LOCUS       NM_001098240            1542 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Rattus norvegicus mitochondrial inner membrane protein MPV17
            (Mpv17), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001098240 XM_001075775 XM_340739
VERSION     NM_001098240.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Dalla Rosa,I., Camara,Y., Durigon,R., Moss,C.F., Vidoni,S.,
            Akman,G., Hunt,L., Johnson,M.A., Grocott,S., Wang,L.,
            Thorburn,D.R., Hirano,M., Poulton,J., Taylor,R.W., Elgar,G.,
            Marti,R., Voshol,P., Holt,I.J. and Spinazzola,A.
  TITLE     MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA
            Replication in Mitochondria
  JOURNAL   PLoS Genet 12 (1), e1005779 (2016)
   PUBMED   26760297
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Li,A., Li,L., Sun,X., Ni,Y., Chen,X., Guo,A. and Chen,X.
  TITLE     Increased Expression of Mitochondrial Inner-Membrane Protein Mpv17
            After Intracerebral Hemorrhage in Adult Rats
  JOURNAL   Neurochem Res 40 (8), 1620-1630 (2015)
   PUBMED   26123482
  REMARK    GeneRIF: Mpv17 expression was increased after intracerebral
            hemorrhage.
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Antonenkov,V.D., Isomursu,A., Mennerich,D., Vapola,M.H., Weiher,H.,
            Kietzmann,T. and Hiltunen,J.K.
  TITLE     The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a
            Non-selective Channel That Modulates Membrane Potential
  JOURNAL   J Biol Chem 290 (22), 13840-13861 (2015)
   PUBMED   25861990
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Spinazzola,A., Viscomi,C., Fernandez-Vizarra,E., Carrara,F.,
            D'Adamo,P., Calvo,S., Marsano,R.M., Donnini,C., Weiher,H.,
            Strisciuglio,P., Parini,R., Sarzi,E., Chan,A., DiMauro,S.,
            Rotig,A., Gasparini,P., Ferrero,I., Mootha,V.K., Tiranti,V. and
            Zeviani,M.
  TITLE     MPV17 encodes an inner mitochondrial membrane protein and is
            mutated in infantile hepatic mitochondrial DNA depletion
  JOURNAL   Nat Genet 38 (5), 570-575 (2006)
   PUBMED   16582910
REFERENCE   5  (bases 1 to 1542)
  AUTHORS   Meyer zum Gottesberge,A.M. and Felix,H.
  TITLE     Abnormal basement membrane in the inner ear and the kidney of the
            Mpv17-/- mouse strain: ultrastructural and immunohistochemical
            investigations
  JOURNAL   Histochem Cell Biol 124 (6), 507-516 (2005)
   PUBMED   16041630
REFERENCE   6  (bases 1 to 1542)
  AUTHORS   Zwacka,R.M., Reuter,A., Pfaff,E., Moll,J., Gorgas,K., Karasawa,M.
            and Weiher,H.
  TITLE     The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein
            producing reactive oxygen species
  JOURNAL   EMBO J 13 (21), 5129-5134 (1994)
   PUBMED   7957077
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091193.1.
            
            On or before May 25, 2007 this sequence version replaced
            XM_340739.2, XM_001075775.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091193.1, DN948643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1542
                     /gene="Mpv17"
                     /gene_synonym="Mpv17l"
                     /note="mitochondrial inner membrane protein MPV17"
                     /db_xref="GeneID:360463"
                     /db_xref="RGD:1310512"
     exon            1..321
                     /gene="Mpv17"
                     /gene_synonym="Mpv17l"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..782
                     /gene="Mpv17"
                     /gene_synonym="Mpv17l"
                     /note="protein Mpv17; Mpv17 transgene, kidney disease
                     mutant-like; MPV17 mitochondrial membrane protein-like;
                     MpV17 mitochondrial inner membrane protein"
                     /codon_start=1
                     /product="mitochondrial inner membrane protein Mpv17"
                     /protein_id="NP_001091710.1"
                     /db_xref="GeneID:360463"
                     /db_xref="RGD:1310512"
                     /translation="MALWRAYQRALAAHPWKVQVLTAGSLMGLGDIISQQLVERRGLQ
                     QHQTGRTLTMASLGCGFVGPVVGGWYRVLDHLIPGTTKVNALKKMLLDQGGFAPCFLG
                     CFLPLVGVLNGMSAQDNWAKLKRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQC
                     VAVVWNSYLSWKAHQL"
     exon            322..437
                     /gene="Mpv17"
                     /gene_synonym="Mpv17l"
                     /inference="alignment:Splign:2.1.0"
     exon            438..530
                     /gene="Mpv17"
                     /gene_synonym="Mpv17l"
                     /inference="alignment:Splign:2.1.0"
     exon            531..626
                     /gene="Mpv17"
                     /gene_synonym="Mpv17l"
                     /inference="alignment:Splign:2.1.0"
     exon            627..659
                     /gene="Mpv17"
                     /gene_synonym="Mpv17l"
                     /inference="alignment:Splign:2.1.0"
     exon            660..712
                     /gene="Mpv17"
                     /gene_synonym="Mpv17l"
                     /inference="alignment:Splign:2.1.0"
     exon            713..1519
                     /gene="Mpv17"
                     /gene_synonym="Mpv17l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtttactt ggggggtgga acccaggctc tgacctcatg agtttctgga ttaggactgg
       61 atgccttact gctgcttctc cagttgtata gtgaccacga ggcaggaacg cggcccagta
      121 agcaactttt ctgcggcctc tgtcatttgc agattttgga agtagggcga gtgaggataa
      181 ggaagtggca ggcatgttct ttactgtgag gtgcagtggg agtgacttct cctcttggtt
      241 tgacaggagg catggcactc tggcgagcat accagagggc cctggctgca catccgtgga
      301 aagtccaggt tctgacagct gggtcactga tgggcctagg tgacattatc tcacagcagc
      361 tggtggaaag gcggggtctc cagcaacacc agactggccg gaccttgacc atggcatccc
      421 ttggctgtgg ctttgtgggc cctgtggtcg gaggctggta cagggttttg gaccacttaa
      481 tccccggcac caccaaggtg aatgcactca agaagatgtt gttagatcag gggggctttg
      541 ccccatgttt ccttggctgc tttctcccac tggtaggggt actcaatgga atgtcagccc
      601 aggacaattg ggccaaactg aagcgggact accccgacgc cctcatcacc aactactatc
      661 tctggcctgc tgtgcagtta gccaacttct acctggtccc cctgcattac aggttggctg
      721 ttgtccagtg cgttgctgtt gtctggaact cctacctgtc ctggaaggca catcagctct
      781 aagcctgccc tgttccgtgg ttcgcacctt gcactgctgc tccgtggccc tctaatgctt
      841 ggacagcttc ttccaactga gcacaacagg actggagagg tggctcagcc gttagagcat
      901 ggactgactg ctctatagga gacctaagtt tggttccaaa cacccacatc gggtagctca
      961 cacctccgtg tctcaagctc caggagatct gatgtcctct tctggcctct gaagcacctg
     1021 cactcacatg tacatatcaa cacatagaca cattcgtaat taagcacaca atgaaatctt
     1081 tttttttttt gggttctttt tttcggagct ggggaccgaa cccagggcct tgcgcttcct
     1141 aggtaagcgc tctaccactg agctaaatcc ccagcccctg aaatctttac aaggagggag
     1201 tgtgtccgtg attcgaggtt gctgatcaga gtagggcgac cactctaaaa acgtaactgc
     1261 ttttgaaatc actaagacct ttatagtatt gctgtcactc tggcacttaa ctgatgggga
     1321 cacactagaa gaattgtgtc ctgagctaga gaaatggctc agaggttaag agcactgact
     1381 gttcttccag aggtcctgag ttcaattccc agcagccaca cagtgtttca caaccatctg
     1441 taatgggatc caatgacctc ttctggtgtg tctgaagaca gcgactattc atatacataa
     1501 ataaatcttt ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
