LOCUS       NM_024001               1949 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus magnesium transporter MRS2 (Mrs2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_024001
VERSION     NM_024001.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1949)
  AUTHORS   Kuwamura,M., Tanimura,S., Hasegawa,Y., Hoshiai,R., Moriyama,Y.,
            Tanaka,M., Takenaka,S., Nagayoshi,H., Izawa,T., Yamate,J.,
            Kuramoto,T. and Serikawa,T.
  TITLE     Downregulation of aspartoacylase during the progression of myelin
            breakdown in the dmy mutant rat with mitochondrial magnesium
            channel MRS2 defect
  JOURNAL   Brain Res 1718, 169-175 (2019)
   PUBMED   31100216
  REMARK    GeneRIF: Downregulation of aspartoacylase during the progression of
            myelin breakdown in the dmy mutant rat with mitochondrial magnesium
            channel MRS2 defect.
REFERENCE   2  (bases 1 to 1949)
  AUTHORS   Kuramoto,T., Kuwamura,M., Tokuda,S., Izawa,T., Nakane,Y.,
            Kitada,K., Akao,M., Guenet,J.L. and Serikawa,T.
  TITLE     A mutation in the gene encoding mitochondrial Mg(2)+ channel MRS2
            results in demyelination in the rat
  JOURNAL   PLoS Genet 7 (1), e1001262 (2011)
   PUBMED   21253565
  REMARK    GeneRIF: transgenic rats showed that MRS2 was dominantly expressed
            in neurons rather than oligodendrocytes and was ultrastructurally
            observed in the inner membrane of mitochondria
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1949)
  AUTHORS   Piskacek,M., Zotova,L., Zsurka,G. and Schweyen,R.J.
  TITLE     Conditional knockdown of hMRS2 results in loss of mitochondrial
            Mg(2+) uptake and cell death
  JOURNAL   J Cell Mol Med 13 (4), 693-700 (2009)
   PUBMED   18384665
REFERENCE   4  (bases 1 to 1949)
  AUTHORS   Zsurka,G., Gregan,J. and Schweyen,R.J.
  TITLE     The human mitochondrial Mrs2 protein functionally substitutes for
            its yeast homologue, a candidate magnesium transporter
  JOURNAL   Genomics 72 (2), 158-168 (2001)
   PUBMED   11401429
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF288289.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1949
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..1949
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /note="magnesium transporter MRS2"
                     /db_xref="GeneID:79032"
                     /db_xref="RGD:708529"
     exon            1..237
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1379
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /note="magnesium transporter MRS2 homolog, mitochondrial;
                     MRS2 magnesium homeostasis factor homolog; MRS2-like
                     protein; MRS2 magnesium transporter; MRS2-like, magnesium
                     homeostasis factor; RPT protein similar to yeast MRS2"
                     /codon_start=1
                     /product="magnesium transporter MRS2 homolog,
                     mitochondrial precursor"
                     /protein_id="NP_076491.1"
                     /db_xref="GeneID:79032"
                     /db_xref="RGD:708529"
                     /translation="MECLRYLPRLLPRAAQSRSALCMAAVRLSLAACCGRATPLTSGS
                     QKAPSTPRTAGDVYRFRTSDASQATLASVAQVFAVTKFDKEGNVTSFERKKTELYHEL
                     ALQARDLRFQHVMSITTRNNRIIMRMEYLKAVITPEYLLILDYRNLNLEHWLFRELPS
                     QLAGEGQLVTYPLPFEFRAIEALLQYWINTLQGKLSILQPLILETLDALVDPKHSSVD
                     RSKLHVLLQNGKSLSELETDIKIFKESILELLDEEEMLEELCLTKWSDPHVFEQSSTG
                     IDHAEEMELLLENYYRLADDLSNEARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLT
                     MGTFSLSLFGLMGVAFGMNLESSLEEDHRVFWLITGIMFMGSGLIWRRLLSFLGRQLE
                     APLPPVMASLPKKTLLADRRMDVKNSLRPEGLGAGRTILASR"
     exon            238..311
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     exon            312..348
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     exon            349..461
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     exon            462..635
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     exon            636..766
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     exon            767..883
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1036
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1154
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1268
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1949
                     /gene="Mrs2"
                     /gene_synonym="Mrs2l; Rpt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgtactga tctacccgag ttcccggcat gccgggccgg cgtcttattg cggcttcccg
       61 attgcccgcg cgccatggag tgcctgcgct acctgcccag gctactgccc cgcgccgcgc
      121 agtcccggag cgctctgtgt atggcggcgg tgcgcctgag cctcgctgcc tgctgtggcc
      181 gcgcgacccc gctgacctcc gggagccaga aggcgccgag cacaccccgc actgcaggtg
      241 atgtgtaccg gtttagaacc tctgatgcct ctcaagctac tttagccagc gtggcccagg
      301 tgtttgctgt gacaaagttt gacaaagaag gaaacgttac ctcttttgag aggaagaaaa
      361 ctgaactata ccatgagtta gcactccagg ccagagactt gaggtttcag cacgtaatga
      421 gcatcactac cagaaacaac aggatcatca tgaggatgga gtacttgaag gctgtgataa
      481 ctccagagta tcttctgata ctagattatc ggaatttaaa cttggagcac tggctgttcc
      541 gggaactgcc atcacagctg gctggagaag gtcagctcgt tacgtacccg ttaccgtttg
      601 agttcagagc tattgaagca ctcctgcagt actggatcaa cacccttcag gggaaactaa
      661 gcatcctgca gccactgatc ctggagaccc tggatgcatt agtggacccc aagcactctt
      721 ctgttgacag aagcaaactg catgtcctac tccaaaacgg caaaagtctc tctgagttag
      781 aaacagacat taaaatcttc aaagagtcaa ttttggagct cttggatgag gaggagatgc
      841 tggaagaact ctgtttaacc aagtggagtg acccgcatgt ctttgagcag agcagcactg
      901 ggattgacca cgcagaggag atggagctgc tgctggaaaa ctactaccga ctggctgacg
      961 acctctccaa tgaggctcgg gagcttcggg tcctgattga tgattcacag agcattatct
     1021 tcatcaatct agatagccat cgcaatgtga tgatgaggtt aaacctccag ctgaccatgg
     1081 gtaccttctc gctttcactc tttggactga tgggagttgc ttttggcatg aatttggaat
     1141 cttcccttga agaggatcat cgtgtgtttt ggctgattac aggaattatg tttatgggaa
     1201 gtggcctcat ctggaggagg ttgctttcgt tccttggaag acagctggaa gctcctttgc
     1261 cccctgtgat ggcctccttg cctaaaaaga cccttctggc agatagaagg atggatgtga
     1321 aaaacagcct caggccggaa ggacttggag caggcaggac tatcctcgca agccgatagc
     1381 agcagcctgg cagacaagga tttttattct tctgaagcta ttatcacttt ctgggggaaa
     1441 acgacaactg gtgtttaaat tatgaatgac taaaaatact gtggcattca cagtactaaa
     1501 cttgatcgca tcttcagaat tctttgagac agtgctttct ttgtaaaagg cccaaaccct
     1561 atgtcctacc aactttgaat actgtttatg ggcattttaa agtatcgatt tatgtactgt
     1621 gagtagactt atctagatca gtgccactat acatatggag gagtgtagct ttgtgctgac
     1681 tgctcaggga ctcagcagag cccgtggccc cgcacagaga ctcacagtcc cgtcagtctc
     1741 gctcagggag gaaggctggt ggatcactta gccttttgac aaattctgca atgtcagtcc
     1801 ttggtggaac tttacttcca ggtatttgct ttcttttata tatgatgaat aaaaaagagg
     1861 tataatttaa tgtcagcata cttggattcc aattaagcaa tattgttact attttttgat
     1921 taattataaa tagaactatg gaaagttaa
//
