LOCUS       NM_001001506            2938 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus MAS related GPR family member D (Mrgprd), mRNA.
ACCESSION   NM_001001506 XM_219567
VERSION     NM_001001506.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2938)
  AUTHORS   Almeida-Santos,A.F., de Melo,L.A., Goncalves,S.C.A., Oliveira
            Amaral,L.B., Santos,R.A.S., Campagnole-Santos,M.J. and
            Kangussu,L.M.
  TITLE     Alamandine through MrgD receptor induces antidepressant-like effect
            in transgenic rats with low brain angiotensinogen
  JOURNAL   Horm Behav 127, 104880 (2021)
   PUBMED   33129833
  REMARK    GeneRIF: Alamandine through MrgD receptor induces
            antidepressant-like effect in transgenic rats with low brain
            angiotensinogen.
REFERENCE   2  (bases 1 to 2938)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian Mas-related G
            protein-coupled receptor genes
  JOURNAL   Gene 540 (1), 16-19 (2014)
   PUBMED   24583173
REFERENCE   3  (bases 1 to 2938)
  AUTHORS   Zhuo,R.G., Ma,X.Y., Zhou,P.L., Liu,X.Y., Zhang,K., Wei,X.L.,
            Yan,H.T., Xu,J.P. and Zheng,J.Q.
  TITLE     Mas-related G protein-coupled receptor D is coupled to endogenous
            calcium-activated chloride channel in Xenopus oocytes
  JOURNAL   J Physiol Biochem 70 (1), 185-191 (2014)
   PUBMED   24078284
  REMARK    GeneRIF: Activation of recombinant rat MrgD protein promotes
            opening of the endogenous calcium-activated chloride channels in
            Xenopus oocytes.
REFERENCE   4  (bases 1 to 2938)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 2938)
  AUTHORS   Crozier,R.A., Ajit,S.K., Kaftan,E.J. and Pausch,M.H.
  TITLE     MrgD activation inhibits KCNQ/M-currents and contributes to
            enhanced neuronal excitability
  JOURNAL   J Neurosci 27 (16), 4492-4496 (2007)
   PUBMED   17442834
  REMARK    GeneRIF: We provide evidence for a novel interaction between MrgD
            and KCNQ/M-type potassium channels that contributes to an increase
            in excitability of DRG neurons and thus may enhance the signaling
            of primary afferent nociceptive neurons.
REFERENCE   6  (bases 1 to 2938)
  AUTHORS   Milasta,S., Pediani,J., Appelbe,S., Trim,S., Wyatt,M., Cox,P.,
            Fidock,M. and Milligan,G.
  TITLE     Interactions between the Mas-related receptors MrgD and MrgE alter
            signalling and trafficking of MrgD
  JOURNAL   Mol Pharmacol 69 (2), 479-491 (2006)
   PUBMED   16282220
  REMARK    GeneRIF: Interactions between rMrgD and rMrgE modulate the function
            of rMrgD.
REFERENCE   7  (bases 1 to 2938)
  AUTHORS   Shinohara,T., Harada,M., Ogi,K., Maruyama,M., Fujii,R., Tanaka,H.,
            Fukusumi,S., Komatsu,H., Hosoya,M., Noguchi,Y., Watanabe,T.,
            Moriya,T., Itoh,Y. and Hinuma,S.
  TITLE     Identification of a G protein-coupled receptor specifically
            responsive to beta-alanine
  JOURNAL   J Biol Chem 279 (22), 23559-23564 (2004)
   PUBMED   15037633
  REMARK    GeneRIF: TGR7 participates in the modulation of neuropathic pain
REFERENCE   8  (bases 1 to 2938)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 13, 2022 this sequence version replaced NM_001001506.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB578884.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000001.1  209908487-209908708
            223-2938            JAXUCZ010000001.1  209914468-209917183
FEATURES             Location/Qualifiers
     source          1..2938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2938
                     /gene="Mrgprd"
                     /gene_synonym="Mgrd; Mrgd; TGR7"
                     /note="MAS related GPR family member D"
                     /db_xref="GeneID:293648"
                     /db_xref="RGD:738040"
     exon            1..222
                     /gene="Mrgprd"
                     /gene_synonym="Mgrd; Mrgd; TGR7"
                     /inference="alignment:Splign:2.1.0"
     exon            223..2938
                     /gene="Mrgprd"
                     /gene_synonym="Mgrd; Mrgd; TGR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1184
                     /gene="Mrgprd"
                     /gene_synonym="Mgrd; Mrgd; TGR7"
                     /note="MAS-related gene D; MAS-related G-protein coupled
                     receptor, member D; MRGD G protein-coupled receptor;
                     beta-alanine receptor; G-protein coupled receptor TGR7;
                     Mas-related G protein-coupled receptor d; MAS-related GPR,
                     member D"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member D"
                     /protein_id="NP_001001506.1"
                     /db_xref="GeneID:293648"
                     /db_xref="RGD:738040"
                     /translation="MNYTPYSSPAPGLTISPTMDPVTWVYFSVTFLAMATCVCGIVGN
                     SMVIWLLSFHRVQRSPFCTYVLNLAVADLLFLLCMASLLSLETGPLLTASTSARVYEG
                     MKRIKYFAYTAGLSLLTAISTQRCLSVLFPIWYKCHRPQHLSGVVCGVLWALALLMNF
                     LASFFCVQFWHPDKYQCFKVDMVFNSLILGIFMPVMVLTSAIIFIRMRKNSLLQRRQP
                     RRLYVVILTSVLVFLTCSLPLGINWFLLYWVELPQAVRLLYVCSSRFSSSLSSSANPV
                     IYFLVGSQKSHRLQESLGAVLGRALQDEPEGRETPSTCTNDGV"
ORIGIN      
        1 aggtccttga ggaagggatc cccaaattaa ggcttctctg gggctgggag aagtagagac
       61 agacgggagc atccttgttt ggtggaagag acactgagcc aggaactaca gaagcagtca
      121 agaggcccag gccccactga gctgctgtag acacctccag ggatcacagc caagagggat
      181 caccattttg gccaaaagac agatcgacac actcagaagc aggcatgaac tacactcctt
      241 atagcagccc agccccaggt ctgaccatca gccccaccat ggaccctgtg acctgggttt
      301 acttttcagt gacattcctg gccatggcca cctgtgtgtg tgggatagtg ggcaactcca
      361 tggtgatttg gctactgagt ttccacaggg tgcagaggtc ccccttctgc acctacgtgc
      421 tcaacctggc ggtggccgac ctcctcttcc tgctctgcat ggcctccctg ctcagtctgg
      481 aaacagggcc cctgctcaca gccagcacct ccgccagagt ctacgagggg atgaagagaa
      541 tcaagtactt tgcctacaca gcaggcctga gcctgctgac ggccatcagc acccagcgct
      601 gtctctccgt gcttttcccc atctggtata agtgccaccg gccccagcac ctgtcggggg
      661 tggtatgtgg tgtgctgtgg gcactggccc tcctgatgaa cttcctggct tctttcttct
      721 gtgttcaatt ctggcatccc gacaaatacc agtgcttcaa ggtggacatg gttttcaaca
      781 gtcttatcct ggggatcttc atgcccgtca tggtcctgac cagcgccatc atcttcatcc
      841 gcatgcgaaa gaacagcctg ctgcagagac ggcagcctcg gcggctctac gtggtcatcc
      901 tgacttccgt ccttgtcttc cttacctgtt ctctgccgtt gggcatcaac tggttcttac
      961 tctactgggt ggaactgccg caggccgtga ggctcctgta cgtctgctca tcacgcttct
     1021 cctcgtcttt gagcagcagc gccaacccag tcatctactt cctcgtgggc agccagaaga
     1081 gccaccggct gcaggagtct ctgggtgctg tgctggggcg ggcacttcag gacgagcctg
     1141 aaggcaggga gacgccatcc acatgtacta atgatggggt ctgaaggcag cccgcctagg
     1201 acctcctcca aaaccctgcc cagcccttcc ctacaaggac ccagaaagct tgctgtgcaa
     1261 aggccttgca cctcaaaatg ttggggtcat tttcctgtct gccaggagag ccaccactct
     1321 caccttgcgt tcctaatcta aagtaggagg tgaggcaaca tttctttctg tttttcctgt
     1381 ttagacaccg atcctagctt taggtcccgt cctgggcaag actggctgtg aaatggagtt
     1441 tcccagtaga gactgcatct catgctggtg gaaaaggtct ttcttagccc ccttaacccc
     1501 ctgacctggc atctgtctta gcttcatttc cattgccgtg acaagttccc tgacaaaagg
     1561 caacacaggg aaagaaactg ttcacttggc ttacaactac agatcatggc ccatcatttc
     1621 agggaagcca aggcagaaat gtaagcagct aatgacatca catacaaagt caagagcaga
     1681 aagagtgcag acgcatagct ccatccccac ttgcttgctc tcagctagct tattatatcc
     1741 tctcttatcc tgttcacaat tatcagccta gggaatggtg ttgcccacag agggctaggg
     1801 cttcctgtgt caatcaacag tgaagacgac ctcttgcaga cacacccaca agctaacctg
     1861 atccagacaa ttcctcactg aggctctcat cccaagtgat tctaggtttt gtcaagttga
     1921 cagttaaagc tgaacagaca gcaccttgga catggggatg tactggtaac atcatttagt
     1981 gcacagagtg gtggctctgc tgcacatgtc accgcgcctc cagcacgagt gtgacttttc
     2041 tggcatgatg tgacacacat cccagatagg gcactgataa agaccaagga aaaattccat
     2101 caaatcagag tctgatgaac cgagtaacac agagaagcgt gggtcagggg ttagttatag
     2161 agatgtagtt cagcattact tatagtgatg tcgctaaaac agccacatca ccaagaaacc
     2221 cctccccagc ctggaagata atttccagag gttctctaga tgaagtgctc cccttaccta
     2281 acctaccctt ctgttactag cacctcccta aaccaagaca actggactgg cgttacatgc
     2341 acctaagagg aagtacaagg gcaagggaga ggggtcttag acccttacta ccctcctttc
     2401 gtaagggaat tcccacaggc ttcatcctga aggtctctgg tgggaactct aagctgcttg
     2461 gttacagtgg caatggctgt gattgatact cagaggagag aatgccacct tctctgacct
     2521 acatctaact gtcatcatcc cccacctgac ctctggctca acctcaggcc ctgatttggc
     2581 ccatggggtt cttttgtacc ccttgttccc tgagacatct gtgccagtta actttgtgac
     2641 aggagagggc ataaacatgg cagccagagg ctgggaagag agagggaccg gacagaaaga
     2701 gatttgaaca ggcaaagctc tgcaggaggt gggcacagca tggagcctga gtcaatagtc
     2761 ttgcagaccc tcttcaggcc acctcctaga gggtctggaa cacttctgca caagccagtg
     2821 caccatgttc gaggtgacag agatgctggt caccccacca tgtgtacata tatcaaaatg
     2881 gtacctcaga ccatatgaac ctgtatgatt cttgcatgtt atcagtaaat gacaacaa
//
