LOCUS       NM_001414223           12958 bp    mRNA    linear   ROD 10-APR-2024
DEFINITION  Rattus norvegicus myosin phosphatase Rho interacting protein
            (Mprip), transcript variant 4, mRNA.
ACCESSION   NM_001414223 XM_006246422
VERSION     NM_001414223.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12958)
  AUTHORS   Zhang,J., Li,X., Zhang,Z., Zhang,J., Ma,L., Wang,S., Guo,X., Li,H.,
            Pan,B. and Niu,Q.
  TITLE     Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells
            necroptosis
  JOURNAL   Ecotoxicol Environ Saf 270, 115860 (2024)
   PUBMED   38142589
  REMARK    GeneRIF: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced
            PC12 cells necroptosis.
REFERENCE   2  (bases 1 to 12958)
  AUTHORS   He,N., Qu,Y.J., Li,D.Y. and Yue,S.W.
  TITLE     RIP3 Inhibition ameliorates chronic constriction injury-induced
            neuropathic pain by suppressing JNK signaling
  JOURNAL   Aging (Albany NY) 13 (21), 24417-24431 (2021)
   PUBMED   34772825
  REMARK    GeneRIF: RIP3 Inhibition ameliorates chronic constriction
            injury-induced neuropathic pain by suppressing JNK signaling.
REFERENCE   3  (bases 1 to 12958)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12958)
  AUTHORS   Huang,J.F., Shang,L., Zhang,M.Q., Wang,H., Chen,D., Tong,J.B.,
            Huang,H., Yan,X.X., Zeng,L.P. and Xiong,K.
  TITLE     Differential neuronal expression of receptor interacting protein 3
            in rat retina: involvement in ischemic stress response
  JOURNAL   BMC Neurosci 14, 16 (2013)
   PUBMED   23374330
  REMARK    GeneRIF: The results indicated that RIP3 is expressed
            differentially in retinal neurons in adult rats, including subsets
            of ganglion cells, amacrine and horizontal cells. RIP3 protein
            levels are elevated rapidly following aHIOP
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12958)
  AUTHORS   Murakami,Y., Matsumoto,H., Roh,M., Suzuki,J., Hisatomi,T.,
            Ikeda,Y., Miller,J.W. and Vavvas,D.G.
  TITLE     Receptor interacting protein kinase mediates necrotic cone but not
            rod cell death in a mouse model of inherited degeneration
  JOURNAL   Proc Natl Acad Sci U S A 109 (36), 14598-14603 (2012)
   PUBMED   22908283
REFERENCE   6  (bases 1 to 12958)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   7  (bases 1 to 12958)
  AUTHORS   Riddick,N., Ohtani,K. and Surks,H.K.
  TITLE     Targeting by myosin phosphatase-RhoA interacting protein mediates
            RhoA/ROCK regulation of myosin phosphatase
  JOURNAL   J Cell Biochem 103 (4), 1158-1170 (2008)
   PUBMED   17661354
  REMARK    GeneRIF: myosin phosphatase-rho interacting protein is a scaffold
            linking RhoA to regulate myosin phosphatase at the stress fiber.
REFERENCE   8  (bases 1 to 12958)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
REFERENCE   9  (bases 1 to 12958)
  AUTHORS   Mulder,J., Ariaens,A., van Horck,F.P. and Moolenaar,W.H.
  TITLE     Inhibition of RhoA-mediated SRF activation by p116Rip
  JOURNAL   FEBS Lett 579 (27), 6121-6127 (2005)
   PUBMED   16243315
REFERENCE   10 (bases 1 to 12958)
  AUTHORS   Mulder,J., Poland,M., Gebbink,M.F., Calafat,J., Moolenaar,W.H. and
            Kranenburg,O.
  TITLE     p116Rip is a novel filamentous actin-binding protein
  JOURNAL   J Biol Chem 278 (29), 27216-27223 (2003)
   PUBMED   12732640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 16, 2022 this sequence version replaced XM_006246422.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               JAXUCZ010000010.1  44953500-44953936
            438-515             JAXUCZ010000010.1  44988725-44988802
            516-581             JAXUCZ010000010.1  44990533-44990598
            582-733             JAXUCZ010000010.1  45020363-45020514
            734-818             JAXUCZ010000010.1  45024208-45024292
            819-1068            JAXUCZ010000010.1  45027888-45028137
            1069-1579           JAXUCZ010000010.1  45029058-45029568
            1580-1721           JAXUCZ010000010.1  45033150-45033291
            1722-1829           JAXUCZ010000010.1  45034013-45034120
            1830-1886           JAXUCZ010000010.1  45035805-45035861
            1887-1955           JAXUCZ010000010.1  45036827-45036895
            1956-2045           JAXUCZ010000010.1  45040632-45040721
            2046-2155           JAXUCZ010000010.1  45041691-45041800
            2156-2726           JAXUCZ010000010.1  45045351-45045921
            2727-2843           JAXUCZ010000010.1  45047621-45047737
            2844-6647           JAXUCZ010000010.1  45050167-45053970
            6648-6795           JAXUCZ010000010.1  45056949-45057096
            6796-6913           JAXUCZ010000010.1  45058003-45058120
            6914-7073           JAXUCZ010000010.1  45059131-45059290
            7074-7193           JAXUCZ010000010.1  45060558-45060677
            7194-7280           JAXUCZ010000010.1  45061982-45062068
            7281-7443           JAXUCZ010000010.1  45062706-45062868
            7444-7529           JAXUCZ010000010.1  45064423-45064508
            7530-12958          JAXUCZ010000010.1  45067960-45073388
FEATURES             Location/Qualifiers
     source          1..12958
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..12958
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /note="myosin phosphatase Rho interacting protein"
                     /db_xref="GeneID:116504"
                     /db_xref="RGD:619947"
     exon            1..437
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..7601
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /note="isoform 4 is encoded by transcript variant 4; RIP3;
                     rho-interacting protein 3; Rho interacting protein 3"
                     /codon_start=1
                     /product="myosin phosphatase Rho-interacting protein
                     isoform 4"
                     /protein_id="NP_001401152.1"
                     /db_xref="GeneID:116504"
                     /db_xref="RGD:619947"
                     /translation="MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKP
                     IYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQ
                     CTDVVDGEARTGQKFSLCILTPDKEHFIRAETKEIISGWLEMLMVYPRTNKQNQKKKR
                     KVEPPTPQEPGPAKMAVTSSSGGSSGSSSSSSSSSIPSAEKVPTTKSTLWQEEMRAKD
                     QPDGTSLSPVQSPSQSQPPAACTPRETGLDSKEDENILSGDRVDGGRKVRVESGYFSL
                     EKAKQDLRAEEQLPPLLSPPSPSTPHSRYGCPGSPSQELSHPLHSPGLPAPSRMVYSI
                     CPDSLGEASRPPNHMDSSSAGGWGTEILGSTFAFKASRQYAALADVPKAIRISHREAF
                     QVERRRLEHRTRARSPGREEVARLFGNERRRSQVIEKFEALDIEKAEHMETNMLILTT
                     PSSDTRQGRSERRAIPRKRDFASETPTAPLSDACPLSPHRRAKSLDRRSTESSMTPDL
                     LNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEINLSTCYDVTEY
                     PVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVLPTSAPDVTSSLPEGKNKST
                     SFDTCLRPSEKQEAEPGEPDPEQKKSRARERRREGRSKTFDWAEFRPIQQALAQERAS
                     TVGSSDSGDPGCLEAEPGELERERARRREERRKRFGMLDTNDGPGMEDTALRMDIDRS
                     PGLLGTPDLKTQNVHVEIEQRWHQVETTPLREEKQVPIAPLHLSLEDRSERLSTHELT
                     SLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQTEVATSPSGAWQR
                     LHRVNQDLQSELEAQCRRQELITQQIQTLKHSYGEAKDAIRHHEAEIQTLQTRLGDAA
                     AELAIKEQALAKLKGELKLEQGKVREQLEEWQHSKAVLRGQLRASEQKLQSTEALLLE
                     KTQELRDLETKQALQRDRQKEVQRLQECIAELSQQLGTSEQAQRLMEKKLKRNYTLLL
                     ESCEQEKQALLQNLKEVEDKASAYEDQLQGHVQQVEALQKEKLSETCKGTERVHKLQE
                     ELEAREASIRQLAQHVQSLHDERDLIKHQFQELMERVATSDGDVAELQEKLKGREADY
                     QNLEHSHHRVSIQLQSVRTLLREKEEELKLIKEAHERVLEKKDQDLNEALVKMIALGS
                     SLEETEIKLQEKEECLRRFVSDSPKDAKEPQSTTDPTEEDSGILTLGSVTRVFPGFPH
                     SQPEDEDPSASLGEEGSSGSLSREENIIPPKSADMPDREGQLQSTVKSDQGAPVKRPR
                     IRFSTIQCQRYIHPEGCAKAWTSSTSSDTSQDQSPSEDSVSSEATPSTLPAAADAETY
                     ISIIHSLETKLYVTEEKLKDVTVRLESQQGQSQEALLALHQQWAGTEAQLREQLRVSL
                     LQASTLASQLEQERQQKVTNIEHHSGELEDFQAKNSQALTCLENCWEKLRSLPQANQE
                     EGQDACAASLANIESMLVSAIKALQPWASPAESRMQAEKEKGHPMESGIAAPMQQPCQ
                     PILNEQEHRKLLSAQIVLEASLINQIADSLKSTTSNVYGVLCELTQSGEWPLKKESAA
                     PSAGAPMEIWAKKVLVNGEFWSQVESLSKHLGTLGEETACTSADKQQHVPQSLADATW
                     IRAELSYATQSVRELFHHRLQSIQETLQGTQAALQQHKCMLGEILGAYQTPDFERVIQ
                     QILETLRHPTDREDHVQTSWDQSPLGEVLRPGTDGSQEPLQAFHQSPEVLAAIQDELA
                     QQLREKASILEEISAALPVLPPTEPLGGCQRLLQMSQHLSYDACLEGLGQYSSLLVQD
                     AIIQAQVCYAACRIRLEYEKELQFYKKACQEARGASCQKRTQAVGALKEEYEELLHKQ
                     KSEYQKVITLIEKENTELKAKVSQLDHQQRCLQEAESKHSESMFALQGRYEEEIRCMV
                     EQLSHTENTLQAERSRVLSQLDASVKDRQAMEQHHVQQMKMLEDRFQLKVRELQAVHQ
                     EELRALQEHYIWSMRGALSLCQPSHPDSPLAPGPSEPRAVPAAKDEAESMTGLRERIQ
                     ELEAQMGVMREELGHKELEGDVAALQEKYQRDFESLKATCERGFAAMEETHQKKIEDL
                     QRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSINS
                     DIEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQEL
                     NAHNQELNNRLAAEITRLRTLLTGEGGGESTGLPLTQGKDAYELEVLLRVKESEIQYL
                     KQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALG
                     EKSPEGTTVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLKEGLTVQERLKLFES
                     RDLKKD"
     exon            438..515
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..581
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..733
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            734..818
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1068
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1579
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1721
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1829
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1886
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1955
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2045
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2155
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2726
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2843
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..6647
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            6648..6795
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            6796..6913
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            6914..7073
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            7074..7193
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            7194..7280
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            7281..7443
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            7444..7529
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
     exon            7530..12958
                     /gene="Mprip"
                     /gene_synonym="M-rip; Mrip; p116Rip; Rhoip3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgcggtg gcggcgggcg cccggtgagc gcgacggctg gacttgccgg ccggcgcctt
       61 gggggcggcc gcggtggagc cagcggccag aggccgcgtc cgtccatggg cccacagcgg
      121 ccgggcggcg gggcggggcg cgaggcggcg cgcgcgctct gaggccgcgg tgagcaggcg
      181 gggcgcggca cgagagggga ggcctttccg ggcctgcggc ggccagcgca aaatgcggcg
      241 gcggccgcgc tgagtccccg acctccggga gcgcgctggg ccgtggcggc ccgctccgcg
      301 gccccctagc cgacatgtcg gcggccaagg agaacccgtg cagaaaattt caggccaaca
      361 tcttcaacaa gagcaagtgt cagaactgct tcaagccccg cgagtcgcat ctgctcaacg
      421 acgaggacct gacgcaggca aaacccattt atggtggctg gctgctcctg gctccagatg
      481 gcaccgactt tgacaaccca gtacaccggt cacggaaatg gcagcgacga ttcttcatcc
      541 tttatgagca tggcctcttg cgatatgccc tggatgagat gcccaccacc cttcctcagg
      601 gcaccatcaa catgaaccag tgcacagatg tggtggatgg ggaggcccgc acagggcaga
      661 agttctccct ctgcatccta acacctgaca aggaacattt tatcagggca gaaacgaagg
      721 agatcatcag tgggtggtta gagatgctca tggtatatcc tcgaaccaac aagcagaacc
      781 agaagaagaa acggaaagta gagccaccta cgccacagga acctgggcct gctaagatgg
      841 ctgtcactag cagtagtggt ggcagcagtg gaagcagcag cagcagcagc agcagcagca
      901 ttcccagtgc tgagaaggtc cccaccacca aatccacact ctggcaggaa gaaatgagag
      961 ccaaagacca acctgatggg accagcctga gtccagttca gagtcccagc caaagccaac
     1021 ctcctgctgc ttgcacccca cgggaaacag ggctagacag caaagaagat gaaaacattt
     1081 taagtgggga ccgtgtggat ggtggtcgga aagtacgggt agaaagcggc tacttctccc
     1141 tggagaaggc caagcaggac ctgagggctg aggaacagct gcccccacta ctctctccac
     1201 ccagccccag caccccacac agcaggtatg gttgtcctgg atcgccttca caggaactca
     1261 gccaccccct tcactcccca ggtcttccag ccccaagccg catggtctac agcatctgtc
     1321 ctgacagcct gggtgaggcc agcaggccgc ccaaccacat ggactccagc agtgctgggg
     1381 ggtggggaac agagatactg gggagcacct ttgcctttaa agccagcagg cagtatgccg
     1441 ccctggccga cgtccctaag gccatccgga tcagccatcg agaagccttc caggtggaga
     1501 gaaggcggtt ggagcatagg actcgggccc gaagccctgg cagggaagag gtggcccgtc
     1561 tgtttggcaa cgagcggagg aggtcccagg taattgagaa atttgaggcc ttggacattg
     1621 aaaaggcaga gcacatggaa accaacatgc tgattctgac cactccatcc agtgacactc
     1681 gtcagggccg cagtgagaga cgggccatcc ctagaaagcg ggactttgcc agcgaaaccc
     1741 ccacagctcc tctctcagat gcttgtcccc tgtctccaca ccgaagagcc aagtcattgg
     1801 acaggaggtc cacagaatcc tccatgacgc ctgacctgct gaatttcaag aaaggctggc
     1861 taaccaagca gtatgaggat ggccagtgga agaaacactg gtttgtcctg gcagatcaga
     1921 gcctgagata ctacagggat tccgtggctg aggaggcagc tgacctagat ggagaaatta
     1981 acttgtccac ttgctatgat gtcactgagt atccagtcca gagaaactat ggctttcaga
     2041 tacataccaa ggagggtgag ttcaccctgt cggccatgac atctggcata cgacggaact
     2101 ggatccagac cattatgaaa catgtgctcc caacatctgc cccagatgtg accagctcat
     2161 tgcctgaggg aaagaataaa agcacatctt ttgatacctg cttaaggcca agtgagaagc
     2221 aagaagctga gccaggagaa ccagatcctg agcagaagaa aagccgtgca cgagagcgga
     2281 ggcgggaggg tcgctccaag acctttgact gggctgaatt ccgccccatc caacaggccc
     2341 tggctcaaga aagggccagc actgttgggt cttctgattc tggtgaccct gggtgtctgg
     2401 aagccgagcc aggtgagctg gagcgtgaac gagctcgacg gcgagaagaa cgccgcaagc
     2461 gctttgggat gctggacacc aatgatggac caggaatgga ggatacagcc ctacgtatgg
     2521 acattgaccg gagcccaggg ctgctgggaa cccctgacct caagacacag aatgtccatg
     2581 tggaaattga gcagcggtgg caccaagtgg agaccacccc tctcagggag gagaaacagg
     2641 tgcccattgc ccctctgcac ctatccttag aggacagaag tgagcggctc tccacacatg
     2701 agctcacctc tctgctagag aaggagctgg agcagagcca gaaagaagct tcggatcttc
     2761 tagagcagaa tcggcttctg caggaccagt taagggtggc cctgggcaga gaacagagtg
     2821 cccgggaggg ctatgtgctg cagactgaag tggccacctc tccatcgggt gcctggcaga
     2881 ggctccatag agtcaaccaa gacctccaaa gtgagctgga agctcagtgc cggcggcagg
     2941 agctcatcac acagcagatt cagaccctga aacatagcta tggggaggcc aaggatgcaa
     3001 tccggcacca tgaggctgag attcagaccc tgcaaacaag acttggtgat gccgctgcag
     3061 agctggccat taaggagcag gctctagcca agctcaaggg cgagctgaag ctggagcagg
     3121 gcaaggttcg tgagcagctg gaggagtggc agcacagcaa ggccgtgctg cgtggccagc
     3181 tgagggcgag cgagcagaaa ctccagagta cagaagccct gctgttagag aagacacagg
     3241 aactcaggga cctggaaaca aaacaggcat tgcaacgaga ccgacagaag gaggtgcaga
     3301 ggctgcagga atgcattgct gagctcagcc aacagctagg taccagtgag caagcccagc
     3361 gtctgatgga gaagaagttg aagaggaact atacattgtt gctggaaagc tgtgagcagg
     3421 aaaagcaggc actgctgcag aacctgaagg aagtagagga caaggccagt gcctatgagg
     3481 atcagctaca aggccatgtg cagcaggtgg aggccctcca gaaagagaag ctgagtgaaa
     3541 cgtgcaaagg cactgagcgg gtacacaagc tacaggaaga gctggaggcc cgagaggcca
     3601 gcatccgcca gttagcccag catgtacaga gcctccatga tgaaagggat ctcatcaagc
     3661 atcagtttca agagctcatg gaacgtgtgg ccacatctga tggggatgtg gctgagctcc
     3721 aagagaagct gaagggaagg gaagctgact accagaacct ggagcactca caccacaggg
     3781 tctccatcca gctgcagagt gtgcgcactc tgcttagaga gaaggaggag gagctgaagc
     3841 tcattaagga agcacatgag agagttctgg aaaaaaaaga ccaagacctc aatgaggctt
     3901 tagttaaaat gattgccttg ggcagcagct tagaggaaac agaaattaag ctacaagaaa
     3961 aggaagagtg cctaaggaga tttgtgagtg attctcctaa ggatgccaaa gagcctcaaa
     4021 gtaccacaga cccaacggag gaggacagtg gcattttgac cttaggctca gtcaccagag
     4081 tatttcctgg ctttccccac tcacagccag aggatgaaga tccaagtgct agcctgggag
     4141 aagagggtag cagtggtagc ctcagcagag aggaaaacat cataccccca aagtcagccg
     4201 atatgcctga tagggagggg cagctgcaaa gcacagttaa gtctgatcag ggagcccctg
     4261 taaaaaggcc aagaatcagg ttctccacaa tccagtgtca aagatacata caccctgagg
     4321 ggtgtgcaaa agcctggact agcagcacat catcagacac cagccaggac cagtcaccat
     4381 cagaggatag tgtgtcctca gaagctaccc ctagcacact cccagcagct gcagatgctg
     4441 aaacatacat ctctataatc cactctctgg agacgaagct ctatgtcaca gaggagaagc
     4501 tcaaagatgt aactgtgagg ctggaaagcc agcaggggca gagtcaggag gcgttgcttg
     4561 cactccacca gcagtgggct ggcactgaag cacagttgcg ggaacagctc cgtgtcagcc
     4621 tgctacaggc tagcactctg gcctctcagc tagagcagga aagacaacag aaggtcacaa
     4681 acattgagca ccactctggg gagctggaag acttccaagc caaaaatagc caagccctga
     4741 catgcttaga aaactgctgg gaaaagctaa ggtctttgcc acaggccaac caggaggagg
     4801 gccaggatgc atgtgcagcc tccctggcta acatagagag tatgcttgtg agtgccatca
     4861 aggccctaca accatgggct tcccctgcag agagcaggat gcaggcagag aaagaaaagg
     4921 ggcaccccat ggaaagtggt atagcagccc ctatgcagca gccctgtcag cccatcttga
     4981 atgagcagga gcacaggaag ctgctttctg ctcaaatagt cctggaggcc tcactcatca
     5041 accagatagc tgactctcta aaaagtacca cttcaaatgt gtatggtgtt ctctgtgagc
     5101 ttactcagtc gggggagtgg ccactgaaga aagaaagtgc tgccccctct gctggggctc
     5161 caatggagat ctgggccaag aaggtactgg tgaatggtga gttctggagc caggtcgagt
     5221 cactaagtaa acacctaggg acactaggag aagaaacagc ctgcacatca gcagacaagc
     5281 aacagcatgt tccccagagt ctggctgatg ccacatggat ccgtgcagag ctcagctatg
     5341 ccacacaatc agtaagagaa ttgttccacc ataggctgca gagcatacag gagaccctac
     5401 aggggaccca ggctgcccta cagcagcaca agtgcatgct gggagaaatc ttgggagcct
     5461 accaaacccc agactttgaa agagtaatac agcagatctt agaaaccctt aggcatccaa
     5521 ctgacaggga agaccatgta cagacatcct gggaccagag cccattagga gaggtactga
     5581 gaccaggcac agatggctcc caagagcctt tgcaggcgtt tcatcagagc cctgaagtcc
     5641 ttgctgccat tcaggatgaa ctggcccagc agctgagaga aaaggctagc atccttgagg
     5701 agatttcagc tgccttgcca gtcctgcctc ccacagagcc acttgggggt tgccagaggc
     5761 ttctgcagat gtcccagcat ctctcatatg atgcttgtct agagggcctt ggtcagtatt
     5821 cttcattact ggttcaagat gcaattattc aggctcaagt atgctatgca gcatgcagaa
     5881 ttcggctgga atatgaaaag gagctgcaat tttacaagaa ggcctgtcag gaggctaggg
     5941 gggcttcttg ccagaagcgt acacaagcag ttggggccct gaaagaagaa tatgaagaac
     6001 ttctccacaa gcagaagagt gagtaccaaa aggttatcac cctcattgaa aaggaaaaca
     6061 ctgagctcaa ggccaaagtg agccagctgg accatcagca gagatgtcta caagaagcag
     6121 aaagcaagca cagtgagagc atgtttgccc tacagggcag gtatgaggaa gagatcaggt
     6181 gcatggtgga gcagctgagc cacactgaaa atacattgca ggctgagcgt agccgggttc
     6241 tcagccagct agacgcctca gtcaaagaca ggcaagccat ggaacagcat catgtgcagc
     6301 agatgaagat gctggaggac agattccagc tgaaggtccg ggagctgcag gctgttcatc
     6361 aggaggaact cagggccttg caggaacact acatatggag catgcgggga gccctcagcc
     6421 tctgccaacc ctcacaccca gattccccac tggcccctgg gccatctgag cccagagctg
     6481 tgccagcagc caaggatgag gctgagtcca tgaccgggct tcgagaacgt atccaggagc
     6541 tggaagccca aatgggtgtc atgcgagagg agctgggcca caaagagctg gagggtgatg
     6601 tggccgccct acaggagaag taccagcggg actttgagag cctcaaggct acatgtgagc
     6661 gaggctttgc cgccatggag gagacacatc agaagaagat tgaagatcta cagaggcaac
     6721 accagcggga gctagagaag ctgcgggagg aaaaagaccg tctcctggct gaggagacag
     6781 ctgccaccat atcagccatt gaagccatga agaatgctca ccgagaggag atggaacggg
     6841 agttagagaa gagccagcgg tctcagatca gcagcatcaa ttcagacata gaagccctga
     6901 ggcgacagta cctggaggag ctacagtcag tgcagcgaga gctggaggtc ctttcggagc
     6961 agtactctca gaagtgcctg gagaatgcac acctagccca ggcgctggaa gctgagcggc
     7021 aagccctgcg gcagtgtcag cgtgagaacc aagagctcaa tgcccacaac caggagctga
     7081 ataaccgcct ggctgcggag atcacacggt tgcggacact actgactgga gaaggtggtg
     7141 gggaatccac tgggttgcct ctcacacagg gcaaggatgc ctatgagtta gaggtcttgt
     7201 tgcgggtcaa agagtcagaa attcagtacc tgaaacagga gatcagctct ctcaaggatg
     7261 aactccagac agccctgcgg gataagaagt atgcgagcga caagtacaaa gacatctaca
     7321 cagagctcag catcgcgaag gccaaggctg actgtgacat cagcaggctg aaggagcagc
     7381 tgaaagcagc cacagaggca ctgggcgaga aatctcctga aggcactact gtgtcaggat
     7441 atgacataat gaaatctaaa agcaatcctg acttcctgaa gaaagacaga tcctgtgtta
     7501 cccggcaact cagaaacatc aggtccaaga gtctgaagga aggcctgacg gtgcaggagc
     7561 gcttgaagct ctttgaatcc agggacttga agaaagatta gctgcatcca ttccactgac
     7621 acatccttcc cagctggtgg cagcacaagc caagagtggc tttcatctgt gctttctcat
     7681 tgttgctgtc attaactgtg ggtatggatg catgagagac tgctgtgggg tgtttgctcc
     7741 attccctccc tgttaattcc aacttcctgt tgtctttatc acagcttttt tcccatggta
     7801 ttctcagatt agtcacgcga aagcagtaga gtggggaggt gtccccactg acacctgagc
     7861 agccccttgt cctcccacca cactgtcagt attaaggcac aacagcctgt taataagcta
     7921 gccctgcctc ggagtgcacg tggggacgga cctgccagtg gctctgctct gccacacaca
     7981 gcggagcacc acccttgctg ggtagagcag agccaccgaa tgttctaggt tgacctggtt
     8041 tctgaagggc ctaggatagt gtccagcctg gcccacttcc ttttgatgtg ggaggaggac
     8101 agcattttgt atttggccca ctaatgcagc ttagaaccat acccagataa tcctggcaaa
     8161 tctttcacga cctggaaaat gttgaaagca accattccta ttttggtttt ttattaaatc
     8221 ttgcacaaaa gtcccagccc tctcattcct tcctccgctc gtgcctccct tgctgtgcta
     8281 atcctggtct ggtcgcctgg aatagtgacc tgcaccctga agctccagcc ttgtcctgtg
     8341 tgatgggtcc ttcccagggt catctaaagg gaacattgct gagttttaat ctgtctgaaa
     8401 agaagctgtc attgcttggg gaagggtgag gagaagactg tgtgctcaga ctctgatttg
     8461 tctgggccct ggaaggttcc cttgaattgt ctgcttctca tggagcctgt gctaattttg
     8521 cttttctagc tgaacaggac ctttccaact acccaaagca ttctacagca cttcctttaa
     8581 aaaaaaaaac aaacaaacaa aaaaaaaacc actttattta tattctcaga agaaagcatt
     8641 catactgtaa ggtgcagcac acacaagagc caccaggtca gatggggagt cagtggcctc
     8701 acaactagat cccacatcct ggcttgttag tactaagtgg gtcagatggt ctctgagtga
     8761 caaactcaag tcatgagtct cctaatggct ctacatgagt tgatgttcaa ggtcatccac
     8821 aaaatctagg ctggcctaat agatggattt gtgacatacc aaagtgtgcc actgaccagc
     8881 agacaagccc tgagcctccc ctttgcacaa gtttttatgt tccactctgg cacatgctca
     8941 gtgacaattt atgttttcag cattctgggc aagtcagacc ttttaaaatg agctgctgtt
     9001 gaaactgagc tttgaactca atgggctggc ctttgggagc tgtagccctg tgttgaggac
     9061 tcctcttctc tgatagggtt tctttgtggc tatcctgctg cccttgggac cccctggccc
     9121 agtgtaatta tcttcctgcc tcgtgattcc tgggatgcta caaagagcct gctgaagatg
     9181 ccaagcctac cattcaaaag gacatttgat cttttgctct tcacctcaga attctaggat
     9241 ctgaactttg ctaaaaatac aagtatctgg gtgtcagagg caagggctgg gagacaggca
     9301 cactgcacct atcttagctg tcactcaagg ctcttactgc aggctggctc attctgccgt
     9361 gatacagcac acactgctcc agggcttggt ttcatgtgtg ggtatttggt atgttggcca
     9421 aatgcggaac cggtacagaa cagagattcc tggattatcc ctcactgtcc aagccagtct
     9481 gagcagtaac atatggatcc gggagcatct tgagattctt ggtggtgact tctggcctct
     9541 gacaaaatga accaaacaag aagttggcct ttctgagtcc ctgatggcca tgcaggtcca
     9601 ctgcagcagt ttaccttgga ctgtccatgt cctctgtcca ttccttccct cactccctga
     9661 gccaggttca cttttccctg acctccctac aggcttccca ttccccagaa agaagctgaa
     9721 gctggtgtat tcagagaggc ggtatcggat gtgcaagtgg agttggtcct ggtatacgta
     9781 gaagaggacg cttggctgag gatgggtggt gtagatcaag aagtcacagg ttgctccccg
     9841 gtccaatcag tggcatgttt tccccacttc atggtaggag cagaatttta ttttcctatg
     9901 aaaacacatt tgtggtctgc cagcatctat aagcaaactg ccattacatg aaacatacct
     9961 gacttcattt gacagttaat gttaatatgc tcaaattacg tcttgcacat gtgcctagca
    10021 ccagagcaaa agcacatttg tcacacaggg cttctggctc cacctttacc agtatggttg
    10081 tggccacagt gccaggacca taataggagg ccagagcccc atgaagtagg gaatcaccag
    10141 agggaacaat gctgggaatg tgtggattca ctgagtgaaa gcaaaggtct aagttgacct
    10201 ctactggatc cagaaaaaca ctgaactggg catagtggtt tatgtctgta ctcctactac
    10261 tcgaggctcc aaagtaccag gtcagtctgg actatatagc aaaactgtct caaaatacag
    10321 ataggctaag ggggatggat ggatggatat ataatttggg gttcaactac agcaccacaa
    10381 agagcacact tgtggtcttt agaacatttg tctaaaggga gcctgagata tttgactagg
    10441 aaacagaatg ggtgtgaaag atatttgacg gaatgtgtac tactgttaac ttccctacag
    10501 gggaagatgg tgcactgact tctttctacc atggaactgc agagaactaa gcacactaca
    10561 ctgctgacac ctagctggtg ctgaggaaag tagctggata gcacacagcc tcaactgttt
    10621 gtgtaaacct gggcatcagc tcagattcct acaggcctgt cccacacacc aaagaaactc
    10681 ctgacctcca gctatgccct ggctctctca aagacaggct ggataagcac ccagagctct
    10741 aagcagcctt cctacttatg ccatactcca tgtaagtacc caatgcaagc tggcagctac
    10801 aggtactaac agtccccaga tgcatagtaa tacccaaacc gcagactttg ctggtagagg
    10861 gacagtaatt acctctcagc tgattgtcct gcacctgcag tgcaggaggg ttagctgttc
    10921 ttgctatgct gtaaagatga catcacctag taaaagctat gctgagacta tcagtgtagg
    10981 ggactcaaac agcctttctc aagggagctc ccagcatacc ataggacacc ctgtgatctg
    11041 cacttcactt gctcagcctt tcctgtatta tcagagcaag taatgtaaag tatttttttt
    11101 tttttttttg gttctttttt tcggagctgg ggaccgaacc cagggccttg cgcttcctag
    11161 gtaagcgctc taccactgag ctaaatcccc agcccccaat gtaaagtatt tctaagatgg
    11221 ggtatagggg atttttgtgc aaattttgta tgagttttta aaatatcttt agctacccct
    11281 tttgaaggta tgtaaaggca gcattcagtg caaacccctc tcaaatatca agttagctag
    11341 gtatgatagc tcacatattt gattggcact tgggaggcag aagttcaaga ccaacctggt
    11401 ctacatagag ttctaaaaga acgaaggtta cacagtaaaa ccctgtctac aaataaaacc
    11461 aaaaaaggct atgttaataa gtaacgtctt aaagttttgg ttatgcgggt tggagagatg
    11521 gctcagtggt taagagcact gactgcactt ccagaagtct tgagttcaat tcccagcaac
    11581 cacatggtgg ctcacaacca tctgtaatag gatgctctct tctgaagtgt atgaagacca
    11641 actacagtgt actcacatat aaataaaata aataaatctt aaaaaaaaaa gttttggttc
    11701 tgcaacaaac tctgaagagt gtgtccttac ccacactcat ggcaagtcct tatcaatacc
    11761 ctgattcctg tttaaagtat tctgtgagat ttgcatgggg ccactcaagg aacaccacta
    11821 ttaggaggac tttcggaatc tgccctcagg tttctcaggg tgttcttgtt aggggaactg
    11881 gctgggagca taggctttag gtccaggtgc ctggctctga tgactgtggc ttatgtgcag
    11941 agcagctcca cagcagggtt tctgtgctgg taaggagcca gcccagtgtg gagttaaaaa
    12001 tgggacagcc caaaactgaa ggacttcaga gcctctccag ttccccatgg gtcacaggtc
    12061 agcctggagc agctcccatt gtggggcagg gttccatagc cagcatttgc cataaagtgg
    12121 tgccattgtt aagaagccta ttccagcctg ccacagtcaa catgccattg gctcattgct
    12181 cctttacaag tcagtcaaac cacacatcta attttatttt agcaaggaat agattgtaaa
    12241 gaacactgac ttcactgata tattttgttt ttatcacaaa ctttgattta attggatttt
    12301 aaatcatttt aagatttacc ttcagtatta atgctttaat gccaggatcc aaaacaagtt
    12361 ctgtggttac taaccaacat ggctttctgt aggtttgctg tatagaatat taaaaaaccc
    12421 tggttacagt ggctccttga caatcagaac tctaggtgac cttccattac tgctgtttga
    12481 ctggaggtgg gggtagagtg cgtgtttgtg aacagaggcc tggcagggcc tcttcactac
    12541 atcttgacag aaacagactt ggaccatctc acctgctact taggtatttt gttctgatac
    12601 agtcaatcca gttgccaaac taaaaattac atgtagaaga aaacggagcc tcactgagcc
    12661 agagtggctt caagcatagc ttctcagagc cagcttaggc ctctgtgtat ccacagagtg
    12721 tggcctcctg cagataaagt gtcccccaac tcatttcaag attttatggt ttggtgtaag
    12781 gcatttccct acaaagttgt ggtcaggtgt tcactacaat tgaaatgcta atttgtagaa
    12841 atatttattc ctttgtgtga caagctagag tccttggctg tagctaacca ttttttattg
    12901 tgtaaatact gcttgatttt acatgaactg tatcataata aactattttt gcattgct
//
