LOCUS       NM_012981               4003 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus muscle RAS oncogene homolog (Mras), transcript
            variant 1, mRNA.
ACCESSION   NM_012981
VERSION     NM_012981.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4003)
  AUTHORS   Higgins,E.M., Bos,J.M., Mason-Suares,H., Tester,D.J.,
            Ackerman,J.P., MacRae,C.A., Sol-Church,K., Gripp,K.W., Urrutia,R.
            and Ackerman,M.J.
  TITLE     Elucidation of MRAS-mediated Noonan syndrome with cardiac
            hypertrophy
  JOURNAL   JCI Insight 2 (5), e91225 (2017)
   PUBMED   28289718
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4003)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   3  (bases 1 to 4003)
  AUTHORS   Saito,Y., Oinuma,I., Fujimoto,S. and Negishi,M.
  TITLE     Plexin-B1 is a GTPase activating protein for M-Ras, remodelling
            dendrite morphology
  JOURNAL   EMBO Rep 10 (6), 614-621 (2009)
   PUBMED   19444311
  REMARK    GeneRIF: Plexin-B1 is a dual functional GTPase activating protein
            for R-Ras and M-Ras, remodelling axon and dendrite morphology,
            respectively.
REFERENCE   4  (bases 1 to 4003)
  AUTHORS   Willard,F.S., Willard,M.D., Kimple,A.J., Soundararajan,M.,
            Oestreich,E.A., Li,X., Sowa,N.A., Kimple,R.J., Doyle,D.A.,
            Der,C.J., Zylka,M.J., Snider,W.D. and Siderovski,D.P.
  TITLE     Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras
            effector
  JOURNAL   PLoS One 4 (3), e4884 (2009)
   PUBMED   19319189
REFERENCE   5  (bases 1 to 4003)
  AUTHORS   Sun,P., Watanabe,H., Takano,K., Yokoyama,T., Fujisawa,J. and
            Endo,T.
  TITLE     Sustained activation of M-Ras induced by nerve growth factor is
            essential for neuronal differentiation of PC12 cells
  JOURNAL   Genes Cells 11 (9), 1097-1113 (2006)
   PUBMED   16923128
  REMARK    GeneRIF: M-Ras is essential for neuronal differentiation in PC12
            cells by inducing sustained activation of ERK pathway.
REFERENCE   6  (bases 1 to 4003)
  AUTHORS   Rebhun,J.F., Castro,A.F. and Quilliam,L.A.
  TITLE     Identification of guanine nucleotide exchange factors (GEFs) for
            the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction
  JOURNAL   J Biol Chem 275 (45), 34901-34908 (2000)
   PUBMED   10934204
REFERENCE   7  (bases 1 to 4003)
  AUTHORS   Matsumoto,K., Asano,T. and Endo,T.
  TITLE     Novel small GTPase M-Ras participates in reorganization of actin
            cytoskeleton
  JOURNAL   Oncogene 15 (20), 2409-2417 (1997)
   PUBMED   9395237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 20, 2020 this sequence version replaced NM_012981.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.21028.1, D89863.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               JAXUCZ010000008.1  108875493-108875911 c
            420-629             JAXUCZ010000008.1  108850989-108851198 c
            630-783             JAXUCZ010000008.1  108832486-108832639 c
            784-883             JAXUCZ010000008.1  108830792-108830891 c
            884-963             JAXUCZ010000008.1  108827645-108827724 c
            964-4003            JAXUCZ010000008.1  108823374-108826413 c
FEATURES             Location/Qualifiers
     source          1..4003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4003
                     /gene="Mras"
                     /note="muscle RAS oncogene homolog"
                     /db_xref="GeneID:25482"
                     /db_xref="RGD:3111"
     exon            1..419
                     /gene="Mras"
                     /inference="alignment:Splign:2.1.0"
     exon            420..629
                     /gene="Mras"
                     /inference="alignment:Splign:2.1.0"
     CDS             437..1063
                     /gene="Mras"
                     /EC_number="3.6.5.2"
                     /note="ras-related protein R-Ras3; muscle and microspikes
                     RAS"
                     /codon_start=1
                     /product="ras-related protein M-Ras"
                     /protein_id="NP_037113.2"
                     /db_xref="GeneID:25482"
                     /db_xref="RGD:3111"
                     /translation="MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDP
                     TIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEH
                     VDRFHQLILRVKDRESFPMILVANKVDLMHLRKITRDQGKEMATKYNIPYIETSAKDP
                     PLNVDKTFHDLVRVIRQQVPEKNQKKKKKTKWRGDRATGTHKLQCVIL"
     exon            630..783
                     /gene="Mras"
                     /inference="alignment:Splign:2.1.0"
     exon            784..883
                     /gene="Mras"
                     /inference="alignment:Splign:2.1.0"
     exon            884..963
                     /gene="Mras"
                     /inference="alignment:Splign:2.1.0"
     exon            964..4003
                     /gene="Mras"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggacg gcggcggcgg ccccgctggc tggcgcggag ccgtcagtcg gcagcgcggg
       61 gcccggcggg cgcgggcgag gcgctccctc ctccccgtgc gagcgaggag gcggtggccg
      121 agggtgggaa cccagccccg gcgggagcgc gccgagagcc acccggcagc cctgcgcttt
      181 gttccgttcc ggggctggag gtgtggccgg cgttgtggcc cgttccgcgc tggtcctgct
      241 gcgctacgct gcacccggct gcacccgggc ggcggcgggc tccggctgtg cgtggcctct
      301 gtccctacca cccgctctgg cgtaacggtg tgcagcggag aagtcgctcg tcactccgac
      361 ccaagtagga gggcctggcc ggcgctcaga cagactcctt tgattgtagt catcctgggg
      421 tctgactacc agaagcatgg cgaccagcgc tgttcccagt gacaaccttc ccacatataa
      481 actggtagtg gtgggagatg gcggtgtggg caagagtgct ctcactattc agtttttcca
      541 gaagatcttc gtgcctgact acgaccccac cattgaagac tcctacctga agcatacaga
      601 gatcgacaat caatgggcca tcttggacgt tctggacaca gctgggcagg aggagttcag
      661 tgccatgcgg gagcaataca tgcgcacagg ggatggcttc ctcattgtct actctgtcac
      721 cgacaaggcc agcttcgagc acgtggaccg cttccaccag ctcattctgc gtgtcaagga
      781 cagggagtca ttcccaatga tcctcgtggc caacaaagtg gacctgatgc acctaaggaa
      841 aatcaccagg gaccaaggaa aagaaatggc gaccaaatac aatatcccat atatagaaac
      901 cagtgccaag gacccgcctc tcaacgtgga caaaaccttc catgacctag ttagagtaat
      961 taggcaacag gttccagaga aaaaccagaa gaagaaaaag aagacaaaat ggcgagggga
     1021 cagggccacc ggcactcaca aactacagtg tgtcatcttg tgacagcctg aagccctggg
     1081 catagcaacc gtgaactgcc agccctggga ccagcccact gcctaactgc actgagaacc
     1141 atttctaacc acagcccttg gctctggact gggcacagga agagaacgag ggaggagggg
     1201 caggagcagg caggggctgg ctttgctgct tctcccatgg agacatggag acagcttcca
     1261 aacccttgtt gttgattgag cccagttccc agtctcttgg tgggcttgtt gtttctttta
     1321 actccatagg gctggtttgc tgtggaagtg cttttatcca cattcaacgc accagacaag
     1381 ccatgagcaa gcttcctccc tgaccccgtc cccagtgtct gagctcttgt gtcttttgta
     1441 gatttttaaa ttatttgagt aatgattatt ttattaaaga ggtctgtgcc cattgcctgg
     1501 caaagcccca agtctttggc agacctccga taaatgtctg gaacagggct gttgtcttct
     1561 taactgagtg ttcctagcag tgccaaactc catggatgga tgaaagacgg ccggccgaat
     1621 cgagtggatt cttatcagaa gcctggagtc aaacccagga agcaaacaga ccccagagac
     1681 tggggtggat ttaccttgag ggctttggtg tggttgaaaa tgtcagagat tagaaaataa
     1741 aaccccctcg ccaatacatc cccatccccg cccacactga agtgagagcc agctggaccc
     1801 gcttcacccc tggaggggat tctctctccc tgagtgtgga gaggccactg actggttttg
     1861 cacaagtact catttgcttt cctgctttct gggcagtgga taaattctgt gttcagatgt
     1921 ggacaggacc ttgggcttct cgaaagtgtc cctgtttgct ctcagactgt gtgttgccgt
     1981 gcctctgaca caaacatagg gacatgttca aggagtcgaa ggtgacagct ctgaaccgaa
     2041 ggcactgctg tctgggaagc cccaggactg aagccatctc cacctgggtc agctgaccat
     2101 caccgttatt ggtccggcca atgagcaagc gccttctagc acgagtggta tggctgcctt
     2161 ttgggacaca cttcctttgc tctctggtca aagtggaaga aaagctgagc cggtggcatg
     2221 gcccacacac ttatttcagc agggacacct cccgccatga tgcacccctc cctctctggt
     2281 gctgctagtg gggtagagat tgccttttcc cagctaagat tccccacgga ggaacagcaa
     2341 gaacaaagta caccctgtga gggggtcaga agcggaggtg gcagcatagt tagtgacctg
     2401 tcagctcacc ttgcaaaact gaggctcccc tcagaggctg ggccaatgtg gagaaagaaa
     2461 caggtggaag gaagtccaag gaaatcaggc accgaatgga tgtccagcct cgtgattctt
     2521 tttcaaccca gaaagtccta agttgttcaa acacagggtc atcaggacag aaggccccca
     2581 ttcaagggaa aattctgctg cagaaggaga tgacccaacg cttgtgccag ctagagatca
     2641 aaattcctac ttaccaaact gccacccacc ccgattttta tttctattcc ttaaaaggat
     2701 gccagatgag gtatcacacc atttctcgga tcctgtaatc cttacgatta ttttcaacac
     2761 taaaaggacc aggcttgctc cagcctcggg ccacagtagc tgcagcctgg agagaggaca
     2821 gttggaagaa aggtcaggat agtccacact cagggcagca gccactgcca gagaagccat
     2881 gtcctgcctg ccacctgctc ccggcacacc cctgcttctg tggaccagca cctccactgt
     2941 gcagagtggg gactctcccc ggaagcagaa cagctgccta gaccaaagcc cccaagtcac
     3001 acagataacc agaagggagg ctcccagcac ccccggccct ctccgaggca gcagtgcatt
     3061 cagacccatc atccagggca tccattccaa actgcccacg tcctaaactg actgcacatg
     3121 cggatggaca aaccggctgg catcccgcct tctgcagtct ctagagcagg gctttcatct
     3181 cccacaatcc cgccccctcc ccgtgtatga cacgcatagc tgacacatca gaattagaaa
     3241 tgagccctct gacagagttt ccagggaggc agagtatgcc tagtgagtcc ccatcaccag
     3301 ctgacagggg acatcgggaa actgttggcc gtgacaccac aggaccgagg atcctttggg
     3361 tctgtattga gctgtcattc cgaggtcccc tctagccaga aacctgtgtt cccatcacat
     3421 ccgatgcacc cctgcgatcc cctcacccct ggcttctatt gtgtgctgat tttcttccat
     3481 tactctgcca tttcttcata ggttcgtttc tccccctagc catcccctct cccccagtat
     3541 agggctatgc tgtgaccccc tccttctcaa gcaccttgcc acacggggaa catctggatg
     3601 tttcctttag gacttcccca tctccccatg actctcgacg tggagtacct gattggatta
     3661 gtgcggcctg tcttgcctcc caggagagat gacccactga ccatgtcagc tctaatccca
     3721 aagcccctca gacccaccac actaagtcca gagccacaga ggggtctctt cttttagcag
     3781 cccacctggt tggagactcc acattgggtc aggtttaccc agaatgccag atacttgaaa
     3841 cactgagccc tttgtgtgac agtattagca ggtggccgtt gtcatgcggc aagcaagaat
     3901 gatgatgcct ggatatcttg ttgatgcttg agccttttat gtacttttta tcaagtcttt
     3961 gtgtatctct acttattaat aaacaaacag agttcctgtc ttc
//
