LOCUS       NM_172158                972 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus MAS related GPR family member X1 (Mrgprx1), mRNA.
ACCESSION   NM_172158 NM_001002286
VERSION     NM_172158.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 972)
  AUTHORS   Zhang,Y., Wang,M., Lu,Q., Li,Q., Lin,M., Huang,J. and Hong,Y.
  TITLE     Inhibitory Effects of Mas-Related Gene C Receptor on Chronic
            Morphine-Induced Spinal Glial Activation in Rats
  JOURNAL   J Pharmacol Exp Ther 368 (2), 237-245 (2019)
   PUBMED   30487293
  REMARK    GeneRIF: The inhibition of morphine tolerance by MrgC receptor was
            associated with the modulation of astrocytes and microglia in the
            spinal dorsal horn.
REFERENCE   2  (bases 1 to 972)
  AUTHORS   Wang,D., Wang,P., Jiang,J., Lv,Q., Zeng,X. and Hong,Y.
  TITLE     Activation of Mas Oncogene-Related G Protein-Coupled Receptors
            Inhibits Neurochemical Alterations in the Spinal Dorsal Horn and
            Dorsal Root Ganglia Associated with Inflammatory Pain in Rats
  JOURNAL   J Pharmacol Exp Ther 354 (3), 431-439 (2015)
   PUBMED   26157044
  REMARK    GeneRIF: MrgC receptors may be a novel target for relieving
            inflammatory pain.
REFERENCE   3  (bases 1 to 972)
  AUTHORS   Li,Z., He,S.Q., Tseng,P.Y., Xu,Q., Tiwari,V., Yang,F., Shu,B.,
            Zhang,T., Tang,Z., Raja,S.N., Wang,Y., Dong,X. and Guan,Y.
  TITLE     The inhibition of high-voltage-activated calcium current by
            activation of MrgC11 involves phospholipase C-dependent mechanisms
  JOURNAL   Neuroscience 300, 393-403 (2015)
   PUBMED   26022362
  REMARK    GeneRIF: Results suggest that activation of phospholipase C by MrgC
            agonism may lead to inhibition of high-voltage-activated calcium
REFERENCE   4  (bases 1 to 972)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian Mas-related G
            protein-coupled receptor genes
  JOURNAL   Gene 540 (1), 16-19 (2014)
   PUBMED   24583173
REFERENCE   5  (bases 1 to 972)
  AUTHORS   He,S.Q., Han,L., Li,Z., Xu,Q., Tiwari,V., Yang,F., Guan,X.,
            Wang,Y., Raja,S.N., Dong,X. and Guan,Y.
  TITLE     Temporal changes in MrgC expression after spinal nerve injury
  JOURNAL   Neuroscience 261, 43-51 (2014)
   PUBMED   24374082
  REMARK    GeneRIF: Study suggests that changes in MrgC expression after nerve
            injury differ temporally in injured and uninjured dorsal root
            ganglion neurons and that activation of Mrgs may constitute an
            endogenous mechanism that inhibits the maintenance of neuropathic
            pain
REFERENCE   6  (bases 1 to 972)
  AUTHORS   Ndong,C., Pradhan,A., Puma,C., Morello,J.P., Hoffert,C.,
            Groblewski,T., O'Donnell,D. and Laird,J.M.
  TITLE     Role of rat sensory neuron-specific receptor (rSNSR1) in
            inflammatory pain: contribution of TRPV1 to SNSR signaling in the
            pain pathway
  JOURNAL   Pain 143 (1-2), 130-137 (2009)
   PUBMED   19307060
  REMARK    GeneRIF: We propose that rSNSR1 represents a new member of the
            receptors expressed on chemosensitive nociceptors responsible for
            detecting the 'inflammatory soup' of mediators generated by tissue
            damage.
REFERENCE   7  (bases 1 to 972)
  AUTHORS   Lee,M.G., Dong,X., Liu,Q., Patel,K.N., Choi,O.H., Vonakis,B. and
            Undem,B.J.
  TITLE     Agonists of the MAS-related gene (Mrgs) orphan receptors as novel
            mediators of mast cell-sensory nerve interactions
  JOURNAL   J Immunol 180 (4), 2251-2255 (2008)
   PUBMED   18250432
  REMARK    GeneRIF: Rat basophilic leukemia-2H3 mast cells express the MrgC11
            receptor agonist, RF-amide precursor gene proneuropeptide FF.
REFERENCE   8  (bases 1 to 972)
  AUTHORS   Hager,U.A., Hein,A., Lennerz,J.K., Zimmermann,K., Neuhuber,W.L. and
            Reeh,P.W.
  TITLE     Morphological characterization of rat Mas-related G-protein-coupled
            receptor C and functional analysis of agonists
  JOURNAL   Neuroscience 151 (1), 242-254 (2008)
   PUBMED   18065157
  REMARK    GeneRIF: in lumbar dorsal root ganglia we found cytoplasmic MrgC
            labeling mainly in small- and medium-sized neurons
REFERENCE   9  (bases 1 to 972)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
REFERENCE   10 (bases 1 to 972)
  AUTHORS   Lembo,P.M., Grazzini,E., Groblewski,T., O'Donnell,D., Roy,M.O.,
            Zhang,J., Hoffert,C., Cao,J., Schmidt,R., Pelletier,M., Labarre,M.,
            Gosselin,M., Fortin,Y., Banville,D., Shen,S.H., Strom,P., Payza,K.,
            Dray,A., Walker,P. and Ahmad,S.
  TITLE     Proenkephalin A gene products activate a new family of sensory
            neuron--specific GPCRs
  JOURNAL   Nat Neurosci 5 (3), 201-209 (2002)
   PUBMED   11850634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Jul 7, 2022 this sequence version replaced
            NM_001002286.1, NM_172158.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-972               JAXUCZ010000001.1  106942343-106943314 c
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..972
                     /gene="Mrgprx1"
                     /gene_synonym="Mgrg2; MrgC; Mrgprc; Mrgprc11; Mrgprx4;
                     Snsr; Snsr1"
                     /note="MAS related GPR family member X1"
                     /db_xref="GeneID:282547"
                     /db_xref="RGD:632284"
     CDS             1..972
                     /gene="Mrgprx1"
                     /gene_synonym="Mgrg2; MrgC; Mrgprc; Mrgprc11; Mrgprx4;
                     Snsr; Snsr1"
                     /note="sensory neuron-specific G-protein coupled receptor
                     1; MAS-related GPR, member C11; G protein-coupled receptor
                     SNSR; Mas-related G protein-coupled receptor g2;
                     MAS-related G-protein coupled receptor, member C; Sensory
                     neuron-specific receptor; MAS-related gene C; MAS-related
                     GPR, member X1; MAS related GPR family member X4;
                     MAS-related GPR, member X4"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     X1"
                     /protein_id="NP_750845.3"
                     /db_xref="GeneID:282547"
                     /db_xref="RGD:632284"
                     /translation="MDPTISSLSTESTTLNKTGHPSCRPILTLSFLVPIITLLGLAGN
                     TIVLWLLGFRMRRKAISVYVLNLSLADSFFLCCHFIDSLMRIMNFYGIYAHKLSKEIL
                     GNAAIIPYISGLSILSAISTERCLSVLWPIWYHCHRPRNMSAIICVLIWVLSFLMGIL
                     DWFFSGFLGETHHHLWKNVDFIVTAFLIFLFMLLFGSSLALLVRILCGSRRKPLSRLY
                     VTISLTVMVYLICGLPLGLYLFLLYWFGIHLHYPFCHIYQVTVLLSCVNSSANPIIYF
                     LVGSFRHRKKHRSLKMVLKRALEETPEEDEYTDSHVQKPTEISERRC"
     exon            1..972
                     /gene="Mrgprx1"
                     /gene_synonym="Mgrg2; MrgC; Mrgprc; Mrgprc11; Mrgprx4;
                     Snsr; Snsr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatccaa ccatctcatc cctcagtaca gaatctacaa cactgaataa aactggtcat
       61 cccagttgca ggccaatcct caccctgtcc ttcctggtcc ccatcatcac cctgcttgga
      121 ttggcaggaa acaccattgt actctggctc ttgggattcc gcatgcgcag gaaagccatc
      181 tcagtctacg tcctcaacct gtctctggca gactccttct tcctctgctg ccattttatt
      241 gactctctga tgcggatcat gaacttctat ggcatctatg cccataaatt aagcaaagaa
      301 atcttaggca atgcagcaat cattccctat atctcaggcc tgagcatcct cagtgctatc
      361 agcacggagc gctgcctgtc tgtattgtgg ccaatctggt accactgcca ccgcccaaga
      421 aacatgtcag ctattatatg tgttctaatc tgggttctgt cctttctcat gggcatcctt
      481 gactggttct tctcaggatt cctgggtgag actcaccatc atttgtggaa aaatgttgac
      541 tttattgtaa ctgcatttct gattttttta tttatgcttc tctttgggtc cagtctggcg
      601 ctactggtga ggatcctctg tggttccaga cggaaaccac tgtccaggct gtacgttaca
      661 atctctctca cagtgatggt ctacctcatc tgcggcctgc ctctcgggct ttacttgttc
      721 ctgctatatt ggtttgggat ccatttacat tatccctttt gtcacattta ccaagttact
      781 gtgctcctgt cctgtgtgaa cagctctgcc aaccccatca tttacttcct tgtagggtcc
      841 tttaggcacc gtaaaaagca tcggtccctc aaaatggttc ttaagagggc tctggaggag
      901 actcctgagg aggatgaata tacagacagc catgttcaga aacccactga gatctcagaa
      961 aggagatgtt ga
//
