LOCUS       NM_022279               2133 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus MRE11 homolog, double strand break repair
            nuclease (Mre11), mRNA.
ACCESSION   NM_022279
VERSION     NM_022279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2133)
  AUTHORS   Jachimowicz,R.D., Beleggia,F., Isensee,J., Velpula,B.B.,
            Goergens,J., Bustos,M.A., Doll,M.A., Shenoy,A., Checa-Rodriguez,C.,
            Wiederstein,J.L., Baranes-Bachar,K., Bartenhagen,C., Hertwig,F.,
            Teper,N., Nishi,T., Schmitt,A., Distelmaier,F., Ludecke,H.J.,
            Albrecht,B., Kruger,M., Schumacher,B., Geiger,T., Hoon,D.S.B.,
            Huertas,P., Fischer,M., Hucho,T., Peifer,M., Ziv,Y.,
            Reinhardt,H.C., Wieczorek,D. and Shiloh,Y.
  TITLE     UBQLN4 Represses Homologous Recombination and Is Overexpressed in
            Aggressive Tumors
  JOURNAL   Cell 176 (3), 505-519 (2019)
   PUBMED   30612738
REFERENCE   2  (bases 1 to 2133)
  AUTHORS   Coquel,F., Silva,M.J., Techer,H., Zadorozhny,K., Sharma,S.,
            Nieminuszczy,J., Mettling,C., Dardillac,E., Barthe,A.,
            Schmitz,A.L., Promonet,A., Cribier,A., Sarrazin,A., Niedzwiedz,W.,
            Lopez,B., Costanzo,V., Krejci,L., Chabes,A., Benkirane,M., Lin,Y.L.
            and Pasero,P.
  TITLE     SAMHD1 acts at stalled replication forks to prevent interferon
            induction
  JOURNAL   Nature 557 (7703), 57-61 (2018)
   PUBMED   29670289
REFERENCE   3  (bases 1 to 2133)
  AUTHORS   Kottemann,M.C., Conti,B.A., Lach,F.P. and Smogorzewska,A.
  TITLE     Removal of RTF2 from Stalled Replisomes Promotes Maintenance of
            Genome Integrity
  JOURNAL   Mol Cell 69 (1), 24-35 (2018)
   PUBMED   29290612
REFERENCE   4  (bases 1 to 2133)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   5  (bases 1 to 2133)
  AUTHORS   Naccarati,A., Rosa,F., Vymetalkova,V., Barone,E., Jiraskova,K., Di
            Gaetano,C., Novotny,J., Levy,M., Vodickova,L., Gemignani,F.,
            Buchler,T., Landi,S., Vodicka,P. and Pardini,B.
  TITLE     Double-strand break repair and colorectal cancer: gene variants
            within 3' UTRs and microRNAs binding as modulators of cancer risk
            and clinical outcome
  JOURNAL   Oncotarget 7 (17), 23156-23169 (2016)
   PUBMED   26735576
REFERENCE   6  (bases 1 to 2133)
  AUTHORS   Lombard,D.B. and Guarente,L.
  TITLE     Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear
            bodies and meiotic telomeres
  JOURNAL   Cancer Res 60 (9), 2331-2334 (2000)
   PUBMED   10811102
REFERENCE   7  (bases 1 to 2133)
  AUTHORS   Trujillo,K.M., Yuan,S.S., Lee,E.Y. and Sung,P.
  TITLE     Nuclease activities in a complex of human recombination and DNA
            repair factors Rad50, Mre11, and p95
  JOURNAL   J Biol Chem 273 (34), 21447-21450 (1998)
   PUBMED   9705271
REFERENCE   8  (bases 1 to 2133)
  AUTHORS   Paull,T.T. and Gellert,M.
  TITLE     The 3' to 5' exonuclease activity of Mre 11 facilitates repair of
            DNA double-strand breaks
  JOURNAL   Mol Cell 1 (7), 969-979 (1998)
   PUBMED   9651580
REFERENCE   9  (bases 1 to 2133)
  AUTHORS   Carney,J.P., Maser,R.S., Olivares,H., Davis,E.M., Le Beau,M.,
            Yates,J.R. 3rd, Hays,L., Morgan,W.F. and Petrini,J.H.
  TITLE     The hMre11/hRad50 protein complex and Nijmegen breakage syndrome:
            linkage of double-strand break repair to the cellular DNA damage
            response
  JOURNAL   Cell 93 (3), 477-486 (1998)
   PUBMED   9590181
REFERENCE   10 (bases 1 to 2133)
  AUTHORS   Xiao,Y. and Weaver,D.T.
  TITLE     Conditional gene targeted deletion by Cre recombinase demonstrates
            the requirement for the double-strand break repair Mre11 protein in
            murine embryonic stem cells
  JOURNAL   Nucleic Acids Res 25 (15), 2985-2991 (1997)
   PUBMED   9224597
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF218574.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF218574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..2133
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /note="MRE11 homolog, double strand break repair nuclease"
                     /db_xref="GeneID:64046"
                     /db_xref="RGD:69263"
     exon            1..29
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2130
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /function="recombinational repair of DNA double-strand
                     breaks"
                     /function="telomere length maintenance"
                     /function="essential for murine embryonic stem cell
                     viability"
                     /note="double-strand break repair protein MRE11A; MRE11
                     homolog 1; meiotic recombination 11 homolog 1; meiotic
                     recombination 11 homolog A; MRE11 meiotic recombination 11
                     homolog A; MRE11 homolog, double strand break repair
                     nuclease A; MRE11 homolog A, double strand break repair
                     nuclease"
                     /codon_start=1
                     /product="double-strand break repair protein MRE11"
                     /protein_id="NP_071615.1"
                     /db_xref="GeneID:64046"
                     /db_xref="RGD:69263"
                     /translation="MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEIL
                     RLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFG
                     FSKFPWVNYRDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVE
                     KVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQ
                     NRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRNEQQLFYVSQPGSSVVTALSP
                     GETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSLFNPDNPKVTQAIQS
                     FCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANP
                     KDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLSLL
                     TERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRES
                     RQRNTNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVP
                     SRGRGRGRGRRGGRGQSTAPRGGSQRGRDTGLGISTRGRSSKATASTSRNMSIIDAFR
                     STRQQPSRNVATKNYSETIEVDESDDDDSFPTSSRADQRWSGTAPSKRMSQSQTAKGV
                     DFESDEDDDDDPFMSGSCPRRNRR"
     exon            30..162
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            163..323
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            324..411
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            412..553
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            554..668
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            669..854
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1026
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1107
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1234
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1338
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1512
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1575
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1792
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1873
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1932
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..1997
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2073
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2133
                     /gene="Mre11"
                     /gene_synonym="Mre11a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actataaaaa tgagccccac agatccgctt gatgatgaag acacatttaa aatcctggtt
       61 gccactgata ttcatcttgg atttatggaa aaagatgcag ttagaggaaa tgacacattt
      121 gtgacatttg atgaaatttt aagacttgcc ctggaaaatg aagtggattt tattttgtta
      181 ggtggtgatc ttttccatga aaacaagccc tcaaggaaaa ccctgcacag ctgcttagag
      241 ctgcttagga agtactgtat gggtgaccgc cctgtgcaat ttgagatcat cagtgaccag
      301 tcagtcaact ttggttttag taagtttcca tgggtgaact accgggatgg caatctcaac
      361 atctccattc cagtgtttag tatccacggc aaccatgatg atcccacagg ggcagatgcc
      421 ctctgtgccc tggatgtttt aagctgtgct gggtttgtga atcactttgg acggtcaatg
      481 tctgtggaga aggttgacat tagtccagtt ctgctgcaga aaggaagcac aaaactcgct
      541 ctgtacggct tagggtccat tccagatgaa aggctctatc ggatgtttgt caataagaaa
      601 gtaacgatgt tgaggcctaa ggaagacgag aactcatggt ttaacttatt cgtgattcat
      661 cagaacagga gtaaacacgg aagcaccaac ttcatcccag agcagttttt ggatgacttc
      721 attgacctgg tcatctgggg ccatgaacat gagtgtaaaa tcggcccaac caggaatgag
      781 cagcagctct tctatgtgtc tcagcccgga agctcggtgg tgacagccct ttcccctgga
      841 gaaactgtga agaaacatgt aggcctgcta cgcgttaaag ggagaaagat gaacatgcag
      901 aagctgcctc tccgcacagt gcgacagttc ttcatggaag atgtggtcct ggctaaccac
      961 ccaagcctgt tcaaccctga caatcctaag gtgacccagg ccatccagag cttctgtttg
     1021 gagaagattg aagaaatgct tgacagtgct gagcgggaac ggctggggaa tcctcagcag
     1081 ccggagaagc ctctcatccg actacgggtg gactacagtg gaggctttga acctttcaac
     1141 gttcttcgtt ttagccagaa gtttgtggat cgggttgcta acccaaaaga tgtcatccac
     1201 tttttcagac acagggaaca aaaaggaaaa acaggagaag agatcaactt tgggaagctc
     1261 atcataaaac ctgcttcaga agggacgacg ctcagagtag aagaccttgt aaagcagtat
     1321 ttccaaactg cagagaagaa tgttcagctc tcactgctga cagaaagagg gatgggtgaa
     1381 gcagttcaag agtttgtgga caaggaagag aaagatgcca tcgaggaatt agtgaagtac
     1441 cagttggaga aaacgcagcg gtttcttaag gagcgccaca tcgatgctct agaagacaag
     1501 attgatgaag aggtccggcg tttcagagaa agcagacaga gaaataccaa cgaagaagac
     1561 gatgaagttc gagaggccat gagcagggcc cgggccctca ggtcacagtc ggagaacgcc
     1621 gcctcagcct tcagtgcaga tgacctgagt tttgatataa cagagcagac agcagatgac
     1681 tctgacgata gccagtcagc agtgccgagc cgaggccgag gtcgaggccg aggacgaaga
     1741 ggaggcagag ggcagagcac tgcacccaga ggaggctctc agagaggccg agacactggg
     1801 ctggggatct ctactcgggg caggagctca aaggccactg cgtcaacatc tagaaatatg
     1861 tccattatag atgctttcag atctacccga cagcagcctt ccagaaatgt agccactaag
     1921 aattactcag agaccattga ggtggatgaa tctgatgacg atgacagttt tcctaccagc
     1981 tccagggctg atcaaaggtg gtcgggcaca gcacctagca aacggatgtc ccagagccag
     2041 acagccaaag gggtggactt tgaatcagac gaggacgatg acgacgaccc tttcatgagt
     2101 ggtagttgcc caagaagaaa ccgaagataa tgt
//
