LOCUS       NM_001322942             796 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus mitochondrial pyruvate carrier 2 (Mpc2),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001322942 XM_006250127
VERSION     NM_001322942.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 796)
  AUTHORS   Wang,Y., Liu,Y., Yuan,Y., Zhang,Y., Luo,Y., Han,S., Yan,Y.,
            Wang,Z., Liu,X. and Zhao,L.
  TITLE     Downregulation of mitochondrial pyruvate carrier 2 aggravates
            neuronal injury in the cortex following cerebral ischemia in rat
  JOURNAL   Brain Res Bull 185, 193-202 (2022)
   PUBMED   35580702
  REMARK    GeneRIF: Downregulation of mitochondrial pyruvate carrier 2
            aggravates neuronal injury in the cortex following cerebral
            ischemia in rat.
REFERENCE   2  (bases 1 to 796)
  AUTHORS   Vigueira,P.A., McCommis,K.S., Schweitzer,G.G., Remedi,M.S.,
            Chambers,K.T., Fu,X., McDonald,W.G., Cole,S.L., Colca,J.R.,
            Kletzien,R.F., Burgess,S.C. and Finck,B.N.
  TITLE     Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to
            defects in glucose-stimulated insulin secretion
  JOURNAL   Cell Rep 7 (6), 2042-2053 (2014)
   PUBMED   24910426
REFERENCE   3  (bases 1 to 796)
  AUTHORS   Bricker,D.K., Taylor,E.B., Schell,J.C., Orsak,T., Boutron,A.,
            Chen,Y.C., Cox,J.E., Cardon,C.M., Van Vranken,J.G., Dephoure,N.,
            Redin,C., Boudina,S., Gygi,S.P., Brivet,M., Thummel,C.S. and
            Rutter,J.
  TITLE     A mitochondrial pyruvate carrier required for pyruvate uptake in
            yeast, Drosophila, and humans
  JOURNAL   Science 337 (6090), 96-100 (2012)
   PUBMED   22628558
REFERENCE   4  (bases 1 to 796)
  AUTHORS   Herzig,S., Raemy,E., Montessuit,S., Veuthey,J.L., Zamboni,N.,
            Westermann,B., Kunji,E.R. and Martinou,J.C.
  TITLE     Identification and functional expression of the mitochondrial
            pyruvate carrier
  JOURNAL   Science 337 (6090), 93-96 (2012)
   PUBMED   22628554
REFERENCE   5  (bases 1 to 796)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 796)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 796)
  AUTHORS   Tsou,A.P., Lai,C., Danielson,P., Noonan,D.J. and Sutcliffe,J.G.
  TITLE     Structural characterization of a heterogeneous family of rat brain
            mRNAs
  JOURNAL   Mol Cell Biol 6 (3), 768-778 (1986)
   PUBMED   3022128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 15, 2016 this sequence version replaced XM_006250127.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE112736.1, FQ216993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               JAXUCZ010000013.1  80261256-80261610
            356-396             JAXUCZ010000013.1  80274112-80274152
            397-481             JAXUCZ010000013.1  80277481-80277565
            482-796             JAXUCZ010000013.1  80280354-80280668
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..796
                     /gene="Mpc2"
                     /gene_synonym="Brp44; RGD1563422; SLC54A2"
                     /note="mitochondrial pyruvate carrier 2"
                     /db_xref="GeneID:100359982"
                     /db_xref="RGD:1563422"
     exon            1..355
                     /gene="Mpc2"
                     /gene_synonym="Brp44; RGD1563422; SLC54A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..573
                     /gene="Mpc2"
                     /gene_synonym="Brp44; RGD1563422; SLC54A2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein 0-44; brain protein 44; solute carrier family 54
                     member 2"
                     /codon_start=1
                     /product="mitochondrial pyruvate carrier 2 isoform 2"
                     /protein_id="NP_001309871.1"
                     /db_xref="GeneID:100359982"
                     /db_xref="RGD:1563422"
                     /translation="MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFW
                     APIMKWGLVCAGLADMARPAEKLSTAQSTVLMATDIIKNSNLKESSKRVPDHLNILDV
                     DRNIET"
     exon            356..396
                     /gene="Mpc2"
                     /gene_synonym="Brp44; RGD1563422; SLC54A2"
                     /inference="alignment:Splign:2.1.0"
     exon            397..481
                     /gene="Mpc2"
                     /gene_synonym="Brp44; RGD1563422; SLC54A2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..796
                     /gene="Mpc2"
                     /gene_synonym="Brp44; RGD1563422; SLC54A2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccactcccg ctcgcagggg gcgggctggg gcgggctttt gctgagcctc caccccctca
       61 gccttctccg gactcggcct caaagtgctt cacctctggc tggcagagcc agggaagggc
      121 gccctagggc ggagacggac acctagcgct gtagagggaa agtgacgagc cgcccttcat
      181 tgtcagccag gaacgcggac acagcggcgc tcccacccag ctgcagtgga tccttaggcc
      241 gccgagatgg cagctgccgg cgcccgaggc ctgcgggcca cctaccaccg actcatggat
      301 aaagtggagt tgttgctgcc aaagaaattg aggccgctat acaaccaccc ggcaggcccc
      361 agaacagttt ttttctgggc tccgataatg aagtggggat tggtatgtgc tggattagct
      421 gacatggcca gacctgcaga gaaactcagc acagctcaat ccactgtgct gatggctaca
      481 gatataatca agaactcaaa tctaaaggaa tccagtaaga gagttcctga tcacctgaac
      541 attctagatg tggacagaaa cattgaaacc tagtgtattt gattactgat aaggtgatgc
      601 taatattctg ataacatttg aaaagaacga aaacaaaatc taactgtaat taatagctag
      661 cacttgactt cacaaaaaaa aaataaataa agcaaacttt tagtaacagt ctgtctttac
      721 atatgcctca aggaactgtg gatagcacca acgttgtttt ctaccctttg tccataataa
      781 atcctacttg gtcata
//
