LOCUS       NM_134410               1329 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus mitochondrial amidoxime reducing component 2
            (Mtarc2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_134410
VERSION     NM_134410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Neve,E.P., Nordling,A., Andersson,T.B., Hellman,U., Diczfalusy,U.,
            Johansson,I. and Ingelman-Sundberg,M.
  TITLE     Amidoxime reductase system containing cytochrome b5 type B (CYB5B)
            and MOSC2 is of importance for lipid synthesis in adipocyte
            mitochondria
  JOURNAL   J Biol Chem 287 (9), 6307-6317 (2012)
   PUBMED   22203676
  REMARK    GeneRIF: The presence of a novel reductive enzyme system of
            importance for lipid synthesis that is exclusively localized to the
            outer mitochondrial membrane and is composed of CYB5B, MOSC2, and a
            third unknown component (a CYB5B reductase).
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Wahl,B., Reichmann,D., Niks,D., Krompholz,N., Havemeyer,A.,
            Clement,B., Messerschmidt,T., Rothkegel,M., Biester,H., Hille,R.,
            Mendel,R.R. and Bittner,F.
  TITLE     Biochemical and spectroscopic characterization of the human
            mitochondrial amidoxime reducing components hmARC-1 and hmARC-2
            suggests the existence of a new molybdenum enzyme family in
            eukaryotes
  JOURNAL   J Biol Chem 285 (48), 37847-37859 (2010)
   PUBMED   20861021
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Malik,A.N., Rossios,C., Al-Kafaji,G., Shah,A. and Page,R.A.
  TITLE     Glucose regulation of CDK7, a putative thiol related gene, in
            experimental diabetic nephropathy
  JOURNAL   Biochem Biophys Res Commun 357 (1), 237-244 (2007)
   PUBMED   17416350
REFERENCE   4  (bases 1 to 1329)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1329)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF095741.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_134410.3.
            
            On Aug 30, 2012 this sequence version replaced NM_134410.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF095741.1, BC061734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1329              AF095741.1         2-1330
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Goto-Kakizaki"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..1329
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /note="mitochondrial amidoxime reducing component 2"
                     /db_xref="GeneID:171451"
                     /db_xref="RGD:621257"
     exon            1..284
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1029
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /note="MOSC domain-containing protein 2, mitochondrial;
                     MOCO sulphurase C-terminal domain containing 2; moco
                     sulfurase C-terminal domain-containing protein 2;
                     molybdenum cofactor sulfurase C-terminal domain-containing
                     protein 2"
                     /codon_start=1
                     /product="mitochondrial amidoxime reducing component 2
                     precursor"
                     /protein_id="NP_599237.1"
                     /db_xref="GeneID:171451"
                     /db_xref="RGD:621257"
                     /translation="MGSSSSTALARLGLPGQPRSTWLGVAALGLAAVALGTVAWRRAR
                     PRRRRQLQQVGTVSKVWIYPIKSCKGVSVCETECTDMGLRCGKVRDRFWMVVKEDGHM
                     ITARQEPRLVLVTITLENNYLMLEAPGMEPIVLPIKLPSSNKIHDCRLFGLDIKGRDC
                     GDEVARWFTSYLKTQAYRLVQFDTKMKGRTTKKLYPSESYLQNYEVAYPDCSPIHLIS
                     EASLVDLNTRLQKKVKMEYFRPNIVVSGCEAFEEDTWDELLIGDVEMKRVLSCPRCVL
                     TTVDPDTGIIDRKEPLETLKSYRLCDPSVKSLYQSSPLFGMYFSVEKIGSLRVGDPVY
                     RMVD"
     exon            285..458
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..627
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..768
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..830
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..902
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1050
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1310
                     /gene="Mtarc2"
                     /gene_synonym="mARC1; Marc2; Mg87; Mosc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttagttta acatgggttc ctccagctcc accgctctgg ctcgccttgg actccccggg
       61 cagccgcggt ccacctggct cggcgtcgcc gcgctgggac tggccgcagt ggcgctgggg
      121 accgtggcct ggcgtcgcgc gcgtccccgg cggcgccggc agctgcagca agtgggcacg
      181 gtgtcgaagg tttggatcta cccgatcaag tcctgcaagg gggtgtcggt gtgcgagact
      241 gagtgcaccg acatggggct gcgctgcggc aaagtgcgcg acaggttttg gatggtggtt
      301 aaggaagatg gtcacatgat cactgcccgc caggagcctc gccttgtgct ggtcaccatc
      361 accttggaga acaattacct gatgctcgaa gctccaggca tggagccgat agttctgcct
      421 atcaagctgc cctcttcgaa taagatccac gactgcaggt tgtttggcct cgacattaaa
      481 ggcagggatt gtggcgatga ggtggcccgg tggttcacca gctacctaaa gacgcaagcc
      541 tacaggttgg ttcagtttga taccaaaatg aaaggaagga caacaaagaa actctacccg
      601 tcggagagct accttcagaa ctatgaggtc gcctacccag actgcagccc tatccacctg
      661 atttctgaag cctccttagt ggatctcaac accaggctgc agaagaaagt gaagatggag
      721 tatttcaggc cgaacatcgt ggtgtcaggc tgcgaggctt tcgaggagga cacctgggat
      781 gagctcttga ttggtgacgt agagatgaag agggtgttga gctgccccag gtgcgtgttg
      841 actacagtgg acccagacac cggcatcata gacaggaaag agccgctgga gaccctgaag
      901 agctatcgcc tgtgtgatcc ttctgtgaag agtttatacc agtcgtctcc actctttggg
      961 atgtatttct cagtggaaaa aattggaagc ctgagagtgg gtgaccctgt gtatcggatg
     1021 gtggattagt ggatcccgtg gactgactcg gtttggatta ttcacaactg acagtctgag
     1081 taacagagtg atggggaatc ttgtcattta ctcggcttcc ctgggagacg acgcatctgc
     1141 aagtcctcac ggccatcttc ctggaaatgg atctctgttc ttcctctgga gctgcacatg
     1201 cccgagttca ttcaagaaag ctaccagagg tggtttggga atgtgacggt gtataaattt
     1261 tagataatga ggttttaaaa aattaaacgg aattgttact cccacggtta aaaaaaaaaa
     1321 aaaaaaaaa
//
