LOCUS       NM_012845               2542 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus membrane spanning 4-domains A2 (Ms4a2), mRNA.
ACCESSION   NM_012845
VERSION     NM_012845.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Halova,I., Draberova,L., Bambouskova,M., Machyna,M., Stegurova,L.,
            Smrz,D. and Draber,P.
  TITLE     Cross-talk between tetraspanin CD9 and transmembrane adaptor
            protein non-T cell activation linker (NTAL) in mast cell activation
            and chemotaxis
  JOURNAL   J Biol Chem 288 (14), 9801-9814 (2013)
   PUBMED   23443658
  REMARK    GeneRIF: chemotaxis toward antigen is controlled in mast cells by a
            cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane
            adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins
            of the ERM family
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Joubert,B.R., Reif,D.M., Edwards,S.W., Leiner,K.A., Hudgens,E.E.,
            Egeghy,P., Gallagher,J.E. and Hubal,E.C.
  TITLE     Evaluation of genetic susceptibility to childhood allergy and
            asthma in an African American urban population
  JOURNAL   BMC Med Genet 12, 25 (2011)
   PUBMED   21320344
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Li,H., Xiaoyan,D., Quanhua,L., Jie,L. and Yixiao,B.
  TITLE     Single-nucleotide polymorphisms in genes predisposing to asthma in
            children of Chinese Han nationality
  JOURNAL   J Investig Allergol Clin Immunol 19 (5), 391-395 (2009)
   PUBMED   19862939
REFERENCE   4  (bases 1 to 2542)
  AUTHORS   Sharma,S. and Ghosh,B.
  TITLE     Promoter polymorphism in the MS4A2 gene and asthma in the Indian
            population
  JOURNAL   Int Arch Allergy Immunol 149 (3), 208-218 (2009)
   PUBMED   19218813
REFERENCE   5  (bases 1 to 2542)
  AUTHORS   Amir-Moazami,O., Alexia,C., Charles,N., Launay,P., Monteiro,R.C.
            and Benhamou,M.
  TITLE     Phospholipid scramblase 1 modulates a selected set of IgE
            receptor-mediated mast cell responses through LAT-dependent pathway
  JOURNAL   J Biol Chem 283 (37), 25514-25523 (2008)
   PUBMED   18579528
  REMARK    GeneRIF: PLSCR1 is a novel amplifier of FcepsilonRI signaling that
            acts selectively on the Lyn-initiated LAT/phospholipase
            Cgamma1/calcium axis, resulting in potentiation of a selected set
            of mast cell responses
REFERENCE   6  (bases 1 to 2542)
  AUTHORS   Kimura,T., Kihara,H., Bhattacharyya,S., Sakamoto,H., Appella,E. and
            Siraganian,R.P.
  TITLE     Downstream signaling molecules bind to different phosphorylated
            immunoreceptor tyrosine-based activation motif (ITAM) peptides of
            the high affinity IgE receptor
  JOURNAL   J Biol Chem 271 (44), 27962-27968 (1996)
   PUBMED   8910399
REFERENCE   7  (bases 1 to 2542)
  AUTHORS   Hill,M.R. and Cookson,W.O.
  TITLE     A new variant of the beta subunit of the high-affinity receptor for
            immunoglobulin E (Fc epsilon RI-beta E237G): associations with
            measures of atopy and bronchial hyper-responsiveness
  JOURNAL   Hum Mol Genet 5 (7), 959-962 (1996)
   PUBMED   8817330
REFERENCE   8  (bases 1 to 2542)
  AUTHORS   Shirakawa,T., Li,A., Dubowitz,M., Dekker,J.W., Shaw,A.E.,
            Faux,J.A., Ra,C., Cookson,W.O. and Hopkin,J.M.
  TITLE     Association between atopy and variants of the beta subunit of the
            high-affinity immunoglobulin E receptor
  JOURNAL   Nat Genet 7 (2), 125-129 (1994)
   PUBMED   7920628
REFERENCE   9  (bases 1 to 2542)
  AUTHORS   Ra,C., Jouvin,M.H. and Kinet,J.P.
  TITLE     Complete structure of the mouse mast cell receptor for IgE (Fc
            epsilon RI) and surface expression of chimeric receptors
            (rat-mouse-human) on transfected cells
  JOURNAL   J Biol Chem 264 (26), 15323-15327 (1989)
   PUBMED   2527850
REFERENCE   10 (bases 1 to 2542)
  AUTHORS   Kinet,J.P., Blank,U., Ra,C., White,K., Metzger,H. and Kochan,J.
  TITLE     Isolation and characterization of cDNAs coding for the beta subunit
            of the high-affinity receptor for immunoglobulin E
  JOURNAL   Proc Natl Acad Sci U S A 85 (17), 6483-6487 (1988)
   PUBMED   2970642
  REMARK    GeneRIF: membrane-spanning 4-domains, subfamily A, member 2
            pathway?
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M22923.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M22923.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2542
                     /gene="Ms4a2"
                     /gene_synonym="Fcer1b; FCIGA; Ms4a1"
                     /note="membrane spanning 4-domains A2"
                     /db_xref="GeneID:25316"
                     /db_xref="RGD:2598"
     exon            1..116
                     /gene="Ms4a2"
                     /gene_synonym="Fcer1b; FCIGA; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..786
                     /gene="Ms4a2"
                     /gene_synonym="Fcer1b; FCIGA; Ms4a1"
                     /note="fcERI; fc epsilon receptor I beta-chain;
                     Membrane-spanning 4-domains, subfamily A, member 1; IgE Fc
                     receptor subunit beta; membrane-spanning 4-domains,
                     subfamily A, member 2 (Fc fragment of IgE, high affinity
                     I, receptor for; beta polypeptide)"
                     /codon_start=1
                     /product="high affinity immunoglobulin epsilon receptor
                     subunit beta"
                     /protein_id="NP_036977.1"
                     /db_xref="GeneID:25316"
                     /db_xref="RGD:2598"
                     /translation="MDTENKSRADLALPNPQESPSAPDIELLEASPPAKALPEKPASP
                     PPQQTWQSFLKKELEFLGVTQVLVGLICLCFGTVVCSTLQTSDFDDEVLLLYRAGYPF
                     WGAVLFVLSGFLSIMSERKNTLYLVRGSLGANIVSSIAAGLGIAILILNLSNNSAYMN
                     YCKDITEDDGCFVTSFITELVLMLLFLTILAFCSAVLLIIYRIGQEFERSKVPDDRLY
                     EELHVYSPIYSALEDTREASAPVVS"
     exon            117..240
                     /gene="Ms4a2"
                     /gene_synonym="Fcer1b; FCIGA; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            241..375
                     /gene="Ms4a2"
                     /gene_synonym="Fcer1b; FCIGA; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..432
                     /gene="Ms4a2"
                     /gene_synonym="Fcer1b; FCIGA; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..588
                     /gene="Ms4a2"
                     /gene_synonym="Fcer1b; FCIGA; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..687
                     /gene="Ms4a2"
                     /gene_synonym="Fcer1b; FCIGA; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..2542
                     /gene="Ms4a2"
                     /gene_synonym="Fcer1b; FCIGA; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtttctgt gtaacaatat cttttattcc tggatagtcc aattaatgaa aaaaatggac
       61 acagaaaata agagcagagc agatcttgct ctcccaaacc cacaagaatc ccccagcgca
      121 cctgacattg aactcttgga agcgtcccct cctgcaaaag ctctaccaga gaagccagcc
      181 tcacccccac cacagcagac atggcagtca tttttgaaga aagagttgga gttcctgggc
      241 gtaacccaag ttctggttgg tttgatatgc ctttgttttg gaacagttgt ctgctccaca
      301 ctccagactt cagactttga cgacgaagtg cttttattat atagagcagg ctacccattc
      361 tggggtgcag tgctgtttgt tttgtctgga tttttgtcaa ttatgtccga aaggaaaaac
      421 acactgtatc tggtgagagg cagcctggga gcaaacattg tcagcagcat cgctgcaggc
      481 ttggggatcg ccatattgat tctcaatctg agcaacaact ccgcttatat gaactactgc
      541 aaggatataa ccgaagacga tggttgcttc gtgacttctt tcatcacaga actggtgttg
      601 atgttgctgt ttctcaccat cctggccttt tgcagtgccg tgctgctcat tatctatagg
      661 attggacaag aatttgagcg tagtaaggtc cccgatgacc gtctctatga agaattacat
      721 gtgtattcac caatttacag tgcgttggaa gacacaaggg aagcgtccgc accagtggtt
      781 tcataagaat caaggggcca ggacaatctg attccagtat agtcttgaga gtcgatcttt
      841 ttgcaacatt atggcaacat ttctgtttcc tccgcactct atcaactttt caattggatt
      901 gttctgtaga tacccctgtt tcagttatga tgcctctggt ctttaattat ctcccttttt
      961 gtggatatcg ttcaatccag ttttcttgtt ttgtgtcaca gtctcacata caacctttct
     1021 ggaaagtcat caaaaacaag ctagctttta ttgcatgtct actttcatga acaaaaggaa
     1081 ggaggagtta ttttgagagt ttaactaaac ttagataatc aggtaatatt tgactcttag
     1141 ttcattttag aattctcaac aatacttgtg catgatatat gcccaccata tcaagccttc
     1201 tatatatatt taatatggta tttacttttc tatgtagata gattttccac cctcaataat
     1261 aatgggtttt tcagagacat aaagctttat gaaaagacac atattatcta attcatgggt
     1321 atattcacta atacagttgt tgctcagtgg tgtttactac ttggtgggta gtaggtaata
     1381 gagaacatta ttaaatcatt cagtgtagtg agatgcatag gtaaaatcag ggacactgtg
     1441 agtgtgtata tcttttggta agacatgtgt gaaaatgaag aataaactga tgaagacttg
     1501 agctggaaag tagtcaatgg gaatgacaag aaatgattgt gtataacact tgtagataaa
     1561 taactaccaa caattggtag agattgccat gtatgcctaa aatctcccag cccaaggcca
     1621 gcctctgtta cacagtgagt tagaggccag tctgggctac acaagatcat acatcaaagg
     1681 acgaaagaag atgttggttc aaactgttaa cacagtaagg gatatttaaa caaacagaag
     1741 tttgactgat atattgagtg cttgagtttt taataaaact gaatgaataa cattgcgggg
     1801 gaggggagca gtgatgcaga agtctggatg atggaggagt agcagaatca gatgaaacat
     1861 tgaaacgtat ttccagactt ttgttctgag atggttataa gagcaatcac cattaaatga
     1921 agaaggtcaa gacaccaaaa gaattatttt gagatagaat taagacagtc aaaatccaca
     1981 tgcctatact tagaaggtga agtaaggatc aaaagtagaa agcctaacga ttagttggaa
     2041 aagcatatta cgttaggcag cagatgtcta tagtggagaa aagttaaaca aggagaaata
     2101 atgaaccacc agagactcta catgttggtt tgggaaataa gagaaaatag caattctaaa
     2161 cgaatgcaaa ctctgaagaa gcatttccca aagggtgtgg gcagaggacc agaacatttg
     2221 caaatgtacc tagagagcaa acctgaatag gaggtaaaat gggggaaaag cagctaagaa
     2281 aatgattttg ttgctgttat ttagatttta aaagaaacaa aaagagtcat taaaaatctg
     2341 tttgctggga tcagttattg tgttctctgt gtatgtccaa agtacaggta acttttctaa
     2401 atcttcctgt aaggctcacc tcatatgtct cttcacatag ccacaccctt gattcacagt
     2461 tactctacca cagtagtaaa ctgtgcttgt ggtctcctta tgtatcttcc actagtgttt
     2521 ataaaataaa tcagaattat tt
//
