LOCUS       NM_001419844            3033 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus MPL proto-oncogene, thrombopoietin receptor
            (Mpl), mRNA.
ACCESSION   NM_001419844 XM_345572
VERSION     NM_001419844.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3033)
  AUTHORS   Sano,Y., Morimoto,M., Kobayashi,S., Ueno,M., Fukushima,T.,
            Asama,H., Kawano,K., Nagashima,S., Tanaka,S., Ohkawa,S. and
            Maeda,S.
  TITLE     Repeated Lusutrombopag Treatment for Thrombocytopenia in Patients
            with Chronic Liver Disease
  JOURNAL   Digestion 102 (4), 654-662 (2021)
   PUBMED   32841939
REFERENCE   2  (bases 1 to 3033)
  AUTHORS   Yan,Z., Ohuchida,K., Zheng,B., Okumura,T., Takesue,S., Nakayama,H.,
            Iwamoto,C., Shindo,K., Moriyama,T., Nakata,K., Miyasaka,Y.,
            Ohtsuka,T., Mizumoto,K., Oda,Y., Hashizume,M. and Nakamura,M.
  TITLE     CD110 promotes pancreatic cancer progression and its expression is
            correlated with poor prognosis
  JOURNAL   J Cancer Res Clin Oncol 145 (5), 1147-1164 (2019)
   PUBMED   30770989
REFERENCE   3  (bases 1 to 3033)
  AUTHORS   Stockklausner,C., Klotter,A.C., Dickemann,N., Kuhlee,I.N.,
            Duffert,C.M., Kerber,C., Gehring,N.H. and Kulozik,A.E.
  TITLE     The thrombopoietin receptor P106L mutation functionally separates
            receptor signaling activity from thrombopoietin homeostasis
  JOURNAL   Blood 125 (7), 1159-1169 (2015)
   PUBMED   25538044
REFERENCE   4  (bases 1 to 3033)
  AUTHORS   Xiao,N., Laha,S., Das,S.P., Morlock,K., Jesneck,J.L. and
            Raffel,G.D.
  TITLE     Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic
            stem cells through alternative splicing of c-Mpl
  JOURNAL   Blood 125 (6), 941-948 (2015)
   PUBMED   25468569
REFERENCE   5  (bases 1 to 3033)
  AUTHORS   Gao,W., Chen,L., Ma,Z., Du,Z., Zhao,Z., Hu,Z. and Li,Q.
  TITLE     Isolation and phenotypic characterization of colorectal cancer stem
            cells with organ-specific metastatic potential
  JOURNAL   Gastroenterology 145 (3), 636-46 (2013)
   PUBMED   23747337
REFERENCE   6  (bases 1 to 3033)
  AUTHORS   Li,J., Xia,Y. and Kuter,D.J.
  TITLE     The platelet thrombopoietin receptor number and function are
            markedly decreased in patients with essential thrombocythaemia
  JOURNAL   Br J Haematol 111 (3), 943-953 (2000)
   PUBMED   11122159
REFERENCE   7  (bases 1 to 3033)
  AUTHORS   Duensing,S., Duensing,A., Meran,J.G., Kreft,A., Busche,G.,
            Ganser,A. and Georgii,A.
  TITLE     Molecular detection of c-mpl thrombopoietin receptor gene
            expression in chronic myeloproliferative disorders
  JOURNAL   Mol Pathol 52 (3), 146-150 (1999)
   PUBMED   10621836
REFERENCE   8  (bases 1 to 3033)
  AUTHORS   Ihara,K., Ishii,E., Eguchi,M., Takada,H., Suminoe,A., Good,R.A. and
            Hara,T.
  TITLE     Identification of mutations in the c-mpl gene in congenital
            amegakaryocytic thrombocytopenia
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 3132-3136 (1999)
   PUBMED   10077649
REFERENCE   9  (bases 1 to 3033)
  AUTHORS   de Serres,M., Yeager,R.L., Dillberger,J.E., Lalonde,G.,
            Gardner,G.H., Rubens,C.A., Simkins,A.H., Sailstad,J.M.,
            McNulty,M.J. and Woolley,J.L.
  TITLE     Pharmacokinetics and hematological effects of the PEGylated
            thrombopoietin peptide mimetic GW395058 in rats and monkeys after
            intravenous or subcutaneous administration
  JOURNAL   Stem Cells 17 (6), 316-326 (1999)
   PUBMED   10606160
REFERENCE   10 (bases 1 to 3033)
  AUTHORS   Alexander,W.S., Roberts,A.W., Nicola,N.A., Li,R. and Metcalf,D.
  TITLE     Deficiencies in progenitor cells of multiple hematopoietic lineages
            and defective megakaryocytopoiesis in mice lacking the
            thrombopoietic receptor c-Mpl
  JOURNAL   Blood 87 (6), 2162-2170 (1996)
   PUBMED   8630375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 19, 2023 this sequence version replaced XM_345572.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.7573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000005.1  137272082-137272177 c
            97-229              JAXUCZ010000005.1  137271803-137271935 c
            230-408             JAXUCZ010000005.1  137271375-137271553 c
            409-707             JAXUCZ010000005.1  137270530-137270828 c
            708-870             JAXUCZ010000005.1  137270006-137270168 c
            871-997             JAXUCZ010000005.1  137269415-137269541 c
            998-1212            JAXUCZ010000005.1  137265752-137265966 c
            1213-1355           JAXUCZ010000005.1  137265427-137265569 c
            1356-1515           JAXUCZ010000005.1  137263268-137263427 c
            1516-1612           JAXUCZ010000005.1  137262958-137263054 c
            1613-1700           JAXUCZ010000005.1  137260943-137261030 c
            1701-3033           JAXUCZ010000005.1  137259288-137260620 c
FEATURES             Location/Qualifiers
     source          1..3033
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3033
                     /gene="Mpl"
                     /note="MPL proto-oncogene, thrombopoietin receptor"
                     /db_xref="GeneID:366455"
                     /db_xref="RGD:1311069"
     exon            1..96
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1952
                     /gene="Mpl"
                     /note="thrombopoietin receptor; myeloproliferative
                     leukemia virus oncogene"
                     /codon_start=1
                     /product="thrombopoietin receptor precursor"
                     /protein_id="NP_001406773.1"
                     /db_xref="GeneID:366455"
                     /db_xref="RGD:1311069"
                     /translation="MPSWALFMVTSCLLLAPPNQAQVTSQDVFLLALGTEPLNCFSQT
                     FEDLTCFWDEEEAAPSWIYQLLYAYPGEKPRPCPLHSQSVPTFGTRYVCQFPALDEVR
                     LFFPLHLWVKNVFLNQTLMQRVLFVDTVGLPAPPSVIKARGGSQPGELQIHWEAPAPE
                     ISNFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLRMPNPVRVLDQHPCVHPTASQ
                     QHGPMRTSPAGEAPSLAVKGGSCLISGLHAGQSYWLQLRSQPDGVSLRGSWGPWSLPV
                     TVDLPGDAVAIGLQCFTVDLKKVICQWQQQDHSSSRGFFRHSRTRCCPTDRDPTWEKC
                     EEEEEEEEEEKEEGELDPGSRPALFSRCHFKSRNDSVIHILVEVTTAQGAIHSYLGSP
                     FWIRQAVLLPTPSLHWREISSGRLELEWQHPSPWAAQETCYQLRYTGEGHEDWKVLEP
                     SLGAQGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTAL
                     LLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATV
                     TDSCEEVEPSLLEILPKSPERTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPTAETGS
                     CCTTHIANHSYLPLSYWQQP"
     exon            97..229
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            230..408
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            409..707
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            708..870
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            871..997
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1212
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1355
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1515
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1612
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1700
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..3033
                     /gene="Mpl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacagtgcc ggagaagatg ccctcttggg ccctctttat ggtcacctcc tgcctcctct
       61 tggcccctcc aaaccaggcc caagtcacca gtcaagatgt cttcttgctg gccttgggca
      121 cagagcccct gaactgtttc tcccagacat ttgaggacct cacctgcttc tgggatgagg
      181 aagaggcagc acccagctgg atataccagc tgctgtacgc ctacccagga gagaagcccc
      241 gtccatgccc cctgcattcc cagagtgtgc ccacctttgg gacccggtat gtgtgccagt
      301 ttccagcgct ggatgaagtg cgtctcttct ttccgctgca cctctgggtg aagaatgtct
      361 tcctcaacca gactttgatg cagcgggtgc tgtttgtgga taccgtgggc ctgccagctc
      421 ctcccagtgt catcaaggcc aggggtggga gccaaccagg ggaacttcag atccactggg
      481 aggcccctgc tcctgaaatc agcaatttcc tgaggcatga actccgctat ggccccacgg
      541 actccagcaa cgccactgcg ccctcagtca ttcagctgct ctccacagaa acctgctgcc
      601 ccactttgag gatgccgaac ccagtccgcg tccttgacca gcatccatgc gttcatccta
      661 cagcgtccca gcagcacgga ccaatgagga cctccccggc tggagaagct ccctctctgg
      721 cagtgaaggg cggaagctgc ctcatctcag gcctccatgc tggccaatcc tactggctcc
      781 agctacgcag ccaacccgac ggggtctccc tccgtggatc ctggggaccc tggtccctcc
      841 ctgtgactgt ggaccttcca ggagatgcag tggcaattgg actccagtgc tttaccgtgg
      901 atctaaagaa ggttatctgc cagtggcagc aacaagacca ctctagctcc cgaggcttct
      961 tccgtcacag caggacacgg tgctgcccca cagacaggga ccctacctgg gagaaatgtg
     1021 aagaggagga ggaggaggaa gaggaagaga aagaggaggg ggagctggat ccaggatcac
     1081 ggcccgctct gttctcccgc tgccacttca agtcacgaaa tgacagtgtt attcacatcc
     1141 ttgtagaagt gaccacggcg caaggtgcca ttcacagcta cctgggctcc cctttctgga
     1201 tccgccaggc tgtgctcctc cctaccccaa gcctgcactg gagggagatc tcaagtggaa
     1261 ggctggagct ggagtggcag cacccgtcac cttgggcagc tcaagagacc tgctaccagc
     1321 tccgctacac aggagaaggc catgaggact ggaaggtgct ggagccatct ctcggggccc
     1381 agggagggac cctagagctg cgccctcgag ctcgctacag cttgcagctg cgtgccaggc
     1441 ttaacggccc cacctaccaa ggtccctgga gtgcctggtc tcctccagct agggtgtcca
     1501 cgggctctga gactgcttgg atcaccttgg tgactgcttt gctcctggtg ctgagcctca
     1561 gtgcccttct gggcctattg ctgctgaagt ggcaatttcc tgcgcactac agaagactga
     1621 ggcatgcttt gtggccctca cttcccgacc tacaccgggt cctaggccag taccttagag
     1681 acactgcagc cctaagtcct tctaaggcca cagttactga tagctgtgaa gaggtggagc
     1741 ccagcctcct ggaaatccta cctaagtctc cagagaggac tcctttgccc ctgtgtccct
     1801 cccagccaca gatggactac agaggactgc aaccttgcct gaggaccatg cccctgtctg
     1861 tgtgcccacc cacggctgag acggggtcct gctgtaccac acacattgcc aaccactcct
     1921 acctaccgct aagctattgg cagcagccct gaaggcagtc tgcatgccac ggcttcccgc
     1981 atcctacctt atccatcctt aaggccaaca aacaccaccc gttctgttta ccccacctcc
     2041 ttgggcttta taacacgatc tctccacacg gctgctcaca aatccagagc tctcttcacg
     2101 gtcacaaggc tctctggctt ttattttcat ttttttttct tttctttttt ttttcggagc
     2161 tggggaccga acccagggcc ttgcgcttct taggcaagcg ctctaccact gagctaaatc
     2221 cccagccctt attttcattt tttagacagt gttttattat ataactcggc ctataacttg
     2281 ctatgtagaa aagactggca cagagatctg cctgctgtga ttaaaggagc catgccctgt
     2341 agctcctcct gagatccaaa ctcttggggg tggggaaagt ctctacttcc tcccctccta
     2401 ccgactcttg agtacttcag tcccctacta tcatgctgtt aaggaaacgg tgcaagcctt
     2461 ctaattatga gatcaaattg ggtcttgctg ccttctattt attccagctc tcttggcatc
     2521 ctcctccacc ctgggtccca cagcatcacc ttccttcctg gctctgttcc tgcctctgag
     2581 cagcagaaga gccagctcag ggctagatcc aggttctggg cctgtcgtgc actcctgcta
     2641 gctgtgcact taggcaaata gtggaaagcc tttgagcctt tgtcctctca gctacacagc
     2701 atggatgaca acagaaccca cagagtggtg tgaacgattg acagcacatc ggctaagata
     2761 gagtcaatgc ttaatatacc tcaactagta tcccaattat ttcctctttt cctactccgg
     2821 cctttatcat acggtgacca tcagaaagtt ctcatctcca gcccagactt ctatagtgcc
     2881 cacagtgttt tgtgtggatt ttaacgtgtg tgattcttgc tcctggatgg tggcttgaag
     2941 gggccagggt taggatctgt cctccccccg gcaccctgaa taccatgtgg tgcatgaggt
     3001 agcggacctt caataaatac cgtctgagtc atg
//
