LOCUS       NM_001108774            1313 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus melanocortin 2 receptor accessory protein 2
            (Mrap2), mRNA.
ACCESSION   NM_001108774 XM_001065048
VERSION     NM_001108774.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1313)
  AUTHORS   Asai,M., Ramachandrappa,S., Joachim,M., Shen,Y., Zhang,R.,
            Nuthalapati,N., Ramanathan,V., Strochlic,D.E., Ferket,P.,
            Linhart,K., Ho,C., Novoselova,T.V., Garg,S., Ridderstrale,M.,
            Marcus,C., Hirschhorn,J.N., Keogh,J.M., O'Rahilly,S., Chan,L.F.,
            Clark,A.J., Farooqi,I.S. and Majzoub,J.A.
  TITLE     Loss of function of the melanocortin 2 receptor accessory protein 2
            is associated with mammalian obesity
  JOURNAL   Science 341 (6143), 275-278 (2013)
   PUBMED   23869016
  REMARK    Erratum:[Science. 2013 Aug 30;341(6149):959]
REFERENCE   2  (bases 1 to 1313)
  AUTHORS   Sebag,J.A. and Hinkle,P.M.
  TITLE     Regulation of G protein-coupled receptor signaling: specific
            dominant-negative effects of melanocortin 2 receptor accessory
            protein 2
  JOURNAL   Sci Signal 3 (116), ra28 (2010)
   PUBMED   20371771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1313)
  AUTHORS   Chan,L.F., Webb,T.R., Chung,T.T., Meimaridou,E., Cooray,S.N.,
            Guasti,L., Chapple,J.P., Egertova,M., Elphick,M.R., Cheetham,M.E.,
            Metherell,L.A. and Clark,A.J.
  TITLE     MRAP and MRAP2 are bidirectional regulators of the melanocortin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 106 (15), 6146-6151 (2009)
   PUBMED   19329486
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            [WARNING] On Mar 14, 2025 this sequence was replaced by
            NM_001108774.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001065048.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB720474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984015, SAMN14984024
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1313
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="melanocortin 2 receptor accessory protein 2"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
     exon            1..69
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            70..182
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            183..316
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..807
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /codon_start=1
                     /product="melanocortin-2 receptor accessory protein 2"
                     /protein_id="NP_001102244.1"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
                     /translation="MEMSAQRLTSNRTSPQSPSNSDYTWEYEYYEIGPVSFEGLKAHK
                     YSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGKPLES
                     DKVFSRQGNEESRSLFHCYINEVEHLDRVKVCHRTTAIDSDVHLQEAIRSSGRPEEEL
                     TRFMQFDIPNFVNTDQNSFGEDDLLISEPPVLLENKPVSQTSRTDLD"
     exon            317..416
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            417..1313
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgaacaca attatgcaaa acctgaatga tgctaaaccc ctgccgaagg gaaggcaagc
       61 ctcagacagg ggaacgactt aattcctgac actggcaggt atctgggccc tggcagttaa
      121 ctctttggac attgtgaatt ggatacgctg tgaagggctc tctgaccagc attgcaaact
      181 aggatggaga tgtctgccca gaggctgact tctaacagaa catccccaca gtcaccatct
      241 aactctgact atacctggga atacgagtac tatgagatcg gaccggtttc cttcgaagga
      301 ctgaaggctc acaaatattc catcgtgatt ggattctggg ttggtcttgc ggtctttgtg
      361 attttcatgt tttttgtgct gactttgctg acaaagacag gcgccccaca ccaagacaat
      421 gcggagtcct cagagaagag gttccgaatg aacagctttg tgtcagactt tgggaagccc
      481 ctggagtcag acaaggtgtt ttctcgtcag ggcaatgagg agtccaggtc tctgttccac
      541 tgttacatca atgaagtgga acacttggac agggttaaag tttgccaccg aacaacagcc
      601 attgacagcg atgtccatct ccaggaagcc atcagaagca gtgggaggcc tgaggaggag
      661 ctaaccaggt ttatgcagtt tgacatcccc aacttcgtga acacagacca gaactccttt
      721 ggggaggatg atcttcttat ttcggaacca cctgttcttc tagaaaataa gccagtttcc
      781 cagacatcac gtacagacct ggactgagac acacttgtgg gtgccttcct gaggatgtgt
      841 tctgtttctg tgcagcaaga aaccacatgc tacctacact tgtgtgtgtg tgtgtggaga
      901 gagagagaga gagagagaga gggagggaga gagagagaga gagagagggg gagggaggag
      961 gcggcagcgg gtggggaaga ggatgatgtt taaagtttaa gacctaggct aggactggga
     1021 tttagtgata gaggggcaga atttgaagat gggaggcacc attttgattt ggggagggtg
     1081 atttttttct ctttggatta aaaatgcctt gacagtatta aagcttcttt attgaaacga
     1141 ttagccaaca catgcaattg agctccctcc tgggtgaggg ctagttcgct gcagtcgggt
     1201 ctagcccttt cccaccatcc tctgcctgta acaagctgct ttgcctctct ggactgccat
     1261 ggctttacag gtaaggtggc ctgtccggag tagatgacct atcccagctc tag
//
