LOCUS       NM_001108576            2188 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S2 (Mrps2), mRNA.
ACCESSION   NM_001108576 XM_001079091 XM_342398
VERSION     NM_001108576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2188)
  AUTHORS   Gardeitchik,T., Mohamed,M., Ruzzenente,B., Karall,D.,
            Guerrero-Castillo,S., Dalloyaux,D., van den Brand,M., van
            Kraaij,S., van Asbeck,E., Assouline,Z., Rio,M., de Lonlay,P.,
            Scholl-Buergi,S., Wolthuis,D.F.G.J., Hoischen,A., Rodenburg,R.J.,
            Sperl,W., Urban,Z., Brandt,U., Mayr,J.A., Wong,S., de
            Brouwer,A.P.M., Nijtmans,L., Munnich,A., Rotig,A., Wevers,R.A.,
            Metodiev,M.D. and Morava,E.
  TITLE     Bi-allelic Mutations in the Mitochondrial Ribosomal Protein MRPS2
            Cause Sensorineural Hearing Loss, Hypoglycemia, and Multiple OXPHOS
            Complex Deficiencies
  JOURNAL   Am J Hum Genet 102 (4), 685-695 (2018)
   PUBMED   29576219
REFERENCE   2  (bases 1 to 2188)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 2188)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jul 30, 2021 this sequence version replaced NM_001108576.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2383727.1,
                                           SRR26643294.12436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000003.1  32201077-32201188
            113-229             JAXUCZ010000003.1  32201289-32201405
            230-359             JAXUCZ010000003.1  32201864-32201993
            360-2188            JAXUCZ010000003.1  32202478-32204306
FEATURES             Location/Qualifiers
     source          1..2188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..2188
                     /gene="Mrps2"
                     /note="mitochondrial ribosomal protein S2"
                     /db_xref="GeneID:362094"
                     /db_xref="RGD:1309116"
     exon            1..112
                     /gene="Mrps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..945
                     /gene="Mrps2"
                     /note="28S ribosomal protein S2, mitochondrial"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS2m"
                     /protein_id="NP_001102046.2"
                     /db_xref="GeneID:362094"
                     /db_xref="RGD:1309116"
                     /translation="MAPAPAVLTRLQCAGLRRWPGFLQKAAPGPAGQNGRKVTGAPVP
                     AVSEPQDGDDFQSRILDVPLQHSDFFNVKELFSVKSLFEARVHLGHKAGCRHRFMEPY
                     IFGNRLGQDIIDLDQTALNLQLALNFTAHVAYRKGIILFVSRNRQFSHLIETTAQACG
                     EYAHTRYFKGGLLTNAQLLFGPTVRLPDLIVFLHTLNNVFESHVAVRDAAKMNIPTVG
                     IVDTNCNPCLITYPIPGNDDSPQAIQLFCKLFRTTINRAKEKRRQMEALHRLQSPKGS
                     EGTGTASAPDQSHSP"
     exon            113..229
                     /gene="Mrps2"
                     /inference="alignment:Splign:2.1.0"
     exon            230..359
                     /gene="Mrps2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..2188
                     /gene="Mrps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcttgacc cgggaggcgc tctgccaggc aggaagagtc tctgcggcat ctcagtccac
       61 gcgcctacca tggcacccgc tccggctgtg ctgacccggc ttcagtgtgc aggtttgcgg
      121 cgctggccag gtttcctgca gaaggcggct ccgggcccag cggggcagaa tggaaggaag
      181 gtcacgggag ccccggtccc cgcagtcagc gagcctcagg acggcgacga tttccagagc
      241 aggatactag atgtgccgtt acaacattca gatttcttca atgtcaagga gctgttttct
      301 gtgaagagcc tcttcgaggc ccgagtacac ctgggacata aagccggttg ccgccatagg
      361 tttatggagc catacatctt tgggaaccgc ctgggccaag atatcattga tctggatcag
      421 acagccttga atctccaact ggctttgaac ttcaccgccc atgtggccta ccgcaagggc
      481 atcatcctgt ttgtgagccg gaatcgtcaa ttctctcact taattgagac tacagcccaa
      541 gcctgcgggg agtatgccca cacccgctac ttcaagggtg gcttgctgac taacgcacaa
      601 ctcctctttg ggcctacagt ccgcctgccg gacctcatcg tcttcctgca cacactcaac
      661 aatgtctttg aatcccatgt agccgtgagg gatgcggcca agatgaacat ccccacagtg
      721 ggcattgtgg acaccaactg caacccatgc ctcatcactt accctatccc tggcaatgat
      781 gactcacccc aagctatcca gctcttctgc aagctcttcc ggacaaccat caacagggcc
      841 aaggagaaga ggaggcagat ggaggccctc catcggctac agagtcccaa ggggtccgag
      901 ggcactggga cagcctctgc acctgatcaa agtcattccc catgacagaa agcccttctc
      961 ccaccctaga tagccaggcc tcttctgagc aggaaggtcc ttgtccaacc ctggtctatg
     1021 tccccattct ccatcctcag catcagcacc acagtcctat attccctaga tatggccacc
     1081 ccaaagttca atcatcttga gctaaccctg gtctgtctct tttctgggaa caaactcagg
     1141 taaagtgcat atccacatgg cctcttgcat ctattaagat ttgaacatag ctagcaaagt
     1201 ggatctctcc ctccctctcc cccttcccct ctctcgctcc cccgccccca tctccctctc
     1261 tctcactctc ctaggtctta cttccacttc agaagtagat ctgtctcacg tgggttccat
     1321 ttggcttctc ttttcagtta gaaattaatc tttcattatc tgctaattaa tccttcattc
     1381 tctgaagaaa attccatgcc agacaatatt gatgtccctc aggaacccca gtagttgcct
     1441 ctagacctgc aaccagacat agggctaagt aagcaggctc ccagagggga ggtggaaata
     1501 cagcccatgc gttgtgacac acctaaagaa cttaggagtt tgctaacccg ttcaggcaga
     1561 agtctgggga atatgtgtag gaatagattt taaaggtggg gtaatggttg gaggaacata
     1621 aaattgaaat caggacgagt ttattgatat gggctctctg agtagagatc tatgtttaaa
     1681 acggaaactc tgatagtgaa aaatgtttgg ctgaagtatt tcttaaaaga gcctactgct
     1741 ggaggcacca aagtccttga gcccacagat caccaagaaa accaggcgtg ttagtcacat
     1801 agggttgtct cctcaaagaa gggaaatcaa tgcctgtttt gcacccagag gactgggagt
     1861 gactgttgtt aatgacctgg tgacctttgc tatctgtgga gccagacctt acccaaatcc
     1921 ccctaaatgc ttatctcgga cttttccttt cctagacctt tacttttagc ttggtttctc
     1981 caccaataga acccatccgt aggggagata tcaagagacc acaccaatcc taggccctta
     2041 agctataaga cccatctttg tggtcatgtg tactttgagc tgagttttga tgtaattatg
     2101 cctcttctac ctggggttgt attacaccag gaagcttttt tccaaaattg tacggtttta
     2161 atatgtttat aataaactac atggtgtc
//
