LOCUS       NM_001191939            5725 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus macrophage scavenger receptor 1 (Msr1),
            transcript variant 1, mRNA.
ACCESSION   NM_001191939 XM_573919
VERSION     NM_001191939.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5725)
  AUTHORS   Zhang,H., Su,Y.J., Zhou,W.W., Wang,S.W., Xu,P.X., Yu,X.L. and
            Liu,R.T.
  TITLE     Activated scavenger receptor A promotes glial internalization of
            abeta
  JOURNAL   PLoS One 9 (4), e94197 (2014)
   PUBMED   24718459
  REMARK    GeneRIF: Heptapeptide XD4 activates the class A scavenger receptor
            (SR-A) on the glia by increasing the binding of Abeta to SR-A,
            thereby promoting glial phagocytosis of Abeta oligomer in
            astrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5725)
  AUTHORS   Chatzigeorgiou,A., Kandaraki,E., Piperi,C., Livadas,S.,
            Papavassiliou,A.G., Koutsilieris,M., Papalois,A. and
            Diamanti-Kandarakis,E.
  TITLE     Dietary glycotoxins affect scavenger receptor expression and the
            hormonal profile of female rats
  JOURNAL   J Endocrinol 218 (3), 331-337 (2013)
   PUBMED   23823020
  REMARK    GeneRIF: The expression of RAGE and Msr1 was significantly
            down-regulated in the high-AGE diet-fed rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5725)
  AUTHORS   Fu,H., Liu,B., Frost,J.L., Hong,S., Jin,M., Ostaszewski,B.,
            Shankar,G.M., Costantino,I.M., Carroll,M.C., Mayadas,T.N. and
            Lemere,C.A.
  TITLE     Complement component C3 and complement receptor type 3 contribute
            to the phagocytosis and clearance of fibrillar Abeta by microglia
  JOURNAL   Glia 60 (6), 993-1003 (2012)
   PUBMED   22438044
REFERENCE   4  (bases 1 to 5725)
  AUTHORS   Sun,L., Wen,J.H., Sun,H.L., Shu,X.C., Hu,F., Yin,D.C., Yang,Q.,
            Zeng,Y.J., Sun,Y. and Liu,L.
  TITLE     Perindopril attenuates renal tubulointerstitium injury by
            inhibiting scavenger receptor A over-expression in diabetic rats
  JOURNAL   J Endocrinol Invest 35 (5), 511-515 (2012)
   PUBMED   21765240
  REMARK    GeneRIF: Scavenger receptor A over-expression is associated with
            diabetes.
REFERENCE   5  (bases 1 to 5725)
  AUTHORS   Kong,S.L., Chui,P., Lim,B. and Salto-Tellez,M.
  TITLE     Elucidating the molecular physiopathology of acute respiratory
            distress syndrome in severe acute respiratory syndrome patients
  JOURNAL   Virus Res 145 (2), 260-269 (2009)
   PUBMED   19635508
REFERENCE   6  (bases 1 to 5725)
  AUTHORS   Kuronuma,K., Sano,H., Kato,K., Kudo,K., Hyakushima,N., Yokota,S.,
            Takahashi,H., Fujii,N., Suzuki,H., Kodama,T., Abe,S. and Kuroki,Y.
  TITLE     Pulmonary surfactant protein A augments the phagocytosis of
            Streptococcus pneumoniae by alveolar macrophages through a casein
            kinase 2-dependent increase of cell surface localization of
            scavenger receptor A
  JOURNAL   J Biol Chem 279 (20), 21421-21430 (2004)
   PUBMED   14993215
REFERENCE   7  (bases 1 to 5725)
  AUTHORS   Jalkanen,J., Leppanen,P., Pajusola,K., Narvanen,O., Mahonen,A.,
            Vahakangas,E., Greaves,D.R., Bueler,H. and Yla-Herttuala,S.
  TITLE     Adeno-associated virus-mediated gene transfer of a secreted decoy
            human macrophage scavenger receptor reduces atherosclerotic lesion
            formation in LDL receptor knockout mice
  JOURNAL   Mol Ther 8 (6), 903-910 (2003)
   PUBMED   14664792
REFERENCE   8  (bases 1 to 5725)
  AUTHORS   Kunjathoor,V.V., Febbraio,M., Podrez,E.A., Moore,K.J.,
            Andersson,L., Koehn,S., Rhee,J.S., Silverstein,R., Hoff,H.F. and
            Freeman,M.W.
  TITLE     Scavenger receptors class A-I/II and CD36 are the principal
            receptors responsible for the uptake of modified low density
            lipoprotein leading to lipid loading in macrophages
  JOURNAL   J Biol Chem 277 (51), 49982-49988 (2002)
   PUBMED   12376530
REFERENCE   9  (bases 1 to 5725)
  AUTHORS   Husemann,J., Loike,J.D., Kodama,T. and Silverstein,S.C.
  TITLE     Scavenger receptor class B type I (SR-BI) mediates adhesion of
            neonatal murine microglia to fibrillar beta-amyloid
  JOURNAL   J Neuroimmunol 114 (1-2), 142-150 (2001)
   PUBMED   11240025
REFERENCE   10 (bases 1 to 5725)
  AUTHORS   Suzuki,H., Kurihara,Y., Takeya,M., Kamada,N., Kataoka,M.,
            Jishage,K., Ueda,O., Sakaguchi,H., Higashi,T., Suzuki,T.,
            Takashima,Y., Kawabe,Y., Cynshi,O., Wada,Y., Honda,M., Kurihara,H.,
            Aburatani,H., Doi,T., Matsumoto,A., Azuma,S., Noda,T., Toyoda,Y.,
            Itakura,H., Yazaki,Y., Kodama,T. et al.
  TITLE     A role for macrophage scavenger receptors in atherosclerosis and
            susceptibility to infection
  JOURNAL   Nature 386 (6622), 292-296 (1997)
   PUBMED   9069289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Sep 1, 2022 this sequence version replaced NM_001191939.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.48307.1,
                                           SRR26360186.2645616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000016.1  59421358-59421420
            64-169              JAXUCZ010000016.1  59437518-59437623
            170-283             JAXUCZ010000016.1  59439091-59439204
            284-693             JAXUCZ010000016.1  59447401-59447810
            694-880             JAXUCZ010000016.1  59451731-59451917
            881-961             JAXUCZ010000016.1  59455130-59455210
            962-1051            JAXUCZ010000016.1  59459426-59459515
            1052-1105           JAXUCZ010000016.1  59462700-59462753
            1106-1294           JAXUCZ010000016.1  59485598-59485786
            1295-5725           JAXUCZ010000016.1  59502640-59507070
FEATURES             Location/Qualifiers
     source          1..5725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..5725
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /note="macrophage scavenger receptor 1"
                     /db_xref="GeneID:498638"
                     /db_xref="RGD:1564316"
     exon            1..63
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1428
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /note="isoform 1 is encoded by transcript variant 1;
                     macrophage scavenger receptor types I and II"
                     /codon_start=1
                     /product="macrophage scavenger receptor types I and II
                     isoform 1"
                     /protein_id="NP_001178868.1"
                     /db_xref="GeneID:498638"
                     /db_xref="RGD:1564316"
                     /translation="MIEKQRLCPPEPEDADCYSESVKFDARSMTASLPHNTINGSSVQ
                     EKLKSFKVALVALYLLVFAVLIPVVGIVTAQLVNWEMKNCLVGSANTSDTSQTLTGKE
                     NTSKAEMGFTIAMERMKALEERVQSISDSKAGLLDTDRFQNFSMATDQRLNDLLLQLN
                     SLISSVQEHGESLDAISKSLQSLNTTLLDVQVHTETLNVKVRESTAKQQEDISKLEER
                     VHKVSAEIQSVKEEQEHVEQEVKQEVKVLNNITNDLRLKDWEHSQTLKNITLIQGPPG
                     PPGEKGDKGLTGQSGPPGVPGARGPPGPKGDQGPVGFPGGRGYPGAPGKAGRSGFPGP
                     KGQKGEKGRAGISTSLKTVRLVDGSGPHEGRVEIFHEGQWGTICDDRWDIRAGQVVCR
                     SLGYQDVLTVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKISKWGELGCSHAEDAGV
                     TCTS"
     exon            64..169
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
     exon            170..283
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
     exon            284..693
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
     exon            694..880
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
     exon            881..961
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1051
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1105
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1294
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..5725
                     /gene="Msr1"
                     /gene_synonym="RGD1564316"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattgtaaaa agagggaagt ggacaaatca gtgctacctt cattaccagc aatgacaaaa
       61 gagatgatag agaaacagag gctctgtcct cctgaaccgg aggacgctga ctgctactca
      121 gaatctgtga aatttgacgc acgttccatg acagcatccc ttcctcacaa cactataaat
      181 ggctcctccg ttcaggagaa actgaagtcc ttcaaagttg ccctcgtcgc tctctacctc
      241 cttgtgtttg cagtactaat acctgttgtt ggaatagtaa cagctcagct tgtgaattgg
      301 gaaatgaaga actgcttagt gggttcagct aacacaagtg atacatcgca aactctgact
      361 ggaaaagaaa acaccagtaa agcagaaatg ggatttacaa ttgccatgga acgcatgaag
      421 gccttggagg agagagtcca aagcatttca gactcaaaag ctggccttct agacacagac
      481 cgcttccaga acttcagcat ggcaaccgac caaagactta atgatcttct tctgcagtta
      541 aattccttga tttcatcagt ccaggaacat ggggagtccc tggatgcaat ttccaagtcc
      601 ttgcagagtc tgaatacaac actgcttgat gtccaggtcc atacagaaac actgaatgtc
      661 aaagtccgcg aatctacagc aaagcaacag gaggacatca gtaagttgga ggaacgtgtg
      721 cacaaagtat cagcagaaat ccagtctgtg aaagaagaac aagagcatgt ggaacaggaa
      781 gtaaaacagg aagtgaaagt attgaacaac atcaccaacg acctcagact gaaggactgg
      841 gaacactcac agacgctgaa aaatatcacc ttaattcaag ggcctcctgg acccccaggt
      901 gaaaagggag acaagggact tactggacaa agtggtccac ctggtgttcc aggtgcaaga
      961 ggtcctccag gtcctaaagg tgatcaggga ccagttggct tccctggtgg gcgaggatac
     1021 ccaggagcac caggaaaggc agggaggtca ggatttcctg gacctaaagg acaaaaggga
     1081 gaaaaggggc gtgcaggaat atcaacctct cttaaaacag ttcgactggt tgatggtagc
     1141 ggaccccatg agggccgagt agagatcttc cacgaaggcc agtggggcac aatctgtgat
     1201 gatcgctggg atatacgagc tggacaagtt gtctgccgga gtctaggata ccaagatgtt
     1261 ctaactgtgc acaagagagc tcactttgga caaggtactg gtccaatatg gctgaatgaa
     1321 gtgatgtgct ttgggagaga atcgtctatt gaaaactgta aaatcagcaa atggggagaa
     1381 ttaggctgtt cacatgcaga agatgctggg gtcacttgta cttcataatg tatcatattt
     1441 tcagtttcat ttatgaaatt gcttttgtaa aactattttt gttgccctgc tctactaaaa
     1501 tcattttaat aatagtaaat ggactcacaa tattggtaat agaaagggaa tatttgaaat
     1561 gagtgggaat agggtcttaa acacggcaaa ctttatgtct atggataaag gattcaaact
     1621 tctcacaatg gttaatgttg attgtcaaat tgcccagaat ttacaaatgc caagaaacac
     1681 aaaaatatgg ttattcatat tagggcattt ccagagaggt ttaactgaaa tagaatcatt
     1741 ggtagcatcg ttcatgggct tgagatgctg actgaaataa aagcagtggg gcaccatcat
     1801 tcatctcttt ctgcttcctg cctgtgaatc actatcctgc ctgacagtat cactatctag
     1861 aacatgcttc ttttaccaag atggaccatt tgatgccatg aatcaaaata agctcttctt
     1921 tcccaagtat catttggcaa taagggaaaa agctaacaga attcttttta ccagaagtgg
     1981 gcttgtcata aatctcatgg cagtttgtca aattgttgaa ttaattttct gaacgaataa
     2041 agacaaaaaa tcttctgagc cataggctat agatgaccta gaatggtata aacaggactt
     2101 tgggagtatt ctgatagaaa tttggatttt tagattggta aacaaatatg caaatgcata
     2161 agtaaggaaa taaaggtcca tttccagaga cgtcagaatg aaataagaat tatataatga
     2221 actgaaaaga ggcattcatg tcacatgctg acaactactc tgacttcatt ctatttgtat
     2281 tctgagactt ggaataagac caagagactt atttctttaa tgttaaaact tcaagatata
     2341 atagaattgg ggtgtggcat tgttacaagt ctccattctt acccatatct gcagtgacaa
     2401 aaagcaacaa gcagagaagg aagatatctc aaaactctgc agttttaggg agaaataagc
     2461 ataagctggt ttaaagttgt tgacaaagat attaaagaga acaaaattgt aatttttaaa
     2521 gagattggaa aaattaatga gaagcttcat cctttgcaga agaaaaaaat aaggggccct
     2581 ggtggcaaaa ccattgaaag gctctaatgt ataaaaaatg caaatttatt tgaaaggata
     2641 aaagttaaac tgaaaattta actctgctag aaaacaattg cctagagaat tatttgtcct
     2701 agaatcagct acaaatgtac agagacacct ttatagctct gctagataaa ggccaggcta
     2761 tattttgaga cagtagctga acttagaaac ctaattcacg tgataaaaaa taaaaaagtg
     2821 atgattcaca aagatttata ataacatgcc agaaagacac ttcgatccag aaatgtgttt
     2881 cagagttggt ttccgtataa caatttccct agaggagcct gtgcgaagct gtaaaggtga
     2941 aacccaattt gaagtagggc tgcaggaact gagagatgcc cctgagacaa gtatcatgta
     3001 tagagtgcaa cttgtccaag aggaagttga agtattctaa gatagcagaa atagagtttc
     3061 taggtaaccc agttctgtag gaactctaaa gattccttca ggaacccatg tgcccaacac
     3121 tggattatgt gatttcagta tttctttagt tgttctttcc ttggcatgct tcagtttgtc
     3181 ctttttgcac tgggaatgtt cattctgtag gactatatac cataagtatg taacttgtag
     3241 tttttgaaaa tagacattca cagttaagcg attgtctgat tctcagaagg gactctgaac
     3301 ttctattttg aaaaatttga aactcttatg actttgggga atctttgaga ctcagtagat
     3361 ttatcatcat catcatcatc attttttatt attatttgca ttatgagatt tagatgagac
     3421 tttagggacc aggagtggaa tattagaact taaaaatgtt gtgtttggat gttaacttga
     3481 caagactgga tatgtgatgg tcaacattac ttgtaaagtt attgggatat agaataatct
     3541 aggatataca cttgtagcct tctcctcgag aacatttcca aagaacttta actgagaagg
     3601 caacacctta atttggtgac tccatcttac tgcttggagt tccagcacca aatgagaatg
     3661 taaatgaagg tggagagcag aagctatttc tttctgtttc ctgatgttaa ccaattggct
     3721 catgctcctg ccatcttgcc ttctctgaag taatggactg tatcccaaat catgtggcag
     3781 agaaacccag caatccttaa attgatctta tccattgtct tggccaacaa tgagaacagt
     3841 gaagaataca ctctctgagc tttgaagtgg aacatttaaa aacaatgatg tattgaggtg
     3901 aatactctta aaactgaaga atctgcaaat gagaagagag tagagaaggt agatgtcctg
     3961 gcatactagc aacacaggga gagttttcta gattttgaaa cttaaataca aaagatagaa
     4021 gagagacttg cagaactgtg tgtatgtgct aggctgggtt cttcaactta ccttttaaag
     4081 aaggatgaca tttaagactt tactgctaaa ctttgtttta tgagggcatt actatgctga
     4141 gatggaataa tatattctca gatatcaaat gagtattata aagcataaaa ctattatatt
     4201 gctatgtagt ttctttctct acaaaaatgt cagataccaa aaatacacgg tgcatcattg
     4261 tattcatttt taaaactaca agtgaatgta actctaaaag ttcaatgagg ttccctgaat
     4321 aaaaaaaata tatgagaaat acatactgga ataattttag ggaataaaac aagagactga
     4381 aatacagtgt taaccatcta tcaggaatct ctccagggct atacaaattt aatagaattt
     4441 cctggaaaat atttcttttg ttaaccacaa aaaaatatct ttgatgcttt gttttcctaa
     4501 aaggggggca aattaaccat cccactgtga gaacgtaatg ctggaacaaa tactattcct
     4561 ctggataaat actgattagg aatttcaaac atgtctcaga cacctggcat accatacatc
     4621 ccttattggc tgctagagtg attagttagg agaagtggta atccaggaaa gttaagaagg
     4681 aaagaaaaat ggaggaaaga aggagggaaa gtaaatggga gtacatggag ggaatttcaa
     4741 gaaataatgt atttgctaat catctccatt atgtgttaaa catttggagt aagtcagttt
     4801 gtgaaaactt gaagtggttt atgatagtca tggggatgag gcagtaaatc aactgaaggg
     4861 gaagtccttc tggaccatag tgatattagg caattatttc tatcttacta cttaaatttt
     4921 attttgtgtg tatgtgtatt tgtatgtata atgtgcatgt ggatgtgtgt atttgtgtat
     4981 atgtgaatgt gtgtgtatgc acacatgtgc atatatgtgc atgtgtgtat ttgtatatat
     5041 gtgtgtatgt gtatgcacat gtgtgtatgt gtatgcacat gtgtgtgtac atgtccatgt
     5101 atgtatgtcc atgtgtatat gtgagcatct ttgtgtttgt gtatatgtgt ctgtgtgggg
     5161 aagccacagg ctgatagtgt tattttcaat cactgtctgc cttagttttt gagactggat
     5221 ctcttaatga acctggacat tactgattca ggtagactat ctggttgaca agccctaggg
     5281 attgccccca aagtggagtg tggagcatgt acatgcttgt gtaagtgaat atgcatgtgc
     5341 atggaggcca gaggtcaaca gttgggtgtc ttcctcattc ctttttcata taaaattcat
     5401 ttatgtgcca tatatgcatg atacttagaa ataaatttat gccatatgtg attctgtttt
     5461 ttttttctga aaatgttcag atgagggtgt ttgacatata ttggggctgg ctgcaagttc
     5521 tatatggaag acagtgaacc tataatgttt atatcatgga aagtagaact attctatgtg
     5581 acctggttaa ttcaggatga tattctaagt ggccaaggtg gacatgaatc atggacagag
     5641 caaaagctac ttgtgttcaa acacttactt gtttctatcc cttcctcatt tgatgtccat
     5701 aaagtgataa taaagaattt tcttt
//
