LOCUS       NM_001004081            1420 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Rattus norvegicus mannose phosphate isomerase (Mpi), mRNA.
ACCESSION   NM_001004081 XM_217168
VERSION     NM_001004081.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Harada,Y., Nakajima,K., Masahara-Negishi,Y., Freeze,H.H.,
            Angata,T., Taniguchi,N. and Suzuki,T.
  TITLE     Metabolically programmed quality control system for dolichol-linked
            oligosaccharides
  JOURNAL   Proc Natl Acad Sci U S A 110 (48), 19366-19371 (2013)
   PUBMED   24218558
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   DeRossi,C., Bode,L., Eklund,E.A., Zhang,F., Davis,J.A.,
            Westphal,V., Wang,L., Borowsky,A.D. and Freeze,H.H.
  TITLE     Ablation of mouse phosphomannose isomerase (Mpi) causes mannose
            6-phosphate accumulation, toxicity, and embryonic lethality
  JOURNAL   J Biol Chem 281 (9), 5916-5927 (2006)
   PUBMED   16339137
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Niehues,R., Hasilik,M., Alton,G., Korner,C., Schiebe-Sukumar,M.,
            Koch,H.G., Zimmer,K.P., Wu,R., Harms,E., Reiter,K., von Figura,K.,
            Freeze,H.H., Harms,H.K. and Marquardt,T.
  TITLE     Carbohydrate-deficient glycoprotein syndrome type Ib.
            Phosphomannose isomerase deficiency and mannose therapy
  JOURNAL   J Clin Invest 101 (7), 1414-1420 (1998)
   PUBMED   9525984
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Otto,J. and von Deimling,O.H.
  TITLE     Esterase-17 (ES-17): characterization and genetic location on
            chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of
            the house mouse (Mus musculus)
  JOURNAL   Biochem Genet 21 (1-2), 37-48 (1983)
   PUBMED   6838491
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Schafer,R., Doehmer,J., Rademacher,I. and Willecke,K.
  TITLE     Assignment of the gene for cytoplasmic glutamate-oxaloacetate
            transaminase to mouse chromosome 19 using chinese hamster x mouse
            somatic cell hybrids
  JOURNAL   Somatic Cell Genet 6 (6), 709-717 (1980)
   PUBMED   7444718
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Kozak,C., Nichols,E. and Ruddle,F.H.
  TITLE     Gene linkage analysis in the mouse by somatic cell hybridization:
            assignment of adenine phosphoribosyltransferase to chromosome 8 and
            alpha-galactosidase to the X chromosome
  JOURNAL   Somatic Cell Genet 1 (4), 371-382 (1975)
   PUBMED   1235912
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Nichols,E.A., Chapman,V.M. and Ruddle,F.H.
  TITLE     Polymorphism and linkage for mannosephosphate isomerase in Mus
            musculus
  JOURNAL   Biochem Genet 8 (1), 47-53 (1973)
   PUBMED   4693062
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079111.1.
            
            On Sep 3, 2004 this sequence version replaced XM_217168.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079111.1, SRR8487226.156089.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1420
                     /gene="Mpi"
                     /note="mannose phosphate isomerase"
                     /db_xref="GeneID:300741"
                     /db_xref="RGD:3107"
     exon            1..26
                     /gene="Mpi"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1282
                     /gene="Mpi"
                     /EC_number="5.3.1.8"
                     /note="PMI; phosphohexomutase; phosphomannose isomerase"
                     /codon_start=1
                     /product="mannose-6-phosphate isomerase"
                     /protein_id="NP_001004081.1"
                     /db_xref="GeneID:300741"
                     /db_xref="RGD:3107"
                     /translation="MANPRVFPLSCVVQQYAWGKVGSKSEVACLLACSDPLTQISEDK
                     PYAELWMGAHPRGDAKILDNRISQKTLGQWIAENQNSLGQKVKDTFNGKLPFLFKVLS
                     VETALSIQAHPNKELAEKLHLQAPEHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTF
                     LKKVPEFQSLIGEDATAQLKKSMNEGSGAMASALKNCFSHLMKSEKKVVVEQLNLLVK
                     RISQQISNGNSMDDICGELLLQLHQQYPGDIGCFAIYLLNLITLKPGEAMFLEANVPH
                     AYLKGDCVECMACSDNTVRAGLTPKFIDVSTLCEMLDYTPSPSKDRLFAPTLSQDDPY
                     LSIYDPPVPDFTVMKIEVPGSVTEYKVLTLDSASILLLVQGTVTAIIPSVQGEIPLSR
                     GGVLFIGANETVLLKLTVPKNLLIFRACCLL"
     exon            27..154
                     /gene="Mpi"
                     /inference="alignment:Splign:2.1.0"
     exon            155..355
                     /gene="Mpi"
                     /inference="alignment:Splign:2.1.0"
     exon            356..497
                     /gene="Mpi"
                     /inference="alignment:Splign:2.1.0"
     exon            498..680
                     /gene="Mpi"
                     /inference="alignment:Splign:2.1.0"
     exon            681..854
                     /gene="Mpi"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1063
                     /gene="Mpi"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1397
                     /gene="Mpi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaactagg atggcgaatc cgcgagtgtt cccactttcc tgtgtggtgc agcagtatgc
       61 ctgggggaag gtgggctcca aaagtgaagt ggcatgccta ctggcttgca gtgacccact
      121 gacccagatc tcagaggaca agccttatgc ggagctgtgg atgggggcac acccccgggg
      181 agatgccaag atccttgaca accgtatttc ccaaaagacc ttaggccagt ggattgctga
      241 gaaccagaac agcttaggcc aaaaggtcaa agacaccttt aacggaaagc tgcccttcct
      301 cttcaaagtg ctctcagtgg aaacggccct gtctatccag gcacacccta acaaggagct
      361 ggcagagaag ctgcaccttc aggctccaga gcactacccc gatgccaacc acaagccaga
      421 aatggccatt gcccttacac ccttccaagg cttgtgtggt ttccggccag tggaggagat
      481 tgtgaccttt ctgaagaagg tgcctgagtt ccagtcactg attggagagg atgccacagc
      541 acagctgaag aagagcatga atgagggttc tggggccatg gcctctgctc tgaagaactg
      601 cttttcccac ctgatgaaga gtgagaagaa ggtggtggtg gagcagctta acctgttggt
      661 gaaacggatc tcccagcaaa tatctaacgg aaacagcatg gatgacattt gtggggagct
      721 cttgctacag ctgcaccagc agtacccggg tgatatcgga tgtttcgcca tctacctcct
      781 gaacctgatc accttgaagc ctggggaagc catgtttctg gaggccaacg tgccccatgc
      841 ctacctgaag ggagactgcg tggaatgcat ggcatgttca gacaataccg tgcgtgctgg
      901 cctgacaccc aaattcattg atgtgtcaac cctgtgtgaa atgctcgact acacacctag
      961 ccccagcaaa gacagactgt ttgcaccaac actgagtcaa gatgacccct acctctctat
     1021 ctacgatccc cctgtgccag acttcacagt tatgaagata gaggtccctg gctccgtcac
     1081 tgaatacaaa gtcttgacac tagactctgc cagcatcctt ctgttggtcc aagggacagt
     1141 gacagctatc ataccttcag tccaaggaga aatccctctg tcccgtggtg gagtgctctt
     1201 cattggggcc aatgagactg tcttactgaa gcttaccgta ccaaagaatc tgctgatatt
     1261 ccgggcctgc tgtctgctgt agagaccagt tcttagtctc tctgcctagc actatattct
     1321 ggccagctcc acatcctgga gatccagccc aatccctgtc cctattgtgc aatctttgaa
     1381 tacatactgg attagaaaaa aaaaaaaaaa aaaaaaaaaa
//
