LOCUS       NM_001106477            3335 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mutS homolog 4 (Msh4), mRNA.
ACCESSION   NM_001106477 XM_227831
VERSION     NM_001106477.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3335)
  AUTHORS   Finsterbusch,F., Ravindranathan,R., Dereli,I., Stanzione,M.,
            Trankner,D. and Toth,A.
  TITLE     Alignment of Homologous Chromosomes and Effective Repair of
            Programmed DNA Double-Strand Breaks during Mouse Meiosis Require
            the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein
  JOURNAL   PLoS Genet 12 (10), e1006393 (2016)
   PUBMED   27760146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3335)
  AUTHORS   Guiraldelli,M.F., Eyster,C., Wilkerson,J.L., Dresser,M.E. and
            Pezza,R.J.
  TITLE     Mouse HFM1/Mer3 is required for crossover formation and complete
            synapsis of homologous chromosomes during meiosis
  JOURNAL   PLoS Genet 9 (3), e1003383 (2013)
   PUBMED   23555294
REFERENCE   3  (bases 1 to 3335)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   4  (bases 1 to 3335)
  AUTHORS   Yang,F., Gell,K., van der Heijden,G.W., Eckardt,S., Leu,N.A.,
            Page,D.C., Benavente,R., Her,C., Hoog,C., McLaughlin,K.J. and
            Wang,P.J.
  TITLE     Meiotic failure in male mice lacking an X-linked factor
  JOURNAL   Genes Dev 22 (5), 682-691 (2008)
   PUBMED   18316482
REFERENCE   5  (bases 1 to 3335)
  AUTHORS   Kolas,N.K., Svetlanov,A., Lenzi,M.L., Macaluso,F.P., Lipkin,S.M.,
            Liskay,R.M., Greally,J., Edelmann,W. and Cohen,P.E.
  TITLE     Localization of MMR proteins on meiotic chromosomes in mice
            indicates distinct functions during prophase I
  JOURNAL   J Cell Biol 171 (3), 447-458 (2005)
   PUBMED   16260499
REFERENCE   6  (bases 1 to 3335)
  AUTHORS   Kolas,N.K. and Cohen,P.E.
  TITLE     Novel and diverse functions of the DNA mismatch repair family in
            mammalian meiosis and recombination
  JOURNAL   Cytogenet Genome Res 107 (3-4), 216-231 (2004)
   PUBMED   15467367
  REMARK    Review article
REFERENCE   7  (bases 1 to 3335)
  AUTHORS   Kneitz,B., Cohen,P.E., Avdievich,E., Zhu,L., Kane,M.F., Hou,H. Jr.,
            Kolodner,R.D., Kucherlapati,R., Pollard,J.W. and Edelmann,W.
  TITLE     MutS homolog 4 localization to meiotic chromosomes is required for
            chromosome pairing during meiosis in male and female mice
  JOURNAL   Genes Dev 14 (9), 1085-1097 (2000)
   PUBMED   10809667
  REMARK    GeneRIF: Functional characterization of the mouse Msh4 ortholog.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 5, 2022 this sequence version replaced NM_001106477.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000002.1  245503000-245503189 c
            191-370             JAXUCZ010000002.1  245499483-245499662 c
            371-528             JAXUCZ010000002.1  245496135-245496292 c
            529-639             JAXUCZ010000002.1  245495657-245495767 c
            640-755             JAXUCZ010000002.1  245487404-245487519 c
            756-929             JAXUCZ010000002.1  245486194-245486367 c
            930-1102            JAXUCZ010000002.1  245484361-245484533 c
            1103-1170           JAXUCZ010000002.1  245481523-245481590 c
            1171-1245           JAXUCZ010000002.1  245477967-245478041 c
            1246-1310           JAXUCZ010000002.1  245476396-245476460 c
            1311-1480           JAXUCZ010000002.1  245475130-245475299 c
            1481-1617           JAXUCZ010000002.1  245473318-245473454 c
            1618-1721           JAXUCZ010000002.1  245472268-245472371 c
            1722-1846           JAXUCZ010000002.1  245471085-245471209 c
            1847-2047           JAXUCZ010000002.1  245468540-245468740 c
            2048-2166           JAXUCZ010000002.1  245466314-245466432 c
            2167-2295           JAXUCZ010000002.1  245464938-245465066 c
            2296-2470           JAXUCZ010000002.1  245459513-245459687 c
            2471-2559           JAXUCZ010000002.1  245457658-245457746 c
            2560-3335           JAXUCZ010000002.1  245452240-245453015 c
FEATURES             Location/Qualifiers
     source          1..3335
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..3335
                     /gene="Msh4"
                     /note="mutS homolog 4"
                     /db_xref="GeneID:295541"
                     /db_xref="RGD:1309190"
     exon            1..190
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2751
                     /gene="Msh4"
                     /codon_start=1
                     /product="mutS protein homolog 4"
                     /protein_id="NP_001099947.2"
                     /db_xref="GeneID:295541"
                     /db_xref="RGD:1309190"
                     /translation="MLRQEATSLSSSPRWTPSRREVPRRRTPASASRPSTEGAVADRS
                     SSSSSSSPAPAAAPGSSFGNKRSYTTHKAASNFPVGTSSSSAQDTTYPHTFRTPLSAG
                     NPQRSYKGWTPQVGLSATSSAVSAHAPSVIVAVVEGRGLARGEIGMASIDLKSPQIML
                     SQFADNTTYAKVITKLQVLSPLEIIMSNTACVVGNSTKLFTLITENFKNVNFTTVQRK
                     YFNETKGLEYIEQLCIAEFSSVLMEVQSRYYCLAAAAALLKYVEFIQNSVYAPKSLKI
                     YFQGSEQTAMIDSSSAQNLELLVNNQDYRSNHTLFGVLNYTKTAGGSRRLRSNILEPL
                     VDVETISMRLDCVQELLQDEELFYGLQSVISRFLDTEQLLSVLVQIPKQDTVNAAESK
                     ITNLIYLKHTLELVDPLKVALKNCSTPLLRAYYGSLEDHRFGLILEKIKTVINDDARY
                     MKGCLNMRTQKCYAVRSNISEFLDIARRTYTEIVDDIAGMISQLAEKYSLPLRTSFSS
                     ARGFFIQMTTDCAALSSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHM
                     TYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDTLAIKQG
                     WHPILEKISAEKPVANNTYITEGSNVLIITGPNMSGKSTFLKQIALCQIMAQIGSFVP
                     AQYASFRIAAQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGT
                     NTEEGTGISYAVCEHLLSTKAFTLFTTHFLELCHIDTLYLNVENMHFEVQHVKNTSRN
                     KDAILYTYKLSRGLTEEKHYGLKAAEASSLPPSIVLDAREITTQITRQISQNRRSSPE
                     MDRQRAVYHLATRLVQVARNSQLEPDRLRTYLSNLKKKYEGDFPRAADLPEKTEE"
     exon            191..370
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            371..528
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            529..639
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            640..755
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            756..929
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1102
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1170
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1245
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1310
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1480
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1617
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1721
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1846
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2047
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2166
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2295
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2470
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2559
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..3335
                     /gene="Msh4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaggcca gagagatgct gaggcaggag gctacttcgc tctcgagttc cccacggtgg
       61 acgccatccc ggagggaggt cccccgccgg aggacgccgg cctccgcgtc caggccgagc
      121 acagaaggtg ccgtggccga caggagcagc agcagcagca gcagcagccc ggcgccggcg
      181 gccgctccag gttcatcatt tggaaacaaa agatcttaca ctacacacaa agctgcatcc
      241 aattttcctg ttggtacgag ctcgtcttct gcacaagata ccacgtatcc acatacgttt
      301 agaactccgt tatctgctgg aaatccccag agatcatata aaggttggac accacaagta
      361 ggactttcag ccacatcctc cgcggtgtct gcacatgccc cgtcagtcat tgtagcagtg
      421 gtggaaggaa gagggctggc tagaggcgag ataggaatgg caagcatcga tttaaaaagc
      481 ccacagatta tgttgtcaca gtttgcagac aacacaacat atgcaaaggt gatcactaaa
      541 ctccaagttt tatcaccttt agaaataata atgtcaaata ctgcttgtgt tgtgggaaat
      601 tcaaccaagt tatttactct gatcacagaa aattttaaga acgttaattt cactacagtc
      661 caaaggaaat acttcaacga aacaaagggc ttagagtaca ttgaacagtt gtgcatagct
      721 gagttcagct ctgtcctaat ggaggttcag tccaggtatt actgccttgc agctgccgca
      781 gccttattaa aatatgttga atttattcaa aattcagtgt atgcacccaa atcgctaaag
      841 atttatttcc aaggtagtga gcagacagcc atgatagatt catcatcagc ccaaaacctg
      901 gagctgttag ttaataacca ggactacagg agtaatcaca ctctctttgg tgttttaaat
      961 tacaccaaga ctgcaggagg gagcagaagg ctgcgctcca acatcctgga gccgctggtt
     1021 gatgtggaaa caatcagcat gaggctggac tgtgtccagg agctgcttca ggacgaggag
     1081 ctcttctatg gactccagtc agtcatatca agattcctgg acacagagca gctgctttct
     1141 gttttggttc agattccaaa gcaagacacg gttaatgcag ctgaatcaaa gataacaaac
     1201 ttgatttatc tgaagcacac attggaactt gtggatcctt taaaggttgc tttaaagaac
     1261 tgtagcacgc ctttactaag agcttactat ggctccttgg aagaccatag gtttgggcta
     1321 atacttgaga agattaaaac agtgataaat gatgatgcaa ggtacatgaa gggctgcctg
     1381 aacatgcgga ctcagaagtg ctatgcagtg cgctccaaca tcagtgagtt cctggacata
     1441 gccaggagga catacacaga gatagtggac gacatagcag gaatgatatc acagctcgca
     1501 gagaagtaca gtcttccctt acggaccagc ttcagctccg cgagggggtt tttcatccag
     1561 atgaccacag actgcgctgc gctctccagt gaccagcttc cttcagagtt tattaagatt
     1621 tctaaagtga aaaactcata tagctttaca tcagcagatt taattaaaat gaatgaaaga
     1681 tgccaagagt ctttgcgaga aatctatcac atgacctaca tgatagtgtg caagctgctc
     1741 agtgagatct acgagcacat ccattgcttg tacaagctct cggacacagt gtcaatgctg
     1801 gacatgctgc tgtcgtttgc tcatgcctgc actctctctg actacgttcg accagagttt
     1861 actgacactt tagccatcaa acaaggatgg catcccattc ttgaaaaaat atctgcagag
     1921 aaacctgttg caaacaatac atatatcaca gaagggagta acgttctgat catcactgga
     1981 ccaaatatga gtggaaagtc cacgttctta aagcagattg ctctttgtca gatcatggcc
     2041 cagatcggct ccttcgtccc agcacagtac gcctccttca ggattgctgc gcagatcttt
     2101 acgagaatca gcactgatga tgatattgaa acaaactctt caacatttat gaaagaaatg
     2161 aaagagatag catatattct tcacaatgct aacgacaagt cactcatact gattgatgag
     2221 cttggcagag gcactaatac agaagaaggg actggtattt cttatgctgt ctgtgagcat
     2281 ctgctgagca caaaggcatt tacactcttc actacccatt tcctggaact gtgccatata
     2341 gacaccctgt atcttaatgt agaaaacatg cattttgaag ttcagcatgt gaagaatacc
     2401 tcaagaaata aggatgcaat tttgtatact tacaaacttt ccaggggact cacagaagaa
     2461 aaacactatg gattaaaagc tgcagaagcc tcctcacttc caccatcaat tgtcttggat
     2521 gccagagaga tcacaacaca aattacaagg caaatctcgc aaaaccgaag gagttcccct
     2581 gagatggata gacagagagc tgtgtaccat ctggctacaa ggcttgtcca ggtcgctcga
     2641 aactctcagt tggagccgga caggctgcgg acatatctga gtaatctcaa gaagaagtat
     2701 gaaggggact ttcccagggc tgcggacctt ccagagaaga ctgaggagtg atcagttcac
     2761 agtgtataca gggttgtatc ttagttgctc agttttatat tttaattgaa aattatagta
     2821 tattaacctc agaatgttca cctatgaact ctaaatgaaa aatatttatt acaatagctt
     2881 aaaaaaaacc cagagctccc aaagactaaa ccattaacta aagagtacac atggagggac
     2941 ccatggctcc agtcacatat gtagcagagg atggccttgt tgggcttcaa tgggaggaga
     3001 gtcccttggc cctgaggcta aatgcccctg tgtaggggaa tgccagggca gggagatggg
     3061 agggaacatt ctcatagtgg cggggagaag gggaaaggga tagggggact ccagagggga
     3121 aatcaggaaa ggggataaca tttgaagtat atgtaaagaa aatatccaat tcaaaaaaaa
     3181 agggacaaat ttttaaagaa aagtttttgt tagaaaaatc gtacaatagt tttcatttgt
     3241 gaagtaagct taagtttgta gttcctatga gtgtatgttt agaatgttaa cagaagtatt
     3301 ctagcctcaa atatacagta aagactaggt ctgaa
//
