LOCUS       NM_212536               2679 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mutS homolog 5 (Msh5), mRNA.
ACCESSION   NM_212536 XM_215314
VERSION     NM_212536.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2679)
  AUTHORS   Liu,J.Y., Qian,C.Y., Gao,Y.F., Chen,J., Zhou,H.H. and Yin,J.Y.
  TITLE     Association between DNA mismatch repair gene polymorphisms and
            platinum-based chemotherapy toxicity in non-small cell lung cancer
            patients
  JOURNAL   Chin J Cancer 36 (1), 12 (2017)
   PUBMED   28093084
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2679)
  AUTHORS   Kolas,N.K., Svetlanov,A., Lenzi,M.L., Macaluso,F.P., Lipkin,S.M.,
            Liskay,R.M., Greally,J., Edelmann,W. and Cohen,P.E.
  TITLE     Localization of MMR proteins on meiotic chromosomes in mice
            indicates distinct functions during prophase I
  JOURNAL   J Cell Biol 171 (3), 447-458 (2005)
   PUBMED   16260499
REFERENCE   3  (bases 1 to 2679)
  AUTHORS   Di Giacomo,M., Barchi,M., Baudat,F., Edelmann,W., Keeney,S. and
            Jasin,M.
  TITLE     Distinct DNA-damage-dependent and -independent responses drive the
            loss of oocytes in recombination-defective mouse mutants
  JOURNAL   Proc Natl Acad Sci U S A 102 (3), 737-742 (2005)
   PUBMED   15640358
REFERENCE   4  (bases 1 to 2679)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   5  (bases 1 to 2679)
  AUTHORS   Kolas,N.K. and Cohen,P.E.
  TITLE     Novel and diverse functions of the DNA mismatch repair family in
            mammalian meiosis and recombination
  JOURNAL   Cytogenet Genome Res 107 (3-4), 216-231 (2004)
   PUBMED   15467367
  REMARK    Review article
REFERENCE   6  (bases 1 to 2679)
  AUTHORS   Kneitz,B., Cohen,P.E., Avdievich,E., Zhu,L., Kane,M.F., Hou,H. Jr.,
            Kolodner,R.D., Kucherlapati,R., Pollard,J.W. and Edelmann,W.
  TITLE     MutS homolog 4 localization to meiotic chromosomes is required for
            chromosome pairing during meiosis in male and female mice
  JOURNAL   Genes Dev 14 (9), 1085-1097 (2000)
   PUBMED   10809667
REFERENCE   7  (bases 1 to 2679)
  AUTHORS   Fox,M. and Tottenham,R.C.
  TITLE     Urinary fistula from segmental infarction in a transplanted kidney:
            recovery following surgical repair
  JOURNAL   Br J Urol 44 (3), 336-338 (1972)
   PUBMED   4557077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083904.1.
            
            On Sep 30, 2009 this sequence version replaced NM_212536.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083904.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2679
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2679
                     /gene="Msh5"
                     /note="mutS homolog 5"
                     /db_xref="GeneID:294252"
                     /db_xref="RGD:1303008"
     exon            1..26
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            27..177
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2532
                     /gene="Msh5"
                     /codon_start=1
                     /product="mutS protein homolog 5"
                     /protein_id="NP_997701.2"
                     /db_xref="GeneID:294252"
                     /db_xref="RGD:1303008"
                     /translation="MAFRATPGRTPPGPGPGVPSASFSSPQPAMAAPGGIEEEDEEEP
                     AEIHLCVLWSSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAK
                     QDEAMTQFLGKLASQEHREPKRPEIILLPSVDFGPEISKQRLLSGNYSFISESMTATE
                     KILFLSSIIPFDCVLTVRALGGLLKFLSRRRVGVELEDYSVGVPILGFKKFVLTHLVS
                     IDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCRWGQKLLRLWFTRPTR
                     ELRELNSRLDVIEFFLMPQNLDMAQMMHRLLSHIKNVPLILKRMKLSHTKVSDWQVLY
                     KTVYSALGLRDACRSLPQSIQLFRDITQEFSDDLHHIASLIGKVDFEESLAENRFTVL
                     PNIDPEIDAKKRRLMGLPSFLTEVAQKELENLDSCIPSCSVIYIPLIGFLLSIPRLSF
                     MVEASDFEIEGLDFMFLSEDKLHYRSARTKELDALLGDLHCEIRDQEMLLMHQLQCQV
                     LARAPVLTRVLDLASRLDVLLALASAARDYGYSRPHYSPCIQGVRIKNGRHPLMELCA
                     RTFVPNSTDCGGDQGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGVI
                     DAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATEHSLVLIDEFGKGTNSVDGLALL
                     TAVLRHWLALGPSCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQL
                     CHGVASASHASYTAAQAGLPDPLIARGKEVSDSIRSGKPVKPMHELVRRTQMENCQAL
                     VDKFLKLDLEDPSLDLDIFISQEVLPAATTIL"
     exon            178..301
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            302..382
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            383..445
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            446..567
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            568..677
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            678..713
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            714..796
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..842
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            843..981
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1044
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1170
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1243
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1353
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1434
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1522
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1712
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1839
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1989
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2064
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2208
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2346
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2420
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2654
                     /gene="Msh5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggaggtg gctcgtcgcg gctgagagtc gccgagccca tggctttcag agcgacccca
       61 ggccggacgc cgccgggacc cggccccggg gtcccctcag ccagcttctc cagccctcag
      121 cctgcaatgg cggcgcctgg aggtatcgag gaagaggacg aggaggagcc ggccgagatc
      181 catctgtgtg tgctgtggag ctcgggttat ctgggcattg cttactatga cactagtgac
      241 tccacgatcc acttcatgcc agatgcccca gaccacgaga gcctgaagct tctccagaga
      301 gttctggatg aaatcaaccc ccagtctgtt gtgacaagcg ccaaacagga tgaggctatg
      361 actcaatttc tagggaagct tgcctcccag gagcacagag agccaaagag accagaaatc
      421 atccttctgc caagcgtgga ttttggtcca gagataagca aacagcgcct cctttccgga
      481 aactactcct tcatctccga gtccatgacc gccactgaga aaatcctctt cctctcctcc
      541 attattccct ttgactgtgt cctcacggtc cgggcacttg gagggctgct caagttcctg
      601 agtcgaagaa gagttggggt tgaactggag gactacagtg ttggcgtccc tatcctggga
      661 tttaagaagt ttgtattgac ccatctggtg agcatagatc aagacactta cagcgttcta
      721 cagattttca agagtgagtc tcacccctca gtgtacaaag tagccagcgg gctgaaggag
      781 gggctcagcc tctttggaat cctcaacaga tgtcgctgta ggtggggaca gaagctgctc
      841 aggctatggt ttacacgtcc gacccgggag ctacgggagc tcaattcccg tctggatgtc
      901 attgagtttt tcctgatgcc tcagaacctg gacatggccc agatgatgca ccgtctcctg
      961 agccacatca agaacgtgcc tctgattctg aaacgcatga agttgtccca taccaaggtc
     1021 agtgactggc aggtgctcta caagactgtg tacagcgccc tcggcctgag ggatgcctgc
     1081 cgttccctgc cccagtccat ccagcttttt cgggacatta cccaggagtt ctctgacgac
     1141 ctgcaccaca ttgccagcct catcgggaag gtggacttcg aggaaagtct tgctgaaaat
     1201 cgcttcacag tcctccccaa catagatcct gaaatagacg ctaaaaagag aaggctgatg
     1261 gggcttccga gtttcctcac ggaagttgct cagaaggagc tggagaacct ggactcttgc
     1321 atcccctcat gcagtgtcat ctacatccct ctgatcggct tcctcctttc cattccccga
     1381 ttgtctttca tggtggaggc cagtgacttt gagattgagg gactggactt catgtttctc
     1441 tcagaggaca agctgcacta ccgtagtgcc cggaccaagg agctggacgc actgctggga
     1501 gacctgcact gcgagatccg ggaccaggag atgctgctga tgcaccagct gcagtgccag
     1561 gtgctggcac gggctccggt cttgactcgg gtactggacc ttgcctcccg cctggacgtc
     1621 ctgttggctc ttgccagtgc cgcccgggac tacggctatt cgagaccgca ttactctccc
     1681 tgcatccagg gagtacgaat caagaatggc cggcatccac tgatggagct gtgcgcacgg
     1741 accttcgtgc ccaactccac agactgcggt ggggaccagg ggagggtcaa agtcatcact
     1801 ggacccaact cttcagggaa aagcatatat ctgaaacagg taggcttgat caccttcatg
     1861 gccctggtgg gcagcttcgt gcctgcagag gaggcagaaa ttggggtaat cgacgccatc
     1921 ttcacccgaa ttcacagctg cgagtccatc tccctcggtc tctccacctt catgattgat
     1981 ctcaaccagg tggcgaaagc agtgaacaat gccacagagc actctctggt ccttattgac
     2041 gaattcggga agggaaccaa ctcggtggat ggtctggcac ttctgactgc tgtgctccgt
     2101 cactggctag cactgggacc cagctgcccg cacatctttg tggccaccaa cttcctgagc
     2161 cttgttcagc tgcagctgct gccgcaagga cccctggtac agtatttgac catggagact
     2221 tgtgaggatg ggaacgacct tgtcttcttc tatcagcttt gccatggcgt cgccagtgcc
     2281 agccatgcct cctacactgc ggcccaggct ggacttcctg acccactcat tgctcgaggc
     2341 aaagaggtct cagactcgat ccgcagcggg aagcccgtca agcccatgca tgaacttgtg
     2401 aggaggaccc agatggaaaa ttgccaggcc ctggtggata aatttctaaa attggacttg
     2461 gaagatccct cactggacct ggacattttc attagtcagg aagtgctccc tgccgccacc
     2521 accatccttt gagagtcctc cctctgcctt ccagctacct gagtctcggg ggctaccaca
     2581 cctcttcctc cccttcttta gcagagttct gtttgtacat tttgtcttgt gttgggaata
     2641 aagtttattt tggaaaaaaa aaaaaaaaaa aaaaaaaaa
//
