LOCUS       NM_080886               1712 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus methylsterol monooxygenase 1 (Msmo1), mRNA.
ACCESSION   NM_080886
VERSION     NM_080886.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1712)
  AUTHORS   Dimopoulou,M., Verhoef,A., Pennings,J.L.A., van Ravenzwaay,B.,
            Rietjens,I.M.C.M. and Piersma,A.H.
  TITLE     A transcriptomic approach for evaluating the relative potency and
            mechanism of action of azoles in the rat Whole Embryo Culture
  JOURNAL   Toxicology 392, 96-105 (2017)
   PUBMED   28970091
  REMARK    GeneRIF: Among the identified sterol associated genes, we detected
            that methylsterol monooxygenase 1 (Msmo1) was more sensitively
            induced compared to Cyp51, a classical biomarker of this pathway.
            Therefore, we suggest that Msmo1 could be a better biomarker for
            screening the fungicidal value of azoles.
REFERENCE   2  (bases 1 to 1712)
  AUTHORS   Uwabe,K., Gahara,Y., Yamada,H., Miyake,T. and Kitamura,T.
  TITLE     Identification and characterization of a novel gene (neurorep 1)
            expressed in nerve cells and up-regulated after axotomy
  JOURNAL   Neuroscience 80 (2), 501-509 (1997)
   PUBMED   9284352
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D50559.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50559.1, EV775450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p13"
     gene            1..1712
                     /gene="Msmo1"
                     /gene_synonym="Sc4mol"
                     /note="methylsterol monooxygenase 1"
                     /db_xref="GeneID:140910"
                     /db_xref="RGD:620281"
     exon            1..56
                     /gene="Msmo1"
                     /gene_synonym="Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     exon            57..341
                     /gene="Msmo1"
                     /gene_synonym="Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..968
                     /gene="Msmo1"
                     /gene_synonym="Sc4mol"
                     /EC_number="1.14.18.9"
                     /note="C-4 methylsterol oxidase; RANP-1; neuropep 1;
                     neurorep 1; sterol-C4-methyl oxidase"
                     /codon_start=1
                     /product="methylsterol monooxygenase 1"
                     /protein_id="NP_543162.1"
                     /db_xref="GeneID:140910"
                     /db_xref="RGD:620281"
                     /translation="MAMNKSVGLFSSASLAVDYVDSLLPENPLQEPFKNAWVYMLDNY
                     TKFQIATWGSLIVHETIYFLFSLPGFLFQFIPFMRKYKIQKDKPETFEGQWKCLKGIL
                     FNHFFIQLPLICGTYYFTEFFNIPYDWERMPRWYFTLARCLGCAVIEDTWHYFLHRLL
                     HHKRIYKYIHKVHHEFQAPFGIEAEYAHPLETLILGTGFFIGIVLLCDHVILLWAWVT
                     MRLLETIDVHSGYDIPLNPLNYIPFYTGARHHDFHHMNFIGNYASTFTWWDRIFGTDV
                     QYHAYTEKMKKLGKKSE"
     exon            342..490
                     /gene="Msmo1"
                     /gene_synonym="Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     exon            491..617
                     /gene="Msmo1"
                     /gene_synonym="Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     exon            618..772
                     /gene="Msmo1"
                     /gene_synonym="Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1712
                     /gene="Msmo1"
                     /gene_synonym="Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1712
                     /gene="Msmo1"
                     /gene_synonym="Sc4mol"
                     /note="21 a nucleotides"
ORIGIN      
        1 ggccgctgca cctgcccggt cttgcgccga gaccgctgtc aatcgcgggg caccaggaat
       61 aaaaggcccc ttgcagagat ttgaaaatgg ccatgaacaa aagtgttggc ctcttcagct
      121 ccgcatccct ggctgtggac tacgtagatt ccctgctgcc tgagaatcct ctgcaggaac
      181 cctttaagaa tgcttgggtc tacatgttgg acaactatac aaagttccag atcgcaacct
      241 ggggctccct gatcgttcat gagacgatct atttcctgtt ctctttacct ggctttctat
      301 tccagtttat acctttcatg agaaagtaca agattcaaaa ggataaacca gaaacctttg
      361 aaggccagtg gaagtgtttg aaaggaattc tgtttaatca tttttttatc cagttgcctc
      421 tgatttgtgg aacatactat tttacagagt ttttcaatat tccttatgat tgggaaagaa
      481 tgccaagatg gtatttcact ttggcaaggt gtttgggctg tgcagtcatc gaggatacct
      541 ggcactattt cctgcacaga ctccttcacc acaagaggat ttataaatac attcataaag
      601 tccatcacga gttccaggct ccatttggaa tcgaagcaga atatgcacat cccttggaaa
      661 ccctaattct tgggactgga tttttcattg gaattgtgct tttgtgtgat catgtaattc
      721 ttctgtgggc atgggtgacc atgcgtttgc tagaaaccat cgatgtgcac agtggttatg
      781 atatccctct caacccgttg aactacatcc ctttttatac cggggctcgg catcacgatt
      841 tccaccacat gaacttcatt gggaattacg cctccacctt cacgtggtgg gacagaatct
      901 ttgggacgga tgtccagtac catgcctaca ctgaaaagat gaagaagctt gggaaaaagt
      961 ctgagtgagc acctgctctc cgccctcctg actgcagctg gcaactaaca ttgcttctgg
     1021 ggagcagaac taagcacgtg actcggctgc tggtgatagg aacattaaca acctttaagt
     1081 actctgcggg atgagaactc ttctgctcga cacccaagat ctgtaaatgt gggaacaaag
     1141 aaatagatac ataagtacag ttttcaggag gaggttttaa aggccatatt gccaacctca
     1201 ccgaaaggtt tcaggaaccc gaggaagtgt taatgtacaa ctcaccactt cacgccaccc
     1261 gaggctgaag ttgacgttgc cttttaagcc tttttacata cactggccat ttcagaaaat
     1321 tctcaacaat aatgtctgcc ttcgagttta agtcatggtg ttttttagaa ttgacttgaa
     1381 atgaaaatat cacaaagtga atatatcagc tggtgatcga gtgactgaaa cccccctggt
     1441 ctgcggttga ccagttcagg actattcttt ctgtgaagga ttgtttgatt gtagtatctt
     1501 tatcagcatc ttgtaaattg gctcatttcc tacgtgatgt acatagaata ctataactta
     1561 acgactttca agttacttgg ggcattttta aattgaggag ccccacttct gatgtccacc
     1621 cccttgtctt tgtgtgtcag gtggtctcgg agctttgtga attctctatc tgcacctgtc
     1681 agagctggtg aaataaatgt gatttttgtc cg
//
