNSITQDTEDLEKDTREELPVNTSKARPKQEKACSLKTMSTSDPVEVLIKNSQPI
                     KTLPPAISAEPSVTLSKGDSDKSSSQVPPMLQDTDKPKSNAKQNSVPPSQTKSETNWE
                     SPKQIKKKKKARRET"
     exon            692..793
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            794..878
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1055
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1121
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1358
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1457
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1582
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1690
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1831
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1988
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2231
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccattgttc cgccggggga ggacagcgag gcctggcgct ggcgccccga cgccacttag
       61 cggccgcctc tggagacact ctgtccccgc cgccccgtgt cctcctggcg gcggcggcgt
      121 gaggccgact ggagggagtg ggaaccctcg gccctccccg tggcggcggc ggccacctat
      181 tccccactct ggagtgaggg gcggccgcga tgcgcttggc ctgaggtgtc gcggccctcg
      241 tcgcttccca cgactgttcc agcggcgtct gtgctccccg gcgtcatccc gagagtctct
      301 gacgggaggg aagatggctg cacgaagctg gcaggacgaa ctggctcagc aggccgagga
      361 gggctctgcc cggctgcggg agttgctctc tgtcggccta ggttttctgc gcacggagtt
      421 gggcctcgac ctggggttgg agccgaagcg gtacccgagc tgggtgatcc tggtgggcac
      481 cggcgctctc gggttgctgc ttctcttcct cctaggttac ggctgggccg ctgcttgcgc
      541 cggcgcccgc aaaaagcgaa ggagcccgcc ccgcaagcgg gaggaggtga ccccgccgac
      601 tccggccccc gaggacccag cccaactgaa gaatctcaga agcgaggagc aaaagaaaaa
      661 gaaccggaag aagctgcctg aaaagcccaa accaaatgga cggactgttg aaatacctga
      721 agatgaagtt gttagaactc cccgaagtat aactgccaag cagccaccag agacagacaa
      781 gaaaaatgaa aagtcaaaga aaaataagaa gaagtcaaag tcagatgcta aagcagtgca
      841 aaacagttca cgccatgatg gaaaggaagt tgatgaagga gcctgggaaa ctaaaattag
      901 tcacagagag aaacgacaac agcgtaaacg tgataaagtg ctgactgatt ctggttcatt
      961 ggattcaact atccctggga tagaaaatac catcacagtt accaccgagc aacttacaac
     1021 tgcatcattt cctgttggtt ccaagaagaa taaaggtgat tctcatctaa atgttcaagt
     1081 tagcaacttt aagtctggaa aaggagattc tacacttcag gtttcttcag ggttgaatga
     1141 aaatattact gtcaatggag gaggctggag tgaaaagtct gtaaaactct cctcacaatt
     1201 gagtgcaggt gaggagaagt ggaactctgt cccacctgct tctgcaggca agagaaaaac
     1261 agagcagtct gcttggactc aagaccctgg tgatactaat gcaaatggga aagactgggg
     1321 aaggaattgg agtgatcgct caatattttc tggcattgga tctactgctg agccagtttc
     1381 tcagtctacc acttctgatt atcagtggga tggtagccgt aatcagcccc atatcgatga
     1441 tgaatggtct gggttaaatg gtttgtcttc tgctgatcct agctcagact ggaatgcacc
     1501 agcagaagag tgggggaact gggtagatga agatagagct tcacttctga agtcccagga
     1561 gccgatttct aatgatcaaa aggattcaga tgatgataag gaaaaaggag aaggagctct
     1621 tccaactgga aaatctaaaa agaaaaaaaa gaaaaagaag aagcaaggtg aagataactc
     1681 tatcacccag gacacagaag acctagaaaa ggacactaga gaagagcttc cagtgaatac
     1741 ctcgaaagcc cgtccaaaac aggagaaagc ttgttccctg aagaccatga gcactagtga
     1801 tccagttgaa gtactcatca aaaatagcca gcctatcaag actcttccac ctgctatctc
     1861 tgccgagcca tctgttactt tatcaaaggg tgactctgac aagagctctt cccaagtgcc
     1921 accgatgtta caagacacag acaaacccaa gtcaaatgct aagcaaaaca gtgtgcctcc
     1981 ctcacagacc aagtctgaaa ctaattggga atctccaaaa caaataaaaa agaagaaaaa
     2041 ggccagacgg gaaacgtgaa tttttttcct aaattggaca tgtgtttaca aacactgtct
     2101 tgaagattat gctgtttatg caataatttg tgaacatgta cagagtttta tataaattta
     2161 aaccaatttt taaaacaaaa ctgaacacaa ccaccataaa atggaatcaa aggaaagtta
     2221 atttatgaaa t
//
