LOCUS       NM_012601               1043 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus N-methylpurine-DNA glycosylase (Mpg), mRNA.
ACCESSION   NM_012601
VERSION     NM_012601.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1043)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   2  (bases 1 to 1043)
  AUTHORS   Ham,A.J., Engelward,B.P., Koc,H., Sangaiah,R., Meira,L.B.,
            Samson,L.D. and Swenberg,J.A.
  TITLE     New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice
            are deficient in their ability to clear 1,N6-etheno-deoxyadenosine
            DNA lesions from lung and liver in vivo
  JOURNAL   DNA Repair (Amst) 3 (3), 257-265 (2004)
   PUBMED   15177041
REFERENCE   3  (bases 1 to 1043)
  AUTHORS   Hang,B., Singer,B., Margison,G.P. and Elder,R.H.
  TITLE     Targeted deletion of alkylpurine-DNA-N-glycosylase in mice
            eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of
            3,N4-ethenocytosine or 8-oxoguanine
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 12869-12874 (1997)
   PUBMED   9371767
REFERENCE   4  (bases 1 to 1043)
  AUTHORS   Engelward,B.P., Boosalis,M.S., Chen,B.J., Deng,Z., Siciliano,M.J.
            and Samson,L.D.
  TITLE     Cloning and characterization of a mouse
            3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase
            cDNA whose gene maps to chromosome 11
  JOURNAL   Carcinogenesis 14 (2), 175-181 (1993)
   PUBMED   8435858
REFERENCE   5  (bases 1 to 1043)
  AUTHORS   O'Connor,T.R. and Laval,F.
  TITLE     Isolation and structure of a cDNA expressing a mammalian
            3-methyladenine-DNA glycosylase
  JOURNAL   EMBO J 9 (10), 3337-3342 (1990)
   PUBMED   1698614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096051.7, AW435341.1, CB765983.1 and AA899760.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_012601.3.
            
            On Oct 17, 2007 this sequence version replaced NM_012601.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X56420.1, FN804928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155318, SAMD00155330
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC096051.7         55780-55784
            6-530               AW435341.1         1-525
            531-657             CB765983.1         278-404
            658-1043            AA899760.1         1-386               c
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1043
                     /gene="Mpg"
                     /note="N-methylpurine-DNA glycosylase"
                     /db_xref="GeneID:24561"
                     /db_xref="RGD:3106"
     CDS             1..990
                     /gene="Mpg"
                     /EC_number="3.2.2.21"
                     /note="ADPG; 3-alkyladenine DNA glycosylase;
                     3-methyladenine DNA glycosidase; N-methylpurine-DNA
                     glycocylase"
                     /codon_start=1
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="NP_036733.2"
                     /db_xref="GeneID:24561"
                     /db_xref="RGD:3106"
                     /translation="MRGRGGTARLGRGSLKPVSVVLPDTEHPAFPGRTRRPGNARAGS
                     QVTGSREVGQMPAPLSRKIGQKKQQLAQSEQQQTPKERLSSTPGLLRSIYFSSPEDRP
                     ARLGPEYFDQPAVTLARAFLGQVLVRRLADGTELRGRIVETEAYLGPEDEAAHSRGGR
                     QTPRNRGMFMKPGTLYVYLIYGMYFCLNVSSQGAGACVLLRALEPLEGLETMRQLRNS
                     LRKSTVGRSLKDRELCNGPSKLCQALAIDKSFDQRDLAQDEAVWLEHGPLESSSPAVV
                     AAARIGIGHAGEWTQKPLRFYVQGSPWVSVVDRVAEQMYQPQQTACSDCSKVK"
     exon            1..174
                     /gene="Mpg"
                     /inference="alignment:Splign:2.1.0"
     exon            175..372
                     /gene="Mpg"
                     /inference="alignment:Splign:2.1.0"
     exon            373..577
                     /gene="Mpg"
                     /inference="alignment:Splign:2.1.0"
     exon            578..1027
                     /gene="Mpg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgcggcc gcggtggtac tgcgcgcctg ggcagaggat ccctaaaacc ggtgtccgtg
       61 gtgctccccg acaccgagca ccctgcattt cctggacgaa cccgccgccc agggaatgcc
      121 agagcaggat cccaagtgac cggatctcgt gaggtcggcc agatgccagc gccgctttca
      181 cgaaagatcg ggcaaaaaaa gcagcaactg gcacagtcag agcagcagca gacccctaag
      241 gagagactct cttcgacccc tggcctcctg cgaagtatct acttctcgag cccagaggac
      301 cgccctgccc ggctaggacc ggagtatttt gaccagcccg cagtcaccct agcccgtgca
      361 tttctgggac aggtccttgt ccggcgactt gctgatggaa cagaactccg tgggcgcatt
      421 gtagagactg aggcatactt ggggccagaa gacgaagctg cccactcaag gggtggccgg
      481 cagacccccc gtaaccgtgg catgttcatg aaacctggaa ctctgtacgt gtacctcatc
      541 tatggcatgt acttctgctt gaatgtctcc agtcaagggg ctggggcttg tgtcttgcta
      601 agagcactag agccattgga gggcctagag accatgcggc agcttcgaaa ctccctccgg
      661 aaaagcactg tcggccgttc cctcaaggac cgcgagctct gtaatggtcc ctccaaactg
      721 tgccaggccc tagccattga taagagcttt gaccagcgag acctggccca agatgaggct
      781 gtgtggctgg agcatggccc tctggagtcc agcagcccag ctgtggtggc ggcagcccgc
      841 ataggtattg gccatgcagg ggaatggaca cagaagccct tgcgcttcta tgtccagggc
      901 agcccatggg tcagtgtggt agatagagtg gctgaacaga tgtatcagcc tcagcaaaca
      961 gcgtgctctg attgttcaaa agtaaaataa ataacttgtt tgtagagaac tgtccaagtc
     1021 tcagccaaaa aaaaaaaaaa aaa
//
