LOCUS       NP_001014133             466 aa            linear   ROD 24-OCT-2024
DEFINITION  male-specific lethal 3 homolog isoform 1 [Rattus norvegicus].
ACCESSION   NP_001014133 XP_228915
VERSION     NP_001014133.1
DBSOURCE    REFSEQ: accession NM_001014111.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 466)
  AUTHORS   Basilicata,M.F., Bruel,A.L., Semplicio,G., Valsecchi,C.I.K.,
            Aktas,T., Duffourd,Y., Rumpf,T., Morton,J., Bache,I.,
            Szymanski,W.G., Gilissen,C., Vanakker,O., Ounap,K., Mittler,G., van
            der Burgt,I., El Chehadeh,S., Cho,M.T., Pfundt,R., Tan,T.Y.,
            Kirchhoff,M., Menten,B., Vergult,S., Lindstrom,K., Reis,A.,
            Johnson,D.S., Fryer,A., McKay,V., Fisher,R.B., Thauvin-Robinet,C.,
            Francis,D., Roscioli,T., Pajusalu,S., Radtke,K., Ganesh,J.,
            Brunner,H.G., Wilson,M., Faivre,L., Kalscheuer,V.M., Thevenon,J.
            and Akhtar,A.
  CONSRTM   DDD Study
  TITLE     De novo mutations in MSL3 cause an X-linked syndrome marked by
            impaired histone H4 lysine 16 acetylation
  JOURNAL   Nat Genet 50 (10), 1442-1451 (2018)
   PUBMED   30224647
REFERENCE   2  (residues 1 to 466)
  AUTHORS   Kim,D., Blus,B.J., Chandra,V., Huang,P., Rastinejad,F. and
            Khorasanizadeh,S.
  TITLE     Corecognition of DNA and a methylated histone tail by the MSL3
            chromodomain
  JOURNAL   Nat Struct Mol Biol 17 (8), 1027-1029 (2010)
   PUBMED   20657587
REFERENCE   3  (residues 1 to 466)
  AUTHORS   Cai,Y., Jin,J., Swanson,S.K., Cole,M.D., Choi,S.H., Florens,L.,
            Washburn,M.P., Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit composition and substrate specificity of a MOF-containing
            histone acetyltransferase distinct from the male-specific lethal
            (MSL) complex
  JOURNAL   J Biol Chem 285 (7), 4268-4272 (2010)
   PUBMED   20018852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Apr 20, 2005 this sequence version replaced XP_228915.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086548.1, SRR26643429.58791.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     Protein         1..466
                     /product="male-specific lethal 3 homolog isoform 1"
                     /note="male-specific lethal-3 homolog 1"
                     /calculated_mol_wt=53400
     Region          <3..22
                     /region_name="CD_CSD"
                     /note="CHROMO (CHRromatin Organization Modifier) domains
                     and chromo shadow domains; cl28914"
                     /db_xref="CDD:475127"
     Region          107..451
                     /region_name="MRG"
                     /note="pfam05712"
                     /db_xref="CDD:461721"
     CDS             1..466
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /coded_by="NM_001014111.2:127..1527"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:317464"
                     /db_xref="RGD:1549763"
ORIGIN      
        1 mpswdrwaae dhvlhdtden rrlqrklakk aiarlrgtgk kkrrcrlpgv dsvlksvpvk
       61 ektkndensi sstchescge knggikehrq rrikvktkgk kkvlslrsrk dmdertitie
      121 ipevlkkqle ddcyyinrrk rlvklpcqtn iitilesyvk hfainaafsa nerprhhham
      181 mhahmnvhyv paeknvdlck emvdglritf dytlplvlly pyeqtqykrv tsskfflpik
      241 esttttnrsq eelspsppll npstpqstes qpptgepatp krrkaepeal qslrrstrhs
      301 tncdrlsess sspqpkrrqq dtstsmpklf lhlekktpvh srssspiplt pskdgsavfa
      361 gfegrrtnei nevlswklvp dnyppgdqpp ppsyiygaqh llrlfvklpe ilgkmsfsek
      421 nlkallkhfd lflrflaeyh ddffpesayv aaceahystk npraiy
//
