LOCUS       NM_001412199            4731 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus macrophage stimulating 1 receptor (Mst1r),
            transcript variant 1, mRNA.
ACCESSION   NM_001412199 XM_039081226
VERSION     NM_001412199.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4731)
  AUTHORS   Wang,T., Chen,X., Zhang,W., Xiang,X., Leng,C. and Jia,Q.
  TITLE     Roles of macrophage stimulating protein and tyrosine kinase
            receptor RON in smoke-induced airway inflammation of rats
  JOURNAL   Int J Clin Exp Pathol 8 (8), 8797-8808 (2015)
   PUBMED   26464622
  REMARK    GeneRIF: MSP and its receptor RON are involved in the smoke-induced
            airway inflammation in rats
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4731)
  AUTHORS   Gregorini,M., Bosio,F., Rocca,C., Corradetti,V., Valsania,T.,
            Pattonieri,E.F., Esposito,P., Bedino,G., Collesi,C., Libetta,C.,
            Frassoni,F., Dal Canton,A. and Rampino,T.
  TITLE     Mesenchymal stromal cells reset the scatter factor system and
            cytokine network in experimental kidney transplantation
  JOURNAL   BMC Immunol 15, 44 (2014)
   PUBMED   25277788
  REMARK    GeneRIF: Mesenchymal stromal cells increased serum and tissue HGF
            levels, Met tubular expression and prevented the suppression of
            tubular MSP/RON expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4731)
  AUTHORS   Gurusamy,D., Ruiz-Torres,S.J., Johnson,A.L., Smith,D.A. and
            Waltz,S.E.
  TITLE     Hepatocyte growth factor-like protein is a positive regulator of
            early mammary gland ductal morphogenesis
  JOURNAL   Mech Dev 133, 11-22 (2014)
   PUBMED   25049204
REFERENCE   4  (bases 1 to 4731)
  AUTHORS   Teckchandani,A., Toida,N., Goodchild,J., Henderson,C., Watts,J.,
            Wollscheid,B. and Cooper,J.A.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
REFERENCE   5  (bases 1 to 4731)
  AUTHORS   Rampino,T., Soccio,G., Gregorini,M., Guidetti,C., Marasa,M.,
            Maggio,M., Panichi,V., Migliori,M., Libetta,C. and Dal Canton,A.
  TITLE     Neutralization of macrophage-stimulating protein ameliorates renal
            injury in anti-thy 1 glomerulonephritis
  JOURNAL   J Am Soc Nephrol 18 (5), 1486-1496 (2007)
   PUBMED   17409315
  REMARK    GeneRIF: A pathogenic role of the MSP/RON system in anti-Thy 1
            nephritis.
REFERENCE   6  (bases 1 to 4731)
  AUTHORS   Tyndall,S.J. and Walikonis,R.S.
  TITLE     The receptor tyrosine kinase Met and its ligand hepatocyte growth
            factor are clustered at excitatory synapses and can enhance
            clustering of synaptic proteins
  JOURNAL   Cell Cycle 5 (14), 1560-1568 (2006)
   PUBMED   16861928
  REMARK    GeneRIF: Met is present in clusters that strongly colocalize with
            the NR2B subunit of the N-methyl-D-aspartate receptor, PSD-95 and
            synapsin at excitatory synapses of hippocampal neurons
REFERENCE   7  (bases 1 to 4731)
  AUTHORS   Danilkovitch-Miagkova,A., Duh,F.M., Kuzmin,I., Angeloni,D.,
            Liu,S.L., Miller,A.D. and Lerman,M.I.
  TITLE     Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase
            and mediates transformation of epithelial cells by jaagsiekte sheep
            retrovirus
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4580-4585 (2003)
   PUBMED   12676986
REFERENCE   8  (bases 1 to 4731)
  AUTHORS   Hess,K.A., Waltz,S.E., Chan,E.L. and Degen,S.J.
  TITLE     Receptor tyrosine kinase Ron is expressed in mouse reproductive
            tissues during embryo implantation and is important in trophoblast
            cell function
  JOURNAL   Biol Reprod 68 (4), 1267-1275 (2003)
   PUBMED   12606483
REFERENCE   9  (bases 1 to 4731)
  AUTHORS   Persons,D.A., Paulson,R.F., Loyd,M.R., Herley,M.T., Bodner,S.M.,
            Bernstein,A., Correll,P.H. and Ney,P.A.
  TITLE     Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
  JOURNAL   Nat Genet 23 (2), 159-165 (1999)
   PUBMED   10508511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 3, 2022 this sequence version replaced NM_001412199.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.33414.1,
                                           SRR26643288.35548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1474              JAXUCZ010000008.1  117475968-117477441
            1475-1651           JAXUCZ010000008.1  117481079-117481255
            1652-1780           JAXUCZ010000008.1  117481340-117481468
            1781-1951           JAXUCZ010000008.1  117481630-117481800
            1952-2112           JAXUCZ010000008.1  117482154-117482314
            2113-2278           JAXUCZ010000008.1  117482650-117482815
            2279-2415           JAXUCZ010000008.1  117482923-117483059
            2416-2577           JAXUCZ010000008.1  117483610-117483771
            2578-2671           JAXUCZ010000008.1  117483862-117483955
            2672-2884           JAXUCZ010000008.1  117484098-117484310
            2885-3031           JAXUCZ010000008.1  117484393-117484539
            3032-3197           JAXUCZ010000008.1  117484620-117484785
            3198-3299           JAXUCZ010000008.1  117484954-117485055
            3300-3479           JAXUCZ010000008.1  117485145-117485324
            3480-3560           JAXUCZ010000008.1  117485789-117485869
            3561-3742           JAXUCZ010000008.1  117486049-117486230
            3743-3852           JAXUCZ010000008.1  117486312-117486421
            3853-4018           JAXUCZ010000008.1  117486683-117486848
            4019-4155           JAXUCZ010000008.1  117487255-117487391
            4156-4731           JAXUCZ010000008.1  117489482-117490057
FEATURES             Location/Qualifiers
     source          1..4731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4731
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /note="macrophage stimulating 1 receptor"
                     /db_xref="GeneID:300999"
                     /db_xref="RGD:1306465"
     exon            1..1474
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..4414
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor protein tyrosine kinase,
                     c-met-related; protein tyrosine kinase 8;
                     macrophage-stimulating protein receptor; macrophage
                     stimulating 1 receptor (c-met-related tyrosine kinase)"
                     /codon_start=1
                     /product="macrophage-stimulating protein receptor isoform
                     1 precursor"
                     /protein_id="NP_001399128.1"
                     /db_xref="GeneID:300999"
                     /db_xref="RGD:1306465"
                     /translation="MGLLLPLLQASLLLMLLLRLPEASTNLDWQCPRIPFAASRDFSV
                     KYVVPSFSAGGRVQATAVYEDSKNSAVFVAIRNRLHVLGPDLQYIESLTTGPIGDPGC
                     QTCASCGPGPHGPPNDTDTLVLVMEPGLPALVSCGSTLQGRCFLHELEPQGEALHLAA
                     PACLFSASNNKPEACTDCVASHLGTRVTVVEQGHASYFYVASSLDPELAASFSPRSVS
                     IRRLKSDTSGFQPGFPSLSVLPKYLASYLIKYVHSFHSGDFVYFLTVQPMDVRSPPSA
                     LQTRLVRLNAIEPEIGDYRELVLDCHFAPKRRRRSGAPKSLQAYQVLQAAHSAPVDAK
                     LALDLSISEGQEVLFGVFVAVKDSSSGPNSVVCAFPINHLDNLIEEGVERCCHPSNSS
                     LLTRRRGLDFFQTPSFCPNPPGAPSSRCHYFPLMVHDSFTRVDLFNGLLGSVKVTALH
                     VTRLGNVTVAHMGTEDGRILQVEIARSLNYLLYVSNFSLGSSGQPVHQDVSRLGNDLL
                     FASGDQVFKVPIQGPGCGHFLTCWRCLRAQRFMGCGWCGDRCGRQKECPGSWQQDYCP
                     PEITEFHPHSGPLRGTTRLTLCGSNFYLRPDGVVPEGTHQITVGQSPCRLLPKDSSTR
                     RSGSQKEFIEELECELEPLETQAVGTTNISLLITNMPAGKHFRVEGVSVREDFSFMEP
                     MLTSIKPDFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLEQVSEEKILCVTPPGA
                     GTASVPLRLQIGGAEVRGSRTFHYKEDPIVLDISPKCGYSGSHVMVHGQHLTSAWHLT
                     VSFNDGQSIVESRCAGQFLEQQHQCRLPEYMVRNPQGWATGNLSLWGDGAAGFTLPGF
                     RFLPPPSLPRTGPVLLKPEEHSVKVEYIGLGAVADCVTVNVTVGGEVCQHELRGDVVI
                     CPLPPSLQLGKDGVPLQVCVDGGCHILGQVVRSGPGRASQRTLLIALLALILLVAGLA
                     IALVCNSRRRKKQLVLTPNLDDLTSRDLSPRAMSLSIFRSGSDYRNGLASRPPNHEES
                     SEGQDGTSVPLLRTDSIRLQDLDKMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYH
                     GEYTDEAQNQIHCAIKSLSRITEVQEVEAFLREGLIMRGLHHPNILALIGIMLPPEGL
                     PRVLLPYMRHGDLLRFIRSPQRNPTVKDLISFGLQVACGMEYLAEQKFVHRDLAARNC
                     MLDESFTVKVADFGLARGILDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWS
                     FGVLLWELLTRGAPPYPHIDPFDLSHFLVQGRRLPQPEYCPDSLYQVMLRCWEADPAA
                     RPTFRALVLEVEQVASSLLGDHYVQLTAAYVNVGPGAVDDGSVFPEQGQSSPLHHRST
                     SRPRPLSEPPLPT"
     exon            1475..1651
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1780
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1951
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2112
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2278
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2415
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2577
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2671
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2884
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3031
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3197
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3299
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3479
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3560
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3742
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3852
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            3853..4018
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4155
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4731
                     /gene="Mst1r"
                     /gene_synonym="Cdw136; Ptk8; Ron; Stk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcagca gctggggccc caggtgaagt gatcgtgcca ttgtcgtgcc cgtgagtcca
       61 cagccaggtg ctcagaccac agggcagaga gaaaagttgg gtttgccagg gaccagggca
      121 gtgggtcagc tgccaaggag ctttcagtgc cgctgcttaa cgctggtctc agctcggacc
      181 cagagtctgg ttcaatcaag tcctggacct tctgggattc ccaagaggcc ccagctcaat
      241 ggggctgctt ctgccgctgc tacaggcctc tctactgctg atgcttcttt tgcggttgcc
      301 ggaggcgtct accaacctgg actggcagtg cccacgaata cccttcgcag cctcccgaga
      361 cttcagtgtt aagtacgtgg tccccagttt ctccgcggga ggccgggtac aggccacggc
      421 agtctacgag gacagtaaaa atagtgcggt gtttgtggcc atacgcaatc gcctgcacgt
      481 gcttgggcct gacctgcagt atatagagag cctgaccact ggccctattg gggaccctgg
      541 ctgccagact tgtgcgagct gtggtccagg ccctcatgga ccaccaaacg acacagacac
      601 attggtgcta gtgatggagc cgggtttgcc agccttggtc agctgcggct caaccctaca
      661 gggccgctgc ttcctgcatg agctggagcc tcagggggaa gccttgcact tagcagctcc
      721 agcctgcctc ttctcagcaa gcaataacaa gcctgaggcc tgcactgact gtgtagctag
      781 ccacctgggc actcgtgtga ccgtggtgga gcagggccat gcttcctact tctatgtggc
      841 atcttcacta gacccagagt tggccgctag ctttagccca cgctcagtgt ccatccgtcg
      901 tttaaagtct gatacgtctg gattccaacc aggttttccg tcgctgtctg tgctgcccaa
      961 atatttggcc tcctacctca tcaaatacgt tcatagcttc cactcaggag actttgtcta
     1021 ctttctgact gtacaaccca tggatgtcag aagccctccc agtgccttgc aaacgcgtct
     1081 ggtccggctc aatgctatag agccagagat tggtgactac cgggagctgg tcttggactg
     1141 tcactttgca cctaaacgcc gtcgacgcag tggagcccca aagagtctac aggcctacca
     1201 agtgcttcag gcagcccact ctgctccagt ggacgccaaa ctggctttgg acctgagcat
     1261 ttcagagggc caggaagtgc tttttggggt ttttgtggct gtcaaggaca gtagctctgg
     1321 ccccaactct gttgtgtgtg ccttccccat taaccacctg gacaacctga ttgaagaggg
     1381 ggtagaacgt tgctgtcacc cttctaattc ttctctcttg acgaggagga gaggccttga
     1441 cttcttccag acgcctagtt tttgtcctaa tccgcctggt gctcccagct cccggtgcca
     1501 ctacttccct ttgatggtcc acgatagctt cacacgtgtg gacctcttca atggactgtt
     1561 aggatcagtg aaggtcactg cactgcatgt gacgcgcctt ggcaatgtta cagtggccca
     1621 catgggcacg gaggatgggc gtatcctaca ggtggagata gccaggtcac tcaactactt
     1681 gctgtatgtg tccaacttct ccctggggag cagcggacag cctgttcacc aggatgtcag
     1741 ccgcctcggg aatgacctac tctttgcctc gggggaccag gtcttcaagg tgcccatcca
     1801 gggccctggc tgtggtcatt ttctcacctg ttggcgttgt ctgagggcac agcgttttat
     1861 gggatgtgga tggtgtggag accggtgtgg ccggcagaag gagtgtccag gctcctggca
     1921 acaggactac tgcccacctg agatcactga gttccatccc cacagtggac ctctaagggg
     1981 cactacgagg ctcaccctat gtggctccaa cttctacctg cgacccgatg gtgtggtacc
     2041 tgagggaaca caccagatca ctgtgggcca aagtccctgc cgactgctgc ctaaggactc
     2101 ttcaacccgt aggtcagggt cgcaaaagga attcatagag gaacttgaat gtgagctaga
     2161 acccctggag acccaggccg tgggaaccac aaatatcagc cttcttatca ctaacatgcc
     2221 agcaggcaag cacttccgag tggaaggcgt ctctgtgcgg gaagacttct ctttcatgga
     2281 gccaatgctg acatcaataa aacccgactt tggcccacgg gctgggggta cctatctcac
     2341 ccttgaaggc cagagcctgt ctgtcggcac cagccgagct gtgttggtca acggaactca
     2401 gtgccggctg gaacaggtca gtgaggagaa gatcctgtgt gtcacgcctc ctggagctgg
     2461 cacagccagc gtcccccttc gtctgcagat agggggtgcc gaggtgcgtg gctcccgcac
     2521 ctttcactac aaggaagacc ctattgtgtt ggacatcagt cccaagtgtg gctacagcgg
     2581 ctcccacgtc atggtccacg gccagcatct gacttcagcg tggcacctca cagtatcatt
     2641 caacgatgga caaagtatag tggagagcag gtgtgcaggg cagtttctgg aacagcagca
     2701 ccagtgtcgt ctgcctgaat acatggtccg aaaccctcag gggtgggcaa cagggaatct
     2761 gagcctctgg ggggatgggg cagccggctt cacgttgcct ggtttccgct tcctgccccc
     2821 acccagtctc cccagaactg gcccagtcct gctgaagcct gaagagcatt cagttaaggt
     2881 cgagtatatt gggctgggcg ctgtggcgga ctgtgtgacg gtgaacgtga ccgtgggtgg
     2941 tgaggtctgc caacatgagc tccgggggga tgtggtgatc tgccctctgc caccttccct
     3001 gcaacttggc aaggatggtg tcccgttgca ggtctgtgta gatggtgggt gtcacatcct
     3061 gggccaggtt gttcggtcag gcccaggcag ggcttcacag aggacacttc ttattgctct
     3121 tctggccttg atcctgctcg tggctgggct ggccatcgca ctggtctgta actcccgaag
     3181 acggaaaaag cagctagtcc ttactcccaa cctggatgac ctgacatccc gggatctgtc
     3241 tcccagagcc atgtccctgt ctatattccg ctctggctct gactacagaa atggccttgc
     3301 ttccagacct ccaaaccatg aagaatcttc agagggtcag gatgggacaa gtgtcccgct
     3361 gctgcggaca gactctatcc ggctccagga tctggacaag atgctcctag ccgaggtcaa
     3421 ggatgtactg attccccatg agcaagtggt catccatact gaccaagtca ttggcaaagg
     3481 ccactttggc gttgtctacc acggagaata cacagacgaa gcacagaatc agatccactg
     3541 tgccatcaag tctctgagtc gcatcacgga ggtacaggag gtagaggctt tcctgcggga
     3601 ggggctgatc atgcgtggcc tccatcaccc aaacattctg gctctcatcg gtatcatgct
     3661 acccccagag ggtcttcccc gcgtgctgtt gccctatatg cgccatggag acctgctccg
     3721 tttcattcgc tcccctcaga ggaaccccac tgtgaaagac ctcatcagct ttggcctgca
     3781 ggtagcctgt ggcatggagt acctggcaga gcagaagttc gtgcacagag acctggctgc
     3841 taggaactgc atgctggacg agtcgttcac agtcaaggtg gctgactttg gtctggcacg
     3901 tggcatccta gacaaggaat actatagtgt tcgacaacat cgccatgctc gcctacctgt
     3961 caagtggatg gcactggaga gccttcagac ctacagattc accaccaagt ctgacgtgtg
     4021 gtcattcggt gtgttactgt gggagctact aacacggggt gccccgccct acccccatat
     4081 tgatcccttc gacctctctc acttcctggt tcagggccgc cgcctgcctc agcctgagta
     4141 ttgtcccgat tcactgtacc aggtgatgct tcgatgctgg gaggctgatc cagcagcacg
     4201 acccaccttc agagccctag tgctggaagt agagcaggta gcgtcctcac tgcttgggga
     4261 ccactacgtg cagctgaccg cagcttacgt gaacgtaggc cccggcgcgg tggatgatgg
     4321 gagtgtgttt ccggaacagg ggcagtcctc gcccctgcat cacaggagca cgtcaaggcc
     4381 ccggcccctc tcagagccac ctctgcccac ttgactaaag ccctaagtag gccacaggaa
     4441 ctagacctgc taagtggcct taagctaatt ccaggctgcc tctggaccta tgacaagctg
     4501 cagcacgtaa aaacctccac tctttaactt tccgaggcta ctgaaggtgg aaaacggggc
     4561 tgtttgagcc cctcgttcca gcatgaacca gtgtaatttt tgtagcatgt atttatttaa
     4621 tgtttgtttt gtacctgttt ctgaatacgg aggatccagc agtgatcaca gagatcctac
     4681 agtgtaaaat actatgaatg aatgaatgaa tgaatgaaca ttcaagcaca a
//
