LOCUS       NM_001044285             902 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus methionine sulfoxide reductase B1 (Msrb1), mRNA.
ACCESSION   NM_001044285 XM_001062118
VERSION     NM_001044285.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 902)
  AUTHORS   Dai,J., Zhou,J., Liu,H. and Huang,K.
  TITLE     Selenite and ebselen supplementation attenuates D-galactose-induced
            oxidative stress and increases expression of SELR and SEP15 in rat
            lens
  JOURNAL   J Biol Inorg Chem 21 (8), 1037-1046 (2016)
   PUBMED   27752786
  REMARK    GeneRIF: Data show that 15kD selenoprotein (SEP15) protein and
            selenoprotein R (SELR) protein expression was decreased in the
            lenses of galactose induced cataract.
REFERENCE   2  (bases 1 to 902)
  AUTHORS   Lee,B.C., Peterfi,Z., Hoffmann,F.W., Moore,R.E., Kaya,A.,
            Avanesov,A., Tarrago,L., Zhou,Y., Weerapana,E., Fomenko,D.E.,
            Hoffmann,P.R. and Gladyshev,V.N.
  TITLE     MsrB1 and MICALs regulate actin assembly and macrophage function
            via reversible stereoselective methionine oxidation
  JOURNAL   Mol Cell 51 (3), 397-404 (2013)
   PUBMED   23911929
REFERENCE   3  (bases 1 to 902)
  AUTHORS   Mariotti,M., Ridge,P.G., Zhang,Y., Lobanov,A.V., Pringle,T.H.,
            Guigo,R., Hatfield,D.L. and Gladyshev,V.N.
  TITLE     Composition and evolution of the vertebrate and mammalian
            selenoproteomes
  JOURNAL   PLoS One 7 (3), e33066 (2012)
   PUBMED   22479358
REFERENCE   4  (bases 1 to 902)
  AUTHORS   Liang,X., Fomenko,D.E., Hua,D., Kaya,A. and Gladyshev,V.N.
  TITLE     Diversity of protein and mRNA forms of mammalian methionine
            sulfoxide reductase B1 due to intronization and protein processing
  JOURNAL   PLoS One 5 (7), e11497 (2010)
   PUBMED   20634897
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 902)
  AUTHORS   Kim,H.Y. and Gladyshev,V.N.
  TITLE     Methionine sulfoxide reduction in mammals: characterization of
            methionine-R-sulfoxide reductases
  JOURNAL   Mol Biol Cell 15 (3), 1055-1064 (2004)
   PUBMED   14699060
REFERENCE   6  (bases 1 to 902)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FQ220312.1, BC094309.1 and
            AI044339.1.
            
            On Oct 24, 2016 this sequence version replaced NM_001044285.2.
            
            Summary: The protein encoded by this gene belongs to the
            methionine-R-sulfoxide reductase B (MsrB) family. Members of this
            family function as repair enzymes that protect proteins from
            oxidative stress by catalyzing the reduction of
            methionine-R-sulfoxides to methionines. This protein is highly
            expressed in liver and kidney, and is localized to the nucleus and
            cytosol. It is the only member of the MsrB family that is a
            selenoprotein, containing a selenocysteine (Sec) residue at its
            active site. It also has the highest methionine-R-sulfoxide
            reductase activity compared to other members containing cysteine in
            place of Sec. Sec is encoded by the UGA codon, which normally
            signals translation termination. The 3' UTRs of selenoprotein mRNAs
            contain a conserved stem-loop structure, designated the Sec
            insertion sequence (SECIS) element, that is necessary for the
            recognition of UGA as a Sec codon, rather than as a stop signal.
            [provided by RefSeq, Oct 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220312.1, BC094309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: inferred from conservation
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                FQ220312.1         1-23
            24-876              BC094309.1         1-853
            877-902             AI044339.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..902
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..902
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
                     /note="methionine sulfoxide reductase B1"
                     /db_xref="GeneID:685059"
                     /db_xref="RGD:1583243"
     exon            1..136
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..432
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
                     /EC_number="1.8.4.12"
                     /EC_number="1.8.4.14"
                     /note="UGA stop codon recoded as selenocysteine;
                     selenoprotein R; selenoprotein X, 1"
                     /codon_start=1
                     /transl_except=(pos:364..366,aa:Sec)
                     /product="methionine-R-sulfoxide reductase B1"
                     /protein_id="NP_001037750.2"
                     /db_xref="GeneID:685059"
                     /db_xref="RGD:1583243"
                     /translation="MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWP
                     AFTETIHEDSVAKCPEKNRPEALKVSCGKCGNGLGHEFLNDGPKRGQSRFUIFSSSLK
                     FIPKGKEAPASQGD"
     exon            137..285
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..400
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..432
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..885
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      457..561
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      859..864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
     polyA_site      885
                     /gene="Msrb1"
                     /gene_synonym="selX; Sepx1"
ORIGIN      
        1 attgggaagg ggtcgggttt gagtccagac ctgagggctt tacttgtctt cgccggggtc
       61 tttgctcgtc cggtcgcgac tatgtcgttc tgcagcttct tcggaggcga ggtcttccag
      121 aatcacttcg agccaggcgt ctacgtgtgt gccaagtgcg gctatgagct gttctccagt
      181 cgctcgaagt acgcacactc atccccatgg ccagcattta ctgaaaccat ccacgaggac
      241 agtgtggcca agtgccctga gaaaaaccga ccggaagctt taaaggtgtc ctgtggcaag
      301 tgtggcaatg ggttgggcca cgagttcctc aatgacggcc ccaagcgggg acagtcgagg
      361 ttctgaatat tcagcagttc tctgaagttc atccccaaag gcaaagaagc tcctgcctcc
      421 cagggagact aggagatgga ctgcgaatgg gactgccctg gccaaccact ccagcctcag
      481 tcactgtatg atctgctctg gttaaatcct tctgtgccag cccagggtgg tgatgacctg
      541 tgaccttcga ggagggaggc gggctgatgc cggcgactct tggatccttg tcttctggca
      601 gagaaaacag aagtccattt cacaatcagc aggctcgtct tgcctcactc tggcttggga
      661 aagtaactgt taccccatta gtcagccagc gtgggggcgg ggggaccctg ttttcaccac
      721 accatccagc atgtccctct taagagaaag ccactgtacc ttatcctgtg tgcttggaag
      781 ctcgtgacat ccgggagagt gggtgacgtt gaggccctct cccccttgat tcctctctgg
      841 agtgagcaag tcaaagtgaa taaacccaaa gcctgagcca gtggcaaaaa aaaaaaaaaa
      901 aa
//
