LOCUS       NM_001398548            4255 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mutS homolog 6 (Msh6), mRNA.
ACCESSION   NM_001398548 XM_006239735
VERSION     NM_001398548.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4255)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 4255)
  AUTHORS   Traver,S., Coulombe,P., Peiffer,I., Hutchins,J.R., Kitzmann,M.,
            Latreille,D. and Mechali,M.
  TITLE     MCM9 Is Required for Mammalian DNA Mismatch Repair
  JOURNAL   Mol Cell 59 (5), 831-839 (2015)
   PUBMED   26300262
REFERENCE   3  (bases 1 to 4255)
  AUTHORS   Jentzsch,T., Robl,B., Husmann,M., Bode-Lesniewska,B. and Fuchs,B.
  TITLE     Expression of MSH2 and MSH6 on a tissue microarray in patients with
            osteosarcoma
  JOURNAL   Anticancer Res 34 (12), 6961-6972 (2014)
   PUBMED   25503122
REFERENCE   4  (bases 1 to 4255)
  AUTHORS   Ghodgaonkar,M.M., Lazzaro,F., Olivera-Pimentel,M., Artola-Boran,M.,
            Cejka,P., Reijns,M.A., Jackson,A.P., Plevani,P., Muzi-Falconi,M.
            and Jiricny,J.
  TITLE     Ribonucleotides misincorporated into DNA act as
            strand-discrimination signals in eukaryotic mismatch repair
  JOURNAL   Mol Cell 50 (3), 323-332 (2013)
   PUBMED   23603115
REFERENCE   5  (bases 1 to 4255)
  AUTHORS   Li,F., Mao,G., Tong,D., Huang,J., Gu,L., Yang,W. and Li,G.M.
  TITLE     The histone mark H3K36me3 regulates human DNA mismatch repair
            through its interaction with MutSalpha
  JOURNAL   Cell 153 (3), 590-600 (2013)
   PUBMED   23622243
REFERENCE   6  (bases 1 to 4255)
  AUTHORS   Geeta Vani,R., Varghese,C.M. and Rao,M.R.
  TITLE     Cloning of rat MLH1 and expression analysis of MSH2, MSH3, MSH6,
            and MLH1 during spermatogenesis
  JOURNAL   Genomics 62 (3), 460-467 (1999)
   PUBMED   10644444
REFERENCE   7  (bases 1 to 4255)
  AUTHORS   de Wind,N., Dekker,M., Claij,N., Jansen,L., van Klink,Y.,
            Radman,M., Riggins,G., van der Valk,M., van't Wout,K. and te
            Riele,H.
  TITLE     HNPCC-like cancer predisposition in mice through simultaneous loss
            of Msh3 and Msh6 mismatch-repair protein functions
  JOURNAL   Nat Genet 23 (3), 359-362 (1999)
   PUBMED   10545954
REFERENCE   8  (bases 1 to 4255)
  AUTHORS   Edelmann,W., Yang,K., Umar,A., Heyer,J., Lau,K., Fan,K.,
            Liedtke,W., Cohen,P.E., Kane,M.F., Lipford,J.R., Yu,N.,
            Crouse,G.F., Pollard,J.W., Kunkel,T., Lipkin,M., Kolodner,R. and
            Kucherlapati,R.
  TITLE     Mutation in the mismatch repair gene Msh6 causes cancer
            susceptibility
  JOURNAL   Cell 91 (4), 467-477 (1997)
   PUBMED   9390556
REFERENCE   9  (bases 1 to 4255)
  AUTHORS   Acharya,S., Wilson,T., Gradia,S., Kane,M.F., Guerrette,S.,
            Marsischky,G.T., Kolodner,R. and Fishel,R.
  TITLE     hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13629-13634 (1996)
   PUBMED   8942985
REFERENCE   10 (bases 1 to 4255)
  AUTHORS   Risinger,J.I., Umar,A., Boyd,J., Berchuck,A., Kunkel,T.A. and
            Barrett,J.C.
  TITLE     Mutation of MSH3 in endometrial cancer and evidence for its
            functional role in heteroduplex repair
  JOURNAL   Nat Genet 14 (1), 102-105 (1996)
   PUBMED   8782829
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000006.1.
            
            On Dec 20, 2021 this sequence version replaced XM_006239735.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.22415.1,
                                           SRR26643299.25982.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               JAXUCZ010000006.1  12333176-12333505   c
            331-533             JAXUCZ010000006.1  12327240-12327442   c
            534-718             JAXUCZ010000006.1  12323160-12323344   c
            719-3254            JAXUCZ010000006.1  12319789-12322324   c
            3255-3523           JAXUCZ010000006.1  12318451-12318719   c
            3524-3641           JAXUCZ010000006.1  12317624-12317741   c
            3642-3731           JAXUCZ010000006.1  12317417-12317506   c
            3732-3886           JAXUCZ010000006.1  12316763-12316917   c
            3887-4086           JAXUCZ010000006.1  12316482-12316681   c
            4087-4255           JAXUCZ010000006.1  12316190-12316358   c
FEATURES             Location/Qualifiers
     source          1..4255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..4255
                     /gene="Msh6"
                     /note="mutS homolog 6"
                     /db_xref="GeneID:100360342"
                     /db_xref="RGD:2322311"
     exon            1..330
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..4168
                     /gene="Msh6"
                     /note="rCG61559-like"
                     /codon_start=1
                     /product="DNA mismatch repair protein Msh6"
                     /protein_id="NP_001385477.1"
                     /db_xref="GeneID:100360342"
                     /db_xref="RGD:2322311"
                     /translation="MSRQSTLYSFFPKSPALGDTKEAAARASRKGAAASGASASRGRD
                     AAWSEAGPGSRPAALSTSLPEAKDLNGGLRRSAAPAVPASSSCDFSPGDLVWAKMEGY
                     PWWPCLVYNHPFDGTFIRKNGKSARVHVQFFDDSPTRGWVSKRMLKPYTGSKSKEAQK
                     GGHFYSSKSEILRAMQRADEALSKDKAQRLELAVCDEPSEPEEEEEEEEEETQVHGAY
                     LSDKSEEENQDESEEETQPNAQGPRRSSRQVKKRRVISDSESDIGGSDVEFKPDSKQE
                     GSSDEVSSGVGDSDSEGLGSFGKGAPKRKRTVAAHGGLKRKSLKKETGSAKQATRILS
                     ETKSTLSAFCAPQNSESQTHVCGGGNDSSGPTIWYHETLEWLKPEKRRDENRRRPDHP
                     DYNSSTLYVPEDFLNSCTPGMRRWWQFKSQNFDLVIFYKVGKFYELYHMDAVIGVSEL
                     GLIFMKGNWAHSGFPEIAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKF
                     DRVVRREICRIITKGTQTYSVLDGDPSENYSRYLLSLKEKEEDSSGHMRAYGVCFVDT
                     SLGKFFLGQFSDDRHCSRLRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGL
                     IPGSQFWDATKTLRTLLEGGYFTGNEGSGAELPPVLKAMTSESDSVGLTPGEESELSL
                     SALGGCVFYLKKCLIDQELLSMANFEEYFPLDSDMVGTVKPGAVFTKASQRMVLDAVT
                     LSNLEIFLNGTNGSTEGTLLERLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAIED
                     LMAVPDKVAEVADLLKKLPDLERLLSKIHNVGSPLKSQNHPDTRAIMYEETTYSKKKI
                     IDFLSALEGFKVMCKITRLMEDVADGFKSKTLKQVVTLQTKSPKGRFPDLTAELNRWD
                     TAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLDKQRSRIGCRNIVYWG
                     IGRNRYQLEIPENFATRNLPEEYELKSTKKGCKRYWTKVIEKKLSNLINAEERRDASL
                     KDCMRRLFYNFDKNHKDWQSAVECTAVLDVLLCLASYSQGGDGPMCRPVLLLPGEDTH
                     PFLELKGSRHPCITKTFFGDDFIPNDILIGCEEDAEADGKAYCVLVTGPNMGGKSTLI
                     RQAGLLAVMAQMGCYVPAELCRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILR
                     HATAHSLVLVDELGRGTATFDGTAIASAVVKELAETIKCRTLFSTHYHSLVEDYSKNV
                     CVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHR
                     KAREFERMNQALQLFREVCLASERPTVNSEAIHRLLALVNQL"
     exon            331..533
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
     exon            534..718
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
     exon            719..3254
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3523
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3641
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..3731
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3886
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..4086
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
     exon            4087..4255
                     /gene="Msh6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccagcagt ggccgcgcgg cggatgccgt ccctgtaggc gctcggagtg gtggaccatt
       61 cggcccgtca gccttcatca tgtcgcgaca aagcacccta tacagcttct tccccaagtc
      121 cccggcgctc ggcgacacca aggaggccgc ggcccgggcc tcacgcaaag gtgccgccgc
      181 ctccggagcc tccgcttccc ggggccggga tgcggcctgg agcgaggctg gacctgggtc
      241 ccggcccgca gcgttatcca cctcgttgcc ggaggcaaag gaccttaacg gagggctgcg
      301 gaggtcggcc gcgcccgcgg tccccgccag tagttcttgt gacttctccc caggtgatct
      361 ggtttgggct aagatggaag gttatccttg gtggccttgc ctggtttaca atcatccctt
      421 tgatgggaca ttcatccgca agaacgggaa atcagcccgt gttcacgtac agttttttga
      481 tgacagtcca acaaggggct gggttagcaa aaggatgtta aaaccatata caggttcaaa
      541 gtcaaaggaa gcccaaaagg gaggtcattt ctacagctca aagtccgaaa tactcagagc
      601 aatgcagcgt gcagacgaag ccttaagtaa agacaaggct cagaggcttg agctggcagt
      661 ctgtgatgag ccttcagagc cggaggagga ggaggaggag gaggaggagg agacacaggt
      721 gcatggggcc tatttatctg ataagagtga agaggaaaat caggacgaga gtgaagaaga
      781 aacacagcca aacgctcagg ggcctaggcg aagtagccgg caagtcaaaa agcgaagggt
      841 catctcagac tctgagagcg acattggcgg ctctgatgta gaattcaagc cagacagtaa
      901 gcaagaaggc agcagtgacg aagtgagcag tggggttgga gacagcgata gcgaaggcct
      961 gggcagcttt ggcaaaggcg ctccaaagcg gaagagaaca gtggcagctc atggtggact
     1021 taaaaggaaa agtctgaaga aggaaacagg ctcagccaaa caagcaactc gcattctgtc
     1081 agaaaccaag agtaccttga gtgctttctg tgccccgcag aattctgagt cccaaaccca
     1141 tgtctgtgga ggaggtaacg acagcagtgg acccactatc tggtatcatg agactttaga
     1201 atggcttaag ccagagaaga gaagagatga gaacaggaga cggccagatc acccagacta
     1261 caactcctcc acactgtatg tgcctgaaga cttcctcaac tcttgcaccc cggggatgag
     1321 gcggtggtgg cagttcaagt ctcagaactt tgaccttgtc atcttctaca aagtgggcaa
     1381 gttttatgag ttgtatcaca tggacgctgt cattggtgtc agtgagctgg gactgatatt
     1441 catgaagggc aactgggccc actctggttt tccagagatc gcatttggcc gattctcgga
     1501 ttccttggtg cagaagggct ataaggtggc ccgagtggaa cagactgaga ccccagagat
     1561 gatggaggca cggtgccgga aaatggcgca tgtgtctaag tttgatagag tggtgagaag
     1621 ggagatttgt aggatcatta ccaagggcac acagacctat agtgtgctgg atggtgatcc
     1681 ctccgagaac tacagtaggt atcttctgag cctcaaagag aaagaggaag attcttctgg
     1741 tcacatgcgt gcatatggtg tgtgctttgt tgatacttca ctgggcaagt ttttcctggg
     1801 ccagttttca gatgatcgcc actgttccag acttaggact ctagtggcac actatcctcc
     1861 agtacagatt ttgtttgaga aaggaaatct ctcaacagaa accaaaacag tcctgaaggg
     1921 ttcactgtca tcttgccttc aggaaggcct gattccaggt tcccaatttt gggatgccac
     1981 taagactttg cgaacactcc tggagggagg gtattttact ggaaatgaag gcagtggtgc
     2041 agagctgccc ccggtgctta aagctatgac gtcagagtca gattctgttg ggctgacacc
     2101 aggagaggag agtgagttat ctctgtctgc tctaggtggt tgtgttttct acctcaaaaa
     2161 atgcctgatt gatcaggagc ttctgtcaat ggctaatttt gaagagtatt ttcccttgga
     2221 ttctgacatg gttggcacag taaaacctgg tgctgtcttt actaaagcca gtcagcgaat
     2281 ggtgctagat gcggtgacat taagcaacct ggagattttc ctgaatggga caaatggctc
     2341 tactgaaggg actctgctag agaggctgga tacctgccat accccttttg gcaagcgact
     2401 cttaaaacag tggctttgtg cccccctctg tagtccttct gctatcagtg accgtctaga
     2461 tgccattgaa gacctgatgg ctgtgcctga caaagtcgcc gaagttgcag acctcctgaa
     2521 gaagctgcca gatcttgaga ggctactgag taagattcat aatgttgggt ctcccctaaa
     2581 gagccagaac catccagata ctagggctat aatgtacgaa gaaacgacat acagcaaaaa
     2641 aaagatcatc gattttcttt ctgctctaga aggattcaaa gtaatgtgta aaattacaag
     2701 gctcatggag gatgtcgctg atgggtttaa gtctaaaacc ctgaagcagg ttgtgactct
     2761 gcaaacaaaa agtcctaaag gccgttttcc tgatctgacc gcagaactga accgatggga
     2821 tacagctttt gaccatgaga aggctcgaaa gactggactc attaccccaa aagcagggtt
     2881 tgactcagat tatgaccaag cacttgctga cataagagag aatgaacaga gcctcttgga
     2941 gtacttagac aaacagcgga gtcggatcgg ctgtagaaac atagtctact ggggaattgg
     3001 taggaaccgt taccagttag agattccaga gaattttgct acccgaaatc tacctgaaga
     3061 atatgagttg aagtctacca aaaagggctg taaacgatac tggaccaaag tgattgagaa
     3121 gaaactgtct aatcttataa acgctgagga acgcagggac gcatctttaa aggactgcat
     3181 gcggcgtctg ttctataact ttgacaagaa tcacaaggac tggcagtctg ctgtggagtg
     3241 cactgcagtg ctggatgtct tactgtgcct ggctagctat agccaaggag gagatggccc
     3301 gatgtgtcgc ccagtacttc tgttaccagg agaagacaca catcccttct tagagcttaa
     3361 aggctcacgg catccctgca ttacaaagac tttctttgga gatgatttta ttcctaatga
     3421 cattctgatc ggctgtgagg aagacgcaga ggcggacggc aaagcctatt gtgtgcttgt
     3481 tactgggcca aatatggggg gcaaatctac actcataaga caggctggtc tgttagctgt
     3541 gatggcccag atgggttgtt atgtacctgc cgagctgtgt aggctcacac cagtggatag
     3601 agtgtttact cgacttggtg cctccgatag aatcatgtca ggggaaagta cattttttgt
     3661 tgagttgagc gaaactgcta gcatactcag gcatgcgaca gcacactctc tggtacttgt
     3721 ggatgaatta ggaagaggga ctgcaacttt tgatgggaca gcaatagcca gtgcggttgt
     3781 taaagaactc gctgaaacca taaagtgtcg aacactgttt tctacacact atcattcatt
     3841 agtagaggat tattctaaaa atgtttgtgt gcgcctagga catatggcat gcatggtgga
     3901 aaatgaatgt gaggatccca gccaggagac cattactttc ctctataaat tcattaaggg
     3961 agcttgtcct aagagctatg gctttaatgc agcaaggctt gctaatcttc cagaggaagt
     4021 tattcagaag ggacacagaa aagcaagaga atttgagagg atgaatcagg cattacaact
     4081 atttcgggaa gtttgtctgg ctagtgaaag gccgactgta aacagtgaag ctatccatag
     4141 gttgctggct ttggttaacc aattgtagac tacattggaa gctgagttga cttttgaaaa
     4201 aggtggtaaa ttcagacaac attatgatct aataaacttt attttttaaa aatga
//
