LOCUS       NM_019188                560 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus microseminoprotein, beta (Msmb), mRNA.
ACCESSION   NM_019188
VERSION     NM_019188.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 560)
  AUTHORS   Bergstrom,S.H., Jaremo,H., Nilsson,M., Adamo,H.H. and Bergh,A.
  TITLE     Prostate tumors downregulate microseminoprotein-beta (MSMB) in the
            surrounding benign prostate epithelium and this response is
            associated with tumor aggressiveness
  JOURNAL   Prostate 78 (4), 257-265 (2018)
   PUBMED   29250809
  REMARK    GeneRIF: Aggressive prostate tumors suppress MSMB synthesis in the
            benign prostate and this could explain why serum levels of MSMB are
            decreased in prostate cancer patients.
REFERENCE   2  (bases 1 to 560)
  AUTHORS   Imasato,Y., Onita,T., Moussa,M., Sakai,H., Chan,F.L.,
            Koropatnick,J., Chin,J.L. and Xuan,J.W.
  TITLE     Rodent PSP94 gene expression is more specific to the dorsolateral
            prostate and less sensitive to androgen ablation than probasin
  JOURNAL   Endocrinology 142 (5), 2138-2146 (2001)
   PUBMED   11316782
REFERENCE   3  (bases 1 to 560)
  AUTHORS   Fernlund,P., Granberg,L.B. and Larsson,I.
  TITLE     Cloning of beta-microseminoprotein of the rat: a rapidly evolving
            mucosal surface protein
  JOURNAL   Arch Biochem Biophys 334 (1), 73-82 (1996)
   PUBMED   8837741
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U65486.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U65486.1, CB779813.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..560
                     /gene="Msmb"
                     /gene_synonym="PSP94"
                     /note="microseminoprotein, beta"
                     /db_xref="GeneID:29311"
                     /db_xref="RGD:3113"
     exon            1..32
                     /gene="Msmb"
                     /gene_synonym="PSP94"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..371
                     /gene="Msmb"
                     /gene_synonym="PSP94"
                     /note="beta-microseminoprotein; PSP-94; prostate secretory
                     protein PSP94; prostate secreted seminal plasma protein;
                     prostate secretory protein of 94 amino acids"
                     /codon_start=1
                     /product="beta-microseminoprotein precursor"
                     /protein_id="NP_062061.1"
                     /db_xref="GeneID:29311"
                     /db_xref="RGD:3113"
                     /translation="MKARLGSLLVLATLVTASNAACSIQRLKRLPNEKSDECTDVDGG
                     KHVLNTYWQKNCEWCFCEKTAITCCTKTLIPVSYDKKRCQRQFHSENCTYSVVERTNP
                     GKTCPVNGWTI"
     exon            33..138
                     /gene="Msmb"
                     /gene_synonym="PSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            139..241
                     /gene="Msmb"
                     /gene_synonym="PSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            242..545
                     /gene="Msmb"
                     /gene_synonym="PSP94"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcctgtaa ggagtcctgc tttgccacca tgaaagctcg gctgggcagc ctcctagtcc
       61 ttgccacctt ggtgacagca tccaatgcag cgtgctctat tcaaagactc aagagacttc
      121 caaacgaaaa gtctgatgaa tgtacagatg tagacggtgg caagcacgtc cttaacactt
      181 actggcagaa gaactgtgag tggtgtttct gtgaaaaaac tgcgatcacc tgctgcacca
      241 aaactcttat acccgtgagc tatgacaaaa agaggtgtca gagacaattc cactcagaga
      301 actgcaccta tagtgtggtg gaacggacga acccaggaaa gacctgtcca gtcaatggct
      361 ggacaatata aatgtgcttc ttgggggccc aaaagtggac caatatttga acattgtatg
      421 aattaaagtt accaatcata acctcgcaag gaggtgacct acaatcccaa gactcagaag
      481 gcagagccag gatgtcttga aaaactcgag taaataaata catgaataaa tctttgccaa
      541 tcctaaaaaa aaaaaaaaaa
//
