LOCUS       NM_001137564             383 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus metallothionein 2A (Mt2A), mRNA.
ACCESSION   NM_001137564 XM_001062488 XM_001070713
VERSION     NM_001137564.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 383)
  AUTHORS   Huang,X., Deng,J., Xu,T., Xin,W., Zhang,Y. and Ruan,X.
  TITLE     Downregulation of metallothionein-2 contributes to
            oxaliplatin-induced neuropathic pain
  JOURNAL   J Neuroinflammation 18 (1), 91 (2021)
   PUBMED   33849565
  REMARK    GeneRIF: Downregulation of metallothionein-2 contributes to
            oxaliplatin-induced neuropathic pain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 383)
  AUTHORS   Grubic Kezele,T., Blagojevic Zagorac,G., Jakovac,H., Domitrovic,R.
            and Radosevic-Stasic,B.
  TITLE     Hippocampal expressions of metallothionein I/II and glycoprotein 96
            in EAE-prone and EAE-resistant strains of rats
  JOURNAL   Histol Histopathol 32 (2), 137-151 (2017)
   PUBMED   27173051
  REMARK    GeneRIF: acute attack of experimental autoimmune encephalomyelitis
            was followed by increased expression of metallothioneins in
            molecular and granular cell layer of hippocampus.
REFERENCE   3  (bases 1 to 383)
  AUTHORS   Scudiero,R., Cigliano,L. and Verderame,M.
  TITLE     Age-related changes of metallothionein 1/2 and metallothionein 3
            expression in rat brain
  JOURNAL   C R Biol 340 (1), 13-17 (2017)
   PUBMED   27939232
  REMARK    GeneRIF: observe a huge increase in MT3 transcripts in both
            cortical and hippocampal areas, while the MT1/2 mRNA content
            increases slightly, returning to the levels measured in adolescent
            rats
REFERENCE   4  (bases 1 to 383)
  AUTHORS   Tian,T., Li,L.L., Zhang,S.Q. and Ni,H.
  TITLE     Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced
            Brain Injury During Early Adulthood: Relationship of Seizure
            Thresholds to Zinc Transporter-Related Gene Expressions
  JOURNAL   Biol Trace Elem Res 174 (2), 369-376 (2016)
   PUBMED   27147436
  REMARK    GeneRIF: The recurrent seizures plus normal diet group showed worse
            performances in neurological reflex tests and reduced latencies to
            myoclonic seizures induced by penicillin compared with the control,
            which was concomitant with altered expressions of ZnT-7, MT-1,
            MT-2, and ZIP7.
REFERENCE   5  (bases 1 to 383)
  AUTHORS   Lin,T.B., Hsieh,M.C., Lai,C.Y., Cheng,J.K., Wang,H.H., Chau,Y.P.,
            Chen,G.D. and Peng,H.Y.
  TITLE     Melatonin relieves neuropathic allodynia through spinal
            MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent
            epigenetic modification of hmgb1 transcription
  JOURNAL   J Pineal Res 60 (3), 263-276 (2016)
   PUBMED   26732138
  REMARK    GeneRIF: Melatonin -exhibited anti-allodynia is mediated by
            MT2-enhanced PP2Ac expression that couples PP2Ac with HDAC4 to
            induce HDAC4 dephosphorylation and nuclear import, herein increases
            HDAC4 binding to the promoter of hmgb1 gene and upregulates HMGB1
            expression in dorsal horn neurons.
REFERENCE   6  (bases 1 to 383)
  AUTHORS   Braun,W., Vasak,M., Robbins,A.H., Stout,C.D., Wagner,G., Kagi,J.H.
            and Wuthrich,K.
  TITLE     Comparison of the NMR solution structure and the x-ray crystal
            structure of rat metallothionein-2
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10124-10128 (1992)
   PUBMED   1438200
REFERENCE   7  (bases 1 to 383)
  AUTHORS   Robbins,A.H., McRee,D.E., Williamson,M., Collett,S.A., Xuong,N.H.,
            Furey,W.F., Wang,B.C. and Stout,C.D.
  TITLE     Refined crystal structure of Cd, Zn metallothionein at 2.0 A
            resolution
  JOURNAL   J Mol Biol 221 (4), 1269-1293 (1991)
   PUBMED   1942051
REFERENCE   8  (bases 1 to 383)
  AUTHORS   Schultze,P., Worgotter,E., Braun,W., Wagner,G., Vasak,M., Kagi,J.H.
            and Wuthrich,K.
  TITLE     Conformation of [Cd7]-metallothionein-2 from rat liver in aqueous
            solution determined by nuclear magnetic resonance spectroscopy
  JOURNAL   J Mol Biol 203 (1), 251-268 (1988)
   PUBMED   3184190
REFERENCE   9  (bases 1 to 383)
  AUTHORS   Worgotter,E., Wagner,G., Vasak,M., Kagi,J.H. and Wuthrich,K.
  TITLE     Sequence-specific 1H-NMR assignments in rat-liver metallothionein-2
  JOURNAL   Eur J Biochem 167 (3), 457-466 (1987)
   PUBMED   3653102
REFERENCE   10 (bases 1 to 383)
  AUTHORS   Andersen,R.D., Taplitz,S.J., Birren,B.W., Bristol,G. and
            Herschman,H.R.
  TITLE     Rat metallothionein multigene family
  JOURNAL   Experientia Suppl 52, 373-384 (1987)
   PUBMED   2959527
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001137564.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218212.1, FQ228458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000019.1  10838619-10838708   c
            91-156              JAXUCZ010000019.1  10838290-10838355   c
            157-383             JAXUCZ010000019.1  10837934-10838160   c
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p12"
     gene            1..383
                     /gene="Mt2A"
                     /gene_synonym="MT-2; MT-II; Mt2"
                     /note="metallothionein 2A"
                     /db_xref="GeneID:689415"
                     /db_xref="RGD:1592345"
     exon            1..90
                     /gene="Mt2A"
                     /gene_synonym="MT-2; MT-II; Mt2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..156
                     /gene="Mt2A"
                     /gene_synonym="MT-2; MT-II; Mt2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..383
                     /gene="Mt2A"
                     /gene_synonym="MT-2; MT-II; Mt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcacgctcc tagaactcta cagcgatctc tcgttgatct ccaactgccg cctccattcg
       61 ccatggaccc caactgctcc tgtgccacag atggatcctg ctcctgcgct ggctcctgca
      121 aatgcaaaca atgcaaatgc acctcctgca agaaaagctg ctgttcctgc tgccccgtgg
      181 gctgtgcgaa gtgctcccag ggctgcatct gcaaagaggc ttcggacaag tgcagctgct
      241 gcgcctgaag tgggggcgtc ctcacaatgg tgtaaataaa acaacgtagg aacctagcct
      301 ttttttgtac aaccctgacc ggttctccac acttttttct ataaagcatg taactgacaa
      361 taaaataaaa aaacttgact tga
//
