LOCUS       NM_031058               3074 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mutS homolog 2 (Msh2), mRNA.
ACCESSION   NM_031058
VERSION     NM_031058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3074)
  AUTHORS   Babic,P., Filipovic,N., Hamzic,L.F., Puljak,L., Vukojevic,K. and
            Benzon,B.
  TITLE     Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2
            (MutS homolog 2) Expression in a Rat Kidney Tissue
  JOURNAL   Genes (Basel) 13 (6), 1053 (2022)
   PUBMED   35741815
  REMARK    GeneRIF: Potential Influence of Age and Diabetes Mellitus Type 1 on
            MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3074)
  AUTHORS   Wu,X.Y., Chen,H.C., Li,W.W., Yan,J.D. and Lv,R.Y.
  TITLE     DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2
            promoters in EGFR-mutated non-small cell lung cancer
  JOURNAL   J Biochem 168 (2), 151-157 (2020)
   PUBMED   32211850
REFERENCE   3  (bases 1 to 3074)
  AUTHORS   Cacev,T., Zapletal,E., Musani,V., Rako,I., Loncar,B., Aralica,G.
            and Kapitanovic,S.
  TITLE     Analysis of MSH2 Loss of Heterozygosity, Expression, and
            IVS10+12G>A Polymorphism in Sporadic Colon Cancer
  JOURNAL   Anticancer Res 38 (5), 2841-2848 (2018)
   PUBMED   29715107
REFERENCE   4  (bases 1 to 3074)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   5  (bases 1 to 3074)
  AUTHORS   Huang,S.C., Huang,S.F., Chen,Y.T., Chang,Y., Chiu,Y.T., Chang,I.C.,
            Wu,H.I. and Chen,J.S.
  TITLE     Overexpression of MutL homolog 1 and MutS homolog 2 proteins have
            reversed prognostic implications for stage I-II colon cancer
            patients
  JOURNAL   Biomed J 40 (1), 39-48 (2017)
   PUBMED   28411881
REFERENCE   6  (bases 1 to 3074)
  AUTHORS   Acharya,S., Wilson,T., Gradia,S., Kane,M.F., Guerrette,S.,
            Marsischky,G.T., Kolodner,R. and Fishel,R.
  TITLE     hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13629-13634 (1996)
   PUBMED   8942985
REFERENCE   7  (bases 1 to 3074)
  AUTHORS   Reitmair,A.H., Redston,M., Cai,J.C., Chuang,T.C., Bjerknes,M.,
            Cheng,H., Hay,K., Gallinger,S., Bapat,B. and Mak,T.W.
  TITLE     Spontaneous intestinal carcinomas and skin neoplasms in
            Msh2-deficient mice
  JOURNAL   Cancer Res 56 (16), 3842-3849 (1996)
   PUBMED   8706033
REFERENCE   8  (bases 1 to 3074)
  AUTHORS   Reitmair,A.H., Schmits,R., Ewel,A., Bapat,B., Redston,M., Mitri,A.,
            Waterhouse,P., Mittrucker,H.W., Wakeham,A., Liu,B. et al.
  TITLE     MSH2 deficient mice are viable and susceptible to lymphoid tumours
  JOURNAL   Nat Genet 11 (1), 64-70 (1995)
   PUBMED   7550317
REFERENCE   9  (bases 1 to 3074)
  AUTHORS   de Wind,N., Dekker,M., Berns,A., Radman,M. and te Riele,H.
  TITLE     Inactivation of the mouse Msh2 gene results in mismatch repair
            deficiency, methylation tolerance, hyperrecombination, and
            predisposition to cancer
  JOURNAL   Cell 82 (2), 321-330 (1995)
   PUBMED   7628020
REFERENCE   10 (bases 1 to 3074)
  AUTHORS   Fishel,R., Ewel,A. and Lescoe,M.K.
  TITLE     Purified human MSH2 protein binds to DNA containing mismatched
            nucleotides
  JOURNAL   Cancer Res 54 (21), 5539-5542 (1994)
   PUBMED   7923193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 2, 2021 this sequence version replaced NM_031058.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161846.1, X93591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000006.1  12626227-12626503   c
            278-432             JAXUCZ010000006.1  12622251-12622405   c
            433-711             JAXUCZ010000006.1  12620339-12620617   c
            712-858             JAXUCZ010000006.1  12619183-12619329   c
            859-1008            JAXUCZ010000006.1  12614434-12614583   c
            1009-1142           JAXUCZ010000006.1  12613757-12613890   c
            1143-1342           JAXUCZ010000006.1  12608969-12609168   c
            1343-1452           JAXUCZ010000006.1  12600594-12600703   c
            1453-1576           JAXUCZ010000006.1  12581436-12581559   c
            1577-1727           JAXUCZ010000006.1  12580455-12580605   c
            1728-1825           JAXUCZ010000006.1  12578610-12578707   c
            1826-2071           JAXUCZ010000006.1  12574961-12575206   c
            2072-2276           JAXUCZ010000006.1  12573854-12574058   c
            2277-2524           JAXUCZ010000006.1  12573092-12573339   c
            2525-2700           JAXUCZ010000006.1  12571376-12571551   c
            2701-3074           JAXUCZ010000006.1  12567368-12567741   c
FEATURES             Location/Qualifiers
     source          1..3074
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..3074
                     /gene="Msh2"
                     /note="mutS homolog 2"
                     /db_xref="GeneID:81709"
                     /db_xref="RGD:620786"
     exon            1..277
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2868
                     /gene="Msh2"
                     /function="mismatch repair"
                     /note="mutS protein homolog 2; mismatch repair protein"
                     /codon_start=1
                     /product="DNA mismatch repair protein Msh2"
                     /protein_id="NP_112320.2"
                     /db_xref="GeneID:81709"
                     /db_xref="RGD:620786"
                     /translation="MAVQPKETLQLEGAAEVGFVRFFEGMPEKPSTTVRLFDRGDFYT
                     AHGEDALLAAREVFKTQGVIKYMGPAGAKTLQTVVLSKMNFESFVKDLLLVRHYRVEV
                     YKNKAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSTSIGIMGIKLSTVDGQRQ
                     VGVGYVDSTQRKLGLCEFPDNDQFSNLEALLIQIGPKECILPGGETAGDMGKLRQVIQ
                     RGGILITERKRIDFSTKDIYQDLNRLLKGRKGEQMNSAVLPEMENQVAVSSLSAVIKF
                     LELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCK
                     TAQGQRLVSQWIKQPLMDKNRIEERLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAK
                     KFQRQAANLQDCYRLYQGVNQLPNVIQALEKYQGRHQALLLAVFVTPLTDLRSDFSKF
                     QEMIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLISAARGLGLDPG
                     KQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKN
                     KGEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAHLDAVVSFAHVSNAAPVPYVRPVI
                     LEKGKGRIILKASRHACVEVQDDVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQT
                     GVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSAT
                     KDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALASQIPTVN
                     NLHVTALTTEETLTMLYQVKTGVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQS
                     IGTSQGHDETQPAAKRRCLEREQGEKIILEFLSKVKQVPFTDLSEESVSVKLKQLKAE
                     VLAKNNSFVNEIISRVKAP"
     exon            278..432
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..711
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..858
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1008
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1142
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1342
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1452
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1576
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1727
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1825
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2071
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2276
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2524
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2700
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..3074
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaaacga cccggcgagc gcagggtccg gctgtactct cttgggttgt gtggcgcgtt
       61 tcggaaatgg cggtgcagcc taaggagacg ctgcagttgg agggcgcggc cgaggtgggc
      121 ttcgtacgct tctttgaggg catgccggag aagccgagca ccacggtgcg cctcttcgac
      181 cgcggcgact tttacaccgc gcacggcgag gacgcgctgc tggcggcccg cgaggtgttc
      241 aagacccaag gcgtgatcaa gtacatgggg ccggcagggg caaagaccct gcagactgtt
      301 gtgctgagta agatgaattt tgagtctttc gtgaaagatc ttcttctggt tcgtcactat
      361 agagttgaag tttataagaa taaagctgga aataaggcat ctaaggagaa cgactggtat
      421 ttggcatata aggcttctcc tggcaatctt tctcagtttg aagacatcct gtttggtaac
      481 aatgacatgt ccacttccat tggcattatg ggtattaaac tgtctacggt tgatggtcag
      541 agacaggttg gagttgggta tgtggattcc acccagagaa agctaggatt gtgtgagttc
      601 cctgacaacg atcagttctc caatctcgag gctcttctga ttcagattgg accaaaggaa
      661 tgcattttac caggcggaga gactgctgga gacatgggga aactgaggca ggttatacag
      721 agaggaggga ttctgatcac agaaagaaag agaatcgact tttccacaaa agacatctac
      781 caggatctca accggttact gaaaggcaga aaaggagagc agatgaacag cgctgtctta
      841 ccagagatgg agaatcaggt tgcagtttca tcgttgtctg cagtgatcaa gttcctagaa
      901 ctcttatcag atgattcgaa ttttgggcag tttgaactgg cgacttttga cttcagccag
      961 tacatgaagt tagacatggc ggcagttaga gccctcaacc ttttccaggg ttctgttgaa
     1021 gacaccacag gctctcagtc tctggctgca ttattgaata aatgcaaaac tgctcaagga
     1081 caaaggctgg ttagccagtg gatcaaacag ccgctcatgg ataaaaacag gattgaagag
     1141 agattaaatt tagtggaagc ttttgttgaa gattcagaat tgaggcagag tctacaggag
     1201 gatttacttc gccgatttcc agatcttaac cggcttgcca agaaatttca gagacaagca
     1261 gcgaatttac aagattgtta ccgactgtat cagggtgtga accagcttcc caacgtcatc
     1321 caggctctgg agaaatacca aggaagacac caggcattgt tgttggcagt ttttgtgact
     1381 cctcttactg atcttcgttc tgatttttca aaatttcaag aaatgataga aacgacttta
     1441 gatatggatc aggtggagaa ccacgaattc cttgtaaaac cttcatttga tcctaacctg
     1501 agtgagctaa gagaagtcat ggatggtctg gagaagaaga tgcagtccac cttaataagt
     1561 gcagcgcggg gtcttggatt ggaccctggc aaacagatta aattggactc cagtgcacag
     1621 tttgggtatt actttcgtgt aacctgcaag gaagagaaag tcctccgcaa caacaagaac
     1681 ttcagcaccg tggatatcca gaagaatggc gttaaattca ccaacagtga attgtcttct
     1741 ttaaatgaag aatacactaa gaacaaagga gagtatgagg aggcccagga tgccattgtt
     1801 aaagaaatcg tcaatatttc ctcaggctac gtggagccaa tgcagacgct caatgacgtg
     1861 ctagctcact tagatgccgt cgttagtttt gctcatgtgt caaacgcagc tcctgtcccc
     1921 tacgtgcgac cggtcatctt ggagaaagga aaaggaagaa ttatattgaa agcctccagg
     1981 catgcttgtg ttgaagttca agatgacgtt gcatttattc caaacgatgt gcactttgaa
     2041 aaagataaac agatgttcca catcattact ggtcccaata tgggaggaaa gtcaacatac
     2101 atccgtcaga cgggggtgat tgtgctcatg gcccaaattg ggtgttttgt gccgtgtgag
     2161 tcagcagagg tgtccattgt ggattgcatc ttggctcgag tcggggctgg tgacagtcaa
     2221 ctgaaaggcg tctccacatt catggctgaa atgctggaaa ctgcttctat cctcaggtcg
     2281 gcaaccaaag attccttaat aatcattgat gagctgggaa gaggaacctc tacatacgac
     2341 ggctttgggt tagcatgggc catatcggag tacatcgcaa cgaagattgg tgccttttgc
     2401 atgtttgcca cccattttca tgaacttacc gctttggcca gtcagatacc aaccgttaac
     2461 aatctccacg tcacagcgct gactaccgaa gagaccctga ctatgcttta ccaagtgaaa
     2521 acaggtgtct gtgatcagag tttcgggatt catgtggctg aactcgctaa tttccctagg
     2581 catgtgatag agtgcgccaa gcagaaggct ctggagcttg aggagtttca gagcattggg
     2641 acctcacagg gacacgatga aacccagcca gctgcaaaga ggcgctgcct ggaaagagag
     2701 caaggtgaga agattattct ggagttcctg tccaaggtca agcaagtgcc cttcactgac
     2761 ttgtcggagg agagcgtctc agtgaagctg aagcaactga aagctgaggt gctggcgaag
     2821 aacaacagct ttgtaaatga aatcatctca cgggtaaagg ctccgtgaga ggacagtgga
     2881 gcgaagccag tagggagagc tcgcccttac cctgctgttt cctgtagtac ttaacaccag
     2941 aacccgggga gcagtgtgct gaagtattta gtgatacttg aaacatgacg gtctatagct
     3001 gagtaccgtt taaatgggca tggacaactt tgagcactat gctgaatttt ataaataaaa
     3061 tcatgtagtt tcta
//
