LOCUS       NM_148890               3013 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus musashi RNA-binding protein 1 (Msi1), mRNA.
ACCESSION   NM_148890 XM_039089119 XM_346437
VERSION     NM_148890.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Skalbania,J., Palasz,A., Blaszczyk,I., Suszka-Switek,A.,
            Krzystanek,M., Tulcanaz,K.P., Worthington,J.J. and
            Mordecka-Chamera,K.
  TITLE     Chlorpromazine affects the numbers of Sox-2, Musashi1 and
            DCX-expressing cells in the rat brain subventricular zone
  JOURNAL   Pharmacol Rep 73 (4), 1164-1169 (2021)
   PUBMED   33843023
  REMARK    GeneRIF: Chlorpromazine affects the numbers of Sox-2, Musashi1 and
            DCX-expressing cells in the rat brain subventricular zone.
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Padial-Molina,M., Crespo-Lora,V., Candido-Corral,C.,
            Martin-Morales,N., Abril-Garcia,D., Galindo-Moreno,P.,
            Hernandez-Cortes,P. and O'Valle,F.
  TITLE     Expression of Musashi-1 Increases in Bone Healing
  JOURNAL   Int J Mol Sci 22 (7), 3395 (2021)
   PUBMED   33810326
  REMARK    GeneRIF: Expression of Musashi-1 Increases in Bone Healing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Sengupta,U., Montalbano,M., McAllen,S., Minuesa,G., Kharas,M. and
            Kayed,R.
  TITLE     Formation of Toxic Oligomeric Assemblies of RNA-binding Protein:
            Musashi in Alzheimer's disease
  JOURNAL   Acta Neuropathol Commun 6 (1), 113 (2018)
   PUBMED   30367664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   MacNicol,M.C., Cragle,C.E., Arumugam,K., Fosso,B., Pesole,G. and
            MacNicol,A.M.
  TITLE     Functional Integration of mRNA Translational Control Programs
  JOURNAL   Biomolecules 5 (3), 1580-1599 (2015)
   PUBMED   26197342
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   MacNicol,A.M., Hardy,L.L., Spencer,H.J. and MacNicol,M.C.
  TITLE     Neural stem and progenitor cell fate transition requires regulation
            of Musashi1 function
  JOURNAL   BMC Dev Biol 15, 15 (2015)
   PUBMED   25888190
  REMARK    GeneRIF: data suggest that in response to environmental cues that
            oppose cell cycle progression, regulation of Musashi function is
            required to promote target mRNA translation and cell fate
            transition
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3013)
  AUTHORS   Zhang,B., Wang,R.Z., Yao,Y., Liu,Z.H., Lian,Z.G., Zou,Y.J. and
            Wei,Y.K.
  TITLE     Proliferation and differentiation of neural stem cells in adult
            rats after cerebral infarction
  JOURNAL   Chin Med Sci J 19 (2), 73-77 (2004)
   PUBMED   15250238
REFERENCE   7  (bases 1 to 3013)
  AUTHORS   Sakaguchi,H., Yaoi,T., Suzuki,T., Okano,H., Hisa,Y. and Fushiki,S.
  TITLE     Spatiotemporal patterns of Musashi1 expression during inner ear
            development
  JOURNAL   Neuroreport 15 (6), 997-1001 (2004)
   PUBMED   15076722
REFERENCE   8  (bases 1 to 3013)
  AUTHORS   Yagita,Y., Kitagawa,K., Sasaki,T., Miyata,T., Okano,H., Hori,M. and
            Matsumoto,M.
  TITLE     Differential expression of Musashi1 and nestin in the adult rat
            hippocampus after ischemia
  JOURNAL   J Neurosci Res 69 (6), 750-756 (2002)
   PUBMED   12205668
  REMARK    GeneRIF: neuronal progenitor cells in the SGZ expressed Msi1 but
            not nestin.
REFERENCE   9  (bases 1 to 3013)
  AUTHORS   Cuadrado,A., Garcia-Fernandez,L.F., Imai,T., Okano,H. and Munoz,A.
  TITLE     Regulation of tau RNA maturation by thyroid hormone is mediated by
            the neural RNA-binding protein musashi-1
  JOURNAL   Mol Cell Neurosci 20 (2), 198-210 (2002)
   PUBMED   12093154
REFERENCE   10 (bases 1 to 3013)
  AUTHORS   Sakakibara,S., Nakamura,Y., Satoh,H. and Okano,H.
  TITLE     Rna-binding protein Musashi2: developmentally regulated expression
            in neural precursor cells and subpopulations of neurons in
            mammalian CNS
  JOURNAL   J Neurosci 21 (20), 8091-8107 (2001)
   PUBMED   11588182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Oct 27, 2022 this sequence version replaced
            XM_039089119.1, NM_148890.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.43522.1,
                                           SRR26643298.81162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000012.1  46845303-46845425   c
            124-164             JAXUCZ010000012.1  46845092-46845132   c
            165-246             JAXUCZ010000012.1  46844418-46844499   c
            247-331             JAXUCZ010000012.1  46844233-46844317   c
            332-373             JAXUCZ010000012.1  46841313-46841354   c
            374-466             JAXUCZ010000012.1  46839725-46839817   c
            467-515             JAXUCZ010000012.1  46836646-46836694   c
            516-598             JAXUCZ010000012.1  46834746-46834828   c
            599-716             JAXUCZ010000012.1  46833906-46834023   c
            717-797             JAXUCZ010000012.1  46829434-46829514   c
            798-854             JAXUCZ010000012.1  46827747-46827803   c
            855-923             JAXUCZ010000012.1  46824713-46824781   c
            924-1111            JAXUCZ010000012.1  46823906-46824093   c
            1112-1175           JAXUCZ010000012.1  46823399-46823462   c
            1176-3013           JAXUCZ010000012.1  46819039-46820876   c
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3013
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /note="musashi RNA-binding protein 1"
                     /db_xref="GeneID:259272"
                     /db_xref="RGD:628778"
     exon            1..123
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1153
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /note="musashi-1; Musashi homolog 1(Drosophila)"
                     /codon_start=1
                     /product="RNA-binding protein Musashi homolog 1"
                     /protein_id="NP_683688.1"
                     /db_xref="GeneID:259272"
                     /db_xref="RGD:628778"
                     /translation="METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFG
                     EVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQP
                     KMVTRTKKIFVGGLSVNTTVEDVKHYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESE
                     DIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLG
                     YPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAA
                     AAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYIS
                     AASPAPSTGFGHSLGGPLIATAFTNGYH"
     exon            124..164
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            165..246
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            247..331
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            332..373
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            374..466
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            467..515
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            516..598
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            599..716
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            717..797
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            798..854
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            855..923
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1111
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1175
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..3013
                     /gene="Msi1"
                     /gene_synonym="Msi1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctgccccg cgccgagcgc cgccgccgcc gccgctccgc tgcccgcgcc gcccgcggct
       61 cccgatggag actgacgcgc cccagcccgg cctcgcctcc ccggactcgc cgcacgaccc
      121 ctgcaagatg ttcatcggag gactcagttg gcagaccacg caggaagggc tgcgcgaata
      181 cttcggccag ttcggggagg tgaaagagtg tctggtgatg cgggaccccc tgaccaaaag
      241 atccaggggt ttcggcttcg tcactttcat ggaccaggcg ggggtggata aagtgctggc
      301 gcaatctcgg cacgagctcg actccaaaac aattgacccc aaggtggcct ttcctcggag
      361 agcacagcct aagatggtca ctcgaactaa gaagatcttt gtgggggggc tgtctgtgaa
      421 caccacggtg gaggacgtga agcactattt tgagcagttc ggaaaggtgg atgatgccat
      481 gctgatgttc gacaaaacta ccaacaggca cagagggttc gggtttgtca cgttcgagag
      541 tgaggacatc gtagagaaag tgtgtgagat ccacttccat gaaatcaaca acaaaatggt
      601 ggaatgcaag aaagctcagc caaaggaggt gatgtccccg acaggctcag cccggggccg
      661 gtctcgagtc atgccctacg ggatggacgc cttcatgctg ggtattggca tgttaggtta
      721 cccaggtttc caagccacga cctacgccag ccggagttac acaggccttg cccctggtta
      781 cacctaccag ttccccgaat tccgtgtaga gcggacccct ctcccgagcg ccccagtcct
      841 ccccgagctt acagccatcc ctctcactgc ttatggtccg atggcagcgg cggcggcagc
      901 ggcggctgta gtccgaggga caggctctca cccctggacg atggctcccc ctccaggttc
      961 tactcccagc cgcacagggg gcttcctggg gaccacaagc cccggcccca tggctgagct
     1021 ctatggggca gccaaccagg actcgggggt cagcagttac atcagcgccg ccagccccgc
     1081 ccccagcact ggttttggcc acagtcttgg gggtcccttg attgcgacag ccttcaccaa
     1141 tgggtaccac tgaagcaggg aggaggcggc aggagcaccc cagcctgcag ctgactgagg
     1201 accagagtga gacagcaagg ggattgggac acctcagccg cagcccagcc ccttcgctgc
     1261 aactcggacc gctactgcct gccccccaac ccctgggccc agtccccgcc ctgccatccc
     1321 tgacgtctgg ctcccctact aacctcccct gttctgacct tgcctcttct ccccccacca
     1381 acccacctct ctccctgttc gcttttattt attttggatt agccagttgc cctccccgca
     1441 ccaggtctgc cctctcgggt ctgccccatt ccctccctgc tgcccccttt aggacacccc
     1501 ccaggaaggc ttttgtatct gaatagctgg agggctggca gagggggcct gttccagact
     1561 gaggccccta cctgtttcgt tttttttgtt tttattctgg cttttccctc tttattcttt
     1621 tttttttttt ttaagaaact gtttttaaac tatttctagg tttgtgaatg tgaagcccca
     1681 ggccgcaggg ggcaaggggc caggtgcccc cccaccagct gagaagaaag tgtctatgtg
     1741 ggtgtgggtg cctggcctcc tccctccagc ctgggagagg agggcagggc tgcggggtag
     1801 gccaggccga gcccctggaa ccatcccgtc ctgtatcata tgtaaatact gtgaggtgaa
     1861 gccctacccc tacccttctc taagatccct tggggtaaca gcatttgcct gaccccacag
     1921 ggctaaggtt tcccctccct ccctgtctct gtccctccct cctcagacac cattactgta
     1981 agcttgcaga cctcagctct ggccacggca ggtccatact ctcaggccct ccccaggttc
     2041 aaggccttgg gcggactctc cccaaaaaac cctggttggg gggcaagggg ccagggaaga
     2101 ggagggcctg cctagagcca ctgctgggaa ggagttagct ctccaaaggc ccctcctggc
     2161 ccctgcctgg gtaggacctt catggtttct gctctgagcc ccccaccacg aggaggagga
     2221 ggcatcggga aacgcttcag caagtagata ccaggaaagc aaagggcttc tcagggaacc
     2281 cccaaattct cactgaagtt tcccaccagg acagtcccgc gaccagagcc cttgctaacc
     2341 ccctacttac cctggagccc ctttcagagg aaagagacgc tcaggggctc agggtgtgaa
     2401 cgtgaagtga gacctggcgt ggcagggctg agtctacctg ctgtcacccc cctctctgtc
     2461 cctcccgagg ctgggggggt tcaagccgcc ttccccagca gagcccccag ccttcaaagc
     2521 cccctttgga gagtcactgt ccgtgtgagg cgctcactca accaataagc cccgggaact
     2581 caaagcaata atcttcatca ccgagacgca cggctgtttg ttgttgggtt ttttggtttt
     2641 ttgggttttt tttgttttgt tttgttttta atatttccta ataaaagaga agctgcattt
     2701 tatcggattt tatcttttaa tttttctaca catctgagct gagccccagg agactttggc
     2761 ttcctctttt tttttttctt ttattctcca tccctgggcc ctctcacccc actgggccta
     2821 agtgggttca gggacctgga tttacatttc tgattcattc gtttgaggaa gaaaaaaaaa
     2881 aactttcttt ttaagatgtt acatggtgtt ttgaagccag caagttccac ccctcggtgt
     2941 cttccctccg catctgtaac ttcttttcca ggttttattt tgttttaaat tcctaataaa
     3001 ttatttgaaa aca
//
