LOCUS       NM_031059               1894 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus msh homeobox 1 (Msx1), mRNA.
ACCESSION   NM_031059
VERSION     NM_031059.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1894)
  AUTHORS   Nishihara H, Kobayashi N, Kimura-Yoshida C, Yan K, Bormuth O, Ding
            Q, Nakanishi A, Sasaki T, Hirakawa M, Sumiyama K, Furuta Y,
            Tarabykin V, Matsuo I and Okada N.
  TITLE     Coordinately Co-opted Multiple Transposable Elements Constitute an
            Enhancer for wnt5a Expression in the Mammalian Secondary Palate
  JOURNAL   PLoS Genet 12 (10), e1006380 (2016)
   PUBMED   27741242
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1894)
  AUTHORS   Le Bouffant R, Souquet B, Duval N, Duquenne C, Herve R, Frydman N,
            Robert B, Habert R and Livera G.
  TITLE     Msx1 and Msx2 promote meiosis initiation
  JOURNAL   Development 138 (24), 5393-5402 (2011)
   PUBMED   22071108
REFERENCE   3  (bases 1 to 1894)
  AUTHORS   Bensoussan-Trigano V, Lallemand Y, Saint Cloment C and Robert B.
  TITLE     Msx1 and Msx2 in limb mesenchyme modulate digit number and identity
  JOURNAL   Dev Dyn 240 (5), 1190-1202 (2011)
   PUBMED   21465616
REFERENCE   4  (bases 1 to 1894)
  AUTHORS   Nakatomi M, Wang XP, Key D, Lund JJ, Turbe-Doan A, Kist R, Aw A,
            Chen Y, Maas RL and Peters H.
  TITLE     Genetic interactions between Pax9 and Msx1 regulate lip development
            and several stages of tooth morphogenesis
  JOURNAL   Dev Biol 340 (2), 438-449 (2010)
   PUBMED   20123092
REFERENCE   5  (bases 1 to 1894)
  AUTHORS   Zhou X, Sheng Y, Yang R and Kong X.
  TITLE     Nicotine promotes cardiomyocyte apoptosis via oxidative stress and
            altered apoptosis-related gene expression
  JOURNAL   Cardiology 115 (4), 243-250 (2010)
   PUBMED   20339300
REFERENCE   6  (bases 1 to 1894)
  AUTHORS   Iler N and Abate-Shen C.
  TITLE     Rapid identification of homeodomain binding sites in the Wnt-5a
            gene using an immunoprecipitation strategy
  JOURNAL   Biochem Biophys Res Commun 227 (1), 257-265 (1996)
   PUBMED   8858134
REFERENCE   7  (bases 1 to 1894)
  AUTHORS   Chen Y, Bei M, Woo I, Satokata I and Maas R.
  TITLE     Msx1 controls inductive signaling in mammalian tooth morphogenesis
  JOURNAL   Development 122 (10), 3035-3044 (1996)
   PUBMED   8898217
REFERENCE   8  (bases 1 to 1894)
  AUTHORS   Vastardis H, Karimbux N, Guthua SW, Seidman JG and Seidman CE.
  TITLE     A human MSX1 homeodomain missense mutation causes selective tooth
            agenesis
  JOURNAL   Nat Genet 13 (4), 417-421 (1996)
   PUBMED   8696335
REFERENCE   9  (bases 1 to 1894)
  AUTHORS   Catron KM, Wang H, Hu G, Shen MM and Abate-Shen C.
  TITLE     Comparison of MSX-1 and MSX-2 suggests a molecular basis for
            functional redundancy
  JOURNAL   Mech Dev 55 (2), 185-199 (1996)
   PUBMED   8861098
  REMARK    Erratum:[Mech Dev 1996 May;56(1-2):223]
REFERENCE   10 (bases 1 to 1894)
  AUTHORS   Kuzuoka M, Takahashi T, Guron C and Raghow R.
  TITLE     Murine homeobox-containing gene, Msx-1: analysis of genomic
            organization, promoter structure, and potential autoregulatory
            cis-acting elements
  JOURNAL   Genomics 21 (1), 85-91 (1994)
   PUBMED   7916326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000254.1 and D83036.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_031059.3.
            
            On Mar 5, 2021 this sequence version replaced NM_031059.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83036.1, SRR8487227.228844.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00155320
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               JACYVU010000254.1  26662374-26662926
            554-969             D83036.1           450-865
            970-1894            JACYVU010000254.1  26665384-26666308
FEATURES             Location/Qualifiers
     source          1..1894
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1894
                     /gene="Msx1"
                     /note="msh homeobox 1"
                     /db_xref="GeneID:81710"
                     /db_xref="RGD:620929"
     exon            1..696
                     /gene="Msx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1139
                     /gene="Msx1"
                     /note="homeo box, msh-like 1"
                     /codon_start=1
                     /product="homeobox protein MSX-1"
                     /protein_id="NP_112321.2"
                     /db_xref="GeneID:81710"
                     /db_xref="RGD:620929"
                     /translation="MAPAAAMTSLPLGVKVEDSAFAKPAGGGAGQAPGAAAATATAMG
                     TDEEGAKPKVPASLLPFSVEALMADHRKPGAKESVLVASEGAQAAGGSVQHLGTRPGS
                     LGAPDAPSSPGPLGHFSVGGLLKLPEDALVKAESPEKLDRTPWMQSPRFSPPPARRLS
                     PPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKI
                     WFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYSASG
                     PFQRAALPVAPVGLYTAHVGYSMYHLT"
     exon            697..1894
                     /gene="Msx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacccggag ccggcgagtg cgcccgggaa ctcggcctgc gcggcgcagg gatccaggcc
       61 cagctcgctg gagttggcct tccagggaag ctgcaggaga ctcgcgcgcg acagcgggcc
      121 ggaccagatc cctgggagct cacagaagcc ggccgcgctc ccagcccgcc cgaaacccat
      181 gatccaggct ggcccgagct gcggctggag tgggggtccg gctctgcatg gccccggctg
      241 ctgctatgac ttctttgcca ctcggtgtca aagtggagga ctccgccttc gccaagcctg
      301 ctgggggagg cgctggccag gcccccgggg ctgctgcggc cactgcaacc gccatgggca
      361 cagatgagga gggggccaag cccaaagtgc ccgcttcact cctgcccttc agcgtggagg
      421 ccctcatggc cgatcacagg aagcccgggg caaaggagag cgtcctggtg gcttccgaag
      481 gggctcaggc ggcgggtggc tcggtgcagc acttgggcac ccggcccggg tctctgggcg
      541 ccccggacgc gccctcctcg ccggggcctc tcggccattt ctctgttggg ggactcctca
      601 agctgccaga agatgctctg gtgaaggccg agagcccgga gaagctagat cggaccccgt
      661 ggatgcagag tccccgcttc tccccgcccc cagccaggcg gctgagtccc ccggcctgca
      721 ccctacgcaa gcacaagacc aaccgcaagc ccaggacgcc cttcaccacg gctcagctac
      781 tggctctgga gcgcaagttc cgccagaagc agtacctgtc tattgccgag cgcgccgagt
      841 tctccagctc gctcagcctt accgagaccc aggtgaagat ctggttccag aaccgccgtg
      901 ctaaggccaa gagactgcag gaggccgagt tggagaagtt gaagatggcc gcgaagccaa
      961 tgttgccgcc tgcggccttc ggcctctcct ttcctcttgg tggccctgca gcggtggctg
     1021 cagctgccgg cgcctcactc tacagtgcct ctggcccttt ccagcgcgcc gcgctgcctg
     1081 tagcgccggt gggactctac accgcccacg taggctacag catgtaccac ctgacatagg
     1141 tgggcccaga gtcacctccc tgtggtgcca tcccttcccc cagccacctc ttctagcagc
     1201 gggagtcctt cctaggaagc tcggctgccc aacaccacct ggccccttct cttaaaccct
     1261 tcgctacaca gttcctcctg gccatcgcat ctaaagttcc tcctccctct tccgacccct
     1321 tctgggaaga aaaaaaagtg gccggaagtg tctaggtttt tcgagaaaaa tttatattta
     1381 cacgtgcgag ttataaatgt ggaaactggg ggatgcaaag gcgaagagat ttatccgtgg
     1441 tccccagcag aattagaagc tgaaggagac cagaggccaa aaggactaga ggccatgaga
     1501 ctcccatcag ctgcttccgg tcctgaaacc aggcaggact tgcacagaga aattgttatt
     1561 tggtgcttca agagacgagc ccagccctat agaaagcaag gagcacagct ccttccactg
     1621 tcagactcca aacgctttgc agcaaagcat tgctctgagg gggcagggtg cgtgctggtg
     1681 cttcacgaag gtaggttgaa gagactttcc caggaccaga aaaaaaagaa gttaaaaaaa
     1741 caaaatctgt ttctatttaa cagtacattt tcgtggctct caaacatccc ttttgaaggg
     1801 atcgtgtgta ctatgtaata tactgtatat ttgaaatttt attatcattt atattatagc
     1861 tatatttgtt aaataaatta attttaagct acaa
//
