LOCUS       NM_024352               2222 bp    mRNA    linear   ROD 05-MAR-2024
DEFINITION  Rattus norvegicus macrophage stimulating 1 (Mst1), mRNA.
ACCESSION   NM_024352
VERSION     NM_024352.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2222)
  AUTHORS   Tan,M., Mao,J., Zheng,J., Meng,Y., Li,J., Hao,J. and Shen,H.
  TITLE     Mammalian STE20-like kinase 1 inhibits synoviocytes activation in
            rheumatoid arthritis through mitochondrial dysfunction mediated by
            SIRT3/mTOR axis
  JOURNAL   Inflamm Res 73 (3), 415-432 (2024)
   PUBMED   38265688
  REMARK    GeneRIF: Mammalian STE20-like kinase 1 inhibits synoviocytes
            activation in rheumatoid arthritis through mitochondrial
            dysfunction mediated by SIRT3/mTOR axis.
REFERENCE   2  (bases 1 to 2222)
  AUTHORS   Mardi,A., Biglar,A., Nejatbakhsh,R. and Abdanipour,A.
  TITLE     Valproic Acid Ameliorates Locomotor Function in the Rat Model of
            Contusion via Alteration of Mst1, Bcl-2, and Nrf2 Gene Expression
  JOURNAL   Iran Biomed J 25 (4), 303-307 (2021)
   PUBMED   34217161
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2222)
  AUTHORS   Su,D., Li,Y., Guan,L., Li,Q., Shi,C., Ma,X. and Song,Y.
  TITLE     Elevated MST1 leads to apoptosis via depletion of YAP1 in
            cardiomyocytes exposed to high glucose
  JOURNAL   Mol Med 27 (1), 13 (2021)
   PUBMED   33568044
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2222)
  AUTHORS   Hu,Y.H., Sun,J., Zhang,J., Hua,F.Z., Liu,Q. and Liang,Y.P.
  TITLE     Long non-coding RNA ROR sponges miR-138 to aggravate
            hypoxia/reoxygenation-induced cardiomyocyte apoptosis via
            upregulating Mst1
  JOURNAL   Exp Mol Pathol 114, 104430 (2020)
   PUBMED   32240614
REFERENCE   5  (bases 1 to 2222)
  AUTHORS   Abdanipour,A., Deheshjo,F., Sohrabi,D., Jafari Anarkooli,I. and
            Nejatbakhsh,R.
  TITLE     Neuroprotective effect of lovastatin through down-regulation of
            pro-apoptotic Mst1 gene expression in rat model pilocarpine
            epilepsy
  JOURNAL   Neurol Res 40 (10), 874-882 (2018)
   PUBMED   30048231
  REMARK    GeneRIF: The results of this study showed that lovastatin
            attenuates hippocampal cell death in Pilocarpine-induced status
            epilepticus rat model through downregulation of the pro-apoptotic
            Mst1 gene.
REFERENCE   6  (bases 1 to 2222)
  AUTHORS   Ebelt,H., Liu,Z., Muller-Werdan,U., Werdan,K. and Braun,T.
  TITLE     Making omelets without breaking eggs: E2F-mediated induction of
            cardiomyoycte cell proliferation without stimulation of apoptosis
  JOURNAL   Cell Cycle 5 (21), 2436-2439 (2006)
   PUBMED   17102628
  REMARK    GeneRIF: E2F2, unlike E2F1, E2F3 and E2F5, does not induce
            apoptosis but even suppresses expression of several pro-apoptotic
            genes in primary cardiomyocytes; E2F1, E2F2, and E2F3 and E2F4
            induce S-phase entry of primary cardiomyocytes
REFERENCE   7  (bases 1 to 2222)
  AUTHORS   Ono,H., Ichiki,T., Ohtsubo,H., Fukuyama,K., Imayama,I.,
            Hashiguchi,Y., Sadoshima,J. and Sunagawa,K.
  TITLE     Critical role of Mst1 in vascular remodeling after injury
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (9), 1871-1876 (2005)
   PUBMED   15961701
  REMARK    GeneRIF: Mst1 plays an important role in the induction of apoptosis
            of vascular smooth muscle cells, mediating the vascular remodeling
            process
REFERENCE   8  (bases 1 to 2222)
  AUTHORS   Hess,K.A., Waltz,S.E., Chan,E.L. and Degen,S.J.
  TITLE     Receptor tyrosine kinase Ron is expressed in mouse reproductive
            tissues during embryo implantation and is important in trophoblast
            cell function
  JOURNAL   Biol Reprod 68 (4), 1267-1275 (2003)
   PUBMED   12606483
REFERENCE   9  (bases 1 to 2222)
  AUTHORS   Ohshiro,K., Iwama,A., Matsuno,K., Ezaki,T., Sakamoto,O.,
            Hamaguchi,I., Takasu,N. and Suda,T.
  TITLE     Molecular cloning of rat macrophage-stimulating protein and its
            involvement in the male reproductive system
  JOURNAL   Biochem Biophys Res Commun 227 (1), 273-280 (1996)
   PUBMED   8858136
REFERENCE   10 (bases 1 to 2222)
  AUTHORS   Wang,M.H., Yoshimura,T., Skeel,A. and Leonard,E.J.
  TITLE     Proteolytic conversion of single chain precursor
            macrophage-stimulating protein to a biologically active heterodimer
            by contact enzymes of the coagulation cascade
  JOURNAL   J Biol Chem 269 (5), 3436-3440 (1994)
   PUBMED   7508914
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X95096.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X95096.1, BC089796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2222
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2222
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /note="macrophage stimulating 1"
                     /db_xref="GeneID:24566"
                     /db_xref="RGD:3114"
     exon            1..64
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2163
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /note="E2F transcription factor 2; D8h3f15s2; Macrophage
                     stimulating 1 (hepatocyte growth factor-like); hepatocyte
                     growth factor-like protein"
                     /codon_start=1
                     /product="hepatocyte growth factor-like protein precursor"
                     /protein_id="NP_077328.1"
                     /db_xref="GeneID:24566"
                     /db_xref="RGD:3114"
                     /translation="MGWLPLLLLLAQCSRALGQRSPLNDFQLLRGTELRNLLHPVVPG
                     PWQEDVADAEECARRCGPLLDCRAFHYNMSSHGCQLLPWTQHSLRAQLHHSSLCDLFQ
                     KKDYVRTCIMDNGASYRGTVARTADGLPCQAWSRRFPNDHKYTPTPKNGLEENFCRNP
                     DGDPRGPWCYTTNRSVRFQSCGIKSCREAVCVWCNGEDYRGEVDVTESGRECQRWDLQ
                     HPHSHPFHPEKFPDKALKDNYCRNPDASERPWCYTTDPNVEREFCDLPSCGPNLPPTT
                     KGSKSQQRNKVKASNCFRGKGEDYRGTTNTTSAGVPCQRWDAQNPHQHRFVPEKYACK
                     DLRENFCRNPDGSEAPWCFTSRPGLRVAFCYQIPRCTEEVVPEGCYHGSGEQYRGSVS
                     KTRKGVQCQHWSSETPHKPQFTPTSAPHAGLEANFCRNPDGDSHGPWCYTLDPETLFD
                     YCALKRCDDDQPPSILDPPVQVQFEKCGKRVDQSNRLRVVGGHPGNSPWTVSLRNRQG
                     QHFCGGSLVKEQWVLTARQCIWSCHDPLTGYEVWLGTINQNPQPGEANLQRVSVAKTV
                     CGPAGSQLVLLKLERPVILNHHVARICLPPEQYVVPPGTNCEIAGWGESKGTSNSTVL
                     HVAKMKVISSQECNVKYRRRVQESEICTEGLLAPTGACEGDYGGPLACYTHDCWVLQG
                     LIIPNRVCARPRWPAIFTRVSVFVDWINKVVQLE"
     exon            65..212
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            213..325
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..440
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..577
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            578..698
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..817
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1013
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1144
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1247
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1384
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1420
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1529
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1607
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1754
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1861
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2001
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2222
                     /gene="Mst1"
                     /gene_synonym="E2F2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcttagga gaatggggtg gctcccacta ctgctgcttc tggcacagtg ttcaagggct
       61 cttgggcagc gctcaccgct gaatgacttc cagctgcttc ggggcacaga gttaaggaac
      121 ctgctacatc cagtggtgcc agggccatgg caggaggatg tggcagatgc cgaggagtgt
      181 gctagacgct gtgggcccct tctggactgc cgagccttcc actacaatat gagcagccat
      241 ggttgccagc tactaccgtg gactcagcac tctctgcgtg cacagctaca ccattctagc
      301 ctgtgcgatc tcttccagaa gaaagactat gtacggacct gcattatgga caatggggcc
      361 agctaccggg gcactgtggc caggacagct gatggcttgc cctgccaagc ctggagccgc
      421 aggttcccca atgaccacaa gtacacgccc acaccgaaga atggcctgga agagaacttc
      481 tgtcggaacc ctgatgggga ccccagaggt ccctggtgct acacgacaaa ccgcagcgtg
      541 cgtttccaga gctgcggcat caaatcatgc agggaggcgg tttgtgtttg gtgcaacggc
      601 gaggattacc gtggcgaggt agacgttaca gaatcgggac gggagtgtca acgctgggac
      661 ctgcagcacc cacactcgca ccctttccac cctgaaaagt tcccagacaa agctctgaaa
      721 gacaactatt gccgtaatcc ggatgcatct gagcgcccct ggtgctacac cacggacccg
      781 aatgttgagc gagagttctg tgacctgccc agttgcgggc ccaacctgcc accgaccacc
      841 aaaggatcca agtcacaaca gcgcaacaag gtcaaggctt cgaactgctt ccgcggaaaa
      901 ggtgaagact atcgaggcac aaccaatacc acctctgcgg gtgtgccctg ccagcgctgg
      961 gatgcgcaga atccgcacca gcaccgcttt gtgccggaga aatatgcttg caaggacctt
     1021 cgtgagaatt tctgccggaa tcctgatggc tccgaggcgc cttggtgctt cacatctcga
     1081 cctggtttgc gtgtggcctt ttgctaccag atcccacgct gcacagaaga agtggtgcca
     1141 gagggctgct accatggctc aggtgaacag tatcgtggct cagtcagcaa gacacgcaag
     1201 ggcgttcagt gccagcactg gtcctcagag acaccacata agccacaatt cacacccacc
     1261 tcagcaccac atgcaggctt ggaggcaaac ttttgccgga atccggatgg agatagccat
     1321 gggccctggt gttatacttt ggacccagag accctgtttg actactgtgc cctaaaacgc
     1381 tgtgatgatg accagccacc atccatcttg gaccccccag tccaggtgca gtttgaaaag
     1441 tgtggcaaga gagttgacca gagtaataga cttcgtgtgg tggggggtca tcctgggaac
     1501 tcaccgtgga cagtcagctt gcggaatcga cagggccagc atttctgtgg gggttcccta
     1561 gtgaaggagc agtgggtact gaccgcccgg caatgcatct ggtcatgcca tgatcctctc
     1621 acaggatatg aggtatggtt gggtacaatt aaccagaacc cacagcctgg agaagcaaac
     1681 ctgcagaggg tctcagtggc caagacagtg tgcggacctg caggctccca acttgttctg
     1741 ctcaagctgg agagacctgt gatcctgaac catcacgtgg ccaggatttg cctacctcct
     1801 gaacagtatg tggtacctcc agggaccaac tgcgagatcg ctggctgggg tgaatccaaa
     1861 ggtacaagca atagcacagt ccttcatgtg gccaaaatga aggtcatctc cagtcaggaa
     1921 tgtaatgtga agtaccggag acgagtacaa gagagtgaga tatgcaccga ggggttgctg
     1981 gcccctacgg gcgcttgtga gggtgactac gggggcccac ttgcctgcta tacccatgac
     2041 tgctgggtcc tacagggact tatcatcccg aacagagtgt gtgcacggcc tcgctggcca
     2101 gctatcttca cacgtgtgtc tgtgtttgtg gactggatta acaaggtcgt gcagctggag
     2161 taggcctgct ttcgatctct tagagatgac aaggctgctt atcaaactaa agcaaacttt
     2221 tc
//
