LOCUS       NM_022588               2743 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus metastasis associated 1 (Mta1), mRNA.
ACCESSION   NM_022588
VERSION     NM_022588.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2743)
  AUTHORS   Qian,W., Cai,X., Qian,Q., Zhang,W. and Tian,L.
  TITLE     Metastasis-associated protein 1 promotes epithelial-mesenchymal
            transition in idiopathic pulmonary fibrosis by up-regulating Snail
            expression
  JOURNAL   J Cell Mol Med 24 (11), 5998-6007 (2020)
   PUBMED   32187849
  REMARK    GeneRIF: Metastasis-associated protein 1 promotes
            epithelial-mesenchymal transition in idiopathic pulmonary fibrosis
            by up-regulating Snail expression.
REFERENCE   2  (bases 1 to 2743)
  AUTHORS   Cheng,P., Zhao,J., Qiao,H., Ma,H., Ma,B., Wei,J., Li,Y. and Li,Z.
  TITLE     Colocalization of metastasis-associated proteins 1/2 and estrogen
            receptor alpha in rat epididymis
  JOURNAL   Tissue Cell 49 (5), 582-588 (2017)
   PUBMED   28789814
  REMARK    GeneRIF: MTA1 and MTA2 may be involved in the regulation of ERalpha
            transactivation activity in the epididymis of rats to facilitate a
            stable environment in the lumen
REFERENCE   3  (bases 1 to 2743)
  AUTHORS   Al-Bader,M.D., Kilarkaje,N., El-Farra,A. and Al-Abdallah,A.A.
  TITLE     Expression and subcellular localization of metastasis-associated
            protein 1, its short form, and estrogen receptors in rat placenta
  JOURNAL   Reprod Sci 22 (4), 484-494 (2015)
   PUBMED   25217305
  REMARK    GeneRIF: MTA1 is coexpressed with ERa and ERb in the nuclei and
            cytoplasm of all placental cell types.
REFERENCE   4  (bases 1 to 2743)
  AUTHORS   Toh,Y. and Nicolson,G.L.
  TITLE     Identification and characterization of metastasis-associated
            gene/protein 1 (MTA1)
  JOURNAL   Cancer Metastasis Rev 33 (4), 837-842 (2014)
   PUBMED   25315816
  REMARK    Review article
REFERENCE   5  (bases 1 to 2743)
  AUTHORS   Yamada,T., Yang,Y., Hemberg,M., Yoshida,T., Cho,H.Y., Murphy,J.P.,
            Fioravante,D., Regehr,W.G., Gygi,S.P., Georgopoulos,K. and Bonni,A.
  TITLE     Promoter decommissioning by the NuRD chromatin remodeling complex
            triggers synaptic connectivity in the mammalian brain
  JOURNAL   Neuron 83 (1), 122-134 (2014)
   PUBMED   24991957
  REMARK    GeneRIF: The core NuRD complex metastasis-associated proteins
            Mta1/2 have been purified from rat NuRD chromatin cerebellar
            remodeling complex
REFERENCE   6  (bases 1 to 2743)
  AUTHORS   Simpson,A., Uitto,J., Rodeck,U. and Mahoney,M.G.
  TITLE     Differential expression and subcellular distribution of the mouse
            metastasis-associated proteins Mta1 and Mta3
  JOURNAL   Gene 273 (1), 29-39 (2001)
   PUBMED   11483358
REFERENCE   7  (bases 1 to 2743)
  AUTHORS   Kleene,R., Classen,B., Zdzieblo,J. and Schrader,M.
  TITLE     SH3 binding sites of ZG29p mediate an interaction with amylase and
            are involved in condensation-sorting in the exocrine rat pancreas
  JOURNAL   Biochemistry 39 (32), 9893-9900 (2000)
   PUBMED   10933808
REFERENCE   8  (bases 1 to 2743)
  AUTHORS   Kleene,R., Zdzieblo,J., Wege,K. and Kern,H.F.
  TITLE     A novel zymogen granule protein (ZG29p) and the nuclear protein
            MTA1p are differentially expressed by alternative transcription
            initiation in pancreatic acinar cells of the rat
  JOURNAL   J Cell Sci 112 (Pt 15), 2539-2548 (1999)
   PUBMED   10393810
REFERENCE   9  (bases 1 to 2743)
  AUTHORS   Toh,Y., Pencil,S.D. and Nicolson,G.L.
  TITLE     Analysis of the complete sequence of the novel
            metastasis-associated candidate gene, mta1, differentially
            expressed in mammary adenocarcinoma and breast cancer cell lines
  JOURNAL   Gene 159 (1), 97-104 (1995)
   PUBMED   7607577
REFERENCE   10 (bases 1 to 2743)
  AUTHORS   Toh,Y., Pencil,S.D. and Nicolson,G.L.
  TITLE     A novel candidate metastasis-associated gene, mta1, differentially
            expressed in highly metastatic mammary adenocarcinoma cell lines.
            cDNA cloning, expression, and protein analyses
  JOURNAL   J Biol Chem 269 (37), 22958-22963 (1994)
   PUBMED   8083195
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000169.1.
            
            [WARNING] On Jul 15, 2024 this sequence was replaced by
            NM_022588.3.
            
            On Nov 27, 2020 this sequence version replaced NM_022588.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U02522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132277, SAMD00132299
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JACYVU010000169.1  4025146-4025271
            127-194             JACYVU010000169.1  4038438-4038505
            195-288             JACYVU010000169.1  4043035-4043128
            289-339             JACYVU010000169.1  4046161-4046211
            340-466             JACYVU010000169.1  4046779-4046905
            467-530             JACYVU010000169.1  4046975-4047038
            531-648             JACYVU010000169.1  4049756-4049873
            649-751             JACYVU010000169.1  4052882-4052984
            752-851             JACYVU010000169.1  4053845-4053944
            852-1040            JACYVU010000169.1  4054243-4054431
            1041-1115           JACYVU010000169.1  4056345-4056419
            1116-1174           JACYVU010000169.1  4056740-4056798
            1175-1290           JACYVU010000169.1  4057065-4057180
            1291-1442           JACYVU010000169.1  4057479-4057630
            1443-1632           JACYVU010000169.1  4057736-4057925
            1633-1722           JACYVU010000169.1  4058058-4058147
            1723-1875           JACYVU010000169.1  4060057-4060209
            1876-1907           JACYVU010000169.1  4062665-4062696
            1908-2059           JACYVU010000169.1  4063016-4063167
            2060-2743           JACYVU010000169.1  4063251-4063934
FEATURES             Location/Qualifiers
     source          1..2743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2743
                     /gene="Mta1"
                     /note="metastasis associated 1"
                     /db_xref="GeneID:64520"
                     /db_xref="RGD:621018"
     exon            1..126
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2210
                     /gene="Mta1"
                     /codon_start=1
                     /product="metastasis-associated protein MTA1"
                     /protein_id="NP_072110.1"
                     /db_xref="GeneID:64520"
                     /db_xref="RGD:621018"
                     /translation="MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVC
                     FYRRRDISSSLIALADKHATLSVCYRAGPGADTGEEGEVEEEVENPEMVDLPEKLKHQ
                     LRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTL
                     LADKGEIRVGNRYQADITDLLKDGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVAR
                     SVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQG
                     GPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTD
                     RYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISVNSVKASVVNGTGTPGQSPGAGRA
                     CESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRNNMSP
                     HGIPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYMPINSAAI
                     KAECTARLPEASQSPLVLKQVVRKPLEAVLRYLETHPRPPKPDPVKSSSSVLSSLTPA
                     KSAPVINNGSPTILGKRSYEQHNGVDGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIR
                     GGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQ
                     ALPLRPPPPAPVNDEPIVIED"
     exon            127..194
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            195..288
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..339
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..466
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..530
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..648
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..751
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1040
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1115
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1174
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1290
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1442
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1632
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1722
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1875
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1907
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2059
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2743
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccggcgc ccccgcgccc gccccccgcc ccggcccgcg cccggcccgc cgcccgcgcc
       61 cgcgccccgc gccccgcggc cccgccgccg gcccggacat ggccgccaac atgtacaggg
      121 tcggagacta tgtctacttt gagaactcct ccagcaaccc gtacctgatc cgcaggattg
      181 aagagctcaa taagacagcc aacgggaatg tggaggccaa agtggtgtgt ttctacagaa
      241 ggcgggacat ttccagcagc ctcatcgcgc tggctgacaa gcatgcaacc ctgtcagtct
      301 gctatagagc cggaccgggg gcggacaccg gcgaggaagg ggaagtggag gaggaggtag
      361 aaaacccaga gatggtagac ctgcctgaga aacttaagca ccagctgcgg catcgggaac
      421 tgttcctctc tcggcagttg gagtctctgc ctgccaccca catcaggggc aagtgcagtg
      481 ttaccctgct caatgagacc gagtcactca agtcctacct ggagcgtgag gatttcttct
      541 tctactctct agtctacgac ccacagcaga agaccctcct ggctgataaa ggcgaaattc
      601 gtgtagggaa ccggtaccag gctgacatca ctgatttgct gaaagacggt gaggaggacg
      661 gccgcgatca gtcgaagctg gagaccaagg tgtgggaagc ccacaatcca cttgtagata
      721 agcagattga ccagtttctg gtggtggccc gctctgtggg tacctttgca cgggccctgg
      781 attgcagcag ctccgtgcgg cagcctagcc tgcacatgag tgccgccgca gcctcccgag
      841 acatcaccct gtttcatgcc atggacacgc tgcacaagaa catctacgac atctccaagg
      901 ccatctctgc ccttgtgcct cagggtgggc cagtgctctg cagggatgag atggaggagt
      961 ggtcagcatc agaagccaac ctttttgagg aagctctgga aaaatatggg aaagatttca
     1021 cagacattca gcaagacttt ctcccatgga agtcgctcac cagcatcatt gagtattact
     1081 acatgtggaa gaccaccgac agatacgtcc agcagaaacg tttgaaagca gctgaagcag
     1141 agagcaagtt aaagcaggtt tatattccca actataacaa gccaaaccca aaccagatca
     1201 gcgtcaacag tgtcaaggcc agtgtagtga atggcacagg gacaccaggc cagagccccg
     1261 gggccggtcg ggcctgcgag agctgttaca ccacacagtc ttaccagtgg tattcttggg
     1321 gtccccctaa catgcagtgt cgcctctgcg catcttgttg gacatattgg aagaaatatg
     1381 gtggcttgaa aatgccaacc cggttagatg gagagaggcc gggaccaaac cgcaataaca
     1441 tgagtcccca tggcatccca gctcggagca gtgggagccc caagtttgcc atgaagacaa
     1501 ggcaggcctt ctacctgcat actaccaagt tgacacgcat tgcccggcgc ttgtgccgtg
     1561 agatcctacg cccatggcat gccgcacgcc acccctacat gcccatcaac agtgcagcaa
     1621 tcaaggctga atgcacagca cggctgcccg aagcttccca gagcccactg gtgctgaagc
     1681 aggtagtacg gaagcccctg gaggctgtgc tccggtatct tgagactcat ccccgcccgc
     1741 ctaagcccga ccctgtgaag agctcatcca gtgtgctcag cagtctgacc cctgccaagt
     1801 cagcccctgt catcaacaat ggctccccta ccatcttggg caagaggagc tatgagcagc
     1861 acaatggggt agatggtctg gcaaaccatg gacagaccag gcacatggga ccaagtcgga
     1921 atctcctgct caatgggaag tcctacccca ccaaagtgcg cctaatccga ggcggctccc
     1981 tgcctccagt caagcggcgg cggatgaact ggattgacgc cccagatgat gtattttaca
     2041 tggccaccga ggagaccagg aaaatccgaa agctgctctc atcttcagaa accaagcgtg
     2101 ctgcccgccg gccctacaag cctattgccc tgcgccagag ccaggccctg ccgctgcggc
     2161 cacccccacc tgcaccagtc aatgatgagc ccattgttat tgaggactag gcggtcaccc
     2221 acagtggcct gcctgggccc ctccatcagc cccagagtat ccagtgaggc ctgcagaggc
     2281 caagcggcct ccctccccca ccagactgct gcccacccca ccctctgttt ccgtagtgcc
     2341 ccaactcccg ccctcacatg cagagaaact gctcctctgg tggacatgcg ggggaagaag
     2401 tgtggtctaa cttattccaa gacaccgagg agtctttttt agctttgtgt ttactttctg
     2461 gctggagcag agatgaggag tgccctgggc cgtgggctgc agggcttctc agctggggtg
     2521 ggctctaagg ttttgttgtg ttctgttgaa ggtgccattt taaattttat ttttattact
     2581 tttttgtaga tgaacttgag ctctgtaact tacacctgga atgttaggat tggtgcagcc
     2641 agcagcggcc aagctgcctg gcagggttgg tcccttgtct tttcaagtaa ttttcatatt
     2701 aaacaaaaac aaagaaaaaa atctcataaa aaggaaaacc cca
//
