LOCUS       NM_019151               2704 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus myostatin (Mstn), mRNA.
ACCESSION   NM_019151
VERSION     NM_019151.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Rahmani,N., Motamedi,P., Amani-Shalamzari,S., Escobar,K.A. and
            Suzuki,K.
  TITLE     Swimming in cold water increases the browning process by
            diminishing the Myostatin pathway
  JOURNAL   Mol Biol Rep 51 (1), 884 (2024)
   PUBMED   39093510
  REMARK    GeneRIF: Swimming in cold water increases the browning process by
            diminishing the Myostatin pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Chen,Y., Banie,L., Breyer,B.N., Tan,Y., Wang,Z., Zhou,F., Wang,G.,
            Lin,G., Liu,J., Qi,L.S. and Lue,T.F.
  TITLE     Enhanced Myogenesis by Silencing Myostatin with Nonviral Delivery
            of a dCas9 Ribonucleoprotein Complex
  JOURNAL   CRISPR J 5 (4), 598-608 (2022)
   PUBMED   35758824
  REMARK    GeneRIF: Enhanced Myogenesis by Silencing Myostatin with Nonviral
            Delivery of a dCas9 Ribonucleoprotein Complex.
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Tang,L., Zhao,T., Kang,Y., An,S., Fan,X. and Sun,L.
  TITLE     MSTN is an important myokine for weight-bearing training to
            attenuate bone loss in ovariectomized rats
  JOURNAL   J Physiol Biochem 78 (1), 61-72 (2022)
   PUBMED   34453705
  REMARK    GeneRIF: MSTN is an important myokine for weight-bearing training
            to attenuate bone loss in ovariectomized rats.
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Barisione,C., Verzola,D., Garibaldi,S., Ferrari,P.F., Garibotto,G.,
            Ameri,P., Pane,B., Spinella,G., Pratesi,G. and Palombo,D.
  TITLE     Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9
            Expression in Rat Kidneys and HK-2 Cells
  JOURNAL   Int J Mol Sci 22 (18), 9884 (2021)
   PUBMED   34576046
  REMARK    GeneRIF: Renal Ischemia/Reperfusion Early Induces Myostatin and
            PCSK9 Expression in Rat Kidneys and HK-2 Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   Szabo,Z., Vainio,L., Lin,R., Swan,J., Hulmi,J.J., Rahtu-Korpela,L.,
            Serpi,R., Laitinen,M., Pasternack,A., Ritvos,O., Kerkela,R. and
            Magga,J.
  TITLE     Systemic blockade of ACVR2B ligands attenuates muscle wasting in
            ischemic heart failure without compromising cardiac function
  JOURNAL   FASEB J 34 (8), 9911-9924 (2020)
   PUBMED   32427381
REFERENCE   6  (bases 1 to 2704)
  AUTHORS   Lee,S.J. and McPherron,A.C.
  TITLE     Regulation of myostatin activity and muscle growth
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 9306-9311 (2001)
   PUBMED   11459935
REFERENCE   7  (bases 1 to 2704)
  AUTHORS   Lalani,R., Bhasin,S., Byhower,F., Tarnuzzer,R., Grant,M., Shen,R.,
            Asa,S., Ezzat,S. and Gonzalez-Cadavid,N.F.
  TITLE     Myostatin and insulin-like growth factor-I and -II expression in
            the muscle of rats exposed to the microgravity environment of the
            NeuroLab space shuttle flight
  JOURNAL   J Endocrinol 167 (3), 417-428 (2000)
   PUBMED   11115768
REFERENCE   8  (bases 1 to 2704)
  AUTHORS   Mendler,L., Zador,E., Ver Heyen,M., Dux,L. and Wuytack,F.
  TITLE     Myostatin levels in regenerating rat muscles and in myogenic cell
            cultures
  JOURNAL   J Muscle Res Cell Motil 21 (6), 551-563 (2000)
   PUBMED   11206133
REFERENCE   9  (bases 1 to 2704)
  AUTHORS   McPherron,A.C. and Lee,S.J.
  TITLE     Double muscling in cattle due to mutations in the myostatin gene
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12457-12461 (1997)
   PUBMED   9356471
REFERENCE   10 (bases 1 to 2704)
  AUTHORS   McPherron,A.C., Lawler,A.M. and Lee,S.J.
  TITLE     Regulation of skeletal muscle mass in mice by a new TGF-beta
            superfamily member
  JOURNAL   Nature 387 (6628), 83-90 (1997)
   PUBMED   9139826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 11, 2022 this sequence version replaced NM_019151.1.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) family of proteins. The encoded preproprotein
            is proteolytically processed to generate an N-terminal propeptide
            and a C-terminal subunit. The C-terminal subunits form the mature
            homodimer, which negatively regulates skeletal muscle cell
            proliferation and differentiation. Mutations in this gene are
            associated with increased skeletal muscle mass in humans and other
            mammals. [provided by RefSeq, Jun 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ224469.1, SRR26643289.25521.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               JAXUCZ010000009.1  55950414-55950913   c
            501-874             JAXUCZ010000009.1  55948281-55948654   c
            875-2704            JAXUCZ010000009.1  55944513-55946342   c
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..2704
                     /gene="Mstn"
                     /gene_synonym="Gdf8"
                     /note="myostatin"
                     /db_xref="GeneID:29152"
                     /db_xref="RGD:3115"
     exon            1..500
                     /gene="Mstn"
                     /gene_synonym="Gdf8"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1255
                     /gene="Mstn"
                     /gene_synonym="Gdf8"
                     /note="growth/differentiation factor 8; GDF-8"
                     /codon_start=1
                     /product="growth/differentiation factor 8 precursor"
                     /protein_id="NP_062024.1"
                     /db_xref="GeneID:29152"
                     /db_xref="RGD:3115"
                     /translation="MIQKPQMYVYIYLFVLIAAGPVDLNEDSEREANVEKEGLCNACA
                     WRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDS
                     SDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIY
                     LRAVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLK
                     QPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEH
                     STESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPR
                     GSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS"
     exon            501..874
                     /gene="Mstn"
                     /gene_synonym="Gdf8"
                     /inference="alignment:Splign:2.1.0"
     exon            875..2704
                     /gene="Mstn"
                     /gene_synonym="Gdf8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggactcact ggcgtggcag gttgtctccc ggacggtaca tgcactgata tttcacttgg
       61 cattattcaa aagcaaaaga gaagaaataa gaacaaggaa aaaagagatt gtgccgattt
      121 taaaatgatt caaaaaccgc aaatgtatgt ttatatttac ctgtttgtgc tgattgctgc
      181 tggcccagtg gatctaaatg aggacagtga gagagaggcg aatgtggaaa aagaggggct
      241 gtgtaatgcg tgtgcgtgga gacaaaacac aaggtactcc agaatagaag ccataaaaat
      301 tcaaatcctc agtaaactcc gcctggaaac agcgcctaac atcagcaaag atgctataag
      361 acaacttctg cccagagcgc ctccactccg ggaactgatc gatcagtacg acgtccagag
      421 ggatgacagc agtgacggct ctttggaaga tgacgattat cacgctacca cggaaacaat
      481 cattaccatg cctaccgagt ctgactttct aatgcaagcg gatggaaagc ccaaatgttg
      541 cttttttaaa tttagctcta aaatacagta caacaaagtg gtaaaggccc agctgtggat
      601 atatctgaga gccgtcaaga ctcctacaac agtgtttgtg caaatcctga gactcatcaa
      661 acccatgaaa gacggtacaa ggtataccgg aatccgatct ctgaaacttg acatgagccc
      721 aggcactggt atttggcaga gtattgatgt gaagacagtg ttgcaaaatt ggctcaaaca
      781 gcctgaatcc aacttaggca ttgaaatcaa agctttggat gagaatgggc atgatcttgc
      841 tgtaaccttc ccaggaccag gagaagatgg gctgaatccc tttttagaag tcaaagtaac
      901 agacacaccc aagaggtccc ggagagactt tgggcttgac tgtgatgaac actccacgga
      961 atcgcggtgc tgtcgctacc ccctcacggt cgatttcgaa gcctttggat gggactggat
     1021 tattgcaccc aaaagatata aggctaatta ctgctctgga gagtgtgaat ttgtgttctt
     1081 acaaaaatat ccgcatactc atcttgtgca ccaagcaaac cccagaggct cggcaggccc
     1141 ttgctgcacg ccaacaaaaa tgtctcccat taatatgcta tattttaatg gcaaagaaca
     1201 aataatatat gggaaaattc cagccatggt agtagaccgg tgtgggtgct cgtgagcttt
     1261 gcattagctt taaaatttcc caaatcgtgg aaggtcttcc cctcgatttc gaaactgtga
     1321 atttatgtac cacaggctgt aggccttgag tatgctctag taacttaagc acgagctaca
     1381 gtgtatgaac taaaagagag aatagatgca atggttggca tttaaccatc aaaataaacc
     1441 acattatagg gtgtttaatg atttccagag tttttgaacc aggaggaaat caaatcacat
     1501 ttatgttcat ttttgtctat cataattaca atctaggcaa ggaaacgaga gcacgtttcc
     1561 ttgtggtctg ctgaattaaa ggggtctgat tcaaaggcaa agtcttattt cctaacagtt
     1621 tcacttaata tttactgaaa agtctatata tagcctttgt aaagtgtaga actgttatca
     1681 tttaaaaaca tcatgtacac ttatatttgt attgtatact tggtaaggta aaattccaca
     1741 aaggaggaat ggggcctcac atatacgttt ccattcctat tataattgga caatacacag
     1801 caacggtgct aatgccatgc cgagtggctc ctactgccga acttttcgaa tacaacactc
     1861 tataaagtaa gattctctcc ctaacaggcg catgtgcaca cagcactaag cgtgcaatgc
     1921 attttctgtg aggaaagaag aatctttttc tttctagagg tcaactttca gttctctagc
     1981 acagtgggag tggctgcttt atcttgaaag gccgacaaac agtattcact ttgatctaaa
     2041 tctcaaaatc accgtctgcc tttgccacat ggcagttttg tggtaaaata atgggaaatg
     2101 actggttcta tcaatattgt ataaatgact ctgaaacaat tgcatttata taatatgtat
     2161 acaatattgt tttgtaaata agtgtctcct tttatatcta ctttggtata tttttacact
     2221 aatgaaattt caaatcatta acgaacaaag acatgtcgtg tatcacagaa aagtgactgc
     2281 ttcttttagc agattcaata atggtcttaa aacttcgtat gttagggtta gatggttata
     2341 ttacaatcat tttatatttt tttaacaata tcaacattca ctgatggatt catggtggct
     2401 gtatctatga atgtgaagtt tcagtggcca ttgtgttcaa atctcaatgc cccactattt
     2461 taaaaattat aagcattact aaacatacca aaatttatct aaagaaaagc aaatatggaa
     2521 tctcaataac agttactttt attttataat ttgacaatga atatgtttct gcatttgttc
     2581 agttcaattt tataaattgg aattttgtta atcaaatgta ttgtactcat agctaaatga
     2641 aactatttct tacataaaat gtgtagaaac tataaattaa agtgttttca catttttgaa
     2701 atgc
//
