LOCUS       NM_001401049            4353 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus myocardin related transcription factor A (Mrtfa),
            mRNA.
ACCESSION   NM_001401049
VERSION     NM_001401049.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4353)
  AUTHORS   Zhong,Z., Luo,X.Y., Xiang,P., Ji,H.H., Wu,X.D., Chong,A.G., Hu,X.Y.
            and Cao,X.L.
  TITLE     MRTF-A alleviates myocardial ischemia reperfusion injury by
            inhibiting the inflammatory response and inducing autophagy
  JOURNAL   Mol Cell Biochem 478 (2), 343-359 (2023)
   PUBMED   35829871
  REMARK    GeneRIF: MRTF-A alleviates myocardial ischemia reperfusion injury
            by inhibiting the inflammatory response and inducing autophagy.
REFERENCE   2  (bases 1 to 4353)
  AUTHORS   Wan,C., Liu,W., Jiang,L., Dong,S., Ma,W., Wang,S. and Liu,D.
  TITLE     Knockdown of MKL1 ameliorates oxidative stress-induced chondrocyte
            apoptosis and cartilage matrix degeneration by activating
            TWIST1-mediated PI3K/AKT signaling pathway in rats
  JOURNAL   Autoimmunity 55 (8), 559-566 (2022)
   PUBMED   36046946
  REMARK    GeneRIF: Knockdown of MKL1 ameliorates oxidative stress-induced
            chondrocyte apoptosis and cartilage matrix degeneration by
            activating TWIST1-mediated PI3K/AKT signaling pathway in rats.
REFERENCE   3  (bases 1 to 4353)
  AUTHORS   Sharma,V.P., Williams,J., Leung,E., Sanders,J., Eddy,R.,
            Castracane,J., Oktay,M.H., Entenberg,D. and Condeelis,J.S.
  TITLE     SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility
            of Breast Carcinoma Cells in Fibrillar ECM Microenvironment
  JOURNAL   Cells 10 (6), 1549 (2021)
   PUBMED   34205257
  REMARK    GeneRIF: SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast
            Motility of Breast Carcinoma Cells in Fibrillar ECM
            Microenvironment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4353)
  AUTHORS   Luo,Y., Liang,C., Liu,Y., Liu,X. and Xu,Y.
  TITLE     RXRalpha and MRTF-A have a synergistic effect in the retinoic
            acid-induced neural-like differentiation of adult bone
            marrow-derived mesenchymal stem cells
  JOURNAL   Cell Biol Int 44 (6), 1373-1381 (2020)
   PUBMED   32125053
  REMARK    GeneRIF: RXRalpha and MRTF-A have a synergistic effect in the
            retinoic acid-induced neural-like differentiation of adult bone
            marrow-derived mesenchymal stem cells.
REFERENCE   5  (bases 1 to 4353)
  AUTHORS   Shi,Z., Ren,M. and Rockey,D.C.
  TITLE     Myocardin and myocardin-related transcription factor-A
            synergistically mediate actin cytoskeletal-dependent inhibition of
            liver fibrogenesis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 318 (3), G504-G517 (2020)
   PUBMED   31928221
  REMARK    GeneRIF: Myocardin and myocardin-related transcription factor-A
            (MRTF-A) are upregulated in activated hepatic stellate cells and
            are closely associated with robustly increased actin cytoskeleton
            remodeling.
            Erratum:[Am J Physiol Gastrointest Liver Physiol. 2020 Nov
            1;319(5):G637. doi: 10.1152/ajpgi.000302.2019-corr. PMID: 33141606]
REFERENCE   6  (bases 1 to 4353)
  AUTHORS   Lockman,K., Hinson,J.S., Medlin,M.D., Morris,D., Taylor,J.M. and
            Mack,C.P.
  TITLE     Sphingosine 1-phosphate stimulates smooth muscle cell
            differentiation and proliferation by activating separate serum
            response factor co-factors
  JOURNAL   J Biol Chem 279 (41), 42422-42430 (2004)
   PUBMED   15292266
  REMARK    GeneRIF: RhoA-dependent activation of MRTF-A has a role in
            sphingosine 1-phosphate activation of multiple signaling pathways
            in smooth muscle cells.
REFERENCE   7  (bases 1 to 4353)
  AUTHORS   Du,K.L., Chen,M., Li,J., Lepore,J.J., Mericko,P. and Parmacek,M.S.
  TITLE     Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals
            and induces smooth muscle cell differentiation from
            undifferentiated embryonic stem cells
  JOURNAL   J Biol Chem 279 (17), 17578-17586 (2004)
   PUBMED   14970199
REFERENCE   8  (bases 1 to 4353)
  AUTHORS   Miralles,F., Posern,G., Zaromytidou,A.I. and Treisman,R.
  TITLE     Actin dynamics control SRF activity by regulation of its
            coactivator MAL
  JOURNAL   Cell 113 (3), 329-342 (2003)
   PUBMED   12732141
REFERENCE   9  (bases 1 to 4353)
  AUTHORS   Sasazuki,T., Sawada,T., Sakon,S., Kitamura,T., Kishi,T.,
            Okazaki,T., Katano,M., Tanaka,M., Watanabe,M., Yagita,H.,
            Okumura,K. and Nakano,H.
  TITLE     Identification of a novel transcriptional activator, BSAC, by a
            functional cloning to inhibit tumor necrosis factor-induced cell
            death
  JOURNAL   J Biol Chem 277 (32), 28853-28860 (2002)
   PUBMED   12019265
REFERENCE   10 (bases 1 to 4353)
  AUTHORS   Ma,Z., Morris,S.W., Valentine,V., Li,M., Herbrick,J.A., Cui,X.,
            Bouman,D., Li,Y., Mehta,P.K., Nizetic,D., Kaneko,Y., Chan,G.C.,
            Chan,L.C., Squire,J., Scherer,S.W. and Hitzler,J.K.
  TITLE     Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13)
            of acute megakaryoblastic leukemia
  JOURNAL   Nat Genet 28 (3), 220-221 (2001)
   PUBMED   11431691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB588919.1, SRR26643291.21300.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000007.1  114594371-114594594 c
            225-486             JAXUCZ010000007.1  114528972-114529233 c
            487-552             JAXUCZ010000007.1  114455467-114455532 c
            553-608             JAXUCZ010000007.1  114438302-114438357 c
            609-684             JAXUCZ010000007.1  114435263-114435338 c
            685-846             JAXUCZ010000007.1  114434255-114434416 c
            847-1022            JAXUCZ010000007.1  114432636-114432811 c
            1023-1172           JAXUCZ010000007.1  114432119-114432268 c
            1173-1438           JAXUCZ010000007.1  114430515-114430780 c
            1439-1607           JAXUCZ010000007.1  114430247-114430415 c
            1608-2603           JAXUCZ010000007.1  114428470-114429465 c
            2604-2756           JAXUCZ010000007.1  114427995-114428147 c
            2757-2817           JAXUCZ010000007.1  114427588-114427648 c
            2818-4353           JAXUCZ010000007.1  114424481-114426016 c
FEATURES             Location/Qualifiers
     source          1..4353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4353
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /note="myocardin related transcription factor A"
                     /db_xref="GeneID:315151"
                     /db_xref="RGD:1304873"
     exon            1..224
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            225..486
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..3332
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /exception="alternative start codon"
                     /note="non-AUG (GUG) translation initiation codon;
                     MKL/myocardin-like protein 1; megakaryoblastic leukemia 1
                     met; basic, SAP, and coiled-coil domain containing
                     protein; MKL1-elongated derivative of yield protein;
                     megakaryoblastic leukemia (translocation) 1"
                     /codon_start=1
                     /transl_except=(pos:246..248,aa:Met)
                     /product="myocardin-related transcription factor A"
                     /protein_id="NP_001387978.1"
                     /db_xref="GeneID:315151"
                     /db_xref="RGD:1304873"
                     /translation="MDFSSVVCLPPSVIAVNGLDGGGAGENDEEPVLLSLSAAPSPQS
                     EAVANELQELSLQPELTLGLHPGRNPNLPPLSERKNVLQLKLQQRRTREELVSQGIMP
                     PLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLK
                     LKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEALIVGQVNYPKVADSSSFDED
                     SSDALSPEQPASHESQGSVPSPLESRASDLLPSATSISPTQVLSQLPMAPDPGETLFL
                     AEQPPLPPPPLLPPSLTSGSIVPTAKPAPTLIKQSQPKSASEKSQRSKKAKELKPKVK
                     KLKYHQYIPPDQKQDKGAPAMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQAI
                     LPAPPKPSGETPGSSAPTPSRSLSTSSSSSSGTPGPGGLARQNSTALAGKPGALPANL
                     DDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQVSPAPGAPKAPATTSVLSKAGE
                     VVVAFPAALLSTGSALVTAGLAPAEMVVATVTSNGMVKFGSTGSTPPVSPTPSERSLL
                     STGDENSTPGDAFGEMVTSPLTQLTLQASPLQIVKEEGARAASCCLSPGARAELEGLD
                     KDQMLQEKDKQIEELTRMLQQKQQLVELLRLQLEQQKRAQQPAPASSPVKRESSFSSC
                     QLSCQPQGAARAFGPGLVVPTTNHGDAQAPAPESPPVVVKQEAGPPEPDLAPASQLLL
                     GSQGTSFLKKVSPPTLVTDSTGTHLILTVTNKSADGPGLPTGSPQQPLSQPGSPAPGP
                     PAQMDLEHPPQPSFATPTSLLKKEPPGYEETVTQQPKQQENGSSSQHMDDLFDILIQS
                     GEISADFKEPPSLPGKEKSPPAEAYGPPLTPQPSPLSELPQAAPPPGSPTLPGRLEDF
                     LESSTGLPLLTSGHEGPEPLSLIDDLHSQMLSSSAILDHPPSPMDTSELHFAPEPSSG
                     MGLDLAVGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSMDFLDGHDLQLHWDSCL"
     exon            487..552
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            553..608
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            609..684
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            685..846
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1022
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1172
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1438
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1607
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..2603
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2756
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2817
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..4353
                     /gene="Mrtfa"
                     /gene_synonym="BSAC; FLMKL1; MELODY; Mkl1; MKL1met;
                     Mrtf-a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtggagcc ggcagcggtc gtgtctgcgg tgtccccgga ggcgagaacg accgtcccac
       61 cctccccacc ccctcgttct cgctagccac gctccctcgg ctcgtgcgga cctctcccca
      121 tcttggtgca gcctgactgg tccttgaggc tcgggaggat acgtgagcgg ctggcaccgg
      181 agtggggcga gccgcggagc ccgggccagg aggcgaacga ggcggttacc atcacgaaag
      241 ccaaggtgga tttctccagt gtggtgtgcc tgcccccttc cgtcattgct gtgaatgggc
      301 tggacggagg aggggctggc gaaaatgatg aggaaccggt gctcctgtct ctgtctgcgg
      361 cccccagccc ccagagcgaa gctgttgcca atgaactgca ggagctgtcc ctgcagcccg
      421 agctgactct gggcctccat cctgggagga accccaattt gcctccactt agtgagcgga
      481 agaatgtgct gcagttgaag ctccagcagc ggcggacccg ggaggagctg gtgagccaag
      541 ggatcatgcc gcctttgaaa agtccggctg catttcatga gcagagaagg agcctggagc
      601 gggccaggac cgaggactat ttgaaacgga agatccgttc ccggccagag agatcagagc
      661 tggtcaggat gcacattctg gaagagacct cggctgagcc ttctctccag gccaagcagc
      721 tgaagctgaa gagagccaga ctggccgatg acctcaatga gaagattgca cagaggcctg
      781 gccccatgga gctggtggaa aagaatatct tgccagtcga gtctagcctg aaggaggctc
      841 tcattgtggg ccaggtgaat tacccaaagg tagcagacag ttcctccttt gacgaggaca
      901 gcagcgatgc cctgtctcct gagcagcctg ccagccatga gtcccagggt tcagtgccat
      961 cacccttgga gtcccgggcc agcgatctac ttcctagtgc cacctccata tcacccactc
     1021 aggttctttc tcagctccca atggctccgg atcctggaga gacgcttttc ctggcagagc
     1081 agcctcctct gcctcccccg cctctgctgc cccccagcct aaccagtgga agcatcgtcc
     1141 ccactgccaa gcccgcgccc acactcatca agcaaagcca accgaagtct gcgagcgaga
     1201 agtcacagcg cagcaagaag gccaaggagc tgaagccaaa agtgaagaag ctcaagtacc
     1261 accagtacat ccccccggac caaaagcagg acaagggggc gcctgccatg gactcttcct
     1321 acgccaagat cctgcagcag cagcagctct tcttgcagct gcagatcctc aaccagcagc
     1381 agcagcagca gcagcagcag cattacaact accaggccat cctgcccgcc cctcccaagc
     1441 cctcgggtga gactcccgga agcagtgccc ccaccccatc acgcagtctc tccaccagta
     1501 gcagctctag ctcaggcacc ccagggcccg gtgggctggc ccgtcagaac agcactgccc
     1561 tggctggcaa accaggagcc ctgccggcca acctggatga catgaaggtg gcagagctga
     1621 agcaggagct gaagttgcgg tcgctgcccg tctcaggcac caagacagag ctgattgagc
     1681 gcctgcgtgc ctaccaagac caagtcagcc cagctccagg agcccccaag gcccctgcca
     1741 ccacctctgt cctgtccaag gctggtgagg tagtggtcgc cttccctgcg gccctgctga
     1801 gcacagggtc agctcttgta acagcaggcc ttgcaccagc tgagatggtg gtggccacag
     1861 taaccagcaa tggcatggtg aagtttggca gcacaggctc cacacccccc gtgtctccca
     1921 ccccttcaga gcgctcactg ctcagcacgg gtgatgagaa ttccacacct ggggatgcct
     1981 ttggtgaaat ggtgacatcg ccgctgacac agctcaccct gcaggcctcc ccactacaga
     2041 tcgtgaagga ggagggtgcc cgtgctgcgt cctgctgtct gagccctggt gcacgggctg
     2101 agctggaggg actggacaag gaccagatgc tgcaggagaa ggacaagcag attgaggagc
     2161 tgacccgaat gctccaacag aagcagcagc tggttgagct gctacggcta cagctggagc
     2221 agcagaagcg ggcccagcag ccagccccag ccagcagccc tgtgaagcgg gaaagtagtt
     2281 tctccagttg ccagctgagc tgccagcccc agggcgctgc ccgtgccttt ggccctggcc
     2341 tagtagttcc caccactaac catggagatg ctcaggctcc agcccccgag tccccacctg
     2401 tggtggtaaa acaggaagct gggccacctg agccagatct ggcccctgcc tctcagctgc
     2461 tcttgggctc gcagggcacc agcttcctca agaaggtcag ccctcctacc ctggtcactg
     2521 actctacagg aactcacctc atcctcactg tgaccaacaa gagtgcagat ggccctggcc
     2581 tgcccacggg gagcccccaa cagcccttgt cccagcctgg ttctccagcc cctggtccac
     2641 ctgcccagat ggacctggag cacccacctc agccttcatt tgcaaccccc acgtctctgc
     2701 tgaagaagga gccgcctggg tatgaagaga ctgtgactca gcagcctaag cagcaggaaa
     2761 atggctcctc cagtcagcac atggatgatc tgtttgatat tcttattcag agtggagaga
     2821 tttcagcaga tttcaaagag ccaccatccc taccaggcaa ggaaaagtca cctccagcag
     2881 aagcatatgg gcctccgtta acaccacaac cctcgccttt gagtgaacta ccacaggctg
     2941 ctcctccacc aggttccccc acgctcccag ggcgccttga agacttcctg gagagcagca
     3001 cagggctgcc cctgctgaca agtgggcatg agggaccaga acccctttcc ctcattgatg
     3061 acctccacag ccagatgctg agcagctctg ccatcctgga ccatccccca tcccccatgg
     3121 acacctctga attgcacttt gctcctgagc ccagcagtgg tatgggcctg gacctggctg
     3181 ttggccacct ggacagcatg gactggctgg agctgtcatc tggtggccct gtgctcagcc
     3241 tggctcccct cagcaccaca gcccccagcc tcttctcgat ggacttcctg gatggccacg
     3301 acttgcagct ccactgggat tcctgcttgt agccctctga ctcagacatg ggctagggaa
     3361 gggtcagaag ttggggagcc acagaaccat aaccagtgtg cgatccctgt gactgtgagc
     3421 cttgacaatc acagtcccta gaggctgcag cagaaaccct gtacttggct caggctcacc
     3481 ctgggcagtg ggcataagct gtcaagaaac cactctgggc ccatgctgag gttttgggag
     3541 gctggccaga gccagttcaa ttcgacctcc ttttctgagg tcagaggtgc acatctgggt
     3601 gaagttttaa acttgcccag gtgggcttag agccaactcg ccttccaagt ctcccattcc
     3661 ttcactgcga ggaagaaact agccaggcct ctactcaccc attccctatt cagccagtcc
     3721 caggacccgg cactctgcca ttttagtctt ggtgtatagt ataaccagtg gttggtggca
     3781 aaaacctgta tagatgtaca tatctctata ttattatata tcaacttaca tatatacata
     3841 tatttttagg ggtggtggga aatgggtgtg gctacctcca cctgctttca cgtgtaagaa
     3901 gcctgaaggg ctgcttaggg cttgatacag ggtcattgtg agaagtgtgc accatgactc
     3961 aggactcaac ctggcatgca gccacccagg cccatcccac acatgtatgt gacatgtaga
     4021 cagacacctg ccattgccta cacgctaccc tgccctgctt cctggctctg tagtgccaca
     4081 agggtagagg tgcgtcccga ccctcctcta ggagctctcc gcccaccaca ttccatccca
     4141 cctcctcact gtagtagcca ccttggcctg ggagtgggag tggggtgggt cagtgcatct
     4201 actgggggct gagaggtacc ttctgcccaa caccagcctt gttctgtcct gactcaatac
     4261 agagaaggga tagagccatc aaaagcagtg ctgggacaaa ggtggggaag ctgtgtgaac
     4321 tttttaaaat aaaacaaaaa cactgacttg cca
//
