LOCUS       NM_001106488            2359 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus mitochondrial carrier 2 (Mtch2), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106488 XM_001065976 XM_001066091 XM_001066144 XM_215769
VERSION     NM_001106488.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2359)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2359)
  AUTHORS   Goldman,A., Rodriguez-Casuriaga,R., Gonzalez-Lopez,E.,
            Capoano,C.A., Santinaque,F.F. and Geisinger,A.
  TITLE     MTCH2 is differentially expressed in rat testis and mainly related
            to apoptosis of spermatocytes
  JOURNAL   Cell Tissue Res 361 (3), 869-883 (2015)
   PUBMED   25813787
  REMARK    GeneRIF: MTCH2 is related to testicular apoptosis, especially
            during meiotic prophase
REFERENCE   3  (bases 1 to 2359)
  AUTHORS   Maryanovich,M., Zaltsman,Y., Ruggiero,A., Goldman,A., Shachnai,L.,
            Zaidman,S.L., Porat,Z., Golan,K., Lapidot,T. and Gross,A.
  TITLE     An MTCH2 pathway repressing mitochondria metabolism regulates
            haematopoietic stem cell fate
  JOURNAL   Nat Commun 6, 7901 (2015)
   PUBMED   26219591
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2359)
  AUTHORS   Eswarappa,S.M., Potdar,A.A., Koch,W.J., Fan,Y., Vasu,K.,
            Lindner,D., Willard,B., Graham,L.M., DiCorleto,P.E. and Fox,P.L.
  TITLE     Programmed translational readthrough generates antiangiogenic
            VEGF-Ax
  JOURNAL   Cell 157 (7), 1605-1618 (2014)
   PUBMED   24949972
REFERENCE   5  (bases 1 to 2359)
  AUTHORS   Shamas-Din,A., Bindner,S., Zhu,W., Zaltsman,Y., Campbell,C.,
            Gross,A., Leber,B., Andrews,D.W. and Fradin,C.
  TITLE     tBid undergoes multiple conformational changes at the membrane
            required for Bax activation
  JOURNAL   J Biol Chem 288 (30), 22111-22127 (2013)
   PUBMED   23744079
REFERENCE   6  (bases 1 to 2359)
  AUTHORS   Zaltsman,Y., Shachnai,L., Yivgi-Ohana,N., Schwarz,M.,
            Maryanovich,M., Houtkooper,R.H., Vaz,F.M., De Leonardis,F.,
            Fiermonte,G., Palmieri,F., Gillissen,B., Daniel,P.T., Jimenez,E.,
            Walsh,S., Koehler,C.M., Roy,S.S., Walter,L., Hajnoczky,G. and
            Gross,A.
  TITLE     MTCH2/MIMP is a major facilitator of tBID recruitment to
            mitochondria
  JOURNAL   Nat Cell Biol 12 (6), 553-562 (2010)
   PUBMED   20436477
REFERENCE   7  (bases 1 to 2359)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 2359)
  AUTHORS   Grinberg,M., Schwarz,M., Zaltsman,Y., Eini,T., Niv,H.,
            Pietrokovski,S. and Gross,A.
  TITLE     Mitochondrial carrier homolog 2 is a target of tBID in cells
            signaled to die by tumor necrosis factor alpha
  JOURNAL   Mol Cell Biol 25 (11), 4579-4590 (2005)
   PUBMED   15899861
  REMARK    GeneRIF: Identification and functional characterization of the
            human Mtch2 ortholog.
REFERENCE   9  (bases 1 to 2359)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 2359)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FM085474.1, EV779017.1,
            FM132670.1, BC158687.1, FM112089.1, BP503204.1, DY315983.1 and
            CB758525.1.
            
            On Nov 25, 2015 this sequence version replaced NM_001106488.2.
            
            Summary: This gene encodes a member of the SLC25 family of
            nuclear-encoded transporters that are localized in the inner
            mitochondrial membrane. Members of this superfamily are involved in
            many metabolic pathways and cell functions. Genome-wide association
            studies in human have identified single-nucleotide polymorphisms in
            several loci associated with obesity. This gene is one such locus,
            which is highly expressed in white adipose tissue and adipocytes,
            and thought to play a regulatory role in adipocyte differentiation
            and biology. A recent study showed this gene to be an authentic
            stop codon readthrough target that can produce two isoforms from
            the same mRNA by use of alternative in-frame translation
            termination codons. [provided by RefSeq, Dec 2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes two isoforms, which result from the use of
            alternative in-frame translation termination codons. The shorter
            isoform (1) results from translation termination at the upstream
            UGA stop codon, while the longer isoform (1x) results from UGA stop
            codon readthrough to the downstream UAG termination codon. This
            RefSeq represents the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158687.1, KF661297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                FM085474.1         2-13
            13-28               EV779017.1         23-38
            29-688              FM132670.1         1-660
            689-1109            BC158687.1         629-1049
            1110-1556           FM112089.1         228-674
            1557-2023           BP503204.1         199-665
            2024-2338           DY315983.1         1-315               c
            2339-2359           CB758525.1         32-52               c
FEATURES             Location/Qualifiers
     source          1..2359
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2359
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /note="mitochondrial carrier 2"
                     /db_xref="GeneID:295922"
                     /db_xref="RGD:1308080"
     exon            1..168
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..993
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="mitochondrial carrier homolog 2 isoform 1"
                     /protein_id="NP_001099958.2"
                     /db_xref="GeneID:295922"
                     /db_xref="RGD:1308080"
                     /translation="MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIF
                     GRQVYQLPGLFCYAQHIASIDGKRGLFTGLTPRLCSGVLGTVVHGKVLQYYQECEKPE
                     DLGSANVQKEYPSSFDRVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYC
                     GLCDSIVTIYREEGIVGFFAGLIPRLLGDIISLWLCNSLAYLINTYALDSGVSTMNEM
                     KSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGSPPYSPIYTSWIDCWCMLQKAG
                     NMSRGNSLFFRKVPCGKTYYCDLRMLI"
     exon            169..253
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            254..360
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            361..387
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            388..450
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            451..508
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            509..560
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            561..620
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            621..714
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            715..762
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            763..830
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            831..906
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     exon            907..2343
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2343
                     /gene="Mtch2"
                     /gene_synonym="Hspc032"
ORIGIN      
        1 agccggcgcc cccgacacgt gatctggaac cggctgtgtc gcttggtgac tccgtctgtc
       61 cgtccgtccg cgggtgccat catggcggac gcggccagtc aggtgctcct gggctccggt
      121 ctcaccatcc tgtcccagcc gctcatgtac gtgaaagtgc tcatccaggt gggatatgag
      181 cctcttcctc caacaatagg acggaatatt tttgggcgac aagtatatca gcttcctggc
      241 ctcttttgct atgctcagca cattgcaagc atcgatggga agcgtgggct gttcacaggc
      301 ttaactccaa gactgtgttc aggagtcctt ggaactgtgg tccatggtaa agttttacag
      361 tattaccagg agtgtgagaa acctgaggac ttaggatctg caaatgtaca aaaagaatat
      421 ccatcctcct ttgaccgagt tatcaaagag acaactcgag agatgattgc tcgttctgct
      481 gctaccctca ttacacatcc cttccacgtg attactctga ggtccatggt acagtttatc
      541 ggcagagagt ctaagtactg cggactgtgt gactccatag taaccatcta ccgggaagaa
      601 ggcatcgtag gattttttgc gggcctcatt cctcgcctcc taggtgacat catttctttg
      661 tggctgtgta actcactggc ttatctcatc aatacctatg cactggacag tggggtctct
      721 accatgaatg aaatgaaaag ttattcccaa gctgtcacag gattctttgc cagtatgttg
      781 acatatccct ttgtgcttgt atctaatctt atggctgtta acaactgtgg gcttgctggt
      841 ggatctcctc cttactcccc aatatatact tcttggatag attgctggtg catgctacaa
      901 aaagcgggaa atatgagccg aggaaacagc ttgtttttcc ggaaggttcc ttgtgggaag
      961 acttactatt gtgacctgag aatgttaatt tgaagatgtg gagcagggac agtgacattt
     1021 ctatagtccc aatgcacaga attatgggag agaatgttga tttctataca gtggcacgct
     1081 tttttaataa tcatttaatc ttgggaaaat ggaggtgatt ggtgtctgct tttttgttct
     1141 ttttcctagc acaacatcat ttaccactag tgttccccag tagttatttg aagtggggca
     1201 tttatttctc caaattcttg ttttaaacag aaaacagacg tattttccta aatattaagc
     1261 aggttgtcat gtagatttga gtcaggtttg tcaaatgaag aatagaattc caattagaag
     1321 gaactaattc cataagagtt gataaattaa gaaaggatac catgtgggag tttatgatta
     1381 cctgagtaca tagatgctag aaagtcaaca gcaaccagca gtctacctcc caccatgttt
     1441 ccaagcagtt gacccatctt atctcttaat gctgctgagt aactgtagct gtatgccttc
     1501 tgttactata gaagagaaag ttgtcaccac caacagaaag gtcagttaca caggcttaag
     1561 caagatttgg ggagaaaata tgatggcctt tcactccaaa gaagctcttg acttcttgta
     1621 gcacaagaag caaacaccgt agcacaacag tagcccctca gtgctcagtg ccctccagcc
     1681 tctaaggtct gtcttcactg cgattccatt actataagct cctgctccta agcatttgtt
     1741 tcctttttgt tactgcagaa ggtgagtagt ttgttttcat ttgtgatgat gcccttgaaa
     1801 agtgtatctg tacctcctta tctggtgacc aggttcctag gatattgtcc agctcgcatg
     1861 tcagaccctc agtgaggctt gttaaaaaca cttactggag gaaaattcac tttacaatga
     1921 aaattctcaa ctcaggcatt gagattctat tcactcaggc cttttaacgt caggttaaaa
     1981 tgctcgtaag atgagaaagc cctaaggtgt caattgttta agtaaattca ctggtacttt
     2041 gccaaatgag taagcactga ctttgctgct tttagacttc tgtcaatgca gcagaggcca
     2101 tgatgttagg tagtgtgagc gagcagggtc ttctgctcag ggttagggag ggatgcaacc
     2161 agaagctcat aagtagctta gtttgaaatg tctttgatgt caaaagtact ttgtctcaaa
     2221 agtaatgtaa attttatatt ctattcaata ctatctgcat ctgttttaat ataaaacatg
     2281 ttttgcatta cctactcttt tctcccaaaa aaaggtcaag taaaaatgat ctaggaaaat
     2341 gcaaaaaaaa aaaaaaaaa
//
