LOCUS       NM_053968                405 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus metallothionein 3 (Mt3), mRNA.
ACCESSION   NM_053968
VERSION     NM_053968.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 405)
  AUTHORS   Xiong,T., Li,Y., Yang,M., Huo,B., Guo,X., Liu,L., Huang,Y., Zhu,X.,
            Hu,Q., Wei,X., Jiang,D.S. and Yi,X.
  TITLE     Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell
            Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated
            Autophagosome Formation
  JOURNAL   Int J Biol Sci 20 (8), 2904-2921 (2024)
   PUBMED   38904023
  REMARK    GeneRIF: Metallothionein 3 Potentiates Pulmonary Artery Smooth
            Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated
            Autophagosome Formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 405)
  AUTHORS   Scudiero,R., Cigliano,L. and Verderame,M.
  TITLE     Age-related changes of metallothionein 1/2 and metallothionein 3
            expression in rat brain
  JOURNAL   C R Biol 340 (1), 13-17 (2017)
   PUBMED   27939232
  REMARK    GeneRIF: After passing middle age we observe a huge increase in MT3
            transcripts in both cortical and hippocampal areas, while the MT1/2
            mRNA content increases slightly
REFERENCE   3  (bases 1 to 405)
  AUTHORS   Tian,T., Ni,H. and Sun,B.L.
  TITLE     Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal
            Seizures Are Prevented by a Ketogenic Diet and Correlate with
            Hippocampal Zinc/Lipid Transporter Signals
  JOURNAL   Biol Trace Elem Res 167 (2), 251-258 (2015)
   PUBMED   25778834
  REMARK    GeneRIF: rats treated with KD (EXP2) showed a significant
            down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and
            ACAT-1 in hippocampus
REFERENCE   4  (bases 1 to 405)
  AUTHORS   Ni,H., Ren,S.Y., Zhang,L.L., Sun,Q., Tian,T. and Feng,X.
  TITLE     Expression profiles of hippocampal regenerative sprouting-related
            genes and their regulation by E-64d in a developmental rat model of
            penicillin-induced recurrent epilepticus
  JOURNAL   Toxicol Lett 217 (2), 162-169 (2013)
   PUBMED   23266720
REFERENCE   5  (bases 1 to 405)
  AUTHORS   Tsuruma,K., Shimazaki,H., Ohno,Y., Inoue,Y., Honda,A., Imai,S.,
            Lee,J., Shimazawa,M., Satoh,M. and Hara,H.
  TITLE     Metallothionein-III deficiency exacerbates light-induced retinal
            degeneration
  JOURNAL   Invest Ophthalmol Vis Sci 53 (12), 7896-7903 (2012)
   PUBMED   23132798
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 405)
  AUTHORS   Amoureux,M.C., Wurch,T. and Pauwels,P.J.
  TITLE     Modulation of metallothionein-III mRNA content and growth rate of
            rat C6-glial cells by transfection with human 5-HT1D receptor genes
  JOURNAL   Biochem Biophys Res Commun 214 (2), 639-645 (1995)
   PUBMED   7677777
REFERENCE   7  (bases 1 to 405)
  AUTHORS   Masters,B.A., Quaife,C.J., Erickson,J.C., Kelly,E.J.,
            Froelick,G.J., Zambrowicz,B.P., Brinster,R.L. and Palmiter,R.D.
  TITLE     Metallothionein III is expressed in neurons that sequester zinc in
            synaptic vesicles
  JOURNAL   J Neurosci 14 (10), 5844-5857 (1994)
   PUBMED   7931547
REFERENCE   8  (bases 1 to 405)
  AUTHORS   Erickson,J.C., Sewell,A.K., Jensen,L.T., Winge,D.R. and
            Palmiter,R.D.
  TITLE     Enhanced neurotrophic activity in Alzheimer's disease cortex is not
            associated with down-regulation of metallothionein-III (GIF)
  JOURNAL   Brain Res 649 (1-2), 297-304 (1994)
   PUBMED   7953645
REFERENCE   9  (bases 1 to 405)
  AUTHORS   Kobayashi,H., Uchida,Y., Ihara,Y., Nakajima,K., Kohsaka,S.,
            Miyatake,T. and Tsuji,S.
  TITLE     Molecular cloning of rat growth inhibitory factor cDNA and the
            expression in the central nervous system
  JOURNAL   Brain Res Mol Brain Res 19 (3), 188-194 (1993)
   PUBMED   8412560
REFERENCE   10 (bases 1 to 405)
  AUTHORS   Tsuji,S., Kobayashi,H., Uchida,Y., Ihara,Y. and Miyatake,T.
  TITLE     Molecular cloning of human growth inhibitory factor cDNA and its
            down-regulation in Alzheimer's disease
  JOURNAL   EMBO J 11 (13), 4843-4850 (1992)
   PUBMED   1464312
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC058453.1.
            
            On Aug 31, 2012 this sequence version replaced NM_053968.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058453.1, BF556086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               BC058453.1         4-408
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p12"
     gene            1..405
                     /gene="Mt3"
                     /gene_synonym="GIF; Mt-3"
                     /note="metallothionein 3"
                     /db_xref="GeneID:117038"
                     /db_xref="RGD:621252"
     exon            1..94
                     /gene="Mt3"
                     /gene_synonym="GIF; Mt-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..264
                     /gene="Mt3"
                     /gene_synonym="GIF; Mt-3"
                     /note="growth inhibitory factor; metallothionein III;
                     MT-III"
                     /codon_start=1
                     /product="metallothionein-3"
                     /protein_id="NP_446420.1"
                     /db_xref="GeneID:117038"
                     /db_xref="RGD:621252"
                     /translation="MDPETCPCPTGGSCTCSDKCKCKGCKCTNCKKSCCSCCPAGCEK
                     CAKDCVCKGEEGAKAEKCSCCQ"
     exon            95..160
                     /gene="Mt3"
                     /gene_synonym="GIF; Mt-3"
                     /inference="alignment:Splign:2.1.0"
     exon            161..376
                     /gene="Mt3"
                     /gene_synonym="GIF; Mt-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcagcgca tccgcttgcc tggaggaact aagctacagt ctctcgcggc tgctggcctg
       61 gatatggacc ctgagacctg cccctgtcct actggtggtt cctgcacctg ctcggacaaa
      121 tgcaaatgca agggctgcaa atgcacgaac tgcaagaaga gctgctgctc ctgttgccct
      181 gcaggatgtg agaagtgtgc caaggactgt gtttgcaaag gcgaagaggg ggccaaggcc
      241 gagaaatgca gctgctgcca gtgaggactc ccacacagcc tatgtgaata gtgctgcgtg
      301 tccctggtgg ggcgtggctg ttgcccccct ccctggcttc ctgctccggg ggtgtgaata
      361 aatcccatgc acagcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
