LOCUS       NM_001401812            2273 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus myeloperoxidase (Mpo), mRNA.
ACCESSION   NM_001401812
VERSION     NM_001401812.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2273)
  AUTHORS   Yao,Y., Cai,X., Zhang,M., Zheng,Y., Fei,W., Zhao,M. and Zheng,C.
  TITLE     Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote
            osteogenic differentiation of bone marrow mesenchymal stem cells
  JOURNAL   Eur J Pharmacol 961, 176192 (2023)
   PUBMED   37981258
  REMARK    GeneRIF: Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to
            promote osteogenic differentiation of bone marrow mesenchymal stem
            cells.
REFERENCE   2  (bases 1 to 2273)
  AUTHORS   Yu,H., Liu,Y., Wang,M., Restrepo,R.J., Wang,D., Kalogeris,T.J.,
            Neumann,W.L., Ford,D.A. and Korthuis,R.J.
  TITLE     Myeloperoxidase instigates proinflammatory responses in a cecal
            ligation and puncture rat model of sepsis
  JOURNAL   Am J Physiol Heart Circ Physiol 319 (3), H705-H721 (2020)
   PUBMED   32762560
  REMARK    GeneRIF: Myeloperoxidase instigates proinflammatory responses in a
            cecal ligation and puncture rat model of sepsis.
REFERENCE   3  (bases 1 to 2273)
  AUTHORS   Wazea,S.A., Wadie,W., Bahgat,A.K. and El-Abhar,H.S.
  TITLE     Galantamine anti-colitic effect: Role of alpha-7 nicotinic
            acetylcholine receptor in modulating Jak/STAT3,
            NF-kappaB/HMGB1/RAGE and p-AKT/Bcl-2 pathways
  JOURNAL   Sci Rep 8 (1), 5110 (2018)
   PUBMED   29572553
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2273)
  AUTHORS   Zhu,M.L., Zhao,J.P., Cui,N., Goncalves-Rizzi,V.H.,
            Possomato-Vieira,J.S., Nascimento,R.A. and Dias-Junior,C.A.
  TITLE     Cardiac myeloperoxidase activity is elevated in hypertensive
            pregnant rats
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 37 (6), 904-909 (2017)
   PUBMED   29270751
  REMARK    GeneRIF: Maternal and fetal detrimental changes along with
            increases in circulating sFlt-1 and VEGF in hypertensive pregnancy
            may be associated with increases in cardiac and circulating MPO
            activities, confirming the causative role of inflammatory response
            in preeclampsia.
REFERENCE   5  (bases 1 to 2273)
  AUTHORS   Gellhaar,S., Sunnemark,D., Eriksson,H., Olson,L. and Galter,D.
  TITLE     Myeloperoxidase-immunoreactive cells are significantly increased in
            brain areas affected by neurodegeneration in Parkinson's and
            Alzheimer's disease
  JOURNAL   Cell Tissue Res 369 (3), 445-454 (2017)
   PUBMED   28466093
  REMARK    GeneRIF: These results indicate significant increases of
            MPO-immunoreactive cells in brain regions affected by
            neurodegeneration in Parkinson's disease and Alzheimer's Disease.
REFERENCE   6  (bases 1 to 2273)
  AUTHORS   Aratani,Y., Koyama,H., Nyui,S., Suzuki,K., Kura,F. and Maeda,N.
  TITLE     Severe impairment in early host defense against Candida albicans in
            mice deficient in myeloperoxidase
  JOURNAL   Infect Immun 67 (4), 1828-1836 (1999)
   PUBMED   10085024
REFERENCE   7  (bases 1 to 2273)
  AUTHORS   Miles,R.R., Turner,C.H., Santerre,R., Tu,Y., McClelland,P.,
            Argot,J., DeHoff,B.S., Mundy,C.W., Rosteck,P.R. Jr., Bidwell,J.,
            Sluka,J.P., Hock,J. and Onyia,J.E.
  TITLE     Analysis of differential gene expression in rat tibia after an
            osteogenic stimulus in vivo: mechanical loading regulates
            osteopontin and myeloperoxidase
  JOURNAL   J Cell Biochem 68 (3), 355-365 (1998)
   PUBMED   9518261
REFERENCE   8  (bases 1 to 2273)
  AUTHORS   Edwards,M.L., Stemerick,D.M., Sabol,J.S., Diekema,K.A. and
            Dinerstein,R.J.
  TITLE     Inhibition of myeloperoxidase release from rat polymorphonuclear
            leukocytes by a series of azachalcone derivatives
  JOURNAL   J Med Chem 37 (25), 4357-4362 (1994)
   PUBMED   7996547
REFERENCE   9  (bases 1 to 2273)
  AUTHORS   Sigurs,N., Bjarnason,R. and Sigurbergsson,F.
  TITLE     Eosinophil cationic protein in nasal secretion and in serum and
            myeloperoxidase in serum in respiratory syncytial virus
            bronchiolitis: relation to asthma and atopy
  JOURNAL   Acta Paediatr 83 (11), 1151-1155 (1994)
   PUBMED   7841728
REFERENCE   10 (bases 1 to 2273)
  AUTHORS   Cramer,E., Pryzwansky,K.B., Villeval,J.L., Testa,U. and
            Breton-Gorius,J.
  TITLE     Ultrastructural localization of lactoferrin and myeloperoxidase in
            human neutrophils by immunogold
  JOURNAL   Blood 65 (2), 423-432 (1985)
   PUBMED   2981589
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.28108.1,
                                           SRR26643295.39971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000010.1  73092402-73092497
            97-190              JAXUCZ010000010.1  73092638-73092731
            191-366             JAXUCZ010000010.1  73093066-73093241
            367-490             JAXUCZ010000010.1  73093664-73093787
            491-620             JAXUCZ010000010.1  73093885-73094014
            621-827             JAXUCZ010000010.1  73094094-73094300
            828-1146            JAXUCZ010000010.1  73095159-73095477
            1147-1307           JAXUCZ010000010.1  73097973-73098133
            1308-1563           JAXUCZ010000010.1  73099038-73099293
            1564-1734           JAXUCZ010000010.1  73099580-73099750
            1735-1972           JAXUCZ010000010.1  73100496-73100733
            1973-2184           JAXUCZ010000010.1  73101435-73101646
            2185-2273           JAXUCZ010000010.1  73101969-73102057
FEATURES             Location/Qualifiers
     source          1..2273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2273
                     /gene="Mpo"
                     /note="myeloperoxidase"
                     /db_xref="GeneID:303413"
                     /db_xref="RGD:1592081"
     exon            1..96
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2177
                     /gene="Mpo"
                     /EC_number="1.11.1.7"
                     /codon_start=1
                     /product="myeloperoxidase precursor"
                     /protein_id="NP_001388741.1"
                     /db_xref="GeneID:303413"
                     /db_xref="RGD:1592081"
                     /translation="MKLFLALAGLLAPLAMLQTSTGATPALPGEVANSVVLDCMEEAK
                     RLVNKAYKERRESIKQSLRSGSASPMELLSYFKQPVAGTRTAVRAADYLHVALDLLKR
                     KLQPLWPRPFNVTDVLTPAQLNLLSVSSGCAYQDVGVTCPPQDKYRTITGHCNNRRSP
                     TLGASNRAFVRWLPAEYEDGISLPFGWTPKVNRSGFKVPLARQVSNAIVRFPNDQLTK
                     DQERALMFMQWGQFLDHDITLTPEPATRFSFLTGLNCETSCLQQQPCFPLKIPPNDPR
                     IKNQKDCIPFFRSCPACTGSNITIRNQINALTSFVDASGVYGSEDPLARRLRNLTNQL
                     GLLAVNTRFQDNGRALLPFDSLHDDPCLLTNRSARIPCFLAGDMRSSEMPELTSMHTL
                     FVREHNRLATELKRLNPRWNGEKLYQEARKIVGAMVQIITYRDYLPLVLGPAAMKKYL
                     PQYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNQYRSTGPNPRVPLSRVFFAS
                     WRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSR
                     DHGLPGYNAWRRFCGLPQPSTVGELGTVLKNLELARKLMAQYGTPNNIDIWMGGVSEP
                     LEPNGRVGQLLACLIGTQFRKLRDGDRFWWENPGVFSKQQRQALATISLPRIICDNTG
                     ITTVSKNNIFMSNSHPRDFVSCNTLPKLNLASWKET"
     exon            97..190
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            191..366
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            367..490
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            491..620
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            621..827
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1146
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1307
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1563
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1734
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1972
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2184
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2273
                     /gene="Mpo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcattttg tcttgcaaag atgaagcttt ttttggcctt ggcaggcctc ctggcccccc
       61 tggccatgct tcagacttcc actggtgcca ctccagcgct cccgggggaa gtggcgaact
      121 cagtggtgct ggactgcatg gaggaggcca agcggctggt gaacaaagcc tacaaggagc
      181 ggagagaaag catcaagcag agtcttcgaa gtggctccgc cagccctatg gaactcctat
      241 cgtatttcaa gcagccggtg gcgggcacca ggacagctgt gagggctgcc gactatctgc
      301 acgtggccct ggacctgctg aagaggaagc tgcagcccct gtggccacgg cctttcaatg
      361 tcacagacgt gttgacgcct gctcagctga atctgttgtc cgtgtcaagt ggctgcgcct
      421 atcaggatgt gggggtgaca tgcccaccgc aggacaagta tcgaaccatc actggacact
      481 gcaacaacag acgcagcccc actctggggg cctccaaccg agcctttgtg cgctggctgc
      541 ctgcagaata tgaggatggc atctccttgc cttttggctg gacgcccaag gtcaatcgca
      601 gtggcttcaa ggtgcccttg gctcgccagg tctccaacgc catcgtacgc ttccccaacg
      661 atcagctgac caaggaccag gagcgtgcac tcatgttcat gcagtggggc cagtttctgg
      721 accatgatat caccttgact ccagagccag ctacccggtt ctccttcctc actggactca
      781 actgtgagac cagctgcctg cagcagcaac cctgctttcc cctcaagatc ccacccaatg
      841 accctcgaat caagaaccaa aaggactgca tccccttctt ccgttcctgc ccggcatgca
      901 ccgggagcaa cattaccatt cgcaaccaga tcaacgcgct cacttccttc gtggatgcca
      961 gcggggtgta tggcagcgag gaccccctgg ccaggagatt gcgaaacctc accaaccagc
     1021 tggggctgtt ggctgtcaat acacgcttcc aagacaatgg cagggccctg ttgccctttg
     1081 acagcctgca tgatgaccca tgcctcctta ccaaccgctc ggcccgcatt ccttgttttc
     1141 tggcagggga catgcgctcc agcgagatgc cagagctcac ctccatgcac accctcttcg
     1201 tgcgagagca taaccgtctg gccacagagc tcaagcgcct gaatcctcgc tggaatgggg
     1261 agaagcttta ccaggaggcc cggaagattg tgggggccat ggtccagatc atcacatacc
     1321 gagactacct gcccttggtg ttggggccag cagccatgaa gaagtaccta ccccagtacc
     1381 gatcctacaa tgactcagta gaccctcgga tcgccaatgt cttcaccaac gctttccgtt
     1441 acggccacac cctcatccaa cccttcatgt tccgcctgga caatcagtac cggtccacag
     1501 gacccaaccc ccgtgtccca ctcagcaggg tcttttttgc cagctggaga gttgtgctgg
     1561 aaggtggcat tgaccccatc ctccgaggcc tcatggctac tcctgccaaa ctgaatcgcc
     1621 agaaccaaat tgcggtggat gagatccggg agcgactgtt tgagcaggtc atgaggatag
     1681 gtcttgactt acctgccctt aacatgcagc gcagccggga tcatggcctc ccgggataca
     1741 atgcctggag acgcttctgt gggcttccac agcccagcac agtgggtgag ctcggcacgg
     1801 tgctgaagaa cctggagctg gcacggaagc tgatggcaca gtatggcacg cccaacaaca
     1861 ttgacatctg gatgggcggt gtgtccgagc ccctagagcc caatggccgc gtaggccagc
     1921 tccttgcctg cctcattggc actcagttta ggaagctacg ggatggcgat aggttttggt
     1981 gggagaaccc gggtgtgttc agtaaacagc agagacaggc cttggctacc atctccttgc
     2041 cccgcatcat ctgtgacaac actggcatca ctaccgtgtc taagaacaac atcttcatgt
     2101 ccaactcaca cccccgagac tttgtgagct gtaacaccct tcctaaactg aatctggctt
     2161 cctggaagga gacctagagg ccgggagtct gcccggagag gaacggaggc cattggcctt
     2221 ttttgtgcta tctgtacctg aggtttacac taataaagca tggtggatgg gga
//
