LOCUS       NM_001192002            2483 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus melanoregulin (Mreg), mRNA.
ACCESSION   NM_001192002 XM_576585
VERSION     NM_001192002.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2483)
  AUTHORS   Rout,A.K., Wu,X., Starich,M.R., Strub,M.P., Hammer,J.A. and
            Tjandra,N.
  TITLE     The Structure of Melanoregulin Reveals a Role for Cholesterol
            Recognition in the Protein's Ability to Promote Dynein Function
  JOURNAL   Structure 26 (10), 1373-1383 (2018)
   PUBMED   30174147
REFERENCE   2  (bases 1 to 2483)
  AUTHORS   Wu,X.S., Martina,J.A. and Hammer,J.A. 3rd.
  TITLE     Melanoregulin is stably targeted to the melanosome membrane by
            palmitoylation
  JOURNAL   Biochem Biophys Res Commun 426 (2), 209-214 (2012)
   PUBMED   22940130
REFERENCE   3  (bases 1 to 2483)
  AUTHORS   Ohbayashi,N., Maruta,Y., Ishida,M. and Fukuda,M.
  TITLE     Melanoregulin regulates retrograde melanosome transport through
            interaction with the RILP-p150Glued complex in melanocytes
  JOURNAL   J Cell Sci 125 (Pt 6), 1508-1518 (2012)
   PUBMED   22275436
REFERENCE   4  (bases 1 to 2483)
  AUTHORS   Damek-Poprawa,M., Diemer,T., Lopes,V.S., Lillo,C., Harper,D.C.,
            Marks,M.S., Wu,Y., Sparrow,J.R., Rachel,R.A., Williams,D.S. and
            Boesze-Battaglia,K.
  TITLE     Melanoregulin (MREG) modulates lysosome function in pigment
            epithelial cells
  JOURNAL   J Biol Chem 284 (16), 10877-10889 (2009)
   PUBMED   19240024
REFERENCE   5  (bases 1 to 2483)
  AUTHORS   O'Sullivan,T.N., Wu,X.S., Rachel,R.A., Huang,J.D., Swing,D.A.,
            Matesic,L.E., Hammer,J.A. 3rd, Copeland,N.G. and Jenkins,N.A.
  TITLE     dsu functions in a MYO5A-independent pathway to suppress the coat
            color of dilute mice
  JOURNAL   Proc Natl Acad Sci U S A 101 (48), 16831-16836 (2004)
   PUBMED   15550542
REFERENCE   6  (bases 1 to 2483)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     The murine dilute suppressor gene encodes a cell autonomous
            suppressor
  JOURNAL   Genetics 138 (2), 491-497 (1994)
   PUBMED   7828830
REFERENCE   7  (bases 1 to 2483)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   8  (bases 1 to 2483)
  AUTHORS   Moore,K.J., Seperack,P.K., Strobel,M.C., Swing,D.A., Copeland,N.G.
            and Jenkins,N.A.
  TITLE     Dilute suppressor dsu acts semidominantly to suppress the coat
            color phenotype of a deletion mutation, dl20J, of the murine dilute
            locus
  JOURNAL   Proc Natl Acad Sci U S A 85 (21), 8131-8135 (1988)
   PUBMED   3141922
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 20, 2022 this sequence version replaced NM_001192002.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.22781.1,
                                           SRR26643298.49321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               JAXUCZ010000009.1  81291068-81291310   c
            244-403             JAXUCZ010000009.1  81269531-81269690   c
            404-494             JAXUCZ010000009.1  81240376-81240466   c
            495-658             JAXUCZ010000009.1  81238674-81238837   c
            659-2483            JAXUCZ010000009.1  81236019-81237843   c
FEATURES             Location/Qualifiers
     source          1..2483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2483
                     /gene="Mreg"
                     /gene_synonym="RGD1562333"
                     /note="melanoregulin"
                     /db_xref="GeneID:501162"
                     /db_xref="RGD:1562333"
     exon            1..243
                     /gene="Mreg"
                     /gene_synonym="RGD1562333"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..793
                     /gene="Mreg"
                     /gene_synonym="RGD1562333"
                     /codon_start=1
                     /product="melanoregulin"
                     /protein_id="NP_001178931.1"
                     /db_xref="GeneID:501162"
                     /db_xref="RGD:1562333"
                     /translation="MGLRRWLRSACCCCPCRCLEEPARPEKEPLVSGNNPYSSFGATL
                     ERDDEKNLWSMPHDVSHTEADDDRILYNLIVVRNQQTKDSEEWQRLNYDIYTLRQIRR
                     EVRNRWRRILEDLGFQREADSLLSVTKLSTMSDSKNTRKAREMLLKLAEETSIFPASW
                     ELSERYLLIVDRLIALDAADDFFKIASQMYPKKPGVPCLVDGQRKLPYLPFPSP"
     exon            244..403
                     /gene="Mreg"
                     /gene_synonym="RGD1562333"
                     /inference="alignment:Splign:2.1.0"
     exon            404..494
                     /gene="Mreg"
                     /gene_synonym="RGD1562333"
                     /inference="alignment:Splign:2.1.0"
     exon            495..658
                     /gene="Mreg"
                     /gene_synonym="RGD1562333"
                     /inference="alignment:Splign:2.1.0"
     exon            659..2483
                     /gene="Mreg"
                     /gene_synonym="RGD1562333"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacgcgcgg cttgcgtctc cccggccggc cgcggcgtga tgctcacggc ccggcccgtg
       61 acgccgcggc cgtccccgtc cctgtccccg tgccccagcc gccatcgcgc gcccggctcc
      121 gggatcccgg cgcccggcct cgctccccat ggggctgcgc cgctggctgc ggagcgcctg
      181 ctgctgctgc ccgtgccggt gcctggagga gcccgcgcgg cccgagaagg agccgctggt
      241 cagtggtaac aatccatatt cctcctttgg agcgactctg gagagggatg atgaaaagaa
      301 tttatggagc atgccccacg acgtgtctca cacagaggca gatgatgaca ggatcttgta
      361 taatctgata gtcgtccgta atcagcagac caaagactca gaggagtggc aaagactcaa
      421 ctatgatatc tacaccctgc ggcagatccg cagggaagtg aggaacaggt ggagacgaat
      481 cttagaagat ttgggctttc aaagggaagc tgactctttg ttgtcagtga ccaaactcag
      541 caccatgagt gattccaaaa acacgaggaa agcccgagag atgctgttaa aactggcaga
      601 agagacctct atcttcccag ccagctggga gctctccgag agatatctct tgattgtgga
      661 ccggctcatt gctctagatg ctgctgatga cttctttaag attgctagcc aaatgtaccc
      721 caagaaacct ggggtcccat gcctggtaga cggccagagg aagctgccct accttccatt
      781 tccaagtccc tgaagggagg cccagaagaa cagagctctt tacacagtaa ttcacccaag
      841 ctggacagct gcccacagtt tccagtgagc caggagaggg ctttctccag tcaaacacta
      901 atgtgaatcc tacgaaacga aaggtcttcc tcaggaccct cccctaagga tgctctggtt
      961 acactaaaac acccggtgac caccgtgcat ccagaaagga aggttaaaga ggtggttggt
     1021 gggcaattct tcctggatag tcaggttcca agaatccatg gcttcattgg ttatgtaagc
     1081 cacagtcatt cattctgtgg agtgtggagg actgatgttt tctaatcaac agaagggtct
     1141 gactaataga gaagggtgta accgagccct caattacatc gccaatgttg aggtaatcat
     1201 tattaagtgt aatactagac agggtgcccc agatttcata aaacctccta aaaccccctg
     1261 tgacctcgct ttgatttgga aacacctgca gcagctgggg cgctgtttag ggcatccctc
     1321 tgagcatcag gcacggttat ttagaagact aggtgagcca gaccatagat ttgtgtagac
     1381 atacagccca gacagcagaa cttcctgtag ctcgtgtctt cctctgtgat gagagcaccc
     1441 cgaatccttg gcaccaatcc tcagccctga agttacccag ttgcctcgat ttttttttcc
     1501 catgttgccc atttctgatc caaaagccct tggcattttt aggaagaata gcatctgtaa
     1561 actggaacgt ttggcctcta ctccctgcct tgaatctgtt tcctgattgt cagctgaggg
     1621 tcgcagccgc ctagggacct tttggtgcaa acttgcagat atgcaggtag tggcacatgc
     1681 tgactgctgg gtcttcactc tgagggtgat tttctaaaat ggagctgtgc taacagtgca
     1741 gcttgcccac cgaatgagaa gccccatctc ccaagatcat aaagcaaagc ttgccaagag
     1801 atcgtggtgc gttttgttga aaggccttta aagacttgtg ggatttatct gtagacttct
     1861 gaggacaata gaaatatttt tattttttaa caattttgca cttctgactt caggtggaaa
     1921 ataaatttgt attagtctgt tcaggggatt gagacttgaa aaatttcata tcctgagaag
     1981 ttttttttcc cccaagcgta tacttcatgt ttaaaatatt tactaggaaa tacatgtcct
     2041 ccattcatta atatattata gactaattta acaggtgcgt ttcaggaaaa ttcttcctag
     2101 tttaataagt aaggtaaaag ttttatttta ttttattttt tttttagtgt ttagtgctta
     2161 ttctctactt catgtttaag attagcccac aactattttc agtctcttct gtgggctatt
     2221 agaagataaa caataaaata aacaaaagac atcttagaat gttgtattgt tttaatcaga
     2281 atttgttttg gctcttgtct tctttgatgt caaaatagat aaaattgtct gcgtctatga
     2341 attataaacc attaaccata gtttttattt ttttggtttc aaacaagtaa ggataaaatt
     2401 atctctgtgg taactaaaat acctgcaatt aacccaggag atgtttcccc aaggaattaa
     2461 aagacttctc tgtgtgcctt caa
//
