LOCUS       NM_001106123            5233 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mannose receptor, C type 1 (Mrc1), mRNA.
ACCESSION   NM_001106123 XM_001072782 XM_225585
VERSION     NM_001106123.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5233)
  AUTHORS   Urdzikova,L.M., Ruzicka,J., LaBagnara,M., Karova,K., Kubinova,S.,
            Jirakova,K., Murali,R., Sykova,E., Jhanwar-Uniyal,M. and
            Jendelova,P.
  TITLE     Human mesenchymal stem cells modulate inflammatory cytokines after
            spinal cord injury in rat
  JOURNAL   Int J Mol Sci 15 (7), 11275-11293 (2014)
   PUBMED   24968269
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5233)
  AUTHORS   Carvalho,L.A., Nobrega,A.F., Soares,I.D., Carvalho,S.L., Allodi,S.,
            Baetas-da-Cruz,W. and Cavalcante,L.A.
  TITLE     The mannose receptor is expressed by olfactory ensheathing cells in
            the rat olfactory bulb
  JOURNAL   J Neurosci Res 91 (12), 1572-1580 (2013)
   PUBMED   24105692
  REMARK    GeneRIF: This study confirmed the occurrence of a mannose-specific
            C-type lectin receptor in olfactory ensheathing cells
REFERENCE   3  (bases 1 to 5233)
  AUTHORS   Ohnishi,H., Oka,K., Mizuno,S. and Nakamura,T.
  TITLE     Identification of mannose receptor as receptor for hepatocyte
            growth factor beta-chain: novel ligand-receptor pathway for
            enhancing macrophage phagocytosis
  JOURNAL   J Biol Chem 287 (16), 13371-13381 (2012)
   PUBMED   22354962
  REMARK    GeneRIF: The HGF-beta.MR complex may provide a new pathway for the
            enhancement of cell clearance systems, which is associated with
            resolution of inflammation.
REFERENCE   4  (bases 1 to 5233)
  AUTHORS   Squadrito,M.L., Pucci,F., Magri,L., Moi,D., Gilfillan,G.D.,
            Ranghetti,A., Casazza,A., Mazzone,M., Lyle,R., Naldini,L. and De
            Palma,M.
  TITLE     miR-511-3p modulates genetic programs of tumor-associated
            macrophages
  JOURNAL   Cell Rep 1 (2), 141-154 (2012)
   PUBMED   22832163
REFERENCE   5  (bases 1 to 5233)
  AUTHORS   Alter,A., de Leseleuc,L., Van Thuc,N., Thai,V.H., Huong,N.T.,
            Ba,N.N., Cardoso,C.C., Grant,A.V., Abel,L., Moraes,M.O., Alcais,A.
            and Schurr,E.
  TITLE     Genetic and functional analysis of common MRC1 exon 7 polymorphisms
            in leprosy susceptibility
  JOURNAL   Hum Genet 127 (3), 337-348 (2010)
   PUBMED   20035344
REFERENCE   6  (bases 1 to 5233)
  AUTHORS   Lai,J., Bernhard,O.K., Turville,S.G., Harman,A.N., Wilkinson,J. and
            Cunningham,A.L.
  TITLE     Oligomerization of the macrophage mannose receptor enhances
            gp120-mediated binding of HIV-1
  JOURNAL   J Biol Chem 284 (17), 11027-11038 (2009)
   PUBMED   19224860
  REMARK    GeneRIF: macrophage mannose receptor oligomerization enhances
            gp120-mediated binding of HIV-1
REFERENCE   7  (bases 1 to 5233)
  AUTHORS   Harris,N., Super,M., Rits,M., Chang,G. and Ezekowitz,R.A.
  TITLE     Characterization of the murine macrophage mannose receptor:
            demonstration that the downregulation of receptor expression
            mediated by interferon-gamma occurs at the level of transcription
  JOURNAL   Blood 80 (9), 2363-2373 (1992)
   PUBMED   1421407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Aug 8, 2013 this sequence version replaced NM_001106123.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1934707.1,
                                           SRR26643290.50517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000017.1  82157725-82157890
            167-568             JAXUCZ010000017.1  82167156-82167557
            569-742             JAXUCZ010000017.1  82171294-82171467
            743-907             JAXUCZ010000017.1  82175317-82175481
            908-1021            JAXUCZ010000017.1  82183560-82183673
            1022-1168           JAXUCZ010000017.1  82188136-82188282
            1169-1354           JAXUCZ010000017.1  82190593-82190778
            1355-1512           JAXUCZ010000017.1  82193444-82193601
            1513-1623           JAXUCZ010000017.1  82194530-82194640
            1624-1739           JAXUCZ010000017.1  82199612-82199727
            1740-1888           JAXUCZ010000017.1  82202870-82203018
            1889-2088           JAXUCZ010000017.1  82205368-82205567
            2089-2216           JAXUCZ010000017.1  82209189-82209316
            2217-2304           JAXUCZ010000017.1  82210146-82210233
            2305-2449           JAXUCZ010000017.1  82211356-82211500
            2450-2491           JAXUCZ010000017.1  82212980-82213021
            2492-2655           JAXUCZ010000017.1  82214165-82214328
            2656-2723           JAXUCZ010000017.1  82215453-82215520
            2724-2824           JAXUCZ010000017.1  82216878-82216978
            2825-2967           JAXUCZ010000017.1  82217645-82217787
            2968-3082           JAXUCZ010000017.1  82218515-82218629
            3083-3249           JAXUCZ010000017.1  82222670-82222836
            3250-3352           JAXUCZ010000017.1  82224278-82224380
            3353-3585           JAXUCZ010000017.1  82229468-82229700
            3586-3751           JAXUCZ010000017.1  82232126-82232291
            3752-3901           JAXUCZ010000017.1  82233209-82233358
            3902-4015           JAXUCZ010000017.1  82235000-82235113
            4016-4180           JAXUCZ010000017.1  82235646-82235810
            4181-4222           JAXUCZ010000017.1  82237130-82237171
            4223-5233           JAXUCZ010000017.1  82238401-82239411
FEATURES             Location/Qualifiers
     source          1..5233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..5233
                     /gene="Mrc1"
                     /note="mannose receptor, C type 1"
                     /db_xref="GeneID:291327"
                     /db_xref="RGD:1309353"
     exon            1..166
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..4476
                     /gene="Mrc1"
                     /note="macrophage mannose receptor 1"
                     /codon_start=1
                     /product="macrophage mannose receptor 1 precursor"
                     /protein_id="NP_001099593.2"
                     /db_xref="GeneID:291327"
                     /db_xref="RGD:1309353"
                     /translation="MRLPLLLAFISVIPVAVQLLDSRQFLIYNEDHKRCVDALSAISV
                     QTATCNPEAESQKFRWVSESQIMSVAFKLCLGVPSKTDWASVTLYACDSKSEFQKWEC
                     KNDTLFGIKGTELYFNYGNRQEKNIKLYKGSGLWSRWKVYGTTDDLCSRGYEAMYSLL
                     GNANGAVCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGFCPLQFEGSKR
                     LWNTDPLTGILYQINSKSALTWHQARASCKQQNAELLSVTEIHEQMYLTGLTSSLTSG
                     LWIGLNSLSLSTGWQWAGGSPFRYLNWLPGSPSSEPGKSCVSLNPGKNAKWENLECVQ
                     KLGYICKKGNNTLNPFIIPSESDVPTACPNQWWPYAGHCYRIYREEKKIQKYALQACR
                     KEGGDLASIHSIEEFDFIFSQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLP
                     GEPSHENNRQEDCVVMKGKDGYWADRACEQPLGYICKMVSQIHTVIPEGAEKGCRKGW
                     KRHGFYCYLIGSTLSTFADANQTCTNEKAYLTTVEDRYEQAFLTSLVGLRPEKYFWTG
                     LSDVQNKGTFRWTVDEQVQFTHWNADMPGRKAGCVAMKTGVAGGLWDVLSCEEKAKFV
                     CKHWAEGVTRPPEPTTTPEPKCPEDWGTTSKTSMCFKLYAKGKHEKKTWFESRDFCKA
                     IGGELASIKSKDEQQVIWRLITSSGSYHELFWLGLTYGSPSEGFTWSDGSPVSYENWA
                     YGEPNNYQNVEYCGELKGDPGMSWNDINCEHLNNWICQIQKGKTLLPEPTPAPQDNPP
                     VTADGWVIYKDYQYYFSKEKETMDNARAFCKKNFGDLATIKSESEKKFLWKYINKNGG
                     QSPYFIGLLISLDKKFIWMDGSKVDFVAWATGEPNFANDDENCVTMYTNSGFWNDINC
                     GYPNNFICQRHNSSINATAMPTTPPTPGGCKEGWHLYNNKCFKIFGFAEEEKKTWKEA
                     RKACIGLKGNLVSIENAKEQAFVTYHMRDSTFNAWTGLNDVNSEHTFLWTDGRGVHYT
                     NWGKGYPGGRRSSLSYEDVDCVVVIGGNSREAGTWMDSTCDSKQGYICQTQTDPSVPI
                     SPTTAPKDGFVKYGKSSYALMKLKSPWHEAEKYCKDRTSLLASILDPYSNAFAWMKMH
                     PFNVPIWIALNSNLTNNEYTWTDKWRVRYTNWGTDEPKLKSACVYMDVDGYWKTSYCN
                     ESFYFLCKKSDEIPATEPPQLPGKCPESEQTAWIPFHGHCYYIESSFTRSWGQASLEC
                     LRMGASLVSIETAAESSFLSYRVEPLKSKTNFWIGMFRNVEGKWLWLNDNPVSFVNWK
                     TGDPSGERNDCVVLSSSSGLWNNIHCTSYKGFICKMPKIIDPVTTHSSITTKADQRKM
                     DPQPKGSSKAAGVVIVVLLIVIGAGVAAYFFYKKRRVLHIPQEATFENTLYFNSNPSP
                     GTSDTKDLVGNIEQNEHAVI"
     exon            167..568
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..742
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..907
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1021
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1168
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1354
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1512
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1623
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1739
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1888
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2088
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2216
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2304
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2449
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2491
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2655
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2723
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2824
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2967
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3082
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3249
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3352
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3585
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3751
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..3901
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..4015
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4016..4180
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4181..4222
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4223..5233
                     /gene="Mrc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccctggac taagccaagg ggcaacccgg ggacttgggc tgtattcttt ggcttttctt
       61 ttcccctttc cctcttctcc ctcaatggaa cacacactct gggccatgag actccccctg
      121 ctcctggctt ttatctctgt gattccggtc gctgttcaac tcttggactc acggcaattt
      181 ttaatctata atgaggacca caagcgctgc gtggacgctc taagcgccat ctccgttcag
      241 acggcaactt gcaacccgga agctgaatcc cagaaattcc gctgggtgtc ggagtcgcag
      301 atcatgagtg ttgctttcaa attgtgtttg ggggtgccat cgaaaactga ctgggcctcc
      361 gtcaccctgt atgcctgcga ctcgaaaagt gaatttcaga aatgggagtg taaaaacgac
      421 acactctttg gaatcaaggg cacagagcta tattttaact atggcaacag gcaagaaaag
      481 aatatcaagc tttacaaagg ttccggtttg tggagcagat ggaaggtcta cgggaccaca
      541 gatgacctgt gctctagggg atatgaagcc atgtactcct tactgggcaa tgcaaacgga
      601 gctgtctgtg catttccatt caagtttgaa aacaagtggt acgcagactg cacctctgcc
      661 gggcggtcag atggatggct ctggtgtgga accaccactg actatgacac cgacaagctg
      721 tttggatttt gtccactgca gtttgagggc agcaagaggc tgtggaatac agacccactg
      781 actggcattc tttaccagat aaactccaag tctgccttaa cctggcacca ggcaagagca
      841 agctgcaagc agcagaatgc tgagctcctg agtgtcacgg agattcacga gcagatgtac
      901 ctcacaggat tgaccagttc cttgacctct ggactctgga ttggactcaa cagtttaagt
      961 ttaagcactg gctggcagtg ggctggggga agcccattcc ggtatctgaa ctggctacca
     1021 ggaagtccat catcagaacc tggaaagagc tgtgtgtcac taaaccctgg aaaaaatgcc
     1081 aagtgggaga atctggaatg tgttcagaaa cttggctaca tttgtaaaaa aggcaacaat
     1141 actttgaatc catttatcat tccctcggaa agtgatgtgc ctactgcctg ccctaatcag
     1201 tggtggccct atgcaggcca ctgctacagg atctacaggg aagagaagaa gatccagaaa
     1261 tacgctttgc aagcctgtag gaaggagggt ggtgacctgg caagtatcca cagcattgag
     1321 gagtttgact tcatcttctc ccagctagga tacgagccaa atgatgagct gtggattggt
     1381 ttaaatgaca tcaagattca gatgtacttt gagtggagcg atgggacccc ggtgacattt
     1441 actaaatggc ttcccggaga gccgagccat gagaacaaca ggcaggagga ctgcgtggtg
     1501 atgaaaggga aggatggata ctgggcagat agagcttgtg agcaaccact gggttacatc
     1561 tgtaagatgg tctcacaaat ccacactgta ataccagagg gtgcagaaaa aggctgccgg
     1621 aaaggctgga aacggcatgg gttttactgc tacttgattg gatccaccct ttcaacgttc
     1681 gctgatgcaa accaaacatg cacaaatgag aaggcttatt tgacaacagt tgaagacaga
     1741 tatgaacaag cattcctgac tagtttggtt ggattgaggc ctgaaaaata tttttggaca
     1801 ggactctcag atgttcaaaa caaagggacg tttcggtgga ctgtggacga gcaggtgcag
     1861 tttacacact ggaacgctga catgccagga cgaaaggcag gatgcgttgc tatgaaaact
     1921 ggagtggcag gtggtttatg ggatgttttg agttgtgaag aaaaggcaaa atttgtgtgc
     1981 aaacactggg cagaaggagt aactcgtcca ccagagccca caacaactcc tgaacccaaa
     2041 tgtccagaag actggggtac caccagtaaa accagcatgt gtttcaagct gtatgcaaaa
     2101 ggaaaacatg aaaagaaaac gtggtttgag tctcgagatt tttgcaaagc tattggggga
     2161 gagctggcga gcatcaagag taaagatgaa cagcaagtga tctggaggct gattacgagc
     2221 agtggaagct accatgagct gttttggctg ggactgacct atggaagtcc ttcagagggg
     2281 ttcacctgga gtgatggttc tcctgtttcc tatgaaaatt gggcttatgg agagccaaat
     2341 aattaccaaa acgttgaata ttgtggtgag ttgaaaggtg accccggcat gtcctggaat
     2401 gatattaact gtgaacacct caacaactgg atctgtcaga tccaaaaagg gaaaacacta
     2461 ctacccgagc ctacacccgc tcctcaagac aatccaccag tgactgcaga tgggtgggtt
     2521 atttacaaag actaccagta ctatttcagc aaggagaagg aaaccatgga caacgcgcgg
     2581 gccttctgca agaagaattt tggtgatctt gctaccatta aaagcgaaag tgaaaagaag
     2641 tttctgtgga aatatataaa caagaatggt gggcagtcac cgtattttat tggcctgttg
     2701 atcagcttgg ataagaagtt catttggatg gacggaagca aagtcgattt tgtagcttgg
     2761 gctacggggg aacccaactt tgcaaatgat gatgaaaact gtgtaacaat gtacacaaat
     2821 tcagggttct ggaatgatat caactgcggt tatccaaata acttcatctg ccagcgacat
     2881 aatagcagca tcaatgccac tgccatgcct accacacccc caactccagg tggctgcaag
     2941 gaaggttggc atttgtacaa caacaagtgc tttaaaattt ttgggtttgc tgaagaagag
     3001 aaaaagacct ggaaagaggc acggaaagct tgcataggat tgaaaggaaa cctggtgtcc
     3061 atagagaatg caaaagagca agcatttgtc acttatcaca tgagagactc cactttcaac
     3121 gcctggactg gactgaatga cgtcaactca gagcacacgt tcctttggac agacggacga
     3181 ggagttcatt atacaaactg ggggaaaggc tatcccggcg gaaggagaag cagtctgtcg
     3241 tacgaagatg ttgactgtgt tgttgtgatt ggtggcaatt cacgagaggc agggacctgg
     3301 atggatagca cctgtgacag taaacaaggc tatatatgcc aaacacagac cgacccttct
     3361 gtgcctatct ctccaaccac ggcaccaaaa gatggctttg ttaagtatgg taaaagcagc
     3421 tatgccctta tgaaattgaa gtcgccatgg cacgaagcag agaaatactg caaggatcgt
     3481 acttccctgc ttgccagcat tcttgacccc tatagtaatg catttgcatg gatgaaaatg
     3541 cacccattta atgtacccat atggattgcc ctgaacagca acttgaccaa caatgagtac
     3601 acttggacag ataaatggag ggtgcggtac actaactggg gaactgatga acccaagctt
     3661 aagtcagcat gcgtttacat ggatgtcgat ggctactgga agacatcata ctgcaatgaa
     3721 agcttttact ttctctgcaa aaaatcagac gaaatcccgg ctacggaacc cccacagctg
     3781 cctggcaaat gtccagagtc agagcaaact gcgtggatcc ctttccacgg ccactgttac
     3841 tacattgaat cttcttttac aaggagttgg ggtcaagcct ccctggagtg ccttcgaatg
     3901 ggtgcctccc tggtttccat cgagactgct gccgaatcca gttttctgtc ataccgtgtt
     3961 gaacctctta aaagtaaaac caatttttgg ataggcatgt tccgaaatgt tgaaggaaag
     4021 tggctttggt tgaatgacaa tcctgtgtcc tttgtcaact ggaaaacggg tgacccttcg
     4081 ggtgaacgga atgattgtgt agttctatct tcatcttctg gcctttggaa taatatccac
     4141 tgtacttcat acaaaggatt tatttgtaaa atgccaaaaa ttattgatcc tgtaactaca
     4201 cattcatcta ttacaaccaa agctgaccaa aggaagatgg atcctcaacc caagggctct
     4261 tccaaagcag cgggagtggt catcgtggtc cttctgattg tgataggtgc cggtgttgcg
     4321 gcctatttct tttacaagaa aaggcgtgta ctgcacatac ctcaagaggc cacctttgaa
     4381 aacactctct acttcaacag taatccaagt cctggaacaa gtgacacgaa agatctcgtg
     4441 ggcaacatcg aacagaatga gcatgcggtc atttagcatc gtaatgtgac tgtcttatat
     4501 ttcaagttca tgaagcctta actaaaattt tcagtttgtt aattcaatat gatcgtttct
     4561 tctaaaaagt tagcactggg ttgcattggc ctgtcttttt tttttttttt ttttcctttg
     4621 cctaatggaa cgataactgc tcattttcta tcctggcaag attagagaaa caaaaaacaa
     4681 aagagggata gtaaggctgc ttgttgattg ccactttcga agataccctt ggtgaacacg
     4741 cagcattaca gtctcaacac cgctacgctg gtggtggtag gtctcatgtc aactctgcag
     4801 atttcaagag ctctagaaat aaccacgtaa gctgctcagg gtcttttcag gacctcccag
     4861 agatgagtta tacactcact tgtaaatcaa cagttagaag accgtgttaa gataaacaag
     4921 tacacataac cccagacgga atgtactcag tttctttttc aacagtcctg attcatggca
     4981 attattgaga actgtattta tccatatgta aaataataaa cgatgctgag aatcttgttt
     5041 gtcccaggca aggtttgaca ggttaaatat tacaaatgtg ttctgttgta tgtatattag
     5101 ggaagtgatt atgtgaagaa aaaaaaaccc tgtaaattta cataactggg cgtacttaga
     5161 taataaataa tgctatttat tatctaattg atgtgatgaa ctaatgtgaa ataaacatta
     5221 aagatgacat cta
//
