LOCUS       XM_006242533            5536 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus MRE11 homolog, double strand break
            repair nuclease (Mre11), transcript variant X2, mRNA.
ACCESSION   XM_006242533
VERSION     XM_006242533.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051343.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006242533.4.
            
            On Jan 21, 2021 this sequence version replaced XM_006242533.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5536
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /note="MRE11 homolog, double strand break repair nuclease;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 27 ESTs, 10 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 138 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:64046"
                     /db_xref="RGD:69263"
     CDS             230..2350
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /codon_start=1
                     /product="double-strand break repair protein MRE11 isoform
                     X1"
                     /protein_id="XP_006242595.1"
                     /db_xref="GeneID:64046"
                     /db_xref="RGD:69263"
                     /translation="MSPADPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEIL
                     RLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFG
                     FSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVE
                     KVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQ
                     NRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRNEQQLFYVSQPGSSVVTALSP
                     GETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSLFNPDNPKVTQAIQS
                     FCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANP
                     KDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLSLL
                     TERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRES
                     RQRNTNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVP
                     SRGRGRGRGRRGGRGQSTAPRGGSQRGRDTGLGISTRGRSSKATASTSRNMSIIDAFR
                     STRQQPSRNVATKNYSETIEVDESDDDDSFPTSSRADQRWSGTAPSKRMSQSQTAKGV
                     DFESDEDDDDDPFMSGSCPRRNRR"
ORIGIN      
        1 gtacggatgc gtttctcccg cgcccaattt aggtttctgg tagcggtttt cttctcgttc
       61 tgacgactcc tgcccctttt ccccgaggta gagatagcct gtggcctcgc tggtcggctc
      121 tgacaagttc agagtttgga atcgggtgtt tttttttctg acgtacctga acacagaacc
      181 ccagggtact tggagaggaa cctggtccta gaggaactct accataaaaa tgagccccgc
      241 agatccgctt gatgatgaag acacatttaa aatcctggtt gccactgata ttcatcttgg
      301 atttatggaa aaagatgcag ttagaggaaa tgacacattt gtgacatttg atgaaatttt
      361 aagacttgcc ctggaaaatg aagtggattt tattttgtta ggtggtgatc ttttccatga
      421 aaacaagccc tcaaggaaaa ccctgcacag ctgcttagag ctgcttagga agtactgtat
      481 gggtgaccgc cctgtgcaat ttgagatcat cagtgaccag tcagtcaact ttggttttag
      541 taagtttcca tgggtgaact accaggatgg caatctcaac atctccattc cagtgtttag
      601 tatccacggc aaccatgatg atcccacagg ggcagatgcc ctctgtgccc tggatgtttt
      661 aagctgtgct gggtttgtga atcactttgg acggtcaatg tctgtggaga aggttgacat
      721 tagtccagtt ctgctgcaga aaggaagcac aaaactcgct ctgtacggct tagggtccat
      781 tccagatgaa aggctctatc ggatgtttgt caataagaaa gtaacgatgt tgaggcctaa
      841 ggaagacgag aactcatggt ttaacttatt cgtgattcat cagaacagga gtaaacacgg
      901 aagcaccaac ttcatcccag agcagttttt ggatgacttc attgacctgg tcatctgggg
      961 ccatgaacat gagtgtaaaa tcggcccaac caggaatgag cagcagctct tctatgtgtc
     1021 tcagcccgga agctcggtgg tgacagccct ttcccctgga gaaactgtga agaaacatgt
     1081 aggcctgcta cgcgttaaag ggagaaagat gaacatgcag aagctgcctc tccgcacagt
     1141 gcgacagttc ttcatggaag atgtggtcct ggctaaccac ccaagcctgt tcaaccctga
     1201 caatcctaag gtgacccagg ccatccagag cttctgtttg gagaagattg aagaaatgct
     1261 tgacagtgct gagcgggaac ggctggggaa tcctcagcag ccggagaagc ctctcatccg
     1321 actacgggtg gactacagtg gaggctttga acctttcaac gttcttcgtt ttagccagaa
     1381 gtttgtggat cgggttgcta acccaaaaga tgtcatccac tttttcagac acagggaaca
     1441 aaaaggaaaa acaggagaag agatcaactt tgggaagctc atcataaaac ctgcttcaga
     1501 agggacgacg ctcagagtag aagaccttgt aaagcagtat ttccaaactg cagagaagaa
     1561 tgttcagctc tcactgctga cagaaagagg gatgggtgaa gcagttcaag agtttgtgga
     1621 caaggaagag aaagatgcca tcgaggaatt agtgaagtac cagctggaga aaacgcagcg
     1681 gtttcttaag gagcgccaca tcgatgctct agaagacaag attgatgaag aggtccggcg
     1741 tttcagagaa agcagacaga gaaataccaa cgaagaagac gatgaagttc gagaggccat
     1801 gagcagggcc cgggccctca ggtcacagtc ggagaacgcc gcctcagcct tcagtgcaga
     1861 tgacctgagt tttgatataa cggagcagac agcagatgac tctgacgata gccagtcagc
     1921 agtgccgagc cgaggccgag gtcgaggccg aggacgaaga ggaggcagag ggcagagcac
     1981 tgcacccaga ggaggctctc agagaggccg agacactggg ctggggatct ctactcgggg
     2041 caggagctca aaggccactg cgtcaacatc tagaaatatg tccattatag atgctttcag
     2101 atctacccga cagcagcctt ccagaaatgt agccactaag aattactcag agaccattga
     2161 ggtggatgaa tctgatgacg atgacagttt tcctaccagc tccagggctg atcaaaggtg
     2221 gtcgggcaca gcacctagca aacggatgtc ccagagccag acagccaaag gggtggactt
     2281 tgaatcagac gaggacgatg atgacgaccc tttcatgagt ggtagttgcc caagaagaaa
     2341 ccgaagataa tgttgttagt agaacttaaa agttgtcccg ctgcaggaag aaatcgcagc
     2401 agcgtatgct aactttacag ctggcggtgt tttatcgctg cagcactaca ggagtctgaa
     2461 aagcctggga ttctatttta aaatattgtt tcctgaaggt gactctctta agccatttcc
     2521 taggcgggtg gtaaggagat tgctgcttct ccttagcctt taatctgctt gttatcattg
     2581 tctggggctg ctttaagaat gttaatttcc tgacataact gtgtttcctg cttgtaagaa
     2641 ctttgctaaa attccattgt tgaatgaaga ttagagaaaa ccctccatta tccattcctg
     2701 cttctgatca gagactgtca gcctccagtg cctcagctag cagagttgat gtgacagctt
     2761 accggggctg taaccatttc ctgtctcccc aggaagcaag gccctcctgt gtgtgtggtg
     2821 gggggagcag tctgagctcc ctggttgtta gcaagtgtgt ggatttcaga gtgtgctgga
     2881 ggacggtcca ctagggccag aagggcctta tatttcagta attagtataa ggtttttgtt
     2941 gaaaccattt tggttgtttt ggttttggtc tttattcacg ttgtagcaga gactcagatc
     3001 ctgtccccac tgagcagtag tcattttctt gatcactctg tcattcatga caagctcttt
     3061 ttctctctca actcttgtca gggagaaaag cttaatagga tttttctgtt tcttaaagat
     3121 agtgaaaaag ctttcttagg ccaaacagcc agctgacctt gtggttagtt caggctgaca
     3181 taccacagtt cagtttctgc ccggagtcgg ggccaggcct ccttgaccag cagcagcact
     3241 gtaccatggc tttggttgct ataaacatct ctgaatacac ggttccaaaa ctgacggaaa
     3301 cagcaagctt acattttctt acttgtttta ggaagaaaat aaaaatgtaa tcctttcaga
     3361 gttgagttaa ataatctttt ttttttcttt ttttccggag ctggggaccg aacccagggc
     3421 cttgcgcttg ctaggcaagc gctctaccac tgagctaaat ccccaacccg agttaaataa
     3481 tcttattccc tctttcacac tctaagaagc tctgctggtc ttttaatttt atagggcaaa
     3541 tgtggtcaaa cattcttgag gaaatctggc tccttctagc acagcaacat gatgttcttc
     3601 ccagatgtag acaccagcat ttaggccaaa cagtgttcat ggccatcaaa ttaatcagtg
     3661 tttggagccc agcacctgac agtaccacca tgtctcgaat gtgatctgag tcagaattac
     3721 agcccagtgc taatgagctg cttagaggag ctttgtaact gatgtgagca caggattgtc
     3781 aggggagcat taagagcaga aggcatggtc ctgtcagatt gcttcaggca gttcttccca
     3841 tccccatctt tatcacatta aatctcaagt gttccagggt ctgaatggag aagaagtgtg
     3901 gggctctgtg gggtggaggc tagtgggagg tggtactccc tgatgcagag ttgtggccag
     3961 catcgggtag tgcctaggca tgtgtgccag caagatgttc ctaggtgagt gacagtgagg
     4021 atttggtcac aaaagtccct gacaggctcc tggaaaggtt agtgagtctt ttcctccatc
     4081 aaaaaccctc agctagagta tagagtgatg ctgatagctg ctaggggaag tgagtccctg
     4141 gcagtgtggg actctaccat gagtagcctg cagcagaccc tagcaggatg ggaagtacaa
     4201 agagctgaga ctggtattga aggtcattca caaagcctgg ggtttagaga cagcagaaat
     4261 ctggccttgg tgacatttgg tgacagtttt caggcctgtg ggtgtcagga tagagtcttg
     4321 ggatctggaa caagttactc ttcactgaca ggtttctgag agggagtgcc acaggttcag
     4381 aaaataaagg agataggaat gctgggctca ggaagtcttg caaagctctg tctttatgcc
     4441 aagcaagttt cttcagaagt acctcttgta gacagtgtgt cttgggaaaa taggacataa
     4501 gcagaaagct accatacaat gggatgaagt tggcgggaag ctatcaagcc atgttgcaca
     4561 agggaaacat gggatatctc aagggcatca tagactgagc tcacagtggc cttggaatgt
     4621 ataaattcag tctcttcaga gggaaaagat aagttctcag gaaccaaaat tttactcctt
     4681 catagcccca gcccagacct tgccaagtgt gccttgggtg aggacaccga actgagctct
     4741 ttgtcctctc atggggcgtc ttgagggtgc cttggatcgg cctggctccc aacagcctac
     4801 cagatgattt ttgagcaccc tgtttgctcc tacgtatgtg acgatccaca cgaatgaaga
     4861 cctttgtcca ttatgcttac caaagagtcc atcccttcct ggcactgcat cctgggagta
     4921 tgtgtggggt gcactgtacc tctagctgct tacaggtcag gctctcaaca ggcacagctt
     4981 aatttacgaa cacgctcacg tttcgtttat ttttataaac ctttaaagtt gctgatgacg
     5041 ataactatag aaaagccatg ccttaaactg tgaagggact cctcttgggc aggagccggt
     5101 gggatggact cgccatggag gagctgtggc tgcagggagc agtgtggcag ttctgccgat
     5161 ggaggcactt cggggttaga acagcgaatg cccatgccta ggtttgtgcg gggattgaga
     5221 atctagtccg aaaagctgca ctcaccctcg attatgtgca ggctgcgtgt ccacctctcc
     5281 ccacccactg catagaaggc tcatttggtg tgttttacat gtaaagattc tggaagagtc
     5341 aatagtcgat gtcttcataa aggaaaaaca aatcttacta gaaaaactaa gtgaaagtgg
     5401 tctcctggca tgaagtgata tttcctccaa actgtatctg tcagatgttt aattccaact
     5461 agtattttga gggttttaag aactgacatt aaaatattat aaaagaatta tataataaag
     5521 atttgttttt gatgaa
//
