LOCUS       NM_001100740            3013 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus metastasis associated 1 family, member 2 (Mta2),
            mRNA.
ACCESSION   NM_001100740 XM_001077908 XM_342015
VERSION     NM_001100740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Cheng P, Zhao J, Qiao H, Ma H, Ma B, Wei J, Li Y and Li Z.
  TITLE     Colocalization of metastasis-associated proteins 1/2 and estrogen
            receptor alpha in rat epididymis
  JOURNAL   Tissue Cell 49 (5), 582-588 (2017)
   PUBMED   28789814
  REMARK    GeneRIF: MTA1 and MTA2 may be involved in the regulation of ERalpha
            transactivation activity in the epididymis of rats to facilitate a
            stable environment in the lumen
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Basta J and Rauchman M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Toh Y and Nicolson GL.
  TITLE     Identification and characterization of metastasis-associated
            gene/protein 1 (MTA1)
  JOURNAL   Cancer Metastasis Rev 33 (4), 837-842 (2014)
   PUBMED   25315816
  REMARK    Review article
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   Yamada T, Yang Y, Hemberg M, Yoshida T, Cho HY, Murphy JP,
            Fioravante D, Regehr WG, Gygi SP, Georgopoulos K and Bonni A.
  TITLE     Promoter decommissioning by the NuRD chromatin remodeling complex
            triggers synaptic connectivity in the mammalian brain
  JOURNAL   Neuron 83 (1), 122-134 (2014)
   PUBMED   24991957
  REMARK    GeneRIF: endogenous Mta1/2 forms a complex with Chd4, Hdac1/2,
            RbAp48, and Mbd3 in the rat cerebellum
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   Zhou J, Zhan S, Tan W, Cheng R, Gong H and Zhu Q.
  TITLE     P300 binds to and acetylates MTA2 to promote colorectal cancer
            cells growth
  JOURNAL   Biochem Biophys Res Commun 444 (3), 387-390 (2014)
   PUBMED   24468085
REFERENCE   6  (bases 1 to 3013)
  AUTHORS   Mahajan MC, Narlikar GJ, Boyapaty G, Kingston RE and Weissman SM.
  TITLE     Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF
            form a chromatin remodeling complex at the beta-globin locus
            control region
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15012-15017 (2005)
   PUBMED   16217013
REFERENCE   7  (bases 1 to 3013)
  AUTHORS   Rodriguez P, Bonte E, Krijgsveld J, Kolodziej KE, Guyot B, Heck AJ,
            Vyas P, de Boer E, Grosveld F and Strouboulis J.
  TITLE     GATA-1 forms distinct activating and repressive complexes in
            erythroid cells
  JOURNAL   EMBO J 24 (13), 2354-2366 (2005)
   PUBMED   15920471
REFERENCE   8  (bases 1 to 3013)
  AUTHORS   Zoltewicz JS, Stewart NJ, Leung R and Peterson AS.
  TITLE     Atrophin 2 recruits histone deacetylase and is required for the
            function of multiple signaling centers during mouse embryogenesis
  JOURNAL   Development 131 (1), 3-14 (2004)
   PUBMED   14645126
REFERENCE   9  (bases 1 to 3013)
  AUTHORS   Matsusue K, Takiguchi S, Toh Y and Kono A.
  TITLE     Characterization of mouse metastasis-associated gene 2: genomic
            structure, nuclear localization signal, and alternative potentials
            as transcriptional activator and repressor
  JOURNAL   DNA Cell Biol 20 (10), 603-611 (2001)
   PUBMED   11749719
REFERENCE   10 (bases 1 to 3013)
  AUTHORS   Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A and Reinberg
            D.
  TITLE     Analysis of the NuRD subunits reveals a histone deacetylase core
            complex and a connection with DNA methylation
  JOURNAL   Genes Dev 13 (15), 1924-1935 (1999)
   PUBMED   10444591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166471.1.
            
            On or before Jun 8, 2008 this sequence version replaced
            XM_342015.3, XM_001077908.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166471.1, BC129130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3013
                     /gene="Mta2"
                     /note="metastasis associated 1 family, member 2"
                     /db_xref="GeneID:361724"
                     /db_xref="RGD:1306743"
     exon            1..411
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..2390
                     /gene="Mta2"
                     /note="metastasis-associated gene family, member 2"
                     /codon_start=1
                     /product="metastasis-associated protein MTA2"
                     /protein_id="NP_001094210.1"
                     /db_xref="GeneID:361724"
                     /db_xref="RGD:1306743"
                     /translation="MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVC
                     LFRRRDISSSLNSLADSNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHI
                     RGKCSVTLLNETDILNQYLEKEDCFFYSLVFDPVQKTLLADQGEIRVGCKFQAEIPDR
                     LAEGESDNRNQQKMEMKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSL
                     HMSAAAASRDITLFHAMDTLQRNGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLF
                     EEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTTDRYIQQKRLKAAEADSKLKQV
                     YIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRLCA
                     SCWIYWKKYGGLKTPTQLEGAARGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKN
                     RQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLK
                     IHPLARLPLAAIVKDLVAQAPLKPKTPRGTKTPINRNQLTQNRGLGGIMVKRSYETMA
                     GAGVPFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLE
                     MRRAARRPNLPLKVKTALMTVRPPVPLPASSHPASTNEPIVLED"
     exon            412..479
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..573
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..691
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..755
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..873
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..976
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1076
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1265
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1340
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1399
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1497
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1637
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1866
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1956
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2075
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2224
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2989
                     /gene="Mta2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgttccgga aggaggcgaa cccggacgcg ggcagggcaa accttcccag cggttggcac
       61 cacacgacgt ctgctgggac tcggtgagga cgctaggagc cggaacctga ctccggtcag
      121 gcaggaaccg agctcgttcc ggaagaaggc gagcagaccg gagccggcct cggtatcccg
      181 gcgtgaggct atagcagcgt tgtcgtcgcg cgggcagtga tgaaccgcga cggctgagtg
      241 agcagaggtg ccggctgctc gggccccatc gacacttccg cgaagcgtca gccccgcgct
      301 gggggcttcg tctggagctg agctttgccc ccgcgagcct cccggacctc tttgtgtggc
      361 cggaggcggc ggcgggaacg gccatggcgg ctaacatgta ccgggtagga gattatgtct
      421 attttgagaa ctcctccagc aatccttacc tggttagacg gattgaggag ctcaataaga
      481 ctgcaaacgg aaatgtggaa gcaaaggttg tctgcctttt ccggcgaagg gatatttcta
      541 gtagcctcaa cagcttggcg gacagcaatg ctagggagtt tgaggaggaa tcaaaacagc
      601 caggggtctc ggagcagcag agacatcaac tgaagcaccg agagcttttt ctttctcggc
      661 agtttgaatc attaccggcc acccacataa gggggaagtg cagtgtgact ctcttgaacg
      721 agacggatat cttaaaccaa tatctggaaa aggaggactg ctttttttac tcactggtgt
      781 tcgaccctgt gcagaagaca cttctggctg atcaagggga gatcagagtt ggttgcaaat
      841 tccaagctga gatcccagat cgtttggcag agggagaatc ggataatcga aaccaacaga
      901 agatggagat gaaagtctgg gacccagaca accctctcac agaccggcag atcgatcagt
      961 ttctcgtggt ggcccgagcc gtgggaacct ttgccagagc cctagactgc agcagctcaa
     1021 tccggcagcc aagcttgcac atgagtgcag ctgctgcgtc ccgagatatc accctgttcc
     1081 atgccatgga cacgttgcaa aggaatggct atgacttggc caaggccatg tcaaccctgg
     1141 tgccacaggg aggtccagtg ctctgtcggg atgagatgga ggaatggtct gcttctgaag
     1201 ctatgctgtt tgaagaagct ctggagaagt atgggaagga tttcaatgac atccgccagg
     1261 actttctacc ctggaagtca cttgcaagca tagtccagtt ttattacatg tggaaaacca
     1321 cagatcggta tattcagcag aaaagactga aagctgctga agcagacagc aaactaaaac
     1381 aggtctacat ccccacttat actaagccaa accctaacca gatcatttct gtgggttcaa
     1441 aacctggcat gaatggggct ggattccaga aaggcctgac ttgtgagagc tgccacacca
     1501 cacagtctgc ccagtggtat gcttggggcc cacctaacat gcagtgccga ctttgtgctt
     1561 cctgttggat ttactggaag aagtatgggg ggctgaagac accgacccag cttgaagggg
     1621 ctgctcgggg caccacagag ccacactcaa gaggtcattt atccagacct gaagcccaaa
     1681 gtctctcccc ctatacaacc agtgctaacc gggctaagtt gctggctaag aacaggcaaa
     1741 ctttcttgct ccagaccaca aagctgactc gtcttgctag acggatgtgc agagacctgt
     1801 tacagccaag gagggctgcc cgaagaccct atgcccccat caatgccaac gccatcaagg
     1861 cagagtgctc tatccgactt cctaaggctg ccaagacacc gttgaagatt caccccctgg
     1921 cgagactgcc cttggcagct attgtcaaag atctggtggc tcaggcacct ctgaaaccaa
     1981 aaacacctcg gggcaccaag acaccaatca acagaaacca gctgacccag aatcgaggcc
     2041 tggggggcat tatggtgaaa cgttcctatg agactatggc aggggcaggg gttcccttct
     2101 ctgccaatgg aaggcctctg gcttcaggga ttcgttcaag ctcacagcca gcagccaagc
     2161 gtcagaaact aaaccctgct gatgctccca atccagtggt atttgtggcc acaaaggata
     2221 ccagggcttt aaggaaagct ctaactcacc tggaaatgcg ccgagctgct cgaaggccca
     2281 acttacccct gaaggtgaag acagcgctga tgacagtgcg gcccccagtt cctctgccgg
     2341 catcttcaca tcctgctagc accaatgagc ccattgtcct ggaggattga gcatcttagg
     2401 ggaagggagg tgggatgaga ggtaaagggt tggttgccca gggcatacaa atcttcattc
     2461 cttttggtat caaagggagt aaggagtgag ggagggttgg agttggtgtg cgtgtgtcct
     2521 tgcaggggtt gaacaccctc tggtgttact gccagtatct cccctttttg ggcttctcca
     2581 tgcctgtgat ggaaaacagc ctataggaac ttacttgtgt gtacctaccc tatttggggc
     2641 ctgggaccca cagtgggttt ggacagttgg ggggagggtt ttttaatttt tttaaaaatt
     2701 taccttcctt tgtaaaagga tggaggaagg gaagagtaaa catatcaggt gttggtccct
     2761 ggcaggggga agggggagta cactgccatg tctcttttct ttattttcta ttggggatgg
     2821 gggggttact cttactgtcc ggtgtccgga ctttccttat tggagtttga gggccctaag
     2881 ctggcatcaa ccccagccca tgctcactct tcttccctcc cctttctccc tctgcctttt
     2941 atatgccaat tctcagaaat aaagatcttt tgtctgtttt ttaacctcaa aaaaaaaaaa
     3001 aaaaaaaaaa aaa
//
