LOCUS       NM_001394049            4835 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus methylthioadenosine phosphorylase (Mtap), mRNA.
ACCESSION   NM_001394049 XM_006238382
VERSION     NM_001394049.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4835)
  AUTHORS   Pang,M., Bai,X.Y., Li,Y., Bai,J.Z., Yuan,L.R., Ren,S.A., Hu,X.Y.,
            Zhang,X.R., Yu,B.F., Guo,R. and Wang,H.L.
  TITLE     Label-free LC-MS/MS shotgun proteomics to investigate the
            anti-inflammatory effect of rCC16
  JOURNAL   Mol Med Rep 14 (5), 4496-4504 (2016)
   PUBMED   27748820
  REMARK    GeneRIF: These protein profiles, and their interacting protein
            network, may facilitate the elucidation of the molecular mechanisms
            underlying the antiinflammatory effects of CC16.
REFERENCE   2  (bases 1 to 4835)
  AUTHORS   Kim,J.B., Deluna,A., Mungrue,I.N., Vu,C., Pouldar,D., Civelek,M.,
            Orozco,L., Wu,J., Wang,X., Charugundla,S., Castellani,L.W.,
            Rusek,M., Jakubowski,H. and Lusis,A.J.
  TITLE     Effect of 9p21.3 coronary artery disease locus neighboring genes on
            atherosclerosis in mice
  JOURNAL   Circulation 126 (15), 1896-1906 (2012)
   PUBMED   22952318
  REMARK    Erratum:[Circulation. 2013 Apr 16;127(15):549. Jakobowski, Hieronim
            [corrected to Jakubowski, Hieronim]]
REFERENCE   3  (bases 1 to 4835)
  AUTHORS   Lu,S.C. and Mato,J.M.
  TITLE     S-adenosylmethionine in liver health, injury, and cancer
  JOURNAL   Physiol Rev 92 (4), 1515-1542 (2012)
   PUBMED   23073625
  REMARK    Review article
REFERENCE   4  (bases 1 to 4835)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 4835)
  AUTHORS   Belenky,P., Christensen,K.C., Gazzaniga,F., Pletnev,A.A. and
            Brenner,C.
  TITLE     Nicotinamide riboside and nicotinic acid riboside salvage in fungi
            and mammals. Quantitative basis for Urh1 and purine nucleoside
            phosphorylase function in NAD+ metabolism
  JOURNAL   J Biol Chem 284 (1), 158-164 (2009)
   PUBMED   19001417
  REMARK    Erratum:[J Biol Chem. 2009 Mar 20;284(12):8208]
REFERENCE   6  (bases 1 to 4835)
  AUTHORS   Eloranta,T.O., Khomutov,A.R., Khomutov,R.M. and Hyvonen,T.
  TITLE     Aminooxy analogues of spermidine as inhibitors of spermine synthase
            and substrates of hepatic polyamine acetylating activity
  JOURNAL   J Biochem 108 (4), 593-598 (1990)
   PUBMED   2292587
REFERENCE   7  (bases 1 to 4835)
  AUTHORS   Abbruzzese,A., Della Pietra,G. and Porta,R.
  TITLE     Occurrence of 5'-deoxy-5'-methylthioadenosine phosphorylase in the
            mammalian CNS: distribution and kinetic studies on the rat brain
            enzyme
  JOURNAL   J Neurochem 40 (2), 487-492 (1983)
   PUBMED   6401802
REFERENCE   8  (bases 1 to 4835)
  AUTHORS   Seidenfeld,J., Wilson,J. and Williams-Ashman,H.G.
  TITLE     Androgenic regulation of 5'-deoxy-5'-methylthioadenosine
            concentrations and methylthioadenosine phosphorylase activity in
            relation to polyamine metabolism of rat prostate
  JOURNAL   Biochem Biophys Res Commun 95 (4), 1861-1868 (1980)
   PUBMED   6774734
REFERENCE   9  (bases 1 to 4835)
  AUTHORS   Nicolette,J.A., Wrobel,N.C. and Ferro,A.J.
  TITLE     The stimulatory effect of testosterone propionate and 17
            beta-estradiol on 5'-methylthioadenosine phosphorylase activity in
            rat target tissues
  JOURNAL   Biochim Biophys Acta 627 (2), 190-198 (1980)
   PUBMED   6766069
REFERENCE   10 (bases 1 to 4835)
  AUTHORS   Garbers,D.L.
  TITLE     Demonstration of 5'-methylthioadenosine phosphorylase activity in
            various rat tissues. Some properties of the enzyme from rat lung
  JOURNAL   Biochim Biophys Acta 523 (1), 82-93 (1978)
   PUBMED   415762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2021 this sequence version replaced XM_006238382.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.914110.1,
                                           SRR26360194.2545822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000005.1  108990270-108990461
            193-279             JAXUCZ010000005.1  109001610-109001696
            280-338             JAXUCZ010000005.1  109005206-109005264
            339-506             JAXUCZ010000005.1  109011163-109011330
            507-609             JAXUCZ010000005.1  109025438-109025540
            610-849             JAXUCZ010000005.1  109026311-109026550
            850-972             JAXUCZ010000005.1  109030157-109030279
            973-4835            JAXUCZ010000005.1  109032632-109036494
FEATURES             Location/Qualifiers
     source          1..4835
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..4835
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /note="methylthioadenosine phosphorylase"
                     /db_xref="GeneID:298227"
                     /db_xref="RGD:1310114"
     exon            1..192
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1011
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /EC_number="2.4.2.28"
                     /note="5'-methylthioadenosine phosphorylase"
                     /codon_start=1
                     /product="S-methyl-5'-thioadenosine phosphorylase"
                     /protein_id="NP_001380978.1"
                     /db_xref="GeneID:298227"
                     /db_xref="RGD:1310114"
                     /translation="MASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDA
                     LILGKIKNVDCVLLARHGRHHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEI
                     QPGDMVIIDQFIDRTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIEMAKKLG
                     LRCHSKGTIVTIEGPRFSSRAESFIFRTWGADVINMTTVPEVVLAKEAGLCYASIAMA
                     TDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKNMAQS
                     SVLPPRH"
     exon            193..279
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /inference="alignment:Splign:2.1.0"
     exon            280..338
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /inference="alignment:Splign:2.1.0"
     exon            339..506
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /inference="alignment:Splign:2.1.0"
     exon            507..609
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /inference="alignment:Splign:2.1.0"
     exon            610..849
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /inference="alignment:Splign:2.1.0"
     exon            850..972
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /inference="alignment:Splign:2.1.0"
     exon            973..4835
                     /gene="Mtap"
                     /gene_synonym="Cc1-6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagggtgcc aggagggcag ccaatcccgc gctccctggg aggaagagga ggagccagag
       61 cccacgggcc cctgcaccgc tcactctcgc gccgtgccag ccccgcagtc tccccttggt
      121 ccagcgctgc ggcccgccgt ggacttcccc ggtgcagaca tggcctcggg ctccgcctgc
      181 acggcagtga agattggaat aattggtgga acaggcttgg atgaccctga aattttagaa
      241 ggaagaacag aaaaatatgt ggatactcca tttggcaagc catctgatgc cttaattttg
      301 gggaagataa agaacgtcga ctgtgtgctt cttgccagac acggcagaca tcacaccatc
      361 atgccttcaa aagtcaacta ccaggcgaac atctgggcct tgaaggaaga gggctgtaca
      421 catgtcattg tgaccacagc ttgcgggtcc ttgagagagg agatccagcc tggtgacatg
      481 gtcatcatcg atcagttcat tgacaggaca tccctgaggc ctcagacctt ctatgatgga
      541 agtcattgca gtgccagagg agtgtgccac atcccaatgg ctgaaccatt ttgccccaaa
      601 acaagagagg tcctcataga aatggctaag aagcttggac tccggtgcca ttcaaagggg
      661 acgatagtca caattgaggg gcctcggttt agctcccggg cagaaagctt tatattccgt
      721 acttggggcg cagatgttat caatatgacc actgttccag aggtggtgct tgcaaaggag
      781 gccggattgt gctacgcaag cattgccatg gcaaccgatt atgattgctg gaaggagcat
      841 gaagaagcag tgtcagtgga tggggtttta aagaccatga aagaaaatgc caataaagcc
      901 aaaagtttac tcctaactac tatacctcag atagggtcaa tggaatggtc agaaacgctc
      961 cgtaacctaa agaacatggc ccagtcttct gttttaccac caagacatta aaacagcatg
     1021 gctgacataa gtagactttc tacttctatt ctttggggga tttgcttaaa caaaaatggg
     1081 aaagatgtgc agccttcatg cctttgcctg gaaagaaaga gagctactgc tggagactca
     1141 gccaagaccc cgactcctcc aggacccaga aagaaagcag acagcctgcc gaagtgtaag
     1201 ggaacaaagt ccgagagcac atctgtctcc gttcctccct atgaaactga cagcaaggaa
     1261 gactggtgag aacatcctct tccctacact gctaaggaac caatatgagc ccgagatggg
     1321 actgtatggt tgtaaactgg tgccatgttt ctggtaccta ggtattctag gagtttctct
     1381 tgaagttatg ggagattcat tcaaagaatc atgtgtaaag gagattacct gtcatagtaa
     1441 aataatcaaa actatctgaa tatcaaaaag attaggcgtg ctgtgtttct gttatactta
     1501 ggctgtggag caatcaaatg ggaatcatgt tttcttacaa agaaacgatc agtctttctc
     1561 tacttttttt ttttttaagt ataatcaaat agtaaagttg taaaagttta aacggactta
     1621 gagaactttg aaactctttt gatggtgaaa caaagacaac catgttataa atgcactgtg
     1681 tatgtggttc aagatataca agccaaacaa ccttcttccc caaaataaag aaataaaaag
     1741 aagtgctgtg tgaggagctt atatctttgc ttaagaaaga ttctgagtca ccacccaggt
     1801 acaacgattg taactgagat agccaaggct ggtgtttaat gctaaaatgt acagaaagtc
     1861 agactgcttc aaggattaag ctagtgtgac gcattacagg gtaccgggta ttttttttaa
     1921 attaccattt gtttctactc ctttctttac agttgacaca taactcagtt ggcagtgttt
     1981 gtgtcttcac attactgttg ttacaggcgc cctgcagccc ttgtaaacag tctgtgaagt
     2041 cagtgtgctt gtgtctgaaa ttgacttcac gacaataagc tgttggttgt aagcataaat
     2101 gaactgtttg ctccagtatt aatgttgagg ccctgggtaa gtgcaagtgt aacttccggc
     2161 ccatgttaca atgcttctgg cgctggctgt tagcagttca tggagactcc gtgagtcctg
     2221 accagggctt ttggttggtt ttattcactg cactgcaagc agttctttcc tttacccttg
     2281 gtagtcactg tgtaataggc atctgttttg ttgcctttag aaaatgctgc tttcttcaac
     2341 atggagaatg attttcttca gtggcctttc tagcatcgtt atgtgcaagc ttctttttcc
     2401 ttaatccttc attaagatga aatatgcata tgataactga ctctggtaca acatgacact
     2461 gtccgttcca tccactttcc actcttctga caaatgagat ctcatctcgt gtcccttcca
     2521 cgtgctttat tcattcattt gttgatagac aggtagactg atgccatcgt gtagctgttc
     2581 tgagtagtgt tccaataaac acgagtttgc agacttctca gatgaccaga ttgtacttct
     2641 gcgtttgtgt tgggtcttgg ctcttgttag tatagaaact ctactttgag aattattatc
     2701 taaaccattt gtctggttgt tctttagata gattccagac ctcagaccta gtcaaaggca
     2761 tcacttggtc catggtactt ttttttttta caactttgta ttggttctaa ttgattgaat
     2821 ttcacatcat gcacaccaat ccactcattc gcccctcccc tcatgcccac cttccaccct
     2881 tgcaacctcc cctgccaaca gaaaaaaaaa aaatctcgtt gtagaagatg taatatgctg
     2941 catcccacag tcccacaata tactcttttg tttatgtttc ttggcttgca aatgttcatt
     3001 gcattgagtt cttggtctgg tataaggctg ctacactacc aatactggaa cttcgctggg
     3061 actcttcata tatcctgttg ttgtcttgtg caatggagat cctgtagttt tggatctgta
     3121 cgaccaaccc cttcactcta gcagctcatc tatggggtac atgttgaagt gtaccaattc
     3181 aaagccatgg atctgagcct gagaggtctg agctggtcag cccaccagcc ctcccacact
     3241 accgggataa gttcttccct gtgccagctg acccatccaa tgctccagca aaaggctggt
     3301 catctttggc tagctccctg agtcatcttg ggctctctcc agcctggggc caatggtcga
     3361 aggcagggtt cttctagtct ccagcttgtt ccctaccctg ggagcctgtc aaggcctgca
     3421 cagtaccaga ctagtggtca tctctggcta gctcccttag ctccctgtcc aggggacctc
     3481 ctggcactgg attagtggtg gactcaggct tgcttttttt tcaggagagg ttagattact
     3541 aatcattcag atgttcataa gtcagaacac tgagcaaagc aatagcttct cctccaccta
     3601 ctgactcaca cgtgcacaac agccacaccc gcaatgcctc taggagcagg tccagtgtac
     3661 ttttgtttta actatttttg gctctttatt aatcagcaca taaatacgct tcgtttctcc
     3721 ttttcaatat gtatgtgtgg tgctgagtat caaactcaaa gccttgtgcg tgccatgcta
     3781 acactgtacc atggagctag acttgttggc ttctattaaa attctttatt gtctagtctc
     3841 tttgacttgc tttagaataa aatcctttct tagtttttct tttttttttt cctgccttag
     3901 tgtatataaa atacctttgt tgctgtgaga aagtaccttg acaaaagcaa caaaaggaaa
     3961 tatgagttta ttttgcttca cagttcaaga gtgcagtcca gagcttgagg cagctgctca
     4021 cattgcatct acaatgaaga agtggacaat gatgaatgct tgtgctcagc tcacattatc
     4081 atttttatac agtccagggt cccagcatag ggaatggtgc cacccatatt gggtccactc
     4141 aagttgggtc ttcccacttt aaaaaaccta ttcaacataa tccttaacag gcatgcccag
     4201 agttcatgtc ctgggtgact ctagagctta tccagagttg acaactgaca ttaagcgtat
     4261 cattctccat tctcttgctc aggttgacca gtaccacctc ctttcccttg atctaatcca
     4321 ctcactatct gacagcctgt tctctgtact tgccaagcac tttattctat tgttacactg
     4381 ttgcaatcgc ctatttcatt tttcattggc atgtggttgt atttagtacc cccaggttct
     4441 ttacatagta actgacacag aagaactgtc tgtacttcct aaataagtcg gcaagtctat
     4501 gagtctttag cctattcata tttcagccat ctttccattt ccagctggaa tcactggtac
     4561 catagaacct tgttagtcaa gcccaaagta aatagtccac tctgggtatg ttcaggccac
     4621 ctagagtctg ttaccaagga ccatttgtca taatgtacaa cataaagctg cctcccaact
     4681 agctagtaaa ctggaaaaat gtaaaatcta gaaaagaaaa tggcttatgt gttagttatt
     4741 taataaaaat ccagtgagtt atttaatgta ttgcctgatt taaattttat gcctagtaat
     4801 attttttctg caataaattt ttctttgtct ttaaa
//
