LOCUS       NM_001130717            3170 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus MDM2 binding protein (Mtbp), mRNA.
ACCESSION   NM_001130717 XM_001064571 XM_001064634 XM_006241655
VERSION     NM_001130717.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3170)
  AUTHORS   Agarwal,N., Tochigi,Y., Adhikari,A.S., Cui,S., Cui,Y. and
            Iwakuma,T.
  TITLE     MTBP plays a crucial role in mitotic progression and chromosome
            segregation
  JOURNAL   Cell Death Differ 18 (7), 1208-1219 (2011)
   PUBMED   21274008
REFERENCE   2  (bases 1 to 3170)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 3170)
  AUTHORS   Boyd,M.T., Vlatkovic,N. and Haines,D.S.
  TITLE     A novel cellular protein (MTBP) binds to MDM2 and induces a G1
            arrest that is suppressed by MDM2
  JOURNAL   J Biol Chem 275 (41), 31883-31890 (2000)
   PUBMED   10906133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Aug 6, 2021 this sequence version replaced
            XM_006241655.3, NM_001130717.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.745632.1,
                                           SRR26360190.1325016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               JAXUCZ010000007.1  88862939-88863270
            333-413             JAXUCZ010000007.1  88864046-88864126
            414-487             JAXUCZ010000007.1  88868431-88868504
            488-639             JAXUCZ010000007.1  88868664-88868815
            640-698             JAXUCZ010000007.1  88870294-88870352
            699-843             JAXUCZ010000007.1  88871955-88872099
            844-961             JAXUCZ010000007.1  88872982-88873099
            962-1096            JAXUCZ010000007.1  88874538-88874672
            1097-1191           JAXUCZ010000007.1  88876067-88876161
            1192-1264           JAXUCZ010000007.1  88877578-88877650
            1265-1382           JAXUCZ010000007.1  88889853-88889970
            1383-1556           JAXUCZ010000007.1  88899315-88899488
            1557-1664           JAXUCZ010000007.1  88901959-88902066
            1665-1826           JAXUCZ010000007.1  88910475-88910636
            1827-1944           JAXUCZ010000007.1  88916051-88916168
            1945-2100           JAXUCZ010000007.1  88919952-88920107
            2101-2196           JAXUCZ010000007.1  88924203-88924298
            2197-2463           JAXUCZ010000007.1  88928261-88928527
            2464-2701           JAXUCZ010000007.1  88930258-88930495
            2702-2815           JAXUCZ010000007.1  88930712-88930825
            2816-2881           JAXUCZ010000007.1  88939458-88939523
            2882-3170           JAXUCZ010000007.1  88940256-88940544
FEATURES             Location/Qualifiers
     source          1..3170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q32"
     gene            1..3170
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /note="MDM2 binding protein"
                     /db_xref="GeneID:500870"
                     /db_xref="RGD:1565672"
     exon            1..332
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2920
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /note="Mdm2, transformed 3T3 cell double minute 2, p53
                     binding protein binding protein, 104kDa"
                     /codon_start=1
                     /product="mdm2-binding protein"
                     /protein_id="NP_001124189.2"
                     /db_xref="GeneID:500870"
                     /db_xref="RGD:1565672"
                     /translation="MDRYLLLVSWREGKFRSVAGGEMEPGTEASSLESTEKQPHLTAT
                     NIYHLLKRSINDSIHPDDSTFPACSVGGTPHSRKWFFAAQAICGFYQFCSSDWQEIHF
                     DAEKDKIEDVLQANVEECQSAVECFEEDDSNSRESLSLADLYEESAENLHQLSDKLPA
                     PGRAMIDVILLPSDKDPPKLKECLPIVGALKHLKEWHSAKVIVAGSHCETNCQKIAEY
                     LSATVVPLEEFGNAIDSRELWRGEIQMRERKFGFEVNFPEFCLKGVTPTNVSAYNLNT
                     CFLAKKIASSKDKNILPKVFHYYGSALEFVQMIKLSDLPSCYVSDIEFELEVTGHCTR
                     QNSMLLLEQISSLCGKVGALFLLPCTISNVLLPPPNQLASRKWKEYIAKKPKTISVPD
                     VDVKGEFSGYHLLLQGSGRRKCRATLLHSASQINGSVALTLIHGKMKARTEAAQPSFP
                     FDFSSLPRFSEEQVLQREKQLASVQVLALKECLKRRKAANQPEAVSTDELKSLLALTR
                     ERFLDRFDVLTPKAVLTQTDTMKAAGMVNDASRVESYSSSSMETNPLEWPERHVLQNL
                     ETSEKAKQKMRTGSLPHSAEQLLGHKEGPRDSITLLDAKELLKYFTSEGLPVGDLQPL
                     QIQRGEKPFVLTPELSPGKLQILPFEKASECHYHGIEYCLDDQKALERDGGFSELQSR
                     LIRYETQTTCTRDSFPVPTVWSPLPSPAVLSEPQSVPEGDALQGELRTEVSGLKRRSK
                     DASCLYPQKRITKSESSDCLLSQASCNSNHYHHVGTSRKPQAERCVSVLPLPGREASK
                     VTVKTSSGQKRAHESKSSKQIKESRSQKHTRMLKEVVTETLKRHHITEAHESFDACSQ
                     RLFDISKFYLKDLKTSRGLFEEMKKTANNNVVQVIEWVVEKMSKR"
     exon            333..413
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            414..487
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            488..639
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            640..698
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            699..843
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            844..961
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1096
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1191
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1264
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1382
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1556
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1664
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1826
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1944
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2100
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2196
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2463
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2701
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2815
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2881
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..3170
                     /gene="Mtbp"
                     /gene_synonym="RGD1565672"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgcttccc tgctactctc gggtccccgc cggtagccgt ttcgttatga aaggagcaaa
       61 cagtgtggct actgagagaa taatttccca aaataattgg caggaaaacc aacgtaggac
      121 agtattttcc agctaaccta agcggcagga aaccggaagt gcgcgttgcg cgcggctctt
      181 ttgagaccta aaactgagcc tgagtgcgaa gaagatggat cggtacttgc tgctggtcag
      241 ctggagggaa ggaaagttcc gatccgtggc tggtggggag atggagcccg ggactgaggc
      301 gtcatccctg gagagcaccg agaaacagcc tcatttgaca gcaaccaata tttatcacct
      361 cttgaagaga agcattaatg attcaatcca tccagatgat agtacgttcc ccgcttgttc
      421 agtgggcggc acccctcact ccaggaagtg gttctttgca gcgcaagcaa tatgtggatt
      481 ttaccagttc tgtagttctg attggcaaga gatacatttc gatgctgaaa aagataaaat
      541 cgaagatgtc cttcaagcaa atgtggaaga atgtcagagc gctgttgagt gctttgaaga
      601 agatgacagt aatagcaggg agtccttgtc cttggctgat ctatatgaag aatcagcaga
      661 aaatctgcat cagttatcag acaagcttcc tgctcctggt agagcaatga tagatgtaat
      721 actattgcct tctgacaaag atcctcctaa attaaaagag tgcttgccca ttgtgggggc
      781 cttgaaacat ctgaaggaat ggcattcagc aaaagttatc gtagcaggaa gtcactgcga
      841 gacaaattgt cagaaaattg cagaatacct ttcagctact gttgtacctt tagaggagtt
      901 cggaaatgcc attgactcga gggaactgtg gaggggagag attcagatgc gggaacgaaa
      961 gtttggattt gaagttaatt ttcctgaatt ttgtttaaaa ggagttacac ctacaaatgt
     1021 tagtgcatat aatttaaata cctgctttct tgccaaaaag atagcatcat ctaaggataa
     1081 gaatattttg cctaaggttt tccattatta tggttctgct ttagaatttg tgcagatgat
     1141 aaaattatca gatcttccct cctgttacgt gtcggatatc gaatttgagt tagaggtgac
     1201 tgggcactgc acaaggcaga attccatgct gctgttggaa cagatctctt ccctgtgtgg
     1261 caaggttggt gctctctttc tattgccatg taccattagt aatgtacttc tcccacctcc
     1321 caaccaactg gcctcaagaa agtggaagga atacatagct aagaagccca agaccatcag
     1381 tgtccccgac gtcgacgtga aaggagagtt ttctggctat catctcctgc tgcagggcag
     1441 tggcaggagg aagtgcagag ccacgctgct tcactcggcc agccagatca atggctcggt
     1501 cgcactcact ctcattcatg ggaagatgaa agcaaggaca gaagcagccc agcccagttt
     1561 cccttttgac ttctcatcac tcccaaggtt ttctgaggag caggttttac agagagagaa
     1621 acaattagcc agcgttcaag ttttggcttt gaaagaatgc ctgaaaagaa gaaaggctgc
     1681 aaaccagcct gaagctgttt ctactgatga actcaaaagt ctgttggcgc tcacaaggga
     1741 gcgcttccta gatcgctttg atgttctcac ccctaaagca gttttaacac agacagacac
     1801 catgaaagct gctggcatgg taaatgatgc cagtagagtt gaatcttatt cttcaagttc
     1861 aatggaaacc aatcctctgg aatggccaga aagacacgtt cttcagaatt tagaaacttc
     1921 tgaaaaagct aaacaaaaaa tgagaactgg ctcattaccg cattcggctg aacagttgct
     1981 gggccataaa gagggtcccc gggactcaat cacattactg gatgctaagg aattgctgaa
     2041 atatttcacc tcggagggat taccagtcgg agatcttcag ccgttacaga ttcaaagggg
     2101 ggaaaagcct tttgttttga caccagagct tagtcctgga aaacttcaga tcttaccttt
     2161 tgaaaaagcc tcggaatgcc attaccacgg gattgaatat tgcctggatg accagaaagc
     2221 tttagaaaga gatgggggat tttctgaact tcaatctcgc cttattcgtt atgagaccca
     2281 gaccacctgc accagagaca gttttccagt ccccaccgtg tggagccctc ttccgtcccc
     2341 tgcagttctg tcagagcctc agagtgtccc tgaaggagac gcattgcaag gcgaactccg
     2401 aactgaagtt tctggattga aacggagatc taaagacgcc agttgccttt acccccagaa
     2461 aagaattaca aaatcagaaa gttctgattg tttgctttct caagcaagtt gcaatagcaa
     2521 tcattaccat cacgtaggga catccaggaa gcctcaggca gagcgctgtg tgtcagtgct
     2581 tccacttcct ggtcgggaag cttccaaagt tactgtaaag accagttcag gacaaaaacg
     2641 agcacacgaa tcaaaatcat caaagcaaat taaggaatct cgatcccaga aacatacacg
     2701 gatgctgaag gaggtggtga cagaaacctt gaagagacac cacatcaccg aggcccatga
     2761 gagctttgat gcctgcagcc agaggctctt tgacatctcc aagttctacc tgaaggatct
     2821 aaaaacatca aggggtctct ttgaagaaat gaagaaaaca gccaacaaca atgtggtgca
     2881 ggtgatcgaa tgggtggtag aaaagatgag caagagataa acttctccat cctcctttac
     2941 ttagaaaacc gcacacaacc ggcaccttta ctcagtagat gctatacttg taaaggggat
     3001 ccgtgctgtc ctgtatttat atagttttgt gatgctcagt taaagtattt ttaactaatg
     3061 cacttatttt tacagtttcc caatattttt aacctatgtt attttttata tattttaaat
     3121 gttttaactc ttgactattt aattgttcaa taaacagtaa tatttcatta
//
