LOCUS       NM_019196               7516 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus multiple PDZ domain crumbs cell polarity complex
            component (Mpdz), mRNA.
ACCESSION   NM_019196
VERSION     NM_019196.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7516)
  AUTHORS   Tanabe,Y., Fujita-Jimbo,E., Momoi,M.Y. and Momoi,T.
  TITLE     CASPR2 forms a complex with GPR37 via MUPP1 but not with
            GPR37(R558Q), an autism spectrum disorder-related mutation
  JOURNAL   J Neurochem 134 (4), 783-793 (2015)
   PUBMED   25977097
  REMARK    GeneRIF: In the dendrite and synapse, MUPP1 transports GPR37.
REFERENCE   2  (bases 1 to 7516)
  AUTHORS   Ozcelik,M., Cotter,L., Jacob,C., Pereira,J.A., Relvas,J.B.,
            Suter,U. and Tricaud,N.
  TITLE     Pals1 is a major regulator of the epithelial-like polarization and
            the extension of the myelin sheath in peripheral nerves
  JOURNAL   J Neurosci 30 (11), 4120-4131 (2010)
   PUBMED   20237282
REFERENCE   3  (bases 1 to 7516)
  AUTHORS   Ackermann,F., Zitranski,N., Borth,H., Buech,T., Gudermann,T. and
            Boekhoff,I.
  TITLE     CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in
            spermatozoa and prevents spontaneous acrosomal exocytosis
  JOURNAL   J Cell Sci 122 (Pt 24), 4547-4557 (2009)
   PUBMED   19934217
  REMARK    GeneRIF: CaMKIIalpha interacts with MUPP1 in spermatozoa to
            prevents spontaneous acrosomal exocytosis.
REFERENCE   4  (bases 1 to 7516)
  AUTHORS   Liew,C.W., Vockel,M., Glassmeier,G., Brandner,J.M.,
            Fernandez-Ballester,G.J., Schwarz,J.R., Schulz,S., Buck,F.,
            Serrano,L., Richter,D. and Kreienkamp,H.J.
  TITLE     Interaction of the human somatostatin receptor 3 with the multiple
            PDZ domain protein MUPP1 enables somatostatin to control
            permeability of epithelial tight junctions
  JOURNAL   FEBS Lett 583 (1), 49-54 (2009)
   PUBMED   19071123
REFERENCE   5  (bases 1 to 7516)
  AUTHORS   Rama,S., Krapivinsky,G., Clapham,D.E. and Medina,I.
  TITLE     The MUPP1-SynGAPalpha protein complex does not mediate
            activity-induced LTP
  JOURNAL   Mol Cell Neurosci 38 (2), 183-188 (2008)
   PUBMED   18417361
  REMARK    GeneRIF: MUPP1-SynGAPalpha complex dissociation triggers a
            mechanism for AMPAR enhancement that is distinct from
            activity-induced long term potentiation
REFERENCE   6  (bases 1 to 7516)
  AUTHORS   Kimber,W.A., Trinkle-Mulcahy,L., Cheung,P.C., Deak,M.,
            Marsden,L.J., Kieloch,A., Watt,S., Javier,R.T., Gray,A.,
            Downes,C.P., Lucocq,J.M. and Alessi,D.R.
  TITLE     Evidence that the tandem-pleckstrin-homology-domain-containing
            protein TAPP1 interacts with Ptd(3,4)P2 and the
            multi-PDZ-domain-containing protein MUPP1 in vivo
  JOURNAL   Biochem J 361 (Pt 3), 525-536 (2002)
   PUBMED   11802782
REFERENCE   7  (bases 1 to 7516)
  AUTHORS   Hamazaki,Y., Itoh,M., Sasaki,H., Furuse,M. and Tsukita,S.
  TITLE     Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight
            junctions through its possible interaction with claudin-1 and
            junctional adhesion molecule
  JOURNAL   J Biol Chem 277 (1), 455-461 (2002)
   PUBMED   11689568
REFERENCE   8  (bases 1 to 7516)
  AUTHORS   Becamel,C., Figge,A., Poliak,S., Dumuis,A., Peles,E., Bockaert,J.,
            Lubbert,H. and Ullmer,C.
  TITLE     Interaction of serotonin 5-hydroxytryptamine type 2C receptors with
            PDZ10 of the multi-PDZ domain protein MUPP1
  JOURNAL   J Biol Chem 276 (16), 12974-12982 (2001)
   PUBMED   11150294
REFERENCE   9  (bases 1 to 7516)
  AUTHORS   Lee,S.S., Glaunsinger,B., Mantovani,F., Banks,L. and Javier,R.T.
  TITLE     Multi-PDZ domain protein MUPP1 is a cellular target for both
            adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6
            oncoproteins
  JOURNAL   J Virol 74 (20), 9680-9693 (2000)
   PUBMED   11000240
REFERENCE   10 (bases 1 to 7516)
  AUTHORS   Ullmer,C., Schmuck,K., Figge,A. and Lubbert,H.
  TITLE     Cloning and characterization of MUPP1, a novel PDZ domain protein
  JOURNAL   FEBS Lett 424 (1-2), 63-68 (1998)
   PUBMED   9537516
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ001320.1.
            
            [WARNING] On Apr 24, 2024 this sequence was replaced by
            NM_019196.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001320.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..7516
                     /gene="Mpdz"
                     /note="multiple PDZ domain crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:29365"
                     /db_xref="RGD:3105"
     exon            1..130
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            131..199
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..6348
                     /gene="Mpdz"
                     /note="multi-PDZ domain protein 1"
                     /codon_start=1
                     /product="multiple PDZ domain protein"
                     /protein_id="NP_062069.1"
                     /db_xref="GeneID:29365"
                     /db_xref="RGD:3105"
                     /translation="MLETIDKNRALQAAERLQSKLKERGDVANEDKLSLLKSVLQSPL
                     FSQILSLQTSLQQLKDQVNVATLATANADHAHTPQFSSAIISNLQSESLLLSPSNGNL
                     EAISGPGAPPAMDGKPACEELDQLIKSMAQGRHVEIFELLKPPCGGLGFSVVGLRSEN
                     RGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQVLDQTITHQQAISILQKAKDTIQ
                     LVIARGSLPHISSPRISRSPSAASTVSAHSNPTHWQHVETIELVNDGSGLGFGIIGGK
                     ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI
                     ARGAVEETPAPSSLGITLSSSTSTSEMRVDASTQKNEESETFDVELTKNVQGLGITIA
                     GYIGDKKLEPSGIFVKSITKSSAVELDGRIQIGDQIVAVDGTNLQGFTNQQAVEVLRH
                     TGQTVRLTLMRKGASQEAEITSREDTAKDVDLPAENYEKDEESLSLKRSTSILPIEEE
                     GYPLLSTELEETEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVG
                     HHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCCR
                     RTVPPTALSEVDSLDIHDLELTEKPHIDLGEFIGSSETEDPMLAMSDVDQNAEEIQTP
                     LAMWEAGIQAIELEKGSRGLGFSILDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPG
                     DRLMFVNDINLENSTLEEAVEALKGAPSGMVRIGVAKPLPLSPEEGYVSAKEDTFLCS
                     PHTCKEMGLSDKALFRADLALIDTPDAESVAESRFESQFSPDNDSVYSTQASVLSLHD
                     GACSDGMNYGPSLPSSPPKDVTNSSDLVLGLHLSLEELYTQNLLQRQHAGSPPTDMSP
                     AATSGFTVSDYTPANAVEQKYECANTVAWTPSQLPSGLSTTELAPALPAVAPKYLTEQ
                     SSLVSDAESVTLQSMSQEAFERTVTIAKGSSSLGMTVSANKDGLGVIVRSIIHGGAIS
                     RDGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFRVSF
                     GQQAGGIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAYSSWSQPRRVELWREPS
                     KSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLR
                     DASHEQAVEAIRKAGSPVVFMVQSIVNRPRKSPLPSLPHSLYPKCSFSSTNPFAESLQ
                     LTSDKAPSQSESESEKATLCSVPSSSPSVFSEMSSDYAQPSATTVAEDEDKEDEFGYS
                     WKNIQERYGTLTGQLHMIELEKGHSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRDGR
                     LQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGSAADP
                     LPSTSESPQNKEVEPSITTSASAVDLSSLTNVYHLELPKDQGGLGIAICEEDTLNGVT
                     IKSLTERGGAAKDGRLKPGDRILAVDDELVAGCPIEKFISLLKTAKTTVKLTVGAENP
                     GCQAVPSAAVTASGERKDSSQTPAVPAPDLEPIPSTSRSSTPAIFASDPATCPIIPGC
                     ETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID
                     LRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEDVCDTFTVELQKRPGKGLGLSIVG
                     KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVT
                     LEVGRIKAAPFHSERRPSQSSQVSESSLSSFSLPRSGIHTSESSESSAKKNALASEIQ
                     GLRTVEIKKGPADALGLSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLRVGDRIVTI
                     CGTSTDGMTHTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAFTGLTSST
                     IFPDDLGPPQSKTITLDRGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAAEDGRLK
                     RGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS"
     exon            200..366
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            367..579
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            580..719
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            720..933
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1062
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1269
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1384
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1473
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1636
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1708
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1815
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1962
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2127
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2313
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2523
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2640
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2808
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..3084
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3199
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3398
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3503
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3596
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3774
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            3775..3885
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..3984
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            3985..4147
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            4148..4344
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            4345..4436
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4527
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4608
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            4609..4701
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            4702..4776
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            4777..4942
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            4943..5088
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            5089..5172
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            5173..5366
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            5367..5514
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            5515..5601
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            5602..5692
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            5693..5736
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            5737..5859
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            5860..5964
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            5965..6077
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            6078..6201
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
     exon            6202..7500
                     /gene="Mpdz"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcgggct ccagttccct ggctacgcgt gagcgttccc gccacaccga gctcttgggg
       61 ccgtggttaa agcggagagg agccgagcgc tctacccacc ctgggagtct cctccaggcc
      121 ggcgagcagg agtctccttt tagttggtgt ttggcatcat tatagtttgg catcttgaag
      181 aagatgttgg aaaccataga caaaaaccgg gccctgcagg cagcagagcg cttgcaaagc
      241 aagctgaagg aacgcgggga tgttgcaaat gaagacaaat tgagcctcct gaagtctgtc
      301 ctgcagagtc cactcttcag tcagatcctg agccttcaga cttctctaca gcagctgaaa
      361 gaccaggtaa acgttgctac tttggcaact gcaaatgctg accatgccca cacaccgcag
      421 ttcagctctg ccatcatctc taatctgcaa agtgagtcac ttttgctgtc tccaagtaat
      481 gggaacctcg aagcaatttc tggacctggt gctccacctg ccatggatgg aaagcctgcc
      541 tgtgaagaac ttgatcagct catcaaaagt atggcccagg gtcgccatgt ggaaatattt
      601 gagctcctca aacctccatg tggaggcctc ggcttcagtg tcgttgggct cagaagtgaa
      661 aacaggggag agctggggat ttttgttcag gagattcaag agggcagtgt ggctcacaga
      721 gatggcagac ttaaggagac tgaccagatc cttgccatta atggccaggt cctagatcag
      781 acgatcacac accagcaggc catcagcatc ctgcagaagg ccaaagacac tatacagctt
      841 gttattgcca gggggtcttt gccgcatatc tccagcccac gaatttcccg ttctccatct
      901 gcagccagca cagtttcagc ccactcgaat ccaactcact ggcagcatgt ggaaactatc
      961 gaacttgtga atgatgggtc tggtctggga tttggcatca taggaggaaa agcaactggt
     1021 gtgatagtca agacaatttt gcctggagga gtagctgacc agcatggtcg actatgcagt
     1081 ggagaccaca ttctgaagat tggtgacacg gacctagcag ggatgagcag tgagcaagta
     1141 gcacaagtcc tcaggcagtg tggaaacaga gttaaactga tgattgccag aggcgctgta
     1201 gaagaaactc cagcaccttc ctctttgggc atcaccctct cctcttccac atctacttca
     1261 gagatgcgag ttgatgcttc tactcagaaa aatgaagaaa gtgagacgtt cgatgtggaa
     1321 ctcactaaaa atgtccaagg attaggaatt accattgctg gctatattgg agataaaaaa
     1381 ttagagcctt caggaatctt tgtaaagagc attacaaaga gcagtgctgt ggagcttgat
     1441 ggaagaatcc agattggaga ccaaattgta gcagtcgatg gcaccaacct tcagggtttt
     1501 accaatcaac aagcagtaga ggtgttacgt cacacgggac agacagtgcg tctgacactg
     1561 atgaggaagg gagccagcca ggaagcagag attacgtcaa gagaagacac cgcaaaagat
     1621 gtggacctcc cagctgaaaa ttatgaaaaa gatgaagagt ctttgtcact gaagagaagt
     1681 accagcatac tgccgattga agaggaagga tatccactgt tgtcaactga gctggaagaa
     1741 actgaagatg tgcagcaaga agctgccttg ctgacaaagt ggcagaggat tatgggaatt
     1801 aactatgaaa tagtggtggc tcatgtgagc aagtttagtg agaacagtgg gctgggaata
     1861 agtctggaag caacagtggg ccaccacttc atccggtctg tgctaccaga aggccctgtg
     1921 ggacacagcg ggaagctctt cagtggagat gagctattgg aagtcaatgg tataaatttg
     1981 cttggggaaa accatcaaga tgtggtcaat attttaaaag aacttcctat cgatgtgaca
     2041 atggtatgtt gccgtcggac tgtgccaccg accgccctgt cagaagtgga tagcctggac
     2101 atacatgatc ttgaactaac agagaagcct catatagacc taggagagtt cattggatcc
     2161 tcggagacag aggatcccat gctggcgatg tccgatgtgg atcagaatgc cgaggagatt
     2221 cagaccccgc tggccatgtg ggaggcaggc attcaggcca tagagctgga gaaagggagc
     2281 aggggcctgg gcttcagcat cttagactac caggacccca tcgatccagc aaacacagta
     2341 atagtcattc gttctctggt gcctggcggc attgctgaaa aggatggacg gctttttcca
     2401 ggagacaggc tcatgtttgt caatgacatt aacctggaaa acagcactct ggaagaggcc
     2461 gtggaagcct tgaagggagc gccctcaggg atggtgcgta taggagtagc caagcctttg
     2521 cctctttcac cagaagaagg gtatgtttct gccaaggaag acacttttct ctgctcaccg
     2581 cacacctgca aggagatggg cctgtctgac aaagccctct tcagggctga cttggctctg
     2641 atagatacac ctgatgctga gtccgtagca gaatcaagat ttgagtctca gttctctcct
     2701 gataacgaca gtgtctactc tacacaagcc tctgtcttat ctcttcatga tggtgcttgt
     2761 agtgatggca tgaactacgg cccctctctg ccctcatctc ctcccaagga cgtgaccaac
     2821 agttctgacc tagtgctcgg tctgcatttg tccctggaag aactctacac acagaacctc
     2881 cttcagagac agcatgctgg ctctcctccc acagacatga gcccagcagc cacctctggt
     2941 ttcaccgtca gtgactacac acctgcaaat gctgttgaac aaaaatatga gtgtgcaaac
     3001 acagtagcgt ggactccctc gcagttgcca agtggcctaa gcaccacaga gctcgctcct
     3061 gcactgcctg ctgtggctcc gaagtattta acagagcaga gctctctggt gtctgatgct
     3121 gagtctgtca ccctgcagag catgtcccag gaagcctttg agaggacggt tactatagca
     3181 aaaggcagct ccagtctagg catgacagta agtgctaata aagatggcct gggagtgatt
     3241 gtgcgaagca ttattcacgg aggcgccatt agtcgggatg gccgaattgc tgttggtgac
     3301 tgcattttgt ccattaatga agaatccacc atcagtttaa ccaatgccca ggcacgggcc
     3361 atgctgagaa gacattctct aattggacct gacataaaaa ttacttacgt gcctgcagaa
     3421 catttggaag agttcagagt aagttttggt caacaagccg gaggaataat ggcactggat
     3481 attttttctt catacactgg cagagatatt ccagaactcc cagagcgaga agaaggagaa
     3541 ggggaagaaa gtgaactgca gaatgctgct tatagcagct ggagccagcc ccggagggtg
     3601 gaactttgga gagagcccag caagtccttg ggcatcagca ttgttggtgg tcgggggatg
     3661 gggagccggc tgagcaacgg cgaggtgatg aggggcatct tcattaaaca tgttcttgaa
     3721 gacagtccag ctggcaaaaa tggaactttg aagccgggag acagaatagt tgaggtggat
     3781 gggatggacc tcagagatgc aagccatgaa caagctgtgg aagccattcg gaaagcaggc
     3841 agccctgtag tgtttatggt acagagcatt gtaaacagac caaggaaatc ccctttgcct
     3901 tccttgccgc acagccttta ccctaagtgc agcttcagca gcactaaccc atttgcagag
     3961 tctctccagc tcacctctga caaggcaccc agccagtcag aatccgagtc ggagaaggcc
     4021 acattgtgca gtgtcccttc ctcctctcct tcagtgttct cagaaatgag cagtgattat
     4081 gcacagccat ctgcaaccac agtcgcagaa gatgaggaca aagaggatga gtttgggtac
     4141 agctggaaaa atatccaaga gcgttatgga acccttacag gccagctcca tatgattgag
     4201 ctggagaaag gtcatagcgg tttgggtcta agtcttgctg ggaacaaaga ccgaaccaga
     4261 atgagtgtgt ttatagtggg gattgatcct actggagcag cagggagaga tggccgacta
     4321 cagattgccg acgagctttt agagatcaat ggccaaatat tatatggcag aagtcatcag
     4381 aatgcttcat caatcattaa atgtgctcca tctaaagtaa aaatcatttt tatcagaaat
     4441 gcagatgcag tgaatcagat ggctgtatgt ccaggaagtg cagcagaccc tctaccttct
     4501 acctcagaaa gtcctcaaaa taaggaggtg gaaccaagta ttactacatc tgcttcagct
     4561 gtggacctca gctcacttac aaatgtgtac catctggagc ttcccaagga tcaaggaggc
     4621 ttaggcattg ctatctgtga ggaagacaca ctcaatggag tcacgatcaa gagcctaact
     4681 gagcgtgggg gagcagccaa ggatggaagg ctcaaacctg gggatcgcat cttggctgta
     4741 gatgatgaac ttgttgctgg ctgtcctatt gaaaagttca tcagtcttct gaagacggca
     4801 aagacaactg taaaactgac tgttggagct gagaacccgg gctgtcaggc tgtcccttca
     4861 gcagctgtca cagccagcgg agaaaggaaa gacagctccc agacccctgc agtcccagct
     4921 ccagacctgg aacccattcc aagtacgagc aggtcatcca caccagcaat ttttgcttct
     4981 gaccctgcca cctgccccat catccctggc tgtgaaacaa caattgagat ttccaaaggc
     5041 caaacaggcc tgggactgag cattgtcggg gggtcagaca cgttgctggg tgctattatt
     5101 atccatgaag tttatgaaga gggagcagca tgtaaagatg gaagactgtg ggctggagac
     5161 cagattttag aggtaaatgg gattgacctg agaaaggcta cacatgatga agcaatcaat
     5221 gtcctgaggc agactccgca aagagtacgg ctgacgctct accgagatga ggccccatac
     5281 aaagaggagg atgtatgtga caccttcact gtcgagctgc agaagaggcc gggcaaaggc
     5341 cttgggttga gtattgttgg caaaagaaat gacactggag tgtttgtatc agacattgtt
     5401 aaaggaggca ttgcagacgc cgatgggaga ctgatgcaag gggaccagat tttaatggtg
     5461 aatggagaag atgtccgtaa tgccacccag gaagcagttg ctgccctgct caagtgttcc
     5521 ctaggcacag taaccctcga ggttggaaga atcaaagccg ctccattcca ctcagagagg
     5581 aggccttctc aaagcagtca ggtgagtgag agcagcctgt catccttcag tctcccacgt
     5641 tctggaatac atacatcaga atcgtcagaa agtagtgcca agaagaatgc gttagcatct
     5701 gaaattcagg gattaaggac agtcgaaata aaaaaggggc ctgctgacgc gctgggactc
     5761 agcattgccg gaggagtggg cagcccgctc ggcgacgtcc cgatatttat tgccatgatg
     5821 cacccaaatg gtgttgcagc tcaaacccaa aaactcagag ttggggatag gattgtcacc
     5881 atctgtggca catccactga tgggatgact cacacacagg cggttaactt gatgaaaaat
     5941 gcctcaggct ccattgaagt gcaggtggtt gctggaggag atgtgagtgt ggtcacgggt
     6001 catcagcaag agcttgccaa tccttgcctt gctttcactg ggctgacttc cagcactata
     6061 tttccggatg acttaggccc tccacagtct aagaccataa cactagaccg aggaccagat
     6121 ggcttaggct tcagcattgt aggtggctat ggcagccctc atggagactt accaatttat
     6181 gttaaaacag tgttcgcaaa gggagcagcg gcagaagatg ggcgtctaaa gaggggtgat
     6241 cagatcattg ctgtcaacgg gcaaagtcta gaaggcgtga cccatgaaga agctgttgcc
     6301 atccttaagc ggacaaaggg cactgtcacc ctcatggttc tctcttgaat tggctgtcag
     6361 agccgaagca gccagctacg tgcccacctc ctactgtaac ggagtggaac tgttcacatg
     6421 acctgttgat tggggaagac tacgcggggc cgagaaacac actgatttgt tcctaacaac
     6481 caaacagcat ttttccttta ccgtggcatt tcatagtctt atgctcaaac agaagggagg
     6541 tttgcagagg taaacctcag ttttatcttg aagatatcta acaatttata gtcatgtgga
     6601 cagaattatt gtatgctcat tttgttagta tggaaacaaa ataatgcaaa gttagccaag
     6661 ggagatggct tcagaaaaat taagataaaa ggtggaaatt tagaaaaaag aaggcagtct
     6721 tgagtcttat agaacttccc caatctagaa gtctacaaaa agaaaataaa gtgcccgcag
     6781 tactcttgaa tagtccactg ttttaaaatt gtgaacattg tgatgtactg gttctcctta
     6841 cctcttatgc gtattttttc tgctaaaatt gttcagcagt cttcataagc tttaaaaaga
     6901 aattgtgttt aatgcatatc tcagtgttct tttttagttt tgacctgcta tattttcatg
     6961 ttgttgtatg taaaataatg ttgctaccct gtgttggccg cagttcttct aagaaacatc
     7021 cactccacgt agtcatggaa gacagagaag aagcccagaa ccttctaatg ctgatttaac
     7081 ggactgatac aacgttgaaa acacgttcag taccatgcta ttgtttttac attagtatta
     7141 atcttaatga catagaaaaa gacaatgtgt tagtaattat tttggttgta tgccattagt
     7201 aaattgacag aaaaattaag ggggttaatg tgacttcatt tcactgctgt atattaacat
     7261 cttacaatac aatagtttaa gtctaaggga aacagatgga gctgtttacc gagcaactgg
     7321 tgaggaatta tgtgttcaat cccattttag agcgtgaaac tcctacatta gaatagataa
     7381 agtcacttta aatattatct atatttgtaa cagaagtcgt atacatatat tttattatag
     7441 cattcttgtg taaatgcaga attaaagtga ataaataagt tttttgtggt gtacagcaaa
     7501 aaaaaaaaaa aaaaaa
//
