LOCUS       NM_001414222            4214 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus MAGUK p55 scaffold protein 2 (Mpp2), transcript
            variant 2, mRNA.
ACCESSION   NM_001414222
VERSION     NM_001414222.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4214)
  AUTHORS   Waldron,S., Pass,R., Griesius,S., Mellor,J.R., Robinson,E.S.J.,
            Thomas,K.L., Wilkinson,L.S., Humby,T., Hall,J. and Dwyer,D.M.
  TITLE     Behavioural and molecular characterisation of the Dlg2
            haploinsufficiency rat model of genetic risk for psychiatric
            disorder
  JOURNAL   Genes Brain Behav 21 (4), e12797 (2022)
   PUBMED   35075790
  REMARK    GeneRIF: Behavioural and molecular characterisation of the Dlg2
            haploinsufficiency rat model of genetic risk for psychiatric
            disorder.
REFERENCE   2  (bases 1 to 4214)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    GeneRIF: proteins. Our results highlight a previously unexplored
            role for MPP2 at postsynaptic sites as a scaffold that links
            SynCAM1 cell adhesion molecules to core proteins of the
            postsynaptic density.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4214)
  AUTHORS   Kim,G., Lujan,R., Schwenk,J., Kelley,M.H., Aguado,C., Watanabe,M.,
            Fakler,B., Maylie,J. and Adelman,J.P.
  TITLE     Membrane palmitoylated protein 2 is a synaptic scaffold protein
            required for synaptic SK2-containing channel function
  JOURNAL   Elife 5, e12637 (2016)
   PUBMED   26880549
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4214)
  AUTHORS   Baumgartner,M., Weiss,A., Fritzius,T., Heinrich,J. and Moelling,K.
  TITLE     The PDZ protein MPP2 interacts with c-Src in epithelial cells
  JOURNAL   Exp Cell Res 315 (17), 2888-2898 (2009)
   PUBMED   19665017
REFERENCE   5  (bases 1 to 4214)
  AUTHORS   Leonoudakis,D., Conti,L.R., Anderson,S., Radeke,C.M., McGuire,L.M.,
            Adams,M.E., Froehner,S.C., Yates,J.R. 3rd and Vandenberg,C.A.
  TITLE     Protein trafficking and anchoring complexes revealed by proteomic
            analysis of inward rectifier potassium channel (Kir2.x)-associated
            proteins
  JOURNAL   J Biol Chem 279 (21), 22331-22346 (2004)
   PUBMED   15024025
REFERENCE   6  (bases 1 to 4214)
  AUTHORS   Butz,S., Okamoto,M. and Sudhof,T.C.
  TITLE     A tripartite protein complex with the potential to couple synaptic
            vesicle exocytosis to cell adhesion in brain
  JOURNAL   Cell 94 (6), 773-782 (1998)
   PUBMED   9753324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211962.1, SRR26360194.1259753.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               JAXUCZ010000010.1  87543656-87544029   c
            375-443             JAXUCZ010000010.1  87540667-87540735   c
            444-562             JAXUCZ010000010.1  87536049-87536167   c
            563-715             JAXUCZ010000010.1  87519053-87519205   c
            716-865             JAXUCZ010000010.1  87518784-87518933   c
            866-1093            JAXUCZ010000010.1  87517732-87517959   c
            1094-1225           JAXUCZ010000010.1  87516939-87517070   c
            1226-1331           JAXUCZ010000010.1  87516744-87516849   c
            1332-1400           JAXUCZ010000010.1  87516594-87516662   c
            1401-1562           JAXUCZ010000010.1  87516232-87516393   c
            1563-1765           JAXUCZ010000010.1  87515530-87515732   c
            1766-1894           JAXUCZ010000010.1  87514963-87515091   c
            1895-4214           JAXUCZ010000010.1  87511638-87513957   c
FEATURES             Location/Qualifiers
     source          1..4214
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..4214
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /note="MAGUK p55 scaffold protein 2"
                     /db_xref="GeneID:85275"
                     /db_xref="RGD:620014"
     exon            1..374
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..443
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..2071
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /note="membrane protein, palmitoylated 2 (MAGUK p55
                     subfamily member 2); membrane palmitoylated protein 2"
                     /codon_start=1
                     /product="MAGUK p55 subfamily member 2"
                     /protein_id="NP_001401151.1"
                     /db_xref="GeneID:85275"
                     /db_xref="RGD:620014"
                     /translation="MPVAATNSESAMQQVLDNLGSLPNATGAAELDLIFLRGIMESPI
                     VRSLAKAHERLEETKLEAVRDNNLELVQEILRDLAELAEQSSTAAELARILQEPHFQS
                     LLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEGG
                     ELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPRALQELLRSASGSVILKILPS
                     YQEPHLPRQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVE
                     GGSAGLIPSQLLEEKRKAFVKRDLELTPTSGTLCGSLSGKKKKRMMYLTTKNAEFDRH
                     ELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLILWDPDRYGTTVPYTSRRPKDS
                     EREGQGYSFVSRGEMEADIRAGRYLEHGEYEGNLYGTRIDSIRGVVASGKVCVLDVNP
                     QAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGVSTKQLTEADLRRTVEESSRI
                     QRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY"
     exon            444..562
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..715
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..865
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1093
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1225
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1331
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1400
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1562
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1765
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1894
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..4214
                     /gene="Mpp2"
                     /gene_synonym="Dlg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgctttaa gagcacggct agcgattgac aagcaataac cgcggagcgc ccgtctgcgc
       61 gcaatcgccc caagctaggg gctccccaaa acgcaggtag gtattctcag gcccctgggc
      121 cagcacccac ctcagaaccc ttgcctcctt ttcgacctag caccgcactt ggggattctg
      181 ttctccaggt ccaaactccg ggcccccttc cccaagtcgc ccccctccct ctccagctgc
      241 agcactccgc tctctgtgtg tgatgccggt ggggggaacc gaacctctca tcccagggat
      301 gctggttccc atgctaggga tgagggctcc agagggacac cggacacaga gatgctgagc
      361 tgagcggagc acaggagact gacttcagaa accctcactg gccccgttca ccatgccggt
      421 tgctgccacg aactctgagt ctgctatgca gcaagtcttg gacaacctgg gatccctgcc
      481 caatgccact ggggctgcgg aactggacct gatcttcctt cgagggataa tggaaagtcc
      541 gatagtcaga tccctggcca aggcccacga gcggctggag gagaccaagc tggaggccgt
      601 tcgggataac aacctggagc tggtgcagga gatccttcgg gacctggcag agctggcaga
      661 gcagagtagc acggctgcgg agctggcacg catcctccaa gagcctcact tccagtccct
      721 cctggagaca catgactcag tggcctcaaa gacctatgag acaccacccc ccagtccagg
      781 tctagatccc acgtttagca accagccggt acctcctgat gctgtgcgca tggtgggcat
      841 tcgaaagacc gcaggagaac atctgggtgt gacattccga gtggagggtg gtgagctggt
      901 gattgcccga attctgcacg ggggcatggt ggcgcagcaa ggtctgctgc atgttggtga
      961 catcatcaag gaagtgaatg ggcagccagt gggcagcgat ccccgggcac tgcaggaact
     1021 cctacgcagc gccagtggta gcgtcatcct caagatcctg cccagttacc aggaacccca
     1081 cctgccccga caggtgtttg ttaaatgcca cttcgattac gaccctgccc gggacagtct
     1141 catcccctgc aaggaagcag gcctgcgctt caacgccgga gacttgctcc agattgtaaa
     1201 ccaagatgat gccaattggt ggcaggcatg ccatgtcgaa gggggcagcg caggactcat
     1261 ccccagccag ttgttggagg agaagcggaa agcatttgtc aaacgggacc tggaactgac
     1321 cccgacctca gggaccctgt gcggcagcct ttcaggaaag aaaaagaagc gaatgatgta
     1381 tttgaccacc aagaatgcag agtttgaccg ccatgagctg cttatctatg aggaggtggc
     1441 ccgcatgccc ccattccgta ggaaaaccct ggtgctgatt ggcgcgcagg gtgtgggccg
     1501 gcgaagcctg aaaaacaagc tcattctgtg ggatccagac cgctacggca ccacagtgcc
     1561 ctacacatcc cggaggccca aggactcaga acgggagggg cagggctaca gctttgtgtc
     1621 tcgtggggag atggaggctg acatccgcgc cgggcgctac ttggagcatg gcgagtatga
     1681 gggcaacctg tacggcacgc ggatcgactc catccggggc gttgttgcct cgggcaaggt
     1741 gtgcgtgctg gatgtcaacc ctcaggcggt gaaggtcctg aggacagctg agtttgtccc
     1801 ttacgtggtg ttcatcgagg ctcctgactt tgagactctg cgggccatga accgagctgc
     1861 cctggagagc ggagtgtcca ctaagcagct gacggaggcg gatctgaggc ggacagtgga
     1921 ggagagcagc cgcatccaga gaggctatgg gcattacttc gacctcagcc tggtcaacag
     1981 caacctggag aggaccttcc gcgagctcca gactgccatg gagaagcttc gcacggagcc
     2041 ccagtgggtg cctgtgagct gggtgtactg agtcttgctc tggaccttgt tactgcctgg
     2101 tcgggaatcc aactttcact cggcctgtga tactccccca ccctgctaat ggtcttcatc
     2161 ctcccatctc cggttttccc tggaccacag ttcccagcag gggctggctt cagatataga
     2221 ggtgtgcact gccagggagg taggtgttca tggggtacct ctgtacccag gtgctgccca
     2281 ctccccacgt ctactggcca ccagacatcc ctttctgagg atcatgctgt gtccgggagc
     2341 atcacagatc actcctgtaa atctcagtcc agggaagagc agagccgcta ggggccttgt
     2401 ggtcagtagg tctgtgaccc tgctagcttt ttctcctctc tggactggcc actgccatcc
     2461 tgttcgctgg ccccctccca tcccttacta tagtctaagg aacagccttg ggctgtcctc
     2521 atacggccag ctactcagac cactggtagt aggcagaccc aagtaatggt gccagtctgg
     2581 gccattttag aggctgggga caccccgtca cgagccgttg ctgcagctgg tgacgcaggc
     2641 ctcagctccc tgaggagtaa acatagtctg gtccctccct tactccaagc ttctcactgc
     2701 cagtctctcc acagactttc tcaatgtgtc cctcttttgt aagccctgct cctcagactt
     2761 gcagctggct tagcccaggt tgggaataag gcctagaaag ctgaaccctc tattgttggg
     2821 accaaaagtc ttccagccca cagcccacag cagggtacat tcatgtcagg cttttctgga
     2881 tggatctggg tgacccgctg gcattagggc ttaggatggg agacagtgag tgagggcttg
     2941 gaaacagatt agctttatgt gtgtgtgtgt gtgtgtgtat gtgttgcaca cgtgtatgca
     3001 cacgtttggt ttagtttgag ggggggcaga ggattgcctt ctcttggaga tagctctctg
     3061 aggtcccctt atgggttccc ctcaactccg acatttctta caatcccccg ttccagactc
     3121 cagaccccgg atcgccctca actcttccat ttccctgtat cctaagtacc agcctttagt
     3181 cctcggggag ggtgattttg taaaatagga taatcctaag aaccccaccc atgacatctg
     3241 gagacatttc attcctcatt ctcaaggggt cccatatcct cacaggagac ccccccggca
     3301 tttctgccct gtgcctccca gttctcctaa gcgtcagtct ttgctgcact gtcagctcaa
     3361 gcttgtccct gaatcactgt gtgcccattt cctagagaag gggagggggg gagaatagac
     3421 agaatattta ttacaaatgc tagacatata tttattatat cagctatctc atttgcactg
     3481 gcatcagatg tgcaggtggg actagaggtg ggcccaccca ctgctcattt gcatagctct
     3541 gctatcgcct atctgtactt ttcctttggt caatcaatgt cctttccttt agttcagtat
     3601 cttgctgtga cccctgaccc ttacttagct gcaggggact gccctccttg acagctcctt
     3661 cctcccctgg aggatgagct cagggtcaga gaagcgtctg tgacagcccc tgaccacccc
     3721 cttgattaac ccacaaagcc ccccaaccaa aagaccatgg cctttgatcg agatctggcg
     3781 ggcaccgtgc tggagagttg gtaccagttc ctccctctga agatccagtg tggtatccaa
     3841 tccccatatc ctcctctcta gtaatgtgcc agggcccctc ctctctcagc agcctcctac
     3901 ctctctctct cccactgagc ctggctctac aacccatcca agcactggcc aggagggaac
     3961 agaggttgtg ggcctcctca gctcacctgg cacagggctg ggttagaaca tgttcgtgcc
     4021 caccatgcta gctctgtgac tccgtcctcc ctccctccca ccatggcctc ttgtatttgg
     4081 ggacctcagg agaaggagga ccctgccccc tccatggtcc acactcagtc cctctgctcc
     4141 cctccatcac caccagcccc atctactttc ttaaatcttc tttcttttcc tttgattaaa
     4201 cgtgacagca agtg
//
