LOCUS       NM_001191957            3780 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mutS homolog 3 (Msh3), mRNA.
ACCESSION   NM_001191957 XM_574830
VERSION     NM_001191957.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3780)
  AUTHORS   Liu,J.Y., Qian,C.Y., Gao,Y.F., Chen,J., Zhou,H.H. and Yin,J.Y.
  TITLE     Association between DNA mismatch repair gene polymorphisms and
            platinum-based chemotherapy toxicity in non-small cell lung cancer
            patients
  JOURNAL   Chin J Cancer 36 (1), 12 (2017)
   PUBMED   28093084
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3780)
  AUTHORS   Traver,S., Coulombe,P., Peiffer,I., Hutchins,J.R., Kitzmann,M.,
            Latreille,D. and Mechali,M.
  TITLE     MCM9 Is Required for Mammalian DNA Mismatch Repair
  JOURNAL   Mol Cell 59 (5), 831-839 (2015)
   PUBMED   26300262
REFERENCE   3  (bases 1 to 3780)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3780)
  AUTHORS   Li,G.M.
  TITLE     Mechanisms and functions of DNA mismatch repair
  JOURNAL   Cell Res 18 (1), 85-98 (2008)
   PUBMED   18157157
  REMARK    Review article
REFERENCE   5  (bases 1 to 3780)
  AUTHORS   Saydam,N., Kanagaraj,R., Dietschy,T., Garcia,P.L., Pena-Diaz,J.,
            Shevelev,I., Stagljar,I. and Janscak,P.
  TITLE     Physical and functional interactions between Werner syndrome
            helicase and mismatch-repair initiation factors
  JOURNAL   Nucleic Acids Res 35 (17), 5706-5716 (2007)
   PUBMED   17715146
REFERENCE   6  (bases 1 to 3780)
  AUTHORS   Geeta Vani,R., Varghese,C.M. and Rao,M.R.
  TITLE     Cloning of rat MLH1 and expression analysis of MSH2, MSH3, MSH6,
            and MLH1 during spermatogenesis
  JOURNAL   Genomics 62 (3), 460-467 (1999)
   PUBMED   10644444
REFERENCE   7  (bases 1 to 3780)
  AUTHORS   de Wind,N., Dekker,M., Claij,N., Jansen,L., van Klink,Y.,
            Radman,M., Riggins,G., van der Valk,M., van't Wout,K. and te
            Riele,H.
  TITLE     HNPCC-like cancer predisposition in mice through simultaneous loss
            of Msh3 and Msh6 mismatch-repair protein functions
  JOURNAL   Nat Genet 23 (3), 359-362 (1999)
   PUBMED   10545954
REFERENCE   8  (bases 1 to 3780)
  AUTHORS   Yin,J., Kong,D., Wang,S., Zou,T.T., Souza,R.F., Smolinski,K.N.,
            Lynch,P.M., Hamilton,S.R., Sugimura,H., Powell,S.M., Young,J.,
            Abraham,J.M. and Meltzer,S.J.
  TITLE     Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically
            unstable human colorectal and gastric carcinomas
  JOURNAL   Hum Mutat 10 (6), 474-478 (1997)
   PUBMED   9401011
REFERENCE   9  (bases 1 to 3780)
  AUTHORS   Acharya,S., Wilson,T., Gradia,S., Kane,M.F., Guerrette,S.,
            Marsischky,G.T., Kolodner,R. and Fishel,R.
  TITLE     hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13629-13634 (1996)
   PUBMED   8942985
REFERENCE   10 (bases 1 to 3780)
  AUTHORS   Risinger,J.I., Umar,A., Boyd,J., Berchuck,A., Kunkel,T.A. and
            Barrett,J.C.
  TITLE     Mutation of MSH3 in endometrial cancer and evidence for its
            functional role in heteroduplex repair
  JOURNAL   Nat Genet 14 (1), 102-105 (1996)
   PUBMED   8782829
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_574830.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000002.1  25320720-25320857   c
            139-256             JAXUCZ010000002.1  25319140-25319257   c
            257-477             JAXUCZ010000002.1  25317297-25317517   c
            478-666             JAXUCZ010000002.1  25314135-25314323   c
            667-783             JAXUCZ010000002.1  25310265-25310381   c
            784-901             JAXUCZ010000002.1  25309617-25309734   c
            902-1047            JAXUCZ010000002.1  25307940-25308085   c
            1048-1214           JAXUCZ010000002.1  25304696-25304862   c
            1215-1327           JAXUCZ010000002.1  25268595-25268707   c
            1328-1442           JAXUCZ010000002.1  25265641-25265755   c
            1443-1527           JAXUCZ010000002.1  25258653-25258737   c
            1528-1637           JAXUCZ010000002.1  25257529-25257638   c
            1638-1770           JAXUCZ010000002.1  25243950-25244082   c
            1771-1958           JAXUCZ010000002.1  25238859-25239046   c
            1959-2127           JAXUCZ010000002.1  25238124-25238292   c
            2128-2192           JAXUCZ010000002.1  25232902-25232966   c
            2193-2309           JAXUCZ010000002.1  25229108-25229224   c
            2310-2417           JAXUCZ010000002.1  25224036-25224143   c
            2418-2529           JAXUCZ010000002.1  25217690-25217801   c
            2530-2687           JAXUCZ010000002.1  25204092-25204249   c
            2688-2874           JAXUCZ010000002.1  25190532-25190718   c
            2875-3004           JAXUCZ010000002.1  25188450-25188579   c
            3005-3176           JAXUCZ010000002.1  25183036-25183207   c
            3177-3780           JAXUCZ010000002.1  25179400-25180003   c
FEATURES             Location/Qualifiers
     source          1..3780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..3780
                     /gene="Msh3"
                     /note="mutS homolog 3"
                     /db_xref="GeneID:499505"
                     /db_xref="RGD:1563954"
     CDS             1..3318
                     /gene="Msh3"
                     /codon_start=1
                     /product="DNA mismatch repair protein Msh3"
                     /protein_id="NP_001178886.1"
                     /db_xref="GeneID:499505"
                     /db_xref="RGD:1563954"
                     /translation="MPRRKSASGGSNAAGPDPGRQVVLSRFFKSAGSLRSSVSPTEPA
                     EKVTEGDSRKRSLGNGEPTNKKAKKVPEEEGENTSVASHNPEPKKCLRPRIVSKSLEK
                     LKEFCCDSALPQNRVQTEALWERLAVLPKCTDFEDITLQRAKNAVLSEDSKSQANQKD
                     TQFGPSPEAFQKTSTCKPFNRRSKSIYTPLELQYLDVKQLHKDAVLCVECGYKYRFFG
                     EDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAI
                     GDNKSSVFSRKLTALYTKSTLIGEDVNPLIRLDDSVNIDEAVTDTSTNYLLCIYEEKE
                     NIKDKKKGNISFGIVGVQPATGEVVFDCFQDSASRLELETRTASLQPVELLLPSQLSE
                     PTEMLIRRATAVSVGDDRIRVERMNNTHFEYSHAFQTVMEFYARETVDTQGSQSLSGV
                     IHLEKPVICALAAIIRYLKEFNLDKVLSKPENFKQLSSGMEFMRINGTTLRNLEILQN
                     QTDMKTRGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLRDINARLDAISDVLHSESSVF
                     EQIENLLRKLPDVERGLCSIYHKKCSTQEFFLIVKNLCQLKSELQALMPAVNSHVQSD
                     LLRARVLEVPELLSPVEPYLKVLNEQAAKAGDKTELFKDLSDFPLIKKRKNEIQEVIH
                     SIQMHLQELRKILKLPSLQYVTVSGQEFMVEIKNSAVSCVPTDWVKVGSTKAVSRFHS
                     PFVVENYRRLNQLREQLVLDCNAEWLDFLENFGEHYHTLCKAVDHLATVDCIFSLAKV
                     AKQGSYCRPTLQEEKKIIIKNGRHPMIDVLLGEQDQFVPNSTNLSQDSERVMIITGPN
                     MGGKSSYIKQVALVVIMAQIGSYVPAEEATIGIVDGIFTRRGAADNIYKGRSTFMEEL
                     TDTAEIIQKATQRSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPV
                     CELEKRYPEQVGNYHMGFLVNEDGSKQDSGDMEQMPDSVTFLYQITRGIAARSYGLNV
                     AKLADVPREILQKAAHKSKELEGLVNLRRKRLEYFIDLWTTHSVKDLHTRAAELEIQE
                     IQTSPHNEMKTTLLELK"
     exon            1..138
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            139..256
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            257..477
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            478..666
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..783
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            784..901
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1047
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1214
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1327
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1442
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1527
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1637
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1770
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1958
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2127
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2192
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2309
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2417
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2529
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2687
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2874
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3004
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3176
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3780
                     /gene="Msh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccccgca ggaaatccgc gtcgggaggc tctaatgccg ccggcccaga cccggggagg
       61 caagtggttc tgagccggtt cttcaagtct gcgggaagcc taagatccag cgtgtccccc
      121 acagaaccag cagagaaggt gacagaaggt gacagcagga agaggtcact ggggaatggt
      181 gagcccacta acaagaaagc aaagaaagtt ccagaggagg aaggagaaaa tacctcagta
      241 gcatctcaca atcctgagcc aaagaaatgt ctgaggccca ggattgtttc aaagtccctg
      301 gaaaagttga aagaattctg ctgtgattct gccctccctc aaaacagagt ccagacagaa
      361 gccctttggg agagacttgc agttctgcca aagtgtactg atttcgaaga tatcactctg
      421 caacgtgcaa agaatgcggt tttgtccgaa gattccaagt ctcaggctaa tcagaaagac
      481 actcaatttg gaccttcccc tgaagctttc cagaagactt ccacttgtaa accttttaac
      541 aggcggtcca agagcatcta tactccacta gaactgcagt accttgatgt gaagcagctg
      601 cataaagacg cggttttgtg tgtggaatgt gggtacaagt acaggttctt tggggaagat
      661 gcagaaattg ctgcccggga actcaatatt tattgccact tggaccacaa ctttatgacg
      721 gcgagcatac ccacccacag actgttcgtg catgtccgcc gactggtggc caaaggatac
      781 aaggtgggag ttgtgaagca aactgaaact gcggcattaa aggccattgg agacaataaa
      841 agttctgtct tttcccggaa attgactgct ctttatacga aatccacact gattggagaa
      901 gatgtgaatc ctctgatcag gctggatgat tctgtaaata ttgatgaggc agtgacggat
      961 acttctacca actatcttct gtgtatctac gaagaaaagg aaaacattaa agacaaaaag
     1021 aaggggaaca tttcttttgg catcgtggga gtgcagcctg cgacgggcga ggtcgtgttc
     1081 gactgcttcc aggactcggc ttccagactg gagctggaga ctcgaacagc aagcctgcag
     1141 cccgtggagc tgctgctccc ctcacagctg tccgagccaa cggagatgct catccgtaga
     1201 gccaccgctg tcagtgttgg ggatgacaga attcgagtag aaaggatgaa taatactcac
     1261 tttgaataca gccatgcttt ccagacagtt atggagttct atgccagaga gacagttgac
     1321 acccagggct ctcagagcct gtctggtgtc attcacttgg agaagcctgt gatctgcgcc
     1381 ctggctgcca taatacggta cctcaaggaa tttaacttgg acaaggtgct gtccaaaccc
     1441 gagaatttta aacagctgtc aagtggaatg gaattcatga gaatcaatgg aacaacgcta
     1501 aggaatctgg aaatcctaca gaatcagact gatatgaaga ccagaggaag tttgctttgg
     1561 gttttagacc acactaaaac ctcatttggg agaaggaagt taaaaaaatg ggttacccaa
     1621 ccattgctta aattaaggga cataaatgcc cgacttgatg caatatccga tgttctccac
     1681 tcagaatcca gtgtgtttga acagatagaa aaccttctac ggaaactacc ggatgtcgag
     1741 agaggactgt gtagcattta tcacaagaag tgctctactc aggagttctt cttgatcgtc
     1801 aaaaacctgt gtcaactcaa atcagagctt caagcgttaa tgcctgctgt taattcccac
     1861 gtacagtcag acttgctccg agcacgcgtc ttagaagtgc ctgagctcct cagtccagtg
     1921 gagccttatt taaaggttct gaatgaacaa gctgccaaag ctggcgataa aactgaatta
     1981 ttcaaagacc tctctgactt ccctttaata aaaaagagga aaaatgaaat tcaagaagtc
     2041 attcacagca tccaaatgca tttacaagaa ttgcgaaaaa tattaaaact tccttcttta
     2101 caatatgtga ctgtatcagg acaagagttt atggttgaaa taaagaactc agctgtgtct
     2161 tgcgtcccga ctgactgggt gaaggttgga agcacaaaag ctgtgagccg ctttcactct
     2221 ccttttgtcg tggaaaacta cagacgtctg aatcaactcc gggagcagct agtccttgac
     2281 tgcaatgctg aatggcttga ctttctagag aattttggtg aacattacca cactttgtgt
     2341 aaggccgtgg atcacctagc aactgtggac tgcattttct ccctggccaa ggtcgccaag
     2401 caaggaagtt actgcaggcc aactctacaa gaagaaaaga aaatcatcat aaaaaatgga
     2461 aggcacccta tgattgatgt gttgctgggt gaacaagatc agtttgtgcc caacagtaca
     2521 aatttatcac aggactctga gagagtaatg ataatcaccg gaccgaacat gggtggcaag
     2581 agctcctaca taaaacaggt tgctctggtt gtgatcatgg ctcagatcgg ctcctacgtt
     2641 cctgcagagg aagccacaat tgggattgtg gacggcattt tcacaaggag gggtgctgca
     2701 gacaatatat acaaaggccg gagtactttc atggaagagc tgacagacac ggcggagata
     2761 atccagaaag caacacagcg gtccctggtt atcctggacg agctgggaag agggaccagc
     2821 acccacgacg gaatcgccat tgcctatgcg actctagagt attttatcag agacgtgaaa
     2881 tccttaaccc tgttcgtcac ccactatcca ccagtctgtg aactagagaa acgttaccca
     2941 gagcaggtgg ggaattacca catgggcttc ttggtcaatg aggacggaag caagcaggac
     3001 tcaggtgaca tggagcagat gccggactct gtcactttcc tctatcagat aaccagagga
     3061 attgcagcga ggagttacgg actgaatgtg gcgaagctag cagatgtgcc cagagaaatc
     3121 ttacagaaag ctgctcacaa gtctaaagag ctggaaggct tagtcaatct gagaaggaaa
     3181 agacttgaat attttataga tctgtggacg acacatagtg taaaggacct gcacacgcgg
     3241 gcagctgagc tggaaataca ggaaatacag acgtctcccc acaatgaaat gaaaactaca
     3301 cttttggagc tgaagtagca ctgtatgatc atgcgagcca gtggccgact ggagatacaa
     3361 actgaacaaa cagctttgag gtagcagctg tcagtggcgt gagcacggag gaagagcgac
     3421 gtcttccctt tgagctggtt ccttctctgt gaagggggag cttttcaggc tctcgtcctc
     3481 cgcactcggt gcctgcacag ccagagcggc agtgtcattt ccgctcagac agctgaccgc
     3541 agggtaacct gacagggatc ttttgtgaga actgaagatt ttataatgct agcggtttgt
     3601 tcaccaaagc catgagcatt tttatgagga gtagaatcat gaagcttcta gaatccagag
     3661 cacagggagg aaacagccat atgaacttgg aggacctaag agtagctgtc actttaaaca
     3721 gctgcggtcg ttaaataaaa ttattttgtc atcacttatt ggaataaata cttgctcaga
//
